Novel cyanocombretastatins as potent tubulin polymerisation inhibitors (2012)
Journal Article
Jalily, P., Hirst, N., Hadfield, J., & Rossington, S. (2012). Novel cyanocombretastatins as potent tubulin polymerisation inhibitors. Bioorganic and Medicinal Chemistry Letters, 22(21), 6731-6734. https://doi.org/10.1016/j.bmcl.2012.08.089

A series of novel cyanocombretastatins bearing a 3,4,5-trimethoxyphenyl moiety combined with a variety of substituted phenyl rings, were synthesised and their antitumour activity was evaluated. The Z-cyanocombretastatins were synthesised in a one-ste... Read More about Novel cyanocombretastatins as potent tubulin polymerisation inhibitors.

Identification of a new species of digenean Notocotylus malhamensis n. sp. (Digenea: Notocotylidae) from the bank vole (Myodes glareolus) and the field vole (Microtus agrestis) (2012)
Journal Article
vole (Myodes glareolus) and the field vole (Microtus agrestis). Parasitology, 139(12), 1630-1639. https://doi.org/10.1017/S0031182012000911

Notocotylus malhamensis n. sp. is described from the caecum of the bank vole (Myodes glareolus) and the field vole (Microtus agrestis) from Malham Tarn Nature Reserve in North Yorkshire, UK. In total, 581 specimens were collected from rodents trapp... Read More about Identification of a new species of digenean Notocotylus malhamensis n. sp. (Digenea: Notocotylidae) from the bank vole (Myodes glareolus) and the field vole (Microtus agrestis).

Age-related divergent remodeling of the cardiac extracellular matrix in heart failure: collagen accumulation in the young and loss in the aged (2012)
Journal Article
Horn, M., Graham, H., Richards, M., Clarke, J., Greensmith, D., Briston, S., …Trafford, A. (2012). Age-related divergent remodeling of the cardiac extracellular matrix in heart failure: collagen accumulation in the young and loss in the aged. Journal of Molecular and Cellular Cardiology, 53(1), 82-90. https://doi.org/10.1016/j.yjmcc.2012.03.011

The incidence of heart failure (HF) increases with age. This study sought to determine whether aging exacerbates structural and functional remodeling of the myocardium in HF. HF was induced in young (~18 months) and aged sheep (>8 years) by right ven... Read More about Age-related divergent remodeling of the cardiac extracellular matrix in heart failure: collagen accumulation in the young and loss in the aged.

Mixed protein–polysaccharide interfacial layers : effect of polysaccharide charge distribution (2012)
Journal Article
Ettelaie, R., Akinshina, A., & Maurer, S. (2012). Mixed protein–polysaccharide interfacial layers : effect of polysaccharide charge distribution. Soft Matter, 8(29), 7582. https://doi.org/10.1039/C2SM25803J

The influence of the polysaccharide charge distribution on the structure, thickness, and charge reversal of the interfacial layers, formed by adsorbed positively charged protein and oppositely charged polysaccharide, has been investigated using a lat... Read More about Mixed protein–polysaccharide interfacial layers : effect of polysaccharide charge distribution.

Use of artificial sputum medium to test antibiotic efficacy against pseudomonas aeruginosa in conditions more relevant to the cystic fibrosis lung (2012)
Journal Article
Kirchner, S., Fothergill, J., Wright, E., James, C., Mowat, E., & Winstanley, C. (2012). Use of artificial sputum medium to test antibiotic efficacy against pseudomonas aeruginosa in conditions more relevant to the cystic fibrosis lung. Journal of Visualized Experiments, 64, 1-8. https://doi.org/10.3791/3857

There is growing concern about the relevance of in vitro antimicrobial susceptibility tests when applied to isolates of P. aeruginosa from cystic fibrosis (CF) patients. Existing methods rely on single or a few isolates grown aerobically and plankto... Read More about Use of artificial sputum medium to test antibiotic efficacy against pseudomonas aeruginosa in conditions more relevant to the cystic fibrosis lung.

Antimicrobial activity against hospital-related pathogens of dual layer CuO/TiO2 coatings prepared by CVD (2012)
Journal Article
dual layer CuO/TiO2 coatings prepared by CVD. Chemical Vapor Deposition, 18(4-6), 140-146. https://doi.org/10.1002/cvde.201106978

Photocatalytically active films of TiO2/CuO grown by atmospheric pressure thermal (APT)CVD are investigated for activity against multiple antibiotic-resistant pathogens namely, Acinetobacter baumannii, Escherichia coli, Klebsiella pneumoniae, vancomy... Read More about Antimicrobial activity against hospital-related pathogens of dual layer CuO/TiO2 coatings prepared by CVD.

