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24-hour blood response comparison between exergaming and aerobic exercise in type-1 diabetes: A randomised study.

de Brito-Gomes, Jorge Luiz; Martins Vancea, Denise Maria; Soltani, Pooya; Rodrigues Ramos Reis, Andressa; da Cunha Costa, Manoel

Authors

Jorge Luiz de Brito-Gomes

Denise Maria Martins Vancea

Pooya Soltani

Andressa Rodrigues Ramos Reis

Manoel da Cunha Costa



Abstract

Aims: Patients with type-1 diabetes mellitus (T1DM) need to maintain optimal lipid profiles, and manage inflammation and leukocyte levels. This requires a combination of insulin therapy, a balanced diet, reduced sedentary behaviour and regular exercise. Active video games (AVG) have been increasingly advocated as a motivating alternative to aerobic sessions (RUN). We aimed to compare the effects of AVG and RUN on blood responses in patients with T1DM.

Methods: We investigated these responses after a 24-hour period, using volume and intensity-matched sessions. We followed a sequential three-week protocol. Blood samples were taken after 24 h on day 2. During the second week, a randomised session (either AVG or RUN) occurred on day 3, followed by blood collection after 24 h (day 4). The same protocol was repeated in the third week. ANOVA, Fisher's test, effect size (ES), and minimal detectable differences (MDD) was performed.

Results: ANOVA and Fisher's tests showed similar biochemical parameters 24 h after AVG and RUN (p > 0.05, small to large ES). However, there was a clinically important increase in HDL levels after 24 h of exergame sessions (MDD = 4.1 mg/dL).

Conclusion: In summary, AVG and RUN showed similar effects on biochemical responses, with exergaming showing potential for enhancing HDL levels with clinical importance.

Journal Article Type Article
Acceptance Date Jul 23, 2025
Online Publication Date Aug 22, 2025
Deposit Date Aug 23, 2025
Publicly Available Date Aug 23, 2026
Journal Science & Sports
Print ISSN 0765-1597
Publisher Elsevier
Peer Reviewed Peer Reviewed
Pages 9
DOI https://doi.org/10.1016/j.scispo.2025.07.009
Keywords Video games, Diabetes mellitus, Blood chemical analysis, Exercise, Running
Publisher URL https://authors.elsevier.com/c/1ledZ2j~YXckg8