All Outputs (11)

A myristoyl amide derivative of doxycycline potently targets cancer stem cells (CSCs) and prevents metastasis, without retaining antibiotic activity (2020)
Journal Article

Here, we describe the chemical synthesis and biological activity of a new Doxycycline derivative, designed specifically to more effectively target cancer stem cells (CSCs). In this analogue, a myristic acid (14 carbon) moiety is covalently attached t... Read More about A myristoyl amide derivative of doxycycline potently targets cancer stem cells (CSCs) and prevents metastasis, without retaining antibiotic activity.

The efficacy and adverse events of delafloxacin for treating acute bacterial skin and skin structure infections : a systematic review and meta-analysis (2020)
Journal Article
Qasim, S., Tanvir, S., Latimer, J., Qamar, Z., & Niazi, F. (2020). The efficacy and adverse events of delafloxacin for treating acute bacterial skin and skin structure infections : a systematic review and meta-analysis. Journal of Pharmacy and Bioallied Sciences, 12(5), 538-545. https://doi.org/10.4103/jpbs.JPBS_154_20

Background: Acute bacterial skin and skin structure infections (ABSSSI) cause significant morbidity and mortality in hospitalized patients and outpatients as well. Newer fluoroquinolones such as delafloxacin might be a useful medication for treating... Read More about The efficacy and adverse events of delafloxacin for treating acute bacterial skin and skin structure infections : a systematic review and meta-analysis.

Towards a clinically relevant model for investigation of host-microbe interactions in ventilator-associated pneumonia (2019)
Journal Article
Tompsett, A., Ngoc ngo, L., Goodhead, I., Withers, S., & Latimer, J. (2019). Towards a clinically relevant model for investigation of host-microbe interactions in ventilator-associated pneumonia. Access Microbiology, 1(1A), https://doi.org/10.1099/acmi.ac2019.po0422

Ventilator-associated pneumonia (VAP) is amongst the most common healthcare-associated infections worldwide. Current understanding of the underlying mechanisms has focussed on either the microbiological or physiological elements but host-microbe inte... Read More about Towards a clinically relevant model for investigation of host-microbe interactions in ventilator-associated pneumonia.

Simultaneous assessment of acidogenesis-mitigation and specific bacterial growth-inhibition by dentifrices (2016)
Journal Article
Yilmaz, Ö., Forbes, S., Latimer, J., Sreenivasan, P., & McBain, A. (2016). Simultaneous assessment of acidogenesis-mitigation and specific bacterial growth-inhibition by dentifrices. PLoS ONE, 11(2), e0149390. https://doi.org/10.1371/journal.pone.0149390

Dentifrices can augment oral hygiene by inactivating bacteria and at sub-lethal concentrations may affect bacterial metabolism, potentially inhibiting acidogenesis, the main cause of caries. Reported herein is the development of a rapid method to sim... Read More about Simultaneous assessment of acidogenesis-mitigation and specific bacterial growth-inhibition by dentifrices.

Antibacterial efficacy of a cetylpyridinium chloride-based mouthrinse against Fusobacterium nucleatum and in vitro plaques (2015)
Journal Article
Latimer, J., Munday, J., Buzza, K., Sreenivasan, P., & McBain, A. (2015). Antibacterial efficacy of a cetylpyridinium chloride-based mouthrinse against Fusobacterium nucleatum and in vitro plaques. American journal of dentistry, 28 Spe, 9A-13A

PURPOSE

To assess the antimicrobial effects of a fluoride-free and alcohol-free mouthrinse containing 0.075% CPC (test rinse, TR) compared with an otherwise-identical CPC-free control rinse (CR).

METHODS

Activity against laboratory cultures... Read More about Antibacterial efficacy of a cetylpyridinium chloride-based mouthrinse against Fusobacterium nucleatum and in vitro plaques.

Antibacterial and anti-biofilm activity of mouthrinses containing cetylpyridinium chloride and sodium fluoride (2015)
Journal Article
Latimer, J., Munday, J., Buzza, K., Forbes, S., Sreenivasan, P., & McBain, A. (2015). Antibacterial and anti-biofilm activity of mouthrinses containing cetylpyridinium chloride and sodium fluoride. BMC Microbiology, 15(169), https://doi.org/10.1186/s12866-015-0501-x

Background

Cetylpyridinium chloride (CPC) and sodium fluoride augment oral hygiene by inactivating bacteria and inhibiting enamel demineralisation, respectively. However, there are few reports in the literature documenting the antibacterial effic... Read More about Antibacterial and anti-biofilm activity of mouthrinses containing cetylpyridinium chloride and sodium fluoride.