Fluorescent probe for detection of bacteria : conformational trigger upon bacterial reduction of an azo bridge (2012)
Journal Article
Rattray, N., Zalloum, W., Mansell, D., Latimer, J., Schwalbe, C., Blake, A., …Freeman, S. (2012). Fluorescent probe for detection of bacteria : conformational trigger upon bacterial reduction of an azo bridge. Chemical Communications, 48, 6393-6395. https://doi.org/10.1039/C2CC32521G

Using biomimetic chemical reduction or Clostridium perfringens cell extract containing azoreductase, the dimer-fluorescent probe 2,4-O-bisdansyl-6,7-diazabicyclooct-6-ene, which possesses a conformationally constrained cis-azo bridge, is reduced to t... Read More about Fluorescent probe for detection of bacteria : conformational trigger upon bacterial reduction of an azo bridge.

Directed assembly of DNA-functionalized gold nanoparticles using pyrrole–imidazole polyamides (2012)
Journal Article
Krpetic, Z., Singh, I., Su, W., Guerrini, L., Faulds, K., Burley, G., & Graham, D. (2012). Directed assembly of DNA-functionalized gold nanoparticles using pyrrole–imidazole polyamides. Abstracts of papers / American Chemical Society, 134(20), 8356-8359. https://doi.org/10.1021/ja3014924

Traditional methods for the construction of nanoparticle arrays and lattices exploit Watson–Crick base pairing of single-stranded DNA sequences as a proxy for self-assembly. Although this approach has been utilized in a variety of applications in nan... Read More about Directed assembly of DNA-functionalized gold nanoparticles using pyrrole–imidazole polyamides.

Positively charged silver nanoparticles and their effect on surface-enhanced Raman scattering of dye-labelled oligonucleotides (2012)
Journal Article
van Lierop, D., Krpetic, Z., Guerrini, L., Larmour, I., Dougan, J., Faulds, K., & Graham, D. (2012). Positively charged silver nanoparticles and their effect on surface-enhanced Raman scattering of dye-labelled oligonucleotides. Chemical Communications, 48(66), 8192. https://doi.org/10.1039/C2CC31731A

Improved positively charged nanoparticles are described to provide a simplified SERS substrate for DNA detection. Complete flocculation of the nanoparticles is prevented due to the controlled analyte induced aggregation. This provides a stable aggreg... Read More about Positively charged silver nanoparticles and their effect on surface-enhanced Raman scattering of dye-labelled oligonucleotides.

Importance of Nanoparticle Size in Colorimetric and SERS-Based Multimodal Trace Detection of Ni(II) Ions with Functional Gold Nanoparticles (2012)
Journal Article
Krpetic, Z., Guerrini, L., Larmour, I., Reglinski, J., Faulds, K., & Graham, D. (2012). Importance of Nanoparticle Size in Colorimetric and SERS-Based Multimodal Trace Detection of Ni(II) Ions with Functional Gold Nanoparticles. Small, 8(5), 707-714. https://doi.org/10.1002/smll.201101980

Colorimetric detection of analytes using gold nanoparticles along with surface-enhanced Raman spectroscopy (SERS) are areas of intense research activity since they both offer sensing of very low concentrations of target species. Multimodal detection... Read More about Importance of Nanoparticle Size in Colorimetric and SERS-Based Multimodal Trace Detection of Ni(II) Ions with Functional Gold Nanoparticles.

Time-resolved nanosecond fluorescence lifetime imaging and picosecond infrared spectroscopy of combretastatin A-4 in solution and in cellular systems (2012)
Journal Article
Bisby, R., Botchway, S., Greetham, G., Hadfield, J., Mcgown, A., Parker, A., …Towrie, M. (2012). Time-resolved nanosecond fluorescence lifetime imaging and picosecond infrared spectroscopy of combretastatin A-4 in solution and in cellular systems. Measurement Science and Technology, 23, 084001. https://doi.org/10.1088/0957-0233/23/8/084001

Fluorescence lifetime images of intrinsic fluorescence obtained with two-photon excitation at 630 nm are shown following uptake of a series of E-combretastatins into live cells, including human umbilical vein endothelial cells (HUVECs) that are the t... Read More about Time-resolved nanosecond fluorescence lifetime imaging and picosecond infrared spectroscopy of combretastatin A-4 in solution and in cellular systems.

Differences in iNOS and arginase expression and activity in the macrophages of rats are responsible for the resistance against T. gondii infection (2012)
Journal Article
Gruner, A., Li, Z., Zhao, Z., Zhu, X., Ren, Q., Nie, F., …Lun, Z. (2012). Differences in iNOS and arginase expression and activity in the macrophages of rats are responsible for the resistance against T. gondii infection. PLoS ONE, 7(4), e35834. https://doi.org/10.1371/journal.pone.0035834

Toxoplasma gondii infects humans and warm blooded animals causing devastating disease worldwide. It has long been a mystery as to why the peritoneal macrophages of rats are naturally resistant to T. gondii infection while those of mice are not. Her... Read More about Differences in iNOS and arginase expression and activity in the macrophages of rats are responsible for the resistance against T. gondii infection.

