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High frequency detection of Toxoplasma gondii DNA in human neonatal tissue from Libya (2016)
Journal Article
Haq, S., Abushahma, M., Gerwash, O., Hughes, J., Wright, E., Elmahaishi, M., …Hide, G. (2016). High frequency detection of Toxoplasma gondii DNA in human neonatal tissue from Libya. Transactions of The Royal Society of Tropical Medicine and Hygiene, 110(9), 551-557. https://doi.org/10.1093/trstmh/trw064

Background: Toxoplasma gondii is a parasite that causes significant disease in humans. Toxoplasmosis is normally asymptomatic, unless associated with congenital transmission, or in immunocompromised people. Congenital transmission generally occurs... Read More about High frequency detection of Toxoplasma gondii DNA in human neonatal tissue from Libya.

Trehalose, an easy, safe and efficient cryoprotectant for the parasitic protozoan Trypanosoma brucei (2016)
Journal Article
Wen, Y., Su, B., Lyu, S., Hide, G., Lun, Z., & Lai, D. (2016). Trehalose, an easy, safe and efficient cryoprotectant for the parasitic protozoan Trypanosoma brucei. Acta tropica, 164, 297-302. https://doi.org/10.1016/j.actatropica.2016.09.024

Trehalose, a non-permeating cryoprotective agent (CPA), has been documented as less toxic and highly efficient at cryopreserving different kinds of cells or organisms. In the present study, trehalose was evaluated for its application in cryopreservat... Read More about Trehalose, an easy, safe and efficient cryoprotectant for the parasitic protozoan Trypanosoma brucei.

Different types of small RNAs in protozoa (2016)
Book Chapter
Zheng, L., Liao, J., Wen, Y., Hide, G., Qu, L., & Lun, Z. (2016). Different types of small RNAs in protozoa. In A. Leitao, & F. Enguita (Eds.), Non-coding RNAs and inter-kingdom communication (177-196). Springer International Publishing. https://doi.org/10.1007/978-3-319-39496-1_11

The origin and evolution of small RNA molecules is a long-standing mystery. The protozoa represent the earliest eukaryotes and encompass rich diverse genetic resources. However, there are many contradictions and disputes prevalent in studies on proto... Read More about Different types of small RNAs in protozoa.

Further evidence from SSCP and ITS DNA sequencing support Trypanosoma evansi and Trypanosoma equiperdum as subspecies or even strains of Trypanosoma brucei (2016)
Journal Article
Wen, Y., Lun, Z., Zhu, X., Hide, G., & Lai, D. (2016). Further evidence from SSCP and ITS DNA sequencing support Trypanosoma evansi and Trypanosoma equiperdum as subspecies or even strains of Trypanosoma brucei. Infection, genetics and evolution (Online), 41, 56-62. https://doi.org/10.1016/j.meegid.2016.03.022

The subgenus Trypanozoon includes three species Trypanosoma brucei, Trypanosoma evansi and Trypanosoma equiperdum, which are morphologically identical and indistinguishable even using some molecular methods. In this study, PCR-based single strand con... Read More about Further evidence from SSCP and ITS DNA sequencing support Trypanosoma evansi and Trypanosoma equiperdum as subspecies or even strains of Trypanosoma brucei.

Role of vertical transmission of Toxoplasma gondii in prevalence of infection (2016)
Journal Article
Hide, G. (2016). Role of vertical transmission of Toxoplasma gondii in prevalence of infection. Expert Review of Anti-infective Therapy, 14(3), 335-44. https://doi.org/10.1586/14787210.2016.1146131

The parasite, Toxoplasma gondii, is a highly successful pathogen that infects around 30% of the global human population. Additionally, it is able to infect all warm blooded animals with high prevalence. This is surprising as it is a parasite of the c... Read More about Role of vertical transmission of Toxoplasma gondii in prevalence of infection.

Current status of Clonorchis sinensis and clonorchiasis in China (2016)
Journal Article
Lai, D., Hong, X., Su, B., Liang, C., Hide, G., Zhang, X., …Lun, Z. (2016). Current status of Clonorchis sinensis and clonorchiasis in China. Transactions of The Royal Society of Tropical Medicine and Hygiene, 110(1), 21-27. https://doi.org/10.1093/trstmh/trv100

The oriental liver fluke, Clonorchis sinensis, a pathogen causing clonorchiasis, is of major socio-economic importance in East Asia, including China, Korea and Vietnam. This parasite is nowrecognized as a biocarcinogen strongly linked to cholangioc... Read More about Current status of Clonorchis sinensis and clonorchiasis in China.

Analysis of the mitochondrial maxicircle of Trypanosoma lewisi, a neglected human pathogen (2015)
Journal Article
Lin, R., Lai, D., Zheng, L., Wu, J., Lukeš, J., Hide, G., & Lun, Z. (2015). Analysis of the mitochondrial maxicircle of Trypanosoma lewisi, a neglected human pathogen. Parasites and Vectors, 8(1), 665. https://doi.org/10.1186/s13071-015-1281-8

BACKGROUND The haemoflagellate Trypanosoma lewisi is a kinetoplastid parasite which, as it has been recently reported to cause human disease, deserves increased attention. Characteristic features of all kinetoplastid flagellates are a uniquely st... Read More about Analysis of the mitochondrial maxicircle of Trypanosoma lewisi, a neglected human pathogen.

