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Prof David Greensmith's Outputs (31)

Calcium flux balance in the heart: how many of the important questions are really unanswered? (2024)
Journal Article
Eisner, D. A., Greensmith, D. J., & Trafford, A. W. (2024). Calcium flux balance in the heart: how many of the important questions are really unanswered?. Journal of Physiology, https://doi.org/10.1113/jp287849

The Journal of Physiology recently published an Opinion article which criticised our interpretation of work carried out over several years relating to calcium flux balance in cardiac myocytes (Terrar, 2024). Here,
we reply and show the importance o... Read More about Calcium flux balance in the heart: how many of the important questions are really unanswered?.

The Role of Tumour Necrosis Factor-α in Coronary Artery Disease (2024)
Thesis
Staley, A. (2024). The Role of Tumour Necrosis Factor-α in Coronary Artery Disease. (Thesis). University of Salford

Coronary artery disease (CAD) is a chronic inflammatory condition associated with high rates
of mortality worldwide. Pro-inflammatory cytokines such as tumour necrosis factor (TNFα)
play a key role in CAD pathogenesis, though the degree to which TN... Read More about The Role of Tumour Necrosis Factor-α in Coronary Artery Disease.

Calcium signaling in endothelial and vascular smooth muscle cells: sex differences and the influence of estrogens and androgens (2024)
Journal Article
Asunción-Alvarez, D., Palacios, J., Ybañez-Julca, R. O., Rodriguez-Silva, C. N., Nwokocha, C., Cifuentes, F., & Greensmith, D. J. (2024). Calcium signaling in endothelial and vascular smooth muscle cells: sex differences and the influence of estrogens and androgens. American journal of physiology. Heart and circulatory physiology, 326(4), H950-H970. https://doi.org/10.1152/ajpheart.00600.2023

Calcium signaling in vascular endothelial cells (ECs) and smooth muscle cells (VSMCs) is essential for the regulation of vascular tone. However, the changes to intracellular Ca2+ concentrations are often influenced by sex differences. Furthermore, a... Read More about Calcium signaling in endothelial and vascular smooth muscle cells: sex differences and the influence of estrogens and androgens.

Boswellia carterii oleoresin extracts induce caspase-mediated apoptosis and G 1 cell cycle arrest in human leukaemia subtypes (2023)
Journal Article
Jones, M. A., Borun, A., & Greensmith, D. J. (2023). Boswellia carterii oleoresin extracts induce caspase-mediated apoptosis and G 1 cell cycle arrest in human leukaemia subtypes. Frontiers in Pharmacology, 14, 1282239. https://doi.org/10.3389/fphar.2023.1282239

Background: Leukemias are a common cancer in adults and children. While existing treatments are effective, they are associated with severe side-effects compounded by the emergence of drug resistance. This necessitates the need to develop new drugs an... Read More about Boswellia carterii oleoresin extracts induce caspase-mediated apoptosis and G 1 cell cycle arrest in human leukaemia subtypes.

The role of interleukin-10 in coronary artery disease (2023)
Thesis
Samphire-Noden, B. (2023). The role of interleukin-10 in coronary artery disease. (Thesis). University of Salford

Coronary artery disease (CAD) is a leading cause of mortality and morbidity worldwide, accounting for 66,000 deaths annually in the UK. Atherosclerosis is the underlying pathophysiological mechanism which drives CAD progression, producing an inflamma... Read More about The role of interleukin-10 in coronary artery disease.

The effects of anthracyclines on calcium handling and contractility in sheep ventricular myocytes; role of oxidative stress (2023)
Thesis
Foster, A. (2023). The effects of anthracyclines on calcium handling and contractility in sheep ventricular myocytes; role of oxidative stress. (Thesis). University of Salford

Anthracyclines such as doxorubicin (DOX) and daunorubicin (DAUN) are effective chemotherapeutics and contribute to improved cancer survival rates in children and adults. However, anthracyclines exhibit acute and chronic cardiotoxicity which can produ... Read More about The effects of anthracyclines on calcium handling and contractility in sheep ventricular myocytes; role of oxidative stress.

Characterisation of inflammatory mediators in ischaemic heart disease (2022)
Thesis
Borun, A. Characterisation of inflammatory mediators in ischaemic heart disease. (Dissertation). University of Salford

Coronary artery disease (CAD) is one of the most common causes of death in general population. In the UK it accounts for 64000 deaths annually and there are currently 2.3 million people living with CAD. Persistent inflammation of myocardium is believ... Read More about Characterisation of inflammatory mediators in ischaemic heart disease.

The role of serum biomarkers and oxidative stress in Ischemic Heart Disease (2022)
Thesis
Riley, C. The role of serum biomarkers and oxidative stress in Ischemic Heart Disease. (Dissertation). University of Salford

Ischemic heart disease also referred to as coronary artery disease (CAD) is a leading cause of death worldwide. The primary pathological mechanism underlying CAD is atherosclerosis, an inflammatory process associated with an accumulation of lipids an... Read More about The role of serum biomarkers and oxidative stress in Ischemic Heart Disease.

