Cells deficient in PARP-1 show an accelerated accumulation of DNA single strand breaks, but not AP sites, over the PARP-1-proficient cells exposed to MMS. (2009)
Journal Article
Pachkowski, B., Tano, K., Afonin, V., Elder, R., Takeda, S., Watanabe, M., …Nakamura, J. (2009). Cells deficient in PARP-1 show an accelerated accumulation of DNA single strand breaks, but not AP sites, over the PARP-1-proficient cells exposed to MMS. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 671(1-2), 93-9. https://doi.org/10.1016/j.mrfmmm.2009.09.006

Poly(ADP-ribose) polymerase-1 (PARP-1) is a base excision repair (BER) protein that binds to DNA single strand breaks (SSBs) and subsequently synthesizes and transfers poly(ADP-ribose) polymers to various nuclear proteins. Numerous biochemical studie... Read More about Cells deficient in PARP-1 show an accelerated accumulation of DNA single strand breaks, but not AP sites, over the PARP-1-proficient cells exposed to MMS..

A riot of rhythms : neuronal and glial circadian oscillators in the mediobasal hypothalamus (2009)
Journal Article
Guilding, C., Hughes, A., Brown, T., Namvar, S., & Piggins, H. (2009). A riot of rhythms : neuronal and glial circadian oscillators in the mediobasal hypothalamus. Molecular Brain, 2(28), https://doi.org/10.1186/1756-6606-2-28

Background: In mammals, the synchronized activity of cell autonomous clocks in the suprachiasmatic nuclei (SCN) enables this structure to function as the master circadian clock, coordinating daily rhythms in physiology and behavior. However, the domi... Read More about A riot of rhythms : neuronal and glial circadian oscillators in the mediobasal hypothalamus.

Structure-activity studies of the binding of the flavonoid scaffold to DNA (2009)
Journal Article
Ragazzon, P., Iley, J., & Missailidis, S. (2009). Structure-activity studies of the binding of the flavonoid scaffold to DNA. Anticancer Research, 29(6), 2285-2293

BACKGROUND: Flavonoids have been shown to have a wide variety of biological activities and proven to be good scaffolds for the design of DNA-binding agents as anticancer therapeutics. MATERIALS AND METHODS: In structure-activity relationship s... Read More about Structure-activity studies of the binding of the flavonoid scaffold to DNA.

How beta-lactam antibiotics enter bacteria: a dialogue with the porins (2009)
Journal Article
James, C., Mahendran, K., Molitor, A., Bolla, J., Bessonov, A., Winterhalter, M., & Pages, J. (2009). How beta-lactam antibiotics enter bacteria: a dialogue with the porins. PLoS ONE, 4(5), e5453. https://doi.org/10.1371/journal.pone.0005453

BACKGROUND:Multi-drug resistant (MDR) infections have become a major concern in hospitals worldwide. This study investigates membrane translocation, which is the first step required for drug action on internal bacterial targets. beta-lactams, a major... Read More about How beta-lactam antibiotics enter bacteria: a dialogue with the porins.

Gold nanoparticles prepared using cape aloe active components (2009)
Journal Article
Krpetic, Z., Scarì, G., Caneva, E., Speranza, G., & Porta, F. (2009). Gold nanoparticles prepared using cape aloe active components. Langmuir, 25(13), 7217-7221. https://doi.org/10.1021/la9009674

A novel use of two components of Cape aloe, aloin A and aloesin, acting as stabilizers in the preparation of gold and silver nanoparticles, is reported. Stable water-soluble particles of different size and shape are prepared by varying the reaction c... Read More about Gold nanoparticles prepared using cape aloe active components.

Photoreactivity of biologically active compounds. XIX: Excited states and free radicals from the antimalarial drug primaquine (2009)
Journal Article
Kristensen, S., Edge, R., Tønnesen, H., Bisby, R., & Navaratnam, S. (2009). Photoreactivity of biologically active compounds. XIX: Excited states and free radicals from the antimalarial drug primaquine. Journal of Photochemistry and Photobiology B: Biology, 94(3), 147-157. https://doi.org/10.1016/j.jphotobiol.2008.11.006

The formation and reactivity of excited states and free radicals from primaquine was studied in order to evaluate the primary photochemical reaction mechanisms. The excited primaquine triplet was not detected, but is likely to be formed with a short... Read More about Photoreactivity of biologically active compounds. XIX: Excited states and free radicals from the antimalarial drug primaquine.

