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Pir2/Rnf144b is a potential endometrial cancer biomarker that promotes cell proliferation (2018)
Journal Article
Eldakhakhny, S., Zhou, Q., Conforti, F., Crosbie, E., Melino, G., & Sayan, B. (2018). Pir2/Rnf144b is a potential endometrial cancer biomarker that promotes cell proliferation. Cell Death and Disease, 9, https://doi.org/10.1038/s41419-018-0521-1

Endometrial cancer is one of the most common gynaecological cancers in developed countries. Its incidence has increased 20% over the last decade and the death rate has increased >100% over the past two decades. Current models for prediction of progno... Read More about Pir2/Rnf144b is a potential endometrial cancer biomarker that promotes cell proliferation.

Human papillomavirus E7 induces p63 expression to modulate DNA damage response (2018)
Journal Article
Eldakhakhny, S., Zhou, Q., Crosbie, E., & Sayan, B. (2018). Human papillomavirus E7 induces p63 expression to modulate DNA damage response. Cell Death and Disease, 9, https://doi.org/10.1038/s41419-017-0149-6

Cervical cancer is the third most common malignancy diagnosed in women worldwide. The major aetiological factor underlying the malignant transformation of cervical cells is the persistent infection with high-risk human papillomaviruses (HR-HPV), with... Read More about Human papillomavirus E7 induces p63 expression to modulate DNA damage response.

Urocortin suppresses endometrial cancer cell migration via CRFR2 and its system components are differentially modulated by estrogen (2017)
Journal Article
Owens, G., Lawrence, K., Jackson, T., Crosbie, E., Sayan, B., Kitchener, H., & Townsend, P. (2017). Urocortin suppresses endometrial cancer cell migration via CRFR2 and its system components are differentially modulated by estrogen. Cancer Medicine, 6(2), 408-415. https://doi.org/10.1002/cam4.967

Urocortin (UCN1) peptide shares structural and functional homology with corticotropin‐releasing factor (CRF). UCN1 is significantly reduced in endometrial adenocarcinoma compared to healthy controls. However, there are no data which evaluate the effe... Read More about Urocortin suppresses endometrial cancer cell migration via CRFR2 and its system components are differentially modulated by estrogen.

Urocortin - from Parkinson's disease to the skeleton (2014)
Journal Article
Lawrence, K., Jackson, T., Jamieson, D., Stevens, A., Owens, G., Sayan, B., …Townsend, P. (2014). Urocortin - from Parkinson's disease to the skeleton. International Journal of Biochemistry and Cell Biology, 60, 130-138. https://doi.org/10.1016/j.biocel.2014.12.005

Urocortin (Ucn 1), a 40 amino acid long peptide related to corticotropin releasing factor (CRF) was discovered 19 years ago, based on its sequence homology to the parent molecule. Its existence was inferred in the CNS because of anatomical and pharma... Read More about Urocortin - from Parkinson's disease to the skeleton.

p73 regulates serine biosynthesis in cancer (2013)
Journal Article
Amelio, I., Markert, E., Rufini, A., Antonov, A., Sayan, B., Tucci, P., …Melino, G. (2013). p73 regulates serine biosynthesis in cancer. Oncogene, 33, https://doi.org/10.1038/onc.2013.456

Activation of serine biosynthesis supports growth and proliferation of cancer cells. Human cancers often exhibit overexpression of phosphoglycerate dehydrogenase (PHGDH), the metabolic enzyme that catalyses the reaction that diverts serine biosynthes... Read More about p73 regulates serine biosynthesis in cancer.

Regulation of myocardial interleukin-6 expression by p53 and STAT1 (2013)
Journal Article
Carroll, C., Sayan, B., Bailey, S., & McCormick, J. (2013). Regulation of myocardial interleukin-6 expression by p53 and STAT1. Journal of Interferon and Cytokine Research, 33(9), https://doi.org/10.1089/jir.2012.0165

Cardiovascular diseases are a major cause of morbidity and mortality worldwide. The interferon inducible transcriptional activator signal transducer and activator of transcription-1 (STAT1) and p53 are two critical transcriptional factors that have p... Read More about Regulation of myocardial interleukin-6 expression by p53 and STAT1.

