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Dental biofilm formation in young children and the long term effects of fluoride varnish
Thesis
Greenwood, D. Dental biofilm formation in young children and the long term effects of fluoride varnish. (Thesis). University of Salford

Introduction: Fluoride is widely used as a method of reducing caries and while much is known about the processes involved in enamel remineralisation the effects of fluoride on indigenous biofilms in vivo are unclear. Aims: The aim of this study was t... Read More about Dental biofilm formation in young children and the long term effects of fluoride varnish.

Novel fusion proteins based on recombinant lectins for delivery of a cytotoxic peptide specifically to cancer cells
Thesis
Mohammed, S. Novel fusion proteins based on recombinant lectins for delivery of a cytotoxic peptide specifically to cancer cells. (Thesis). University of Salford

One of the most common post-translational modifications is covalent attachment of carbohydrates to proteins. At the cell surface, molecular recognition events involved in cancer metastasis are mediated by sugar moieties of glycoproteins. Evidence fro... Read More about Novel fusion proteins based on recombinant lectins for delivery of a cytotoxic peptide specifically to cancer cells.

Single-phase bimetallic system for the selective oxidation of glycerol to glycerate
Journal Article
Prati, L., Villa, A., Su, D., Wang, D., Krpetic, Z., & Porta, F. Single-phase bimetallic system for the selective oxidation of glycerol to glycerate. Studies in surface science and catalysis, 162, 553-560. https://doi.org/10.1016/S0167-2991%2806%2980952-3

Au-Pd bimetallic systems on carbon, (Pd@Au)/C (1) and Pd@Au/C (2), have been prepared by using metallic colloidal solutions, following two different procedures. The total metal loading was 1%wt and Au/Pd molar ratio 6/4. The catalytic activities have... Read More about Single-phase bimetallic system for the selective oxidation of glycerol to glycerate.

In vitro analysis of volatile organic compounds in search of potential biomarkers of lung cancer
Thesis
Schmidt, K. (in press). In vitro analysis of volatile organic compounds in search of potential biomarkers of lung cancer. (Thesis). University of Salford

Lung cancer is a leading cause of death from cancer worldwide. An early diagnosis and appropriate treatment are crucial in reducing mortality among people suffering from the disease. Therefore, one of the main focuses of lung cancer studies is on a... Read More about In vitro analysis of volatile organic compounds in search of potential biomarkers of lung cancer.

Antimicrobial evaluation of selected medicinal plants using molecular approach
Thesis
Qaddoori, A. G. Antimicrobial evaluation of selected medicinal plants using molecular approach. (Thesis). University of Salford

Resistance to antibiotics is one of the greatest menaces to the success of modern medication. It has lately become more dangerous because we can no longer be certain that any antibiotic chosen will work and because of the emergence of multidrug res... Read More about Antimicrobial evaluation of selected medicinal plants using molecular approach.

Use of molecular and bioinformatics tools for developing methods of epidemiological identification of trypanosomes
Thesis
Adwik, G. (in press). Use of molecular and bioinformatics tools for developing methods of epidemiological identification of trypanosomes. (Thesis). University of Salford

Human African trypanosomiasis (HAT), also known as sleeping sickness, has been a major health problem for populations in Africa caused by the Trypanosoma brucei spp parasite. Although, the current number of the reported cases is on the decrease, more... Read More about Use of molecular and bioinformatics tools for developing methods of epidemiological identification of trypanosomes.

Genetic diversity of African isolates of Toxoplasma gondii
Thesis
Alruhaili, M. (in press). Genetic diversity of African isolates of Toxoplasma gondii. (Thesis). University of Salford

Toxoplasma gondii is an intracellular protozoan parasite and has the ability to infect all warm-blooded animals, including humans. While the three clonal lineages of T. gondii (I, II and III) predominate in North America and Europe, strains from ot... Read More about Genetic diversity of African isolates of Toxoplasma gondii.

