All Outputs (32)

The microRNA and p53 families join forces against cancer (2010)
Journal Article
Barlev, N., Sayan, B., Candi, E., & Okorokov, A. (2010). The microRNA and p53 families join forces against cancer. Cell Death and Differentiation, 17, 373-375. https://doi.org/10.1038/cdd.2009.73

The product of the TP53 gene, p53, is one of the most recognised and extensively studied molecules that protects multicellular organisms from cancer. The well-deserved fame of p53 stems from the nature of its function – to coordinate an appropriate c... Read More about The microRNA and p53 families join forces against cancer.

Induction of TAp63 by histone deacetylase inhibitors (2009)
Journal Article
Sayan, B., Yang, A., Conforti, F., Bernanrdini, S., Tucci, P., Vasa-Nicotera, M., …Melino, G. (2009). Induction of TAp63 by histone deacetylase inhibitors. Biochemical and Biophysical Research Communications, 391(4), https://doi.org/10.1016/j.bbrc.2009.12.147

TAp63 belongs to the p53-tumour suppressor family and is capable of transactivating a set of target genes to induce cell cycle arrest and apoptosis. We showed that treatment of cancer cells with chemo-therapeutic drugs or the histone deacetylase (HDA... Read More about Induction of TAp63 by histone deacetylase inhibitors.

Nuclear exclusion of p33ING1b tumor suppressor protein: explored in HCC cells using a new highly specific antibody (2009)
Journal Article
Sayan, B., Emre, N., Irmak, M., Ozturk, M., & Cetin-Atalay, R. (2009). Nuclear exclusion of p33ING1b tumor suppressor protein: explored in HCC cells using a new highly specific antibody. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, 28(1), 1-6. https://doi.org/10.1089/hyb.2008.0058

Mouse monoclonal antibodies (MAb) were generated against p33ING1b tumor suppressor protein. 15B9 MAb was highly specific in recognizing a single protein band of ∼33 kDa endogenous p33ING1b protein from HCC cell lines and normal liver tissue by Wester... Read More about Nuclear exclusion of p33ING1b tumor suppressor protein: explored in HCC cells using a new highly specific antibody.

p73 and caspase-cleaved p73 fragments localize to mitochondria and augment TRAIL-induced apoptosis (2008)
Journal Article
Sayan, A., Sayan, B., Gogvadze, V., Dinsdale, G., Nyman, U., Hansen, T., …Melino, G. (2008). p73 and caspase-cleaved p73 fragments localize to mitochondria and augment TRAIL-induced apoptosis. Oncogene, 27, 4363-4372. https://doi.org/10.1038/onc.2008.64

The p73 protein, a member of the p53 family, has both developmental and tumorigenic functions. Here we show that p73 is cleaved by caspase-3 and -8 both in vitro and in vivo during apoptosis elicited by DNA-damaging drugs and tumor necrosis factor-re... Read More about p73 and caspase-cleaved p73 fragments localize to mitochondria and augment TRAIL-induced apoptosis.

Cleavage of the transactivation-inhibitory domain of p63 by caspases enhances apoptosis (2007)
Journal Article
Sayan, B., Sayan, A., Ying, A., Aqeilan, R., Candi, E., Cohen, G., …Melino, G. (2007). Cleavage of the transactivation-inhibitory domain of p63 by caspases enhances apoptosis. Proceedings of the National Academy of Sciences of the United States of America, 104(26), 10871-10876. https://doi.org/10.1073/pnas.0700761104

p63 is a p53-related transcription factor. Utilization of two different promoters and alternative splicing at the C terminus lead to generation of six isoforms. The α isoforms of TAp63 and ΔNp63 contain a transactivation-inhibitory (TI) domain at the... Read More about Cleavage of the transactivation-inhibitory domain of p63 by caspases enhances apoptosis.

