Outputs (31)

Regulation of p73 activity by post-translational modifications (2012)
Journal Article
Conforti, F., Sayan, A., Sreekamur, R., & Sayan, B. (2012). Regulation of p73 activity by post-translational modifications. Cell Death and Disease, 3, https://doi.org/10.1038/cddis.2012.27

The transcription factor p73 is a member of the p53 family that can be expressed as at least 24 different isoforms with pro- or anti-apoptotic attributes. The TAp73 isoforms are expressed from an upstream promoter and are regarded as bona fide tumor... Read More about Regulation of p73 activity by post-translational modifications.

Relative expression of TAp73 and ΔNp73 isoforms (2012)
Journal Article
Conforti, F., Yang, A., Agostini, M., Rufini, A., Tucci, P., Nicklison-Chirou, M., …Sayan, B. (2012). Relative expression of TAp73 and ΔNp73 isoforms. Aging, 4(3), https://doi.org/10.18632/aging.100441

The transcription factor p73 belongs to the p53 family of tumour suppressors and similar to other family members, transcribed as different isoforms with opposing pro- and anti-apoptotic functions. Unlike p53, p73 mutations are extremely rare in cance... Read More about Relative expression of TAp73 and ΔNp73 isoforms.

Neuronal differentiation by TAp73 is mediated by microRNA-34a regulation of synaptic protein targets (2011)
Journal Article
Agostini, M., Tucci, P., Killick, R., Candi, E., & Sayan, B. (2011). Neuronal differentiation by TAp73 is mediated by microRNA-34a regulation of synaptic protein targets. Proceedings of the National Academy of Sciences, 108(52), https://doi.org/10.1073/pnas.1112061109

The p53-family member TAp73 is a transcription factor that plays a key role in many biological processes. Here, we show that p73 drives the expression of microRNA (miR)-34a, but not miR-34b and -c, by acting on specific binding sites on the miR-34a p... Read More about Neuronal differentiation by TAp73 is mediated by microRNA-34a regulation of synaptic protein targets.

MicroRNA control of invasion and metastasis pathways (2011)
Journal Article
Sreekumar, R., Sayan, B., Mirnezami, A., & Sayan, A. (2011). MicroRNA control of invasion and metastasis pathways. Frontiers in Genetics, 2, https://doi.org/10.3389/fgene.2011.00058

Despite recent advances, cancer remains a leading cause of death worldwide. In developed countries, the incidence of colorectal and breast cancer has been stable, but no improvement in prognosis has been observed if the patient presents with metastas... Read More about MicroRNA control of invasion and metastasis pathways.

P73 regulates cisplatin-induced apoptosis in ovarian cancer cells via a calcium/calpain-dependent mechanism (2011)
Journal Article
Al-Bahlani, S., Fraser, M., Wong, A., Sayan, B., Bergeron, R., Melino, G., & Tsang, B. (2011). P73 regulates cisplatin-induced apoptosis in ovarian cancer cells via a calcium/calpain-dependent mechanism. Oncogene, 30, https://doi.org/10.1038/onc.2011.134

P73 is important in drug-induced apoptosis in some cancer cells, yet its role in the regulation of chemosensitivity in ovarian cancer (OVCA) is poorly understood. Furthermore, if and how the deregulation of p73-mediated apoptosis confers resistance t... Read More about P73 regulates cisplatin-induced apoptosis in ovarian cancer cells via a calcium/calpain-dependent mechanism.

P73 in cancer (2011)
Journal Article
Rufini, A., Agostini, M., Grespi, F., Tomasini, R., & Sayan, B. (2011). P73 in cancer. Genes and Cancer, 2(4), 491-502. https://doi.org/10.1177/1947601911408890

p73 is a tumor suppressor belonging to the p53 family of transcription factors. Distinct isoforms are transcribed from the p73 locus. The use of 2 promoters at the N-terminus allows the expression of an isoform containing (TAp73) or not containing (Δ... Read More about P73 in cancer.

p73: a multifunctional protein in neurobiology (2011)
Journal Article
Killick, R., Niklison-Chirou, M., Tomasini, R., Bano, D., Rufini, A., Grespi, F., …et, A. (2011). p73: a multifunctional protein in neurobiology. Molecular Neurobiology, 43, 139-146. https://doi.org/10.1007/s12035-011-8172-6

p73, a transcription factor of the p53 family, plays a key role in many biological processes including neuronal development. Indeed, mice deficient for both TAp73 and ΔNp73 isoforms display neuronal pathologies, including hydrocephalus and hippocampa... Read More about p73: a multifunctional protein in neurobiology.

Differential control of TAp73 and ΔNp73 protein stability by the ring finger ubiquitin ligase PIR2 (2010)
Journal Article
Sayan, B., Yang, A., Conforti, F., Tucci, P., Piro, M., Browne, G., …Melino, G. (2010). Differential control of TAp73 and ΔNp73 protein stability by the ring finger ubiquitin ligase PIR2. Proceedings of the National Academy of Sciences, 107(29), https://doi.org/10.1073/pnas.0911828107

p73 is a p53-related transcription factor with fundamental roles in development and tumor suppression. Transcription from two different promoters on the p73 gene results in generation of transcriptionally active TAp73 isoforms and dominant negative D... Read More about Differential control of TAp73 and ΔNp73 protein stability by the ring finger ubiquitin ligase PIR2.

p73 and p63 regulate the expression of fibroblast growth factor receptor 3 (2010)
Journal Article
Sayan, A., D'Angelo, B., Sayan, B., Tucci, P., Cimini, A., Ceru, M., …Melino, G. (2010). p73 and p63 regulate the expression of fibroblast growth factor receptor 3. Biochemical and Biophysical Research Communications, 394(3), 824-828. https://doi.org/10.1016/j.bbrc.2010.03.084

p53, p63 and p73 make a family of transcription factors that play a vital role in development and cancer. All p53 family members have more than one promoter producing Transactivating (TA) and Dominant Negative (ΔN) isoforms and their mRNAs are subjec... Read More about p73 and p63 regulate the expression of fibroblast growth factor receptor 3.

The microRNA and p53 families join forces against cancer (2010)
Journal Article
Barlev, N., Sayan, B., Candi, E., & Okorokov, A. (2010). The microRNA and p53 families join forces against cancer. Cell Death and Differentiation, 17, 373-375. https://doi.org/10.1038/cdd.2009.73

The product of the TP53 gene, p53, is one of the most recognised and extensively studied molecules that protects multicellular organisms from cancer. The well-deserved fame of p53 stems from the nature of its function – to coordinate an appropriate c... Read More about The microRNA and p53 families join forces against cancer.