Cancer stem cell metabolism (2016)
Journal Article
Peiris-Pagès, M., Martinez-Outschoorn, U., Pestell, R., Sotgia, F., & Lisanti, M. (2016). Cancer stem cell metabolism. Breast Cancer Research, 18(55), https://doi.org/10.1186/s13058-016-0712-6

Cancer is now viewed as a stem cell disease. There is still no consensus on the metabolic characteristics of cancer stem cells, with several studies indicating that they are mainly glycolytic and others pointing instead to mitochondrial metabolism as... Read More about Cancer stem cell metabolism.

Angiostrongylus cantonensis and human angiostrongyliasis (2016)
Journal Article
Lai, D., Dai, X., Hide, G., & Lun, Z. (2016). Angiostrongylus cantonensis and human angiostrongyliasis

Effects of sub-lethal concentrations of mupirocin on global transcription in Staphylococcus aureus 8325-4 and a model for escape from inhibition (2016)
Journal Article
Alhoufie, S., & Foster, H. (2016). Effects of sub-lethal concentrations of mupirocin on global transcription in Staphylococcus aureus 8325-4 and a model for escape from inhibition. Journal of Medical Microbiology, 65, https://doi.org/10.1099/jmm.0.000270

Staphylococcus aureus is a major pathogen in both hospital and community settings causing infections ranging from mild skin and wound infections to life-threatening systemic illness. Gene expression changes due to the stringent response have been stu... Read More about Effects of sub-lethal concentrations of mupirocin on global transcription in Staphylococcus aureus 8325-4 and a model for escape from inhibition.

Cancer metabolism : a therapeutic perspective (2016)
Journal Article
Martinez-Outschoorn, U., Peiris-Pagés, M., Pestell, R., Sotgia, F., & Lisanti, M. (2016). Cancer metabolism : a therapeutic perspective. Nature Reviews Clinical Oncology, 14, 11-31. https://doi.org/10.1038/nrclinonc.2016.60

Awareness that the metabolic phenotype of cells within tumours is heterogeneous — and distinct from that of their normal counterparts — is growing. In general, tumour cells metabolize glucose, lactate, pyruvate, hydroxybutyrate, acetate, glutamine, a... Read More about Cancer metabolism : a therapeutic perspective.

Pharmaceutical extracts and uses thereof (2016)
Patent
Pye, D., & Olanrewaju, O. (2016). Pharmaceutical extracts and uses thereof

The invention provides an isolated extract comprising glycosaminoglycans from whelk and/or cockle species.

Repurposing atovaquone : targeting mitochondrial complex III and OXPHOS to eradicate cancer stem cells (2016)
Journal Article
Fiorillo, M., Lamb, R., Tanowitz, H., Mutti, L., Krstic- Demonacos, M., Cappello, A., …Lisanti, M. (2016). Repurposing atovaquone : targeting mitochondrial complex III and OXPHOS to eradicate cancer stem cells. Oncotarget, 7(23), 34084-34099. https://doi.org/10.18632/oncotarget.9122

Atovaquone is an FDA-approved anti-malarial drug, which first became clinically available in the year 2000. Currently, its main usage is for the treatment of pneumocystis pneumonia (PCP) and/or toxoplasmosis in immune-compromised patients. Atovaquone... Read More about Repurposing atovaquone : targeting mitochondrial complex III and OXPHOS to eradicate cancer stem cells.

TBK1 duplication is found in normal tension and not in high tension glaucoma patients of Indian origin (2016)
Journal Article
Kaurani, L., Vishal, M., Ray, J., Sen, A., Ray, K., & Mukhopadhyay, A. (2016). TBK1 duplication is found in normal tension and not in high tension glaucoma patients of Indian origin. Journal of Genetics, 95(2), 459-461. https://doi.org/10.1007/s12041-016-0637-y

Dietary fat and corticosterone levels are contributing factors to meal anticipation (2016)
Journal Article
Namvar, S., Gyte, A., Denn, M., Leighton, B., & Piggins, H. (2016). Dietary fat and corticosterone levels are contributing factors to meal anticipation. American Journal of Physiology, 310(8), R711-R723. https://doi.org/10.1152/ajpregu.00308.2015

Daily restricted access to food leads to the development of food anticipatory activity and metabolism, which depends upon an as yet unidentified food-entrainable oscillator(s). A premeal anticipatory peak in circulating hormones, including corticoste... Read More about Dietary fat and corticosterone levels are contributing factors to meal anticipation.