Cancer in the parasitic protozoans Trypanosoma brucei and Toxoplasma gondii (2015)
Journal Article
Lun, Z., Lai, D., Wen, Y., Zheng, L., Shen, J., Yang, T., …Ayala, F. (2015). Cancer in the parasitic protozoans Trypanosoma brucei and Toxoplasma gondii. Proceedings of the National Academy of Sciences of the United States of America, 112(29), 8835-8842. https://doi.org/10.1073/pnas.1502599112

Cancer is a general name for more than 100 malignant diseases. It is postulated that all cancers start from a single abnormal cell that grows out of control. Untreated cancers can cause serious consequences and deaths. Great progress has been made in... Read More about Cancer in the parasitic protozoans Trypanosoma brucei and Toxoplasma gondii.

Book review : Parasitism. The diversity and ecology of animal parasites, 2nd edn. By Timothy M. Goater,Cameron P. Goater and Gerald W. Esch,editors, p. 497. Cambridge University Press, UK, 2014. (2015)
Journal Article
Hide, G. (2015). Book review : Parasitism. The diversity and ecology of animal parasites, 2nd edn. By Timothy M. Goater,Cameron P. Goater and Gerald W. Esch,editors, p. 497. Cambridge University Press, UK, 2014. Parasitology, 142(10), 1348-1349. https://doi.org/10.1017/S0031182015000645

Infection by Toxoplasma gondii, a severe parasite in neonates and AIDS patients, causes impaired anion secretion in airway epithelia (2015)
Journal Article
Guo, H., Gao, J., Luo, Y., Wen, Y., Zhang, Y., Hide, G., …Lun, Z. (2015). Infection by Toxoplasma gondii, a severe parasite in neonates and AIDS patients, causes impaired anion secretion in airway epithelia. Proceedings of the National Academy of Sciences, 112(14), 4435-40. https://doi.org/10.1073/pnas.1503474112

The airway epithelia initiate and modulate the inflammatory responses to various pathogens. The cystic fibrosis transmembrane conductance regulator-mediated Cl(-) secretion system plays a key role in mucociliary clearance of inhaled pathogens. We hav... Read More about Infection by Toxoplasma gondii, a severe parasite in neonates and AIDS patients, causes impaired anion secretion in airway epithelia.

Investigation of infectivity of neonates and adults from different rat strains to toxoplasma gondii prugniaud shows both variation which correlates with iNOS and Arginase-1 activity and increased susceptibility of neonates to infection (2014)
Journal Article
Gao, J., Yi, S., Wu, M., Geng, G., Shen, J., Lu, F., …Lun, Z. (2015). Investigation of infectivity of neonates and adults from different rat strains to toxoplasma gondii prugniaud shows both variation which correlates with iNOS and Arginase-1 activity and increased susceptibility of neonates to infection. Experimental Parasitology, 149, 47-53. https://doi.org/10.1016/j.exppara.2014.12.008

Mouse models differ considerably fromhumans with regard to clinical symptoms of toxoplasmosis caused by Toxoplasma gondii and, by comparison, the rat model is more representative of this disease in humans. In the present study, we found that differ... Read More about Investigation of infectivity of neonates and adults from different rat strains to toxoplasma gondii prugniaud shows both variation which correlates with iNOS and Arginase-1 activity and increased susceptibility of neonates to infection.

Prevalence of Toxoplasma gondii in localized populations of Apodemus sylvaticus is linked to population genotype not to population location (2014)
Journal Article
Bajnok, J., Boyce, K., Rogan, M., Craig, P., Lun, Z., & Hide, G. (2015). Prevalence of Toxoplasma gondii in localized populations of Apodemus sylvaticus is linked to population genotype not to population location. Parasitology, 142(5), 680-690. https://doi.org/10.1017/S0031182014001760

Toxoplasma gondii is a globally distributed parasite infecting humans and warm-blooded animals. Although many surveys have been conducted for T. gondii infection in mammals, little is known about the detailed distribution in localized natural populat... Read More about Prevalence of Toxoplasma gondii in localized populations of Apodemus sylvaticus is linked to population genotype not to population location.