Discovery of novel triple helical DNA intercalators by an integrated virtual and actual screening platform (2009)
Journal Article
Holt, A., Ragazzon, P., Strekowski, L., Chaires, J., & Trent, J. (2009). Discovery of novel triple helical DNA intercalators by an integrated virtual and actual screening platform. Nucleic Acids Research, 37(4), 1280-1287. https://doi.org/10.1093/nar/gkn1043

Virtual Screening is an increasingly attractive way to discover new small molecules with potential medicinal value. We introduce a novel strategy that integrates use of the molecular docking software Surflex with experimental validation by the method... Read More about Discovery of novel triple helical DNA intercalators by an integrated virtual and actual screening platform.

A multidentate peptide for stabilization and facile bioconjugation of gold nanoparticles (2009)
Journal Article
Krpetic, Z., Nativo, P., Porta, F., & Brust, M. (2009). A multidentate peptide for stabilization and facile bioconjugation of gold nanoparticles. Bioconjugate Chemistry, 20(3), 619-624. https://doi.org/10.1021/bc8003028

Gold nanoparticles of two different sizes stabilized by a 15-mer peptide ligand specifically designed for this purpose have been prepared in aqueous solution and characterized by UV−vis spectroscopy and TEM. The presence of the ligand and its binding... Read More about A multidentate peptide for stabilization and facile bioconjugation of gold nanoparticles.

Methionine restriction reduces the chemosensitivity of central nervous system tumour cell lines (2009)
Journal Article
Najim, N., Podmore, I., Mcgown, A., & Estlin, E. (2009). Methionine restriction reduces the chemosensitivity of central nervous system tumour cell lines. Anticancer Research, 29(8), 3101-3108

The aim of this study was to investigate the effects of methionine depletion with cytotoxic agents that are potentially influenced by depletion of methionine, and are known to have a role in CNS tumour treatments for children. MATERIALS AND METHODS:... Read More about Methionine restriction reduces the chemosensitivity of central nervous system tumour cell lines.

Biochemical changes and cytotoxicity associated with methionine depletion in paediatric central nervous system tumour cell lines (2009)
Journal Article
Najim, N., Podmore, I., Mcgown, A., & Estlin, E. (2009). Biochemical changes and cytotoxicity associated with methionine depletion in paediatric central nervous system tumour cell lines. Anticancer Research, 29(8), 2971-2976

The aim of this study was to investigate the importance of the extent and duration of methionine depletion as a cause of cytotoxicity for CNS tumour cell lines, and also to investigate the associated in vitro cellular biochemical responses. MATERIALS... Read More about Biochemical changes and cytotoxicity associated with methionine depletion in paediatric central nervous system tumour cell lines.

Analogues of Y27632 increase gap junction communication and suppress the formation of transformed NIH3T3 colonies (2009)
Journal Article
Hampson, L., He, X., Hadfield, J., Kemp, T., Butler, J., Mcgown, A., …Hampson, I. (2009). Analogues of Y27632 increase gap junction communication and suppress the formation of transformed NIH3T3 colonies. British Journal of Cancer, 101(5), 829-839. https://doi.org/10.1038/sj.bjc.6605208

Constitutive activation of RhoA-dependent RhoA kinase (ROCK) signalling is known to promote cellular transformation and the ROCK inhibitor Y-27632 has the ability to suppress focus formation of RhoA transformed NIH3T3 cells. METHODS: Sixty-four novel... Read More about Analogues of Y27632 increase gap junction communication and suppress the formation of transformed NIH3T3 colonies.

