Novel syntheses of cis and trans isomers of combretastatin A-4
(2001)
Journal Article
Gaukroger, K., Hadfield, J., Hepworth, L., Lawrence, N., & McGown, A. (2001). Novel syntheses of cis and trans isomers of combretastatin A-4. Journal of Organic Chemistry, 66(24), 8135-8138. https://doi.org/10.1021/jo015959z
A high-yielding, two-step stereoselective synthesis of the anticancer drug (Z)-combretastatin A-4 (1) has been devised. The method uses the Perkin condensation of 3,4,5-trimethoxyphenylacetic acid and 3-hydroxy-4-methoxybenzaldehyde followed by decar... Read More about Novel syntheses of cis and trans isomers of combretastatin A-4.