Naturally occurring Toll-like receptor 11 (TLR11) and Toll-like receptor 12 (TLR12) polymorphisms are not associated with Toxoplasma gondii infection in wild wood mice (2014)
Journal Article
Morger, J., Bajnok, J., Boyce, K., Craig, P., Rogan, M., Lun, Z., …Tschirren, B. (2014). Naturally occurring Toll-like receptor 11 (TLR11) and Toll-like receptor 12 (TLR12) polymorphisms are not associated with Toxoplasma gondii infection in wild wood mice. Infection, Genetics and Evolution, 26, 180-184

Toxoplasma gondii is a highly successful parasite with a worldwide prevalence. Small rodents are the main intermediate hosts, and there is growing evidence that T. gondii modifies their behaviour. Chronically infected rodents show impaired learning c... Read More about Naturally occurring Toll-like receptor 11 (TLR11) and Toll-like receptor 12 (TLR12) polymorphisms are not associated with Toxoplasma gondii infection in wild wood mice.

Naturally occurring Toll-like receptor 11 (TLR11) and Toll-like receptor 12 (TLR12) polymorphisms are not associated with Toxoplasma gondii infection in wild wood mice (2014)
Journal Article
Morger, J., Bajnok, J., Boyce, K., Craig, P., Rogan, M., Lun, Z., …Tschirren, B. (2014). Naturally occurring Toll-like receptor 11 (TLR11) and Toll-like receptor 12 (TLR12) polymorphisms are not associated with Toxoplasma gondii infection in wild wood mice. Infection, Genetics and Evolution, 26, 180-184. https://doi.org/10.1016/j.meegid.2014.05.032

Toxoplasma gondii is a highly successful parasite with a worldwide prevalence. Small rodents are the main intermediate hosts, and there is growing evidence that T. gondii modifies their behaviour. Chronically infected rodents show impaired learning... Read More about Naturally occurring Toll-like receptor 11 (TLR11) and Toll-like receptor 12 (TLR12) polymorphisms are not associated with Toxoplasma gondii infection in wild wood mice.

Toxoplasma gondii: Prevalence in species and genotypes of British bats (Pipistrellus pipistrellus and P. pygmaeus) (2014)
Journal Article
Dodd, N. S., Lord, J. S., Jehle, R., Parker, S., Parker, F., Brooks, D. R., & Hide, G. (2014). Toxoplasma gondii: Prevalence in species and genotypes of British bats (Pipistrellus pipistrellus and P. pygmaeus). Experimental Parasitology, 139, 6-11. https://doi.org/10.1016/j.exppara.2014.02.007

Few studies have investigated Toxoplasma gondii infections in bat populations and none have reported its presence in protected British bat species. Using a collection of dead/euthanased bats collected from Lancashire, UK, two species of bats (Pipis... Read More about Toxoplasma gondii: Prevalence in species and genotypes of British bats (Pipistrellus pipistrellus and P. pygmaeus).

Toxoplasma gondii : prevalence in species and genotypes of British bats (Pipistrellus pipistrellus and P. pygmaeus) (2014)
Journal Article
Dodd, N., Lord, J., Jehle, R., Parker, S., Parker, F., Brooks, D., & Hide, G. (2014). Toxoplasma gondii : prevalence in species and genotypes of British bats (Pipistrellus pipistrellus and P. pygmaeus). Experimental Parasitology, 139, 6-11. https://doi.org/10.1016/j.exppara.2014.02.007

Few studies have investigated Toxoplasma gondii infections in bat populations and none have reported its presence in protected British bat species. Using a collection of dead/euthanased bats collected from Lancashire, UK, two species of bats (Pipis... Read More about Toxoplasma gondii : prevalence in species and genotypes of British bats (Pipistrellus pipistrellus and P. pygmaeus).

Toxoplasma gondii infection in the peritoneal macrophages of rats treated with glucocorticoids (2013)
Journal Article
Wang, T., Gao, J., Yi, S., Geng, G., Gao, X., Shen, J., …Lun, Z. (2014). Toxoplasma gondii infection in the peritoneal macrophages of rats treated with glucocorticoids. Parasitology Research, 113(1), 351-358. https://doi.org/10.1007/s00436-013-3661-3

It is well known that toxoplasmosis can be life threatening to immunocompromised individuals such as AIDS and organ transplantation patients. Glucocorticoids (GCs) are widely used in the clinic for the treatment of autoimmune diseases and organ t... Read More about Toxoplasma gondii infection in the peritoneal macrophages of rats treated with glucocorticoids.

A molecular and ecological analysis of the trematode plagiorchis elegans in the wood mouse apodemus sylvaticus from a periaquatic ecosystem in the UK (2013)
Journal Article
Boyce, K., Hide, G., Craig, P., Reynolds, C., Hussain, M., Bodell, A., …Rogan, M. (2013). A molecular and ecological analysis of the trematode plagiorchis elegans in the wood mouse apodemus sylvaticus from a periaquatic ecosystem in the UK. Journal of Helminthology, 88(03), 310-320. https://doi.org/10.1017/S0022149X13000199

The prevalence of the digenean Plagiorchis sp. was investigated in a natural wood mouse population (Apodemus sylvaticus) in a periaquatic environment. Classical identification was complemented with the use of molecular differentiation to determine... Read More about A molecular and ecological analysis of the trematode plagiorchis elegans in the wood mouse apodemus sylvaticus from a periaquatic ecosystem in the UK.