Pharmacoproteomic study of the natural product Ebenfuran III in DU-145 prostate cancer cells: The quantitative and temporal interrogation of chemically induced cell death at the protein level (2013)
Journal Article
Roumeltios, T., Halabalaki, M., Alexi, X., Ankrett, D., Giannopoulou, E., Sayan, B., & Skaltsounis, A. (2013). Pharmacoproteomic study of the natural product Ebenfuran III in DU-145 prostate cancer cells: The quantitative and temporal interrogation of chemically induced cell death at the protein level. Journal of Proteome Research, 12(4), 1591-1603. https://doi.org/10.1021/pr300968q

A naturally occurring benzofuran derivative, Ebenfuran III (Eb III), was investigated for its antiproliferative effects using the DU-145 prostate cell line. Eb III was isolated from Onobrychis ebenoides of the Leguminosae family, a plant endemic in C... Read More about Pharmacoproteomic study of the natural product Ebenfuran III in DU-145 prostate cancer cells: The quantitative and temporal interrogation of chemically induced cell death at the protein level.

PIR2/Rnf144B regulates epithelial homeostasis by mediating degradation of p21 WAF1 and p63 (2012)
Journal Article
Conforti, F., Yang, A., Piro, M., Mellone, M., Terrinoni, A., Candi, E., …Sayan, B. (2012). PIR2/Rnf144B regulates epithelial homeostasis by mediating degradation of p21 WAF1 and p63. Oncogene, 32, https://doi.org/10.1038/onc.2012.497

ΔNp63 is a transcription factor that is critical for the development of stratified epithelia and is overexpressed or amplified in >80% of squamous cell carcinomas (SCCs). We identified the RING finger E3 ubiquitin ligase PIR2/Rnf144b as a direct tran... Read More about PIR2/Rnf144B regulates epithelial homeostasis by mediating degradation of p21 WAF1 and p63.

Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer (2012)
Journal Article
Tucci, P., Agostini, M., Grespi, F., Merkert, E., Terrinoni, A., Vousden, K., …Sayan, B. (2012). Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer. Proceedings of the National Academy of Sciences, 109(38), https://doi.org/10.1073/pnas.1110977109

p63 inhibits metastasis. Here, we show that p63 (both TAp63 and ΔNp63 isoforms) regulates expression of miR-205 in prostate cancer (PCa) cells, and miR-205 is essential for the inhibitory effects of p63 on markers of epithelial–mesenchymal transition... Read More about Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer.

Apoptin induces apoptosis by changing the equilibrium between the stability of TAp73 and DNp73 isoforms through ubiquitin ligase PIR2 (2012)
Journal Article
Taebunpakul, P., Sayan, B., Flinterman, M., Klanrit, P., Gaken, J., Odell, E., …Tavassoli, M. (2012). Apoptin induces apoptosis by changing the equilibrium between the stability of TAp73 and DNp73 isoforms through ubiquitin ligase PIR2. Apoptosis, 17, https://doi.org/10.1007/s10495-012-0720-7

Apoptin, a protein derived from the chicken anaemia virus, induces cell death in various cancer cells but shows little or no cytotoxicity in normal cells. The mechanism of apoptin-induced cell death is currently unknown but it appears to induce apopt... Read More about Apoptin induces apoptosis by changing the equilibrium between the stability of TAp73 and DNp73 isoforms through ubiquitin ligase PIR2.

Regulation of p73 activity by post-translational modifications (2012)
Journal Article
Conforti, F., Sayan, A., Sreekamur, R., & Sayan, B. (2012). Regulation of p73 activity by post-translational modifications. Cell Death and Disease, 3, https://doi.org/10.1038/cddis.2012.27

The transcription factor p73 is a member of the p53 family that can be expressed as at least 24 different isoforms with pro- or anti-apoptotic attributes. The TAp73 isoforms are expressed from an upstream promoter and are regarded as bona fide tumor... Read More about Regulation of p73 activity by post-translational modifications.

Relative expression of TAp73 and ΔNp73 isoforms (2012)
Journal Article
Conforti, F., Yang, A., Agostini, M., Rufini, A., Tucci, P., Nicklison-Chirou, M., …Sayan, B. (2012). Relative expression of TAp73 and ΔNp73 isoforms. Aging, 4(3), https://doi.org/10.18632/aging.100441

The transcription factor p73 belongs to the p53 family of tumour suppressors and similar to other family members, transcribed as different isoforms with opposing pro- and anti-apoptotic functions. Unlike p53, p73 mutations are extremely rare in cance... Read More about Relative expression of TAp73 and ΔNp73 isoforms.

