Exploring the influence of adipokines on neuronal function in Alzheimer’s disease (2021)
Thesis
Tomar, N. Exploring the influence of adipokines on neuronal function in Alzheimer’s disease. (Thesis). University of Salford

Alzheimer’s disease (AD) is one of the major causes of dementia. Alzheimer’s disease is an irreversible, slow neurodegenerative disease leading to memory and language impairment and amyloid-β plaques and intraneuronal neurofibrillary tangles are the... Read More about Exploring the influence of adipokines on neuronal function in Alzheimer’s disease.

Synthesis and Evaluation of Benzoyl containing compounds as potential anti-cancer agents (2021)
Thesis
Ahmed, S. M. Synthesis and Evaluation of Benzoyl containing compounds as potential anti-cancer agents. (Thesis). University of Salford

Seen as one of the major causes of death worldwide, Cancer requires the development of effective treatments to combat the disease. However, pharmaceutical companies are faced by the challenge of finding and developing a suitable compound that can ove... Read More about Synthesis and Evaluation of Benzoyl containing compounds as potential anti-cancer agents.

Is there already a need of reckoning on cancer immunotherapy? (2021)
Journal Article
Correale, P., Pentimalli, F., Baglio, G., Krstic- Demonacos, M., Saladino, R., Giordano, A., & Mutti, L. (2021). Is there already a need of reckoning on cancer immunotherapy?. Frontiers in Pharmacology, 12, 638279. https://doi.org/10.3389/fphar.2021.638279

In depth characterisation of the biomolecular coronas of polymer coated inorganic nanoparticles with differential centrifugal sedimentation (2021)
Journal Article
Perez-Potti, A., Lopez, H., Pelaz, B., Abdelmonem, A., Soliman, M., Schoen, I., …Monopoli, M. (2021). In depth characterisation of the biomolecular coronas of polymer coated inorganic nanoparticles with differential centrifugal sedimentation. Scientific reports, 11(1), 6443. https://doi.org/10.1038/s41598-021-84029-8

Advances in nanofabrication methods have enabled the tailoring of new strategies towards the controlled production of nanoparticles with attractive applications in healthcare. In many cases, their characterisation remains a big challenge, particularl... Read More about In depth characterisation of the biomolecular coronas of polymer coated inorganic nanoparticles with differential centrifugal sedimentation.

Restoring perivascular adipose tissue function in obesity using exercise (2021)
Journal Article
Saxton, S., Toms, L., Aldous, R., Withers, S., Ohanian, J., & Heagerty, A. (2021). Restoring perivascular adipose tissue function in obesity using exercise. Cardiovascular Drugs and Therapy, 35(6), 1291-1304. https://doi.org/10.1007/s10557-020-07136-0

Perivascular adipose tissue (PVAT) exerts an anti-contractile effect which is vital in regulating vascular tone. This effect is mediated via sympathetic nervous stimulation of PVAT by a mechanism which involves noradrenaline uptake through organic ca... Read More about Restoring perivascular adipose tissue function in obesity using exercise.

An investigation into Toxoplasma gondii infection and the expression of Arginase-1 and iNOS in human lung tissue (2021)
Thesis
Soothill, H. An investigation into Toxoplasma gondii infection and the expression of Arginase-1 and iNOS in human lung tissue. (Dissertation). University of Salford

This study aimed to investigate the relationship between Toxoplasma gondii infection and the expression of the immune modulating proteins Arginase-1 and iNOS in human lung biopsy samples. Previously, a 100% toxoplasmosis infection rate was found in 7... Read More about An investigation into Toxoplasma gondii infection and the expression of Arginase-1 and iNOS in human lung tissue.

Investigating Interleukin – 8 and TGF Beta as early biomarkers predicting poor clinical outcome in major trauma (2021)
Thesis
Abbood, L. Investigating Interleukin – 8 and TGF Beta as early biomarkers predicting poor clinical outcome in major trauma. (Dissertation). University of Salford

Trauma is a leading cause of death and disability. Globally, traumatic injury is the main cause of death under the age of 45. Recent studies from the UK report a demographic change in major trauma. The most common mechanism of traumatic injury is fal... Read More about Investigating Interleukin – 8 and TGF Beta as early biomarkers predicting poor clinical outcome in major trauma.