Further evidence from SSCP and ITS DNA sequencing support Trypanosoma evansi and Trypanosoma equiperdum as subspecies or even strains of Trypanosoma brucei (2016)
Journal Article
Wen, Y., Lun, Z., Zhu, X., Hide, G., & Lai, D. (2016). Further evidence from SSCP and ITS DNA sequencing support Trypanosoma evansi and Trypanosoma equiperdum as subspecies or even strains of Trypanosoma brucei. Infection, genetics and evolution (Online), 41, 56-62. https://doi.org/10.1016/j.meegid.2016.03.022

The subgenus Trypanozoon includes three species Trypanosoma brucei, Trypanosoma evansi and Trypanosoma equiperdum, which are morphologically identical and indistinguishable even using some molecular methods. In this study, PCR-based single strand con... Read More about Further evidence from SSCP and ITS DNA sequencing support Trypanosoma evansi and Trypanosoma equiperdum as subspecies or even strains of Trypanosoma brucei.

Genetic association and stress mediated down-regulation in trabecular meshwork implicates MPP7 as a novel candidate gene in primary open angle glaucoma (2016)
Journal Article
Vishal, M., Sharma, A., Kaurani, L., Alfano, G., Mookerjee, S., Narta, K., …Mukhopadhyay, A. (2016). Genetic association and stress mediated down-regulation in trabecular meshwork implicates MPP7 as a novel candidate gene in primary open angle glaucoma. BMC Medical Genomics, 9(15), https://doi.org/10.1186/s12920-016-0177-6

Background: Glaucoma is the largest cause of irreversible blindness affecting more than 60 million people globally.
The disease is defined as a gradual loss of peripheral vision due to death of Retinal Ganglion Cells (RGC). The RGC death is largely... Read More about Genetic association and stress mediated down-regulation in trabecular meshwork implicates MPP7 as a novel candidate gene in primary open angle glaucoma.

Role of vertical transmission of Toxoplasma gondii in prevalence of infection (2016)
Journal Article
Hide, G. (2016). Role of vertical transmission of Toxoplasma gondii in prevalence of infection. Expert Review of Anti-infective Therapy, 14(3), 335-44. https://doi.org/10.1586/14787210.2016.1146131

The parasite, Toxoplasma gondii, is a highly successful pathogen that infects around 30% of the global human population. Additionally, it is able to infect all warm blooded animals with high prevalence. This is surprising as it is a parasite of the c... Read More about Role of vertical transmission of Toxoplasma gondii in prevalence of infection.

Erratum to : Analysis of the mitochondrial maxicircle of Trypanosoma lewisi, a neglected human pathogen (2016)
Journal Article
Lin, R., Lai, D., Zheng, L., Wu, J., Lukeš, J., Hide, G., & Lun, Z. (2016). Erratum to : Analysis of the mitochondrial maxicircle of Trypanosoma lewisi, a neglected human pathogen. Parasites and Vectors, 9(1), https://doi.org/10.1186/s13071-016-1297-8

Mcl-1 dynamics influence mitotic slippage and death in mitosis (2016)
Journal Article
Sloss, O., Topham, C., Diez, M., & Taylor, S. (2016). Mcl-1 dynamics influence mitotic slippage and death in mitosis. Oncotarget, 7, 5176-5192. https://doi.org/10.18632/oncotarget.6894

Microtubule-binding drugs such as taxol are frontline treatments for a variety of cancers but exactly how they yield patient benefit is unclear. In cell culture, inhibiting microtubule dynamics prevents spindle assembly, leading to mitotic arrest fol... Read More about Mcl-1 dynamics influence mitotic slippage and death in mitosis.

Current status of Clonorchis sinensis and clonorchiasis in China (2016)
Journal Article
Lai, D., Hong, X., Su, B., Liang, C., Hide, G., Zhang, X., …Lun, Z. (2016). Current status of Clonorchis sinensis and clonorchiasis in China. Transactions of The Royal Society of Tropical Medicine and Hygiene, 110(1), 21-27. https://doi.org/10.1093/trstmh/trv100

The oriental liver fluke, Clonorchis sinensis, a pathogen causing clonorchiasis, is of major socio-economic importance
in East Asia, including China, Korea and Vietnam. This parasite is nowrecognized as a biocarcinogen strongly
linked to cholangioc... Read More about Current status of Clonorchis sinensis and clonorchiasis in China.