Neuronal differentiation by TAp73 is mediated by microRNA-34a regulation of synaptic protein targets (2011)
Journal Article
Agostini, M., Tucci, P., Killick, R., Candi, E., & Sayan, B. (2011). Neuronal differentiation by TAp73 is mediated by microRNA-34a regulation of synaptic protein targets. Proceedings of the National Academy of Sciences, 108(52), https://doi.org/10.1073/pnas.1112061109

The p53-family member TAp73 is a transcription factor that plays a key role in many biological processes. Here, we show that p73 drives the expression of microRNA (miR)-34a, but not miR-34b and -c, by acting on specific binding sites on the miR-34a p... Read More about Neuronal differentiation by TAp73 is mediated by microRNA-34a regulation of synaptic protein targets.

MicroRNA control of invasion and metastasis pathways (2011)
Journal Article
Sreekumar, R., Sayan, B., Mirnezami, A., & Sayan, A. (2011). MicroRNA control of invasion and metastasis pathways. Frontiers in Genetics, 2, https://doi.org/10.3389/fgene.2011.00058

Despite recent advances, cancer remains a leading cause of death worldwide. In developed countries, the incidence of colorectal and breast cancer has been stable, but no improvement in prognosis has been observed if the patient presents with metastas... Read More about MicroRNA control of invasion and metastasis pathways.

P73 regulates cisplatin-induced apoptosis in ovarian cancer cells via a calcium/calpain-dependent mechanism (2011)
Journal Article
Al-Bahlani, S., Fraser, M., Wong, A., Sayan, B., Bergeron, R., Melino, G., & Tsang, B. (2011). P73 regulates cisplatin-induced apoptosis in ovarian cancer cells via a calcium/calpain-dependent mechanism. Oncogene, 30, https://doi.org/10.1038/onc.2011.134

P73 is important in drug-induced apoptosis in some cancer cells, yet its role in the regulation of chemosensitivity in ovarian cancer (OVCA) is poorly understood. Furthermore, if and how the deregulation of p73-mediated apoptosis confers resistance t... Read More about P73 regulates cisplatin-induced apoptosis in ovarian cancer cells via a calcium/calpain-dependent mechanism.

P73 in cancer (2011)
Journal Article
Rufini, A., Agostini, M., Grespi, F., Tomasini, R., & Sayan, B. (2011). P73 in cancer. Genes and Cancer, 2(4), 491-502. https://doi.org/10.1177/1947601911408890

p73 is a tumor suppressor belonging to the p53 family of transcription factors. Distinct isoforms are transcribed from the p73 locus. The use of 2 promoters at the N-terminus allows the expression of an isoform containing (TAp73) or not containing (Δ... Read More about P73 in cancer.

p73: a multifunctional protein in neurobiology (2011)
Journal Article
Killick, R., Niklison-Chirou, M., Tomasini, R., Bano, D., Rufini, A., Grespi, F., …et, A. (2011). p73: a multifunctional protein in neurobiology. Molecular Neurobiology, 43, 139-146. https://doi.org/10.1007/s12035-011-8172-6

p73, a transcription factor of the p53 family, plays a key role in many biological processes including neuronal development. Indeed, mice deficient for both TAp73 and ΔNp73 isoforms display neuronal pathologies, including hydrocephalus and hippocampa... Read More about p73: a multifunctional protein in neurobiology.

Differential control of TAp73 and ΔNp73 protein stability by the ring finger ubiquitin ligase PIR2 (2010)
Journal Article
Sayan, B., Yang, A., Conforti, F., Tucci, P., Piro, M., Browne, G., …Melino, G. (2010). Differential control of TAp73 and ΔNp73 protein stability by the ring finger ubiquitin ligase PIR2. Proceedings of the National Academy of Sciences, 107(29), https://doi.org/10.1073/pnas.0911828107

p73 is a p53-related transcription factor with fundamental roles in development and tumor suppression. Transcription from two different promoters on the p73 gene results in generation of transcriptionally active TAp73 isoforms and dominant negative D... Read More about Differential control of TAp73 and ΔNp73 protein stability by the ring finger ubiquitin ligase PIR2.

p73 and p63 regulate the expression of fibroblast growth factor receptor 3 (2010)
Journal Article
Sayan, A., D'Angelo, B., Sayan, B., Tucci, P., Cimini, A., Ceru, M., …Melino, G. (2010). p73 and p63 regulate the expression of fibroblast growth factor receptor 3. Biochemical and Biophysical Research Communications, 394(3), 824-828. https://doi.org/10.1016/j.bbrc.2010.03.084

p53, p63 and p73 make a family of transcription factors that play a vital role in development and cancer. All p53 family members have more than one promoter producing Transactivating (TA) and Dominant Negative (ΔN) isoforms and their mRNAs are subjec... Read More about p73 and p63 regulate the expression of fibroblast growth factor receptor 3.