Canine echinococcosis in Kyrgyzstan : detection, diagnosis, and dynamics
Thesis
Mastin, A. (in press). Canine echinococcosis in Kyrgyzstan : detection, diagnosis, and dynamics. (Thesis). University of Salford

Human echinococcosis is an increasing public health issue in Kyrgyzstan, where Echinococcus granulosus and Echinococcus multilocularis are coendemic and domestic dogs are considered the primary source of human infection. A control scheme based upon d... Read More about Canine echinococcosis in Kyrgyzstan : detection, diagnosis, and dynamics.

The use of molecular tools for Pan-Trypanosoma analysis and epigenetics of the host
Thesis
Ideozu, E. (in press). The use of molecular tools for Pan-Trypanosoma analysis and epigenetics of the host. (Thesis). University of Salford Manchester

Trypanosomes are a major cause of disease and death in both animal and human populations. Resistance or susceptibility to African trypanosomes has been associated with TLR9 gene. Hence, the primary objectives of this study were to apply molecular... Read More about The use of molecular tools for Pan-Trypanosoma analysis and epigenetics of the host.

An investigation into the diversity of genes of the innate immune system in the European Badger (Meles meles) and possible associations with trypanosome infection
Thesis
Whiteoak, A. (in press). An investigation into the diversity of genes of the innate immune system in the European Badger (Meles meles) and possible associations with trypanosome infection. (Dissertation). University of Salford

Toll-like receptor (TLR) genes encode for conserved proteins of the innate immune system which trigger pathways in response to pathogen invasion by recognising molecules essential for endoparasite survival. An endoparasite lives within the host and r... Read More about An investigation into the diversity of genes of the innate immune system in the European Badger (Meles meles) and possible associations with trypanosome infection.

Canine echinococcosis in the Alay Valley, southern Kyrgyzstan
Thesis
van Kesteren, F. Canine echinococcosis in the Alay Valley, southern Kyrgyzstan. (Thesis). University of Salford

Echinococcosis is a serious and often fatal zoonotic disease caused by parasites in the genus Echinococcus. Echinococcus spp. cycle between intermediate and final hosts, and it is the accidental ingestion of eggs in faeces of final hosts (usually can... Read More about Canine echinococcosis in the Alay Valley, southern Kyrgyzstan.

The characterisation of flavone-DNA isoform interactions as a basis for anticancer drug development
Journal Article
Ragazzon, P., Bradshaw, T., Mathews, C., Iley, J., & Missailidis, S. The characterisation of flavone-DNA isoform interactions as a basis for anticancer drug development. Anticancer Research, 29(6), 2273-2283

BACKGROUND: The interactions of small molecules with nucleic acids are of considerable interest for the design of novel anticancer compounds. The physical properties and sequence specificity observed in the interactions between a group of flavonoi... Read More about The characterisation of flavone-DNA isoform interactions as a basis for anticancer drug development.

Synthesis and biological evaluation of bisindenoisoquinolines as topoisomerase I inhibitors
Journal Article
Muthukaman, N., Morrell, A., Smitha, A., Kohlhagen, G., Agama, K., Pommier, Y., …Cushman, M. Synthesis and biological evaluation of bisindenoisoquinolines as topoisomerase I inhibitors. Journal of Medicinal Chemistry, 24(49), 5129-5140

The indenoisoquinolines represent a class of non-camptothecin topoisomerase I (Top1) inhibitors that exert cytotoxicity by trapping the covalent complex formed between DNA and Top1 during relaxation of DNA supercoils. As an ongoing evaluation of Top1... Read More about Synthesis and biological evaluation of bisindenoisoquinolines as topoisomerase I inhibitors.

Drug repositioning as a route to anti-malarial drug discovery: preliminary investigation of the in vitro anti-malarial efficacy of emetine dihydrochloride hydrate
Journal Article
Matthews, H., Usman-Idris, M., Khan, F., Read, M., & Nirmalan, N. Drug repositioning as a route to anti-malarial drug discovery: preliminary investigation of the in vitro anti-malarial efficacy of emetine dihydrochloride hydrate. Malaria Journal, 12(1), 359. https://doi.org/10.1186/1475-2875-12-359

Background Drug repurposing or repositioning refers to the usage of existing drugs in diseases other than those it was originally used for. For diseases like malaria, where there is an urgent need for active drug candidates, the strategy offers a... Read More about Drug repositioning as a route to anti-malarial drug discovery: preliminary investigation of the in vitro anti-malarial efficacy of emetine dihydrochloride hydrate.

