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Apicomplexa micropore: history, function, and formation

Yang, Jiong; Long, Shaojun; Hide, Geoff; Lun, Zhao-Rong; Lai, De-Hua


Jiong Yang

Shaojun Long

Zhao-Rong Lun

De-Hua Lai


The micropore, a mysterious structure found in apicomplexan species, was recently shown to be essential for nutrient acquisition in Plasmodium falciparum and Toxoplasma gondii. However, the differences between the micropores of these two parasites questions the nature of a general apicomplexan micropore structure and whether the formation process model from Plasmodium can be applied to other apicomplexans. We analyzed the literature on different apicomplexan micropores and found that T. gondii probably harbors a more representative micropore type than the more widely studied ones in Plasmodium. Using recent knowledge of the Kelch 13 (K13) protein interactome and gene depletion phenotypes in the T. gondii micropore, we propose a model of micropore formation, thus enriching our wider understanding of micropore protein function. [Abstract copyright: Copyright © 2024 Elsevier Ltd. All rights reserved.]


Yang, J., Long, S., Hide, G., Lun, Z., & Lai, D. (2024). Apicomplexa micropore: history, function, and formation. Trends in Parasitology, 40(5), S1471-4922(24)00079-5.

Journal Article Type Article
Acceptance Date Mar 21, 2024
Online Publication Date Apr 17, 2024
Publication Date 2024-04
Deposit Date May 2, 2024
Publicly Available Date Apr 18, 2025
Journal Trends in parasitology
Print ISSN 1471-4922
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 40
Issue 5
Pages S1471-4922(24)00079-5
Keywords EPS15, Kelch 13, formation model, micropore, Apicomplexa