Generation of ΔTAp73 proteins by translation from a putative internal ribosome entry site (2007)
Journal Article
Sayan, A., Roperch, J., Sayan, B., Rossi, M., Pinkoski, M., Knight, R., …Melino, G. (2007). Generation of ΔTAp73 proteins by translation from a putative internal ribosome entry site. Annals of the New York Academy of Sciences, 1095(1), 315-324. https://doi.org/10.1196/annals.1397.035

p73 belongs to a family of transcription factors, including p53 and p63, that mediate response to DNA damage and cellular stress by inducing DNA repair, cell cycle arrest, and apoptosis. TP73 gene contains two promotors and several splice variants re... Read More about Generation of ΔTAp73 proteins by translation from a putative internal ribosome entry site.

p63 is upstream of IKKα in epidermal development (2006)
Journal Article
Candi, E., Terrinoni, A., Rufini, A., Chikh, A., Lena, A., Suzuki, Y., …Melino, G. (2006). p63 is upstream of IKKα in epidermal development. Journal of Cell Science, 119(22), 4617-4622. https://doi.org/10.1242/jcs.03265

The epidermis, the outer layer of the skin composed of keratinocytes, develops following the action of the transcription factor p63. The mouse Trp63 gene contains two promoters, driving the production of distinct proteins, one with an N-terminal tran... Read More about p63 is upstream of IKKα in epidermal development.

p63 and p73, members of the p53 gene family, transactivate PKCδ (2006)
Journal Article
Ponassi, R., Terrinoni, A., Chikh, A., Rufini, A., Lena, A., Sayan, B., …Candi, E. (2006). p63 and p73, members of the p53 gene family, transactivate PKCδ. Biochemical Pharmacology, 72(11), 1417-1422. https://doi.org/10.1016/j.bcp.2006.07.031

The p53 family comprises three genes that encode for p53, p63 and p73. These genes have a significant degree of sequence homology, especially in the central sequence-specific DNA-binding domain. The high homology among the three DNA-binding domains i... Read More about p63 and p73, members of the p53 gene family, transactivate PKCδ.

p53 is cleaved by caspases generating fragments localizing to mitochondria (2006)
Journal Article
Sayan, B., Sayan, A., Knight, R., Melino, G., & Cohen, G. (2006). p53 is cleaved by caspases generating fragments localizing to mitochondria. Journal of Biological Chemistry, 281(19), 13566-13573. https://doi.org/10.1074/jbc.M512467200

The p53 tumor suppressor protein exerts most of its anti-tumorigenic activity by transcriptionally activating several pro-apoptotic genes. Accumulating evidence also suggests a transcription-independent function of p53 during apoptosis. It has recent... Read More about p53 is cleaved by caspases generating fragments localizing to mitochondria.

NAPO as a novel marker for apoptosis (2001)
Journal Article
Sayan, B., Ince, G., Sayan, A., & Ozturk, M. (2001). NAPO as a novel marker for apoptosis. Journal of Cell Biology, 155(5), 719-724. https://doi.org/10.1083/jcb.200106044

Apoptosis or programmed cell death plays a pivotal role in embryonic development and maintenance of homeostasis. It is also involved in the etiology of pathophysiological conditions such as cancer, neurodegenerative, autoimmune, infectious, and heart... Read More about NAPO as a novel marker for apoptosis.

Acquired expression of transcriptionally active p73 in hepatocellular carcinoma cells (2001)
Journal Article
Sayan, A., Sayan, B., Findikli, N., & Ozturk, M. (2001). Acquired expression of transcriptionally active p73 in hepatocellular carcinoma cells. Oncogene, 20, 5111-5117. https://doi.org/10.1038/sj.onc.1204669

p53 and p73 proteins activate similar target genes and induce apoptosis and cell cycle arrest. However, p53, but not p73 is considered a tumour-suppressor gene. Unlike p53, p73 deficiency in mice does not lead to a cancer-prone phenotype, and p73 gen... Read More about Acquired expression of transcriptionally active p73 in hepatocellular carcinoma cells.

A monoclonal antibody against DNA binding helix of p53 protein (2001)
Journal Article
Yolcu, E., Sayan, B., Yagci, T., Cetin-Atalay, R., Soussi, T., Yurdusev, N., & Ozturk, M. (2001). A monoclonal antibody against DNA binding helix of p53 protein. Oncogene, 20, 1398-1401. https://doi.org/10.1038/sj.onc.1204240

Three monoclonal antibodies (Mabs) were generated against p53 DNA-binding core domain. When tested by immunoprecipitation, Western blot and immunofluorescence techniques, Mab 9E4, as well as 7D3 and 6B10 reacted with both wild-type and various mutant... Read More about A monoclonal antibody against DNA binding helix of p53 protein.