Combretastatin-like chalcones as inhibitors of microtubule polymerization. Part 1: synthesis and biological evaluation of antivascular activity. (2009)
Journal Article
Ducki, S., Renninson, D., Woo, M., Kendall, A., Mcgown, A., & Lawrence, N. (2009). Combretastatin-like chalcones as inhibitors of microtubule polymerization. Part 1: synthesis and biological evaluation of antivascular activity. Bioorganic and Medicinal Chemistry, 17(22), 7698-7710. https://doi.org/10.1016/j.bmc.2009.09.039

The alpha-methyl chalcone SD400 is a potent inhibitor of tubulin assembly and possesses potent anticancer activity. Various chalcone analogues were synthesized and evaluated for their cell growth inhibitory properties against the K562 human chronic m... Read More about Combretastatin-like chalcones as inhibitors of microtubule polymerization. Part 1: synthesis and biological evaluation of antivascular activity..

Helminth species richness in wild wood mice, Apodemus sylvaticus, is enhanced by the presence of the intestinal nematode Heligmosomoides polygyrus (2009)
Journal Article
Behnke, J., Eira, C., Rogan, M., Gilbert, F., Torres, J., Miquel, J., & Lewis, J. (2009). Helminth species richness in wild wood mice, Apodemus sylvaticus, is enhanced by the presence of the intestinal nematode Heligmosomoides polygyrus. Parasitology, 136(07), 793-804. https://doi.org/10.1017/S0031182009006039

We analysed 3 independently collected datasets of fully censused helminth burdens in wood mice, Apodemus sylvaticus, testing the a priori hypothesis of Behnke et al. (2005) that the presence of the intestinal nematode Heligmosomoides polygyrus pred... Read More about Helminth species richness in wild wood mice, Apodemus sylvaticus, is enhanced by the presence of the intestinal nematode Heligmosomoides polygyrus.

MafB/c-Maf deficiency enables self-renewal of differentiated functional macrophages (2009)
Journal Article
Aziz, A., Soucie, E., Sarrazin, S., & Sieweke, M. (2009). MafB/c-Maf deficiency enables self-renewal of differentiated functional macrophages. Science, 326(5954), 867-871. https://doi.org/10.1126/science.1176056

In metazoan organisms, terminal differentiation is generally tightly linked to cell cycle exit, whereas the undifferentiated state of pluripotent stem cells is associated with unlimited self-renewal. Here, we report that combined deficiency for the t... Read More about MafB/c-Maf deficiency enables self-renewal of differentiated functional macrophages.

MafB restricts M-CSF-Dependent myeloid commitment divisions of hematopoietic stem cells (2009)
Journal Article
Sarrazin, S., Mossadegh-Keller, N., Fukao, T., Aziz, A., Mourcin, F., Vanhille, L., …Sieweke, M. (2009). MafB restricts M-CSF-Dependent myeloid commitment divisions of hematopoietic stem cells. Cell, 138(2), 300-313. https://doi.org/10.1016/j.cell.2009.04.057

While hematopoietic stem cell (HSC) self-renewal is well studied, it remains unknown whether distinct control mechanisms enable HSC divisions that generate progeny cells with specific lineage bias. Here, we report that the monocytic transcription fac... Read More about MafB restricts M-CSF-Dependent myeloid commitment divisions of hematopoietic stem cells.

Electroreductions on silver-based electrocatalysts : the use of Ag Nanoparticles for CHCl3to CH4Conversion (2009)
Journal Article
Rondinini, S., Aricci, G., Krpetic, Z., Locatelli, C., Minguzzi, A., Porta, F., & Vertova, A. (2009). Electroreductions on silver-based electrocatalysts : the use of Ag Nanoparticles for CHCl3to CH4Conversion. Fuel Cells, 9(3), 253-263. https://doi.org/10.1002/fuce.200800083

A preliminary investigation on a new class on electrocatalytic materials for the electroreduction of organic halides is presented and discussed. The electrocatalysts are based on silver nanoparticles (Ag_NP), ad hoc synthesised by chemical reduct... Read More about Electroreductions on silver-based electrocatalysts : the use of Ag Nanoparticles for CHCl3to CH4Conversion.