Anticancer Innovative Therapy Congress : highlights from the 10th anniversary edition (2021)
Journal Article
De Santis, F., Fucà, G., Schadendorf, D., Mantovani, A., Magnani, L., Lisanti, M., …Di Nicola, M. (2021). Anticancer Innovative Therapy Congress : highlights from the 10th anniversary edition. Cytokine and Growth Factor Reviews, 59, 1-8. https://doi.org/10.1016/j.cytogfr.2021.02.001

During the Tenth Edition of the Annual Congress on “Anticancer Innovative Therapy” [Milan, 23/24 January 2020], experts in the fields of immuno-oncology, epigenetics, tumor cell signaling, and cancer metabolism shared their latest knowledge on the ro... Read More about Anticancer Innovative Therapy Congress : highlights from the 10th anniversary edition.

Transcriptome of CD8+ tumor-infiltrating T cells : a link between diabetes and colorectal cancer (2021)
Journal Article
Saleh, R., Sasidharan Nair, V., Murshed, K., Abu Nada, M., Elkord, E., & Shaheen, R. (2021). Transcriptome of CD8+ tumor-infiltrating T cells : a link between diabetes and colorectal cancer. Cancer Immunology, Immunotherapy, 70(9), 2625-2638. https://doi.org/10.1007/s00262-021-02879-7

There is an increased risk of colorectal cancer (CRC) development in patients with non-insulin-dependent type 2 diabetes. CD8 T cells have been implicated in diabetes and are crucial for anti-tumor immunity. However, transcriptomic profiling for CD8... Read More about Transcriptome of CD8+ tumor-infiltrating T cells : a link between diabetes and colorectal cancer.

Role of circular RNAs in colorectal tumor microenvironment (2021)
Journal Article
Viralippurath Ashraf, J., Sasidharan Nair, V., Saleh, R., & Elkord, E. (2021). Role of circular RNAs in colorectal tumor microenvironment. Biomedicine and Pharmacotherapy, 137, 111351. https://doi.org/10.1016/j.biopha.2021.111351

Circular RNAs (circRNAs) are a class of endogenous noncoding RNA, which were previously considered as a byproduct of RNA splicing error. Numerous studies have demonstrated the altered expression of circRNAs in organ tissues during pathological condit... Read More about Role of circular RNAs in colorectal tumor microenvironment.

Infection with Trypanosoma lewisi or Trypanosoma musculi may promote the spread of Toxoplasma gondii (2021)
Journal Article
Gao, J., Yi, S., Geng, G., Xu, Z., Hide, G., Lun, Z., & Lai, D. (2021). Infection with Trypanosoma lewisi or Trypanosoma musculi may promote the spread of Toxoplasma gondii. Parasitology, 148(6), 703-711. https://doi.org/10.1017/S0031182021000196

Toxoplasma gondii can infect almost all warm-blooded vertebrates with pathogensis being largely influenced by the host immune status. As important epidemiological hosts, rodents are globally distributed and are also commonly found infected with ha... Read More about Infection with Trypanosoma lewisi or Trypanosoma musculi may promote the spread of Toxoplasma gondii.

Metabolic reprogramming of T regulatory cells in the hypoxic tumor microenvironment (2021)
Journal Article
Sasidharan Nair, V., Saleh, R., Toor, S., Cyprian, F., & Elkord, E. (2021). Metabolic reprogramming of T regulatory cells in the hypoxic tumor microenvironment. Cancer Immunology, Immunotherapy, 70(8), 2103-2121. https://doi.org/10.1007/s00262-020-02842-y

Metabolic dysregulation in the hypoxic tumor microenvironment (TME) is considered as a hallmark of solid tumors, leading to changes in biosynthetic pathways favoring onset, survival and proliferation of malignant cells. Within the TME, hypoxic milieu... Read More about Metabolic reprogramming of T regulatory cells in the hypoxic tumor microenvironment.