A hydroalcoholic extract of Senecio nutans SCh. Bip (Asteraceae); its effects on cardiac function and chemical characterization (2022)
Journal Article
Palacios, J., Paredes, A., Cifuentes, F., Catalan, M., Garcia-Villalon, A., Borquez, J., …Greensmith, D. (2023). A hydroalcoholic extract of Senecio nutans SCh. Bip (Asteraceae); its effects on cardiac function and chemical characterization. Journal of Ethnopharmacology, 300, https://doi.org/10.1016/j.jep.2022.115747

Ethnopharmacology relevance
The plant Senecio nutans SCh. Bip. is used by Andean communities to treat altitude sickness. Recent evidence suggests it may produce vasodilation and negative cardiac inotropy, though the cellular mechanisms have not been... Read More about A hydroalcoholic extract of Senecio nutans SCh. Bip (Asteraceae); its effects on cardiac function and chemical characterization.

Co-creation and empowerment: pathways to better student engagement (2021)
Other
Namvar, S., Greensmith, D., & Nirmalan, N. (2021). Co-creation and empowerment: pathways to better student engagement. THE Campus

Progression and employability are at the forefront of current conversations in higher education, with much effort invested in developing complex interventions to improve graduate outcomes. Pedagogy research indicates that factors such as a sense of b... Read More about Co-creation and empowerment: pathways to better student engagement.

The chemotherapeutic potential of Boswellia carterii oleoresins (2021)
Thesis
Jones, M. The chemotherapeutic potential of Boswellia carterii oleoresins. (Thesis). University of Salford

Cancer is a leading cause of death worldwide. Though effective treatments are available and reduce mortality, issues such as debilitating side-effects and drug resistance necessitate a need to develop alternatives. Natural products are a key and dive... Read More about The chemotherapeutic potential of Boswellia carterii oleoresins.

SPARC 2019 Fake news & home truths : Salford postgraduate annual research conference book of abstracts (2019)
Book
Aarons, T., Abduljawad, S. A. S., Aboelkheir, A., Addis, M. C., Adeboye, O., Adeniyi, I. A., …Yusup, N. H. (2019). E. M. Barnes, D. Greensmith, M. Griffiths, U. Hurley, T. Ireland, C. Starbuck, …D. Whitnall (Eds.), SPARC 2019 Fake news & home truths : Salford postgraduate annual research conference book of abstracts. Salford, UK: University of Salford

Welcome to the Book of Abstracts for the 2019 SPARC conference. This year we not only celebrate the work of our PGRs but also our first ever Doctoral School Best Supervisor awards, which makes this year’s conference extra special. Once again we have... Read More about SPARC 2019 Fake news & home truths : Salford postgraduate annual research conference book of abstracts.

Systolic [Ca2+ ]i regulates diastolic levels in rat ventricular myocytes (2017)
Journal Article
Sankaranarayanan, R., Kistamas, K., Greensmith, D., Venetucci, L., & Eisner, D. (2017). Systolic [Ca2+ ]i regulates diastolic levels in rat ventricular myocytes. Journal of Physiology, 595(16), 5545-5555. https://doi.org/10.1113/JP274366

[Ca2+]i must be low enough in diastole so that the ventricle is relaxed and can refill with blood. Interference with this will impair relaxation. The factors responsible for regulation of diastolic [Ca2+]i, in particular the relative roles of the sar... Read More about Systolic [Ca2+ ]i regulates diastolic levels in rat ventricular myocytes.

Disulfide-activated protein kinase G Iα regulates cardiac diastolic relaxation and fine-tunes the Frank–Starling response (2016)
Journal Article
Scotcher, J., Prysyazhna, O., Boguslavskyi, A., Kistamas, K., Hadgraft, N., Martin, E., …Eaton, P. (2016). Disulfide-activated protein kinase G Iα regulates cardiac diastolic relaxation and fine-tunes the Frank–Starling response. Nature communications, 7, 13187. https://doi.org/10.1038/ncomms13187

The Frank–Starling mechanism allows the amount of blood entering the heart from the veins to be precisely matched with the amount pumped out to the arterial circulation. As the heart fills with blood during diastole, the myocardium is stretched and o... Read More about Disulfide-activated protein kinase G Iα regulates cardiac diastolic relaxation and fine-tunes the Frank–Starling response.

Biphasic decay of the Ca transient results from increased sarcoplasmic reticulum Ca leak (2015)
Journal Article
Sankaranarayanan, R., Li, Y., Greensmith, D., Eisner, D., & Venetucci, L. (2016). Biphasic decay of the Ca transient results from increased sarcoplasmic reticulum Ca leak. Journal of Physiology, 594(3), 611-623. https://doi.org/10.1113/JP271473

In heart failure, a reduction in Ca transient amplitude and contractile dysfunction can by caused by Ca leak through the sarcoplasmic reticulum (SR) Ca channel (ryanodine receptor, RyR) and/or decreased activity of the SR Ca ATPase (SERCA). We have c... Read More about Biphasic decay of the Ca transient results from increased sarcoplasmic reticulum Ca leak.