Detection of Trypanosoma lewisi from wild rats in Southern China and its genetic diversity based on the ITS1 and ITS2 sequences (2012)
Journal Article
Tang, H., Lan, Y., Wen, Y., Zhang, X., Desquesnes, M., Yang, T., …Lun, Z. (2012). Detection of Trypanosoma lewisi from wild rats in Southern China and its genetic diversity based on the ITS1 and ITS2 sequences. Infection, Genetics and Evolution, 12(5), 1046-1051. https://doi.org/10.1016/j.meegid.2012.02.018

Trypanosoma lewisi has widely been considered as a non-pathogenic rat trypanosome. However, more and more cases of humans infected with T. lewisi have been reported around the world, indicating that it can infect humans in some undetermined circums... Read More about Detection of Trypanosoma lewisi from wild rats in Southern China and its genetic diversity based on the ITS1 and ITS2 sequences.

Differential infection properties of three inducible prophages from an epidemic strain of Pseudomonas aeruginosa (2012)
Journal Article
James, C., Fothergill, J., Kalwij, H., Hall, A., Cottell, J., Brockhurst, M., & Winstanley, C. (2012). Differential infection properties of three inducible prophages from an epidemic strain of Pseudomonas aeruginosa. BMC Microbiology, 12(216), 1-10. https://doi.org/10.1186/1471-2180-12-216

Background: Pseudomonas aeruginosa is the most common bacterial pathogen infecting the lungs of patients with cystic fibrosis (CF). The Liverpool Epidemic Strain (LES) is transmissible, capable of superseding other P. aeruginosa populations and is... Read More about Differential infection properties of three inducible prophages from an epidemic strain of Pseudomonas aeruginosa.

Prevention of artificial dental plaque formation in vitro by plant extracts (2012)
Journal Article
Smullen, J., Finney, M., Storey, D., & Foster, H. (2012). Prevention of artificial dental plaque formation in vitro by plant extracts. Journal of Applied Microbiology, 113(4), 964-973. https://doi.org/10.1111/j.1365-2672.2012.05380.x

Aims A number of previous studies have shown that plant extracts can inhibit formation of dental plaque. The ability of extracts of Rosemarinus officianalis L., Salvia officianalis L., unfermented cocoa, red grape seed and green tea to inhibit plaque... Read More about Prevention of artificial dental plaque formation in vitro by plant extracts.

PPARγ as a molecular target of EPA anti-inflammatory activity during TNF-α-impaired skeletal muscle cell differentiation (2012)
Journal Article
Magee, P., Pearson, S., Whittingham-Dowd, J., & Allen, J. (2012). PPARγ as a molecular target of EPA anti-inflammatory activity during TNF-α-impaired skeletal muscle cell differentiation. Journal of Nutritional Biochemistry, 23(11), 1440-1448. https://doi.org/10.1016/j.jnutbio.2011.09.005

Activated skeletal muscle satellite cells facilitate muscle repair or growth through proliferation, differentiation and fusion into new or existing myotubes. Elevated levels of the proinflammatory cytokine tumor necrosis factor-α (TNF-α) impair this... Read More about PPARγ as a molecular target of EPA anti-inflammatory activity during TNF-α-impaired skeletal muscle cell differentiation.

Fluorescence lifetime imaging of propranolol uptake in living glial C6 cells (2012)
Journal Article
Bisby, R., Botchway, S., Crisostomo, A., Parker, A., & Scherer, K. (2012). Fluorescence lifetime imaging of propranolol uptake in living glial C6 cells. Journal of Spectroscopy, 27(5-6), 533-540. https://doi.org/10.1155/2012/518353

Uptake of the β-blocker drug propranolol by living glial C6 cells has been observed using fluorescence lifetime imaging with two-photon excitation at 630 nm. Both uptake and release of propranolol occur within minutes and are temperature dependent, b... Read More about Fluorescence lifetime imaging of propranolol uptake in living glial C6 cells.

Mercaptocarborane-capped gold nanoparticles : electron pools and ion traps with switchable hydrophilicity (2012)
Journal Article
Cioran, A., Musteti, A., Teixidor, F., Krpetic, Z., Prior, I., He, Q., …Viñas, C. (2012). Mercaptocarborane-capped gold nanoparticles : electron pools and ion traps with switchable hydrophilicity. Abstracts of papers / American Chemical Society, 134(1), 212-221. https://doi.org/10.1021/ja203367h

A simple single-phase method for the preparation of ca. 2 nm gold nanoparticles capped with mercaptocarborane ligands is introduced. The resultant monolayer protected clusters (MPCs) exhibit redox-dependent solubility and readily phase transfer betwe... Read More about Mercaptocarborane-capped gold nanoparticles : electron pools and ion traps with switchable hydrophilicity.