Detection of Echinococcus granulosus and Echinococcus equinus in dogs and epidemiology of canine echinococcosis in the UK
Thesis
Echinococcus granulosus and Echinococcus equinus in dogs and epidemiology of canine echinococcosis in the UK. (Thesis). University of Salford

Echinococcus granulosus is a canid cestode species that causes hydatid disease or cystic echinococcosis (CE) in domestic animals or humans. Echinococcus equinus formerly recognised as the ‘horse strain’ (E.granulosus genotype G4) is not known to be... Read More about Detection of Echinococcus granulosus and Echinococcus equinus in dogs and epidemiology of canine echinococcosis in the UK.

HIV protease inhibitors are substrates for OATP1A2, OATP1B1 and OATP1B3 and lopinavir plasma concentrations are influenced by SLCO1B1 polymorphisms
Journal Article
Hartkoorn, R., Kwan, W., Shallcross, V., Chaikan, A., Liptrott, N., Egan, D., …Owen, A. HIV protease inhibitors are substrates for OATP1A2, OATP1B1 and OATP1B3 and lopinavir plasma concentrations are influenced by SLCO1B1 polymorphisms. Pharmacogenetics and Genomics, 20(2), 112-120. https://doi.org/10.1097/FPC.0b013e328335b02d

OBJECTIVE: OATP1B1 and OATP1B3 are major hepatic drug transporters whilst OATP1A2 is mainly located in the brain but is also located in liver and several other organs. These transporters affect the distribution and clearance of many endobiotics and x... Read More about HIV protease inhibitors are substrates for OATP1A2, OATP1B1 and OATP1B3 and lopinavir plasma concentrations are influenced by SLCO1B1 polymorphisms.

Novel therapeutic strategies to counter pseudomonas aeruginosa infections
Journal Article
Fothergill, J., Winstanley, C., & James, C. Novel therapeutic strategies to counter pseudomonas aeruginosa infections. Expert Review of Anti-infective Therapy, 10(2), 219-235. https://doi.org/10.1586/eri.11.168

Pseudomonas aeruginosa is a highly successful opportunistic pathogen that displays intrinsic multidrug resistance and has a tremendous capacity to acquire further resistance mechanisms. During chronic infection, the bacterium can form a protective... Read More about Novel therapeutic strategies to counter pseudomonas aeruginosa infections.

Inflammatory bowel disease and trichuris muris
Presentation / Conference
Bhardwaj, E., Else, K., Warhurst, G., & Rogan, M. Inflammatory bowel disease and trichuris muris. Poster presented at Crohns and Colitis Foundations National Clinical and Research Conference on Advances in Inflammatory Bowel Diseases, Hollywood, Florida

Inflammatory bowel disease (IBD) is a group of idiopathic chronic relapsing inflammatory conditions of the gastrointestinal tract. The precise etiology of IBD is unknown, although it is clearly multifactorial resulting from interplay of genetic, en... Read More about Inflammatory bowel disease and trichuris muris.

An MVA-based vaccine targeting the oncofetal antigen 5T4 in patients undergoing surgical resection of colorectal cancer liver metastases
Journal Article
Elkord, E., Dangoor, A., Drury, N., Harrop, R., Burt, D., Drijfhout, J., …Stern, P. An MVA-based vaccine targeting the oncofetal antigen 5T4 in patients undergoing surgical resection of colorectal cancer liver metastases. Journal of Immunotherapy, 31(9), 820-829

We investigated the use of a therapeutic vaccine, TroVax in patients undergoing surgical resection of colorectal cancer liver metastases. Systemic immunity generated by vaccination before and after resection of metastases was measured in addition to... Read More about An MVA-based vaccine targeting the oncofetal antigen 5T4 in patients undergoing surgical resection of colorectal cancer liver metastases.