Altered Competitive Fitness, Antimicrobial Susceptibility, and Cellular Morphology in a Triclosan-Induced Small-Colony Variant of Staphylococcus aureus (2015)
Journal Article
Forbes, S., Latimer, J., Bazaid, A., & McBain, A. (2015). Altered Competitive Fitness, Antimicrobial Susceptibility, and Cellular Morphology in a Triclosan-Induced Small-Colony Variant of Staphylococcus aureus. Antimicrobial Agents and Chemotherapy, 59(8), 4809-4816. https://doi.org/10.1128/AAC.00352-15

Staphylococcus aureus can produce small-colony variants (SCVs) that express various phenotypes. While their significance is unclear, SCV propagation may be influenced by relative fitness, antimicrobial susceptibility, and the underlying mechanism. We... Read More about Altered Competitive Fitness, Antimicrobial Susceptibility, and Cellular Morphology in a Triclosan-Induced Small-Colony Variant of Staphylococcus aureus.

Bacteriological effects of dentifrices with and without active ingredients of natural origin (2014)
Journal Article
Ledder, R., Latimer, J., Humphreys, G., Sreenivasan, P., & McBain, A. (2014). Bacteriological effects of dentifrices with and without active ingredients of natural origin. Applied and Environmental Microbiology, 80(20), 6490-6498. https://doi.org/10.1128/AEM.02315-14

Compounds of natural origin are increasingly used as adjuncts to oral hygiene. We have adopted four distinct approaches to assess the antibacterial activity of dentifrices containing natural active ingredients against oral bacteria in several test sy... Read More about Bacteriological effects of dentifrices with and without active ingredients of natural origin.

Fluorescent probe for detection of bacteria : conformational trigger upon bacterial reduction of an azo bridge (2012)
Journal Article

Using biomimetic chemical reduction or Clostridium perfringens cell extract containing azoreductase, the dimer-fluorescent probe 2,4-O-bisdansyl-6,7-diazabicyclooct-6-ene, which possesses a conformationally constrained cis-azo bridge, is reduced to t... Read More about Fluorescent probe for detection of bacteria : conformational trigger upon bacterial reduction of an azo bridge.

Attenuated Virulence and Biofilm Formation in Staphylococcus aureus following Sublethal Exposure to Triclosan (2012)
Journal Article
Latimer, J., Forbes, S., & McBain, A. (2012). Attenuated Virulence and Biofilm Formation in Staphylococcus aureus following Sublethal Exposure to Triclosan. Antimicrobial Agents and Chemotherapy, 56(6), 3092-3100. https://doi.org/10.1128/AAC.05904-11

Subeffective exposure of Staphylococcus aureus to the biocide triclosan can reportedly induce a small-colony variant (SCV) phenotype. S. aureus SCVs are characterized by low growth rates, reduced pigmentation, and lowered antimicrobial susceptibility... Read More about Attenuated Virulence and Biofilm Formation in Staphylococcus aureus following Sublethal Exposure to Triclosan.

A novel method for exploring elemental composition of microbial communities : laser ablation-inductively coupled plasma-mass spectrometry of intact bacterial colonies (2009)
Journal Article
Latimer, J., Stokes, S., Graham, A., Bunch, J., Jackson, R., McLeod, C., & Poole, R. (2009). A novel method for exploring elemental composition of microbial communities : laser ablation-inductively coupled plasma-mass spectrometry of intact bacterial colonies. Journal of Microbiological Methods, 79(3), 329-335. https://doi.org/10.1016/j.mimet.2009.10.001

Bacterial colonies are spatially complex structures whose physiology is profoundly dependent on interactions between cells and with the underlying semi-solid substratum. Here, we use bacterial colonies as a model of a microbial community to evaluate... Read More about A novel method for exploring elemental composition of microbial communities : laser ablation-inductively coupled plasma-mass spectrometry of intact bacterial colonies.