All Outputs (26)

ApiAP2 factors as candidate regulators of stochastic commitment to merozoite production in Theileria annulata (2015)
Journal Article
Pieszko, M., Weir, W., Goodhead, I., Kinnaird, J., & Shiels, B. (2015). ApiAP2 factors as candidate regulators of stochastic commitment to merozoite production in Theileria annulata. PLoS Neglected Tropical Diseases, 9(8), 1-26. https://doi.org/10.1371/journal.pntd.0003933

The ability of vector-borne Apicomplexan parasites (Babesia, Plasmodium and Theileria) to change from one life-cycle stage to the next is critical for establishment of infection and transmission to new hosts. Stage differentiation steps of both Plasm... Read More about ApiAP2 factors as candidate regulators of stochastic commitment to merozoite production in Theileria annulata.

Taking the pseudo out of pseudogenes (2014)
Journal Article
Goodhead, I., & Darby, A. (2015). Taking the pseudo out of pseudogenes. Current Opinion in Microbiology, 23, 102-109. https://doi.org/10.1016/j.mib.2014.11.012

Pseudogenes are defined as fragments of once-functional genes that have been silenced by one or more nonsense, frameshift or missense mutations. Despite continuing increases in the speed of sequencing and annotating bacterial genomes, the identificat... Read More about Taking the pseudo out of pseudogenes.

Long non-coding RNAs and enhancer RNAs regulate the lipopolysaccharide-induced inflammatory response in human monocytes (2014)
Journal Article
IIott, N., Heward, J., Roux, B., Tsitsiou, E., Fenwick, P., Lenzi, L., …Lindsay, M. (2014). Long non-coding RNAs and enhancer RNAs regulate the lipopolysaccharide-induced inflammatory response in human monocytes. Nature communications, 5, 3979-3979. https://doi.org/10.1038/ncomms4979

Early reports indicate that long non-coding RNAs (lncRNAs) are novel regulators of biological responses. However, their role in the human innate immune response, which provides the initial defence against infection, is largely unexplored. To address... Read More about Long non-coding RNAs and enhancer RNAs regulate the lipopolysaccharide-induced inflammatory response in human monocytes.

Whole-Genome sequencing of Trypanosoma brucei reveals introgression between subspecies that is associated with virulence (2013)
Journal Article
Goodhead, I., Capewell, P., Bailey, J., Beament, T., Chance, M., Kay, S., …Noyes, H. (2013). Whole-Genome sequencing of Trypanosoma brucei reveals introgression between subspecies that is associated with virulence. mBio, 4(4), e00197. https://doi.org/10.1128/mBio.00197-13

Human African trypanosomiasis is caused by two subspecies of Trypanosoma brucei. Trypanosoma brucei rhodesiense is found in East Africa and frequently causes acute disease, while Trypanosoma brucei gambiense is found in West Africa and is associated... Read More about Whole-Genome sequencing of Trypanosoma brucei reveals introgression between subspecies that is associated with virulence.

Insights into hominid evolution from the gorilla genome sequence (2012)
Journal Article
Scally, A., Dutheil, J., Hillier, L., Jordan, G., Goodhead, I., Herrero, J., …Marques-Bonet, T. (2012). Insights into hominid evolution from the gorilla genome sequence. Nature, 483(7388), 169-175. https://doi.org/10.1038/nature10842

Gorillas are humans’ closest living relatives after chimpanzees, and are of comparable importance for the study of human origins and evolution. Here we present the assembly and analysis of a genome sequence for the western lowland gorilla,and compare... Read More about Insights into hominid evolution from the gorilla genome sequence.

A comprehensive genetic analysis of candidate genes regulating response to Trypanosoma congolense infection in mice (2010)
Journal Article
Goodhead, I., Archibald, A., Amwayi, P., Brass, A., Gibson, J., Hall, N., …Kemp, S. (2010). A comprehensive genetic analysis of candidate genes regulating response to Trypanosoma congolense infection in mice. PLoS Neglected Tropical Diseases, 4(11), e880-e880. https://doi.org/10.1371/journal.pntd.0000880

African trypanosomes are protozoan parasites that cause “sleeping sickness” in humans and a similar disease in livestock. Trypanosomes also infect laboratory mice and three major quantitative trait loci (QTL) that regulate survival time after infecti... Read More about A comprehensive genetic analysis of candidate genes regulating response to Trypanosoma congolense infection in mice.