Outputs (23)

Myosin-1C augments secretion of von Willebrand factor by linking contractile actomyosin machinery to the plasma membrane. (2024)
Journal Article
El-Mansi, S., Mitchell, T. P., Mobyen, G., McKinnon, T. A. J., Miklavc, P., Frick, M., …McKinnon, T. A. (in press). Myosin-1C augments secretion of von Willebrand factor by linking contractile actomyosin machinery to the plasma membrane. #Journal not on list, https://doi.org/10.1182/bloodadvances.2024012590

Blood endothelial cells control the hemostatic and inflammatory response by secreting von Willebrand factor (VWF) and P-selectin from storage organelles called Weibel-Palade bodies (WPB). Actin-associated motor proteins regulate this secretory pathwa... Read More about Myosin-1C augments secretion of von Willebrand factor by linking contractile actomyosin machinery to the plasma membrane..

Wedge resection versus lobectomy in T1 lung cancer patients: a propensity matched analysis (2023)
Journal Article
Moon, R. J., Taylor, R., Miklavc, P., Mehdi, S. B., Grant, S. W., & Bittar, M. N. (in press). Wedge resection versus lobectomy in T1 lung cancer patients: a propensity matched analysis. Journal of Cardiothoracic Surgery, 18(1), 252. https://doi.org/10.1186/s13019-023-02303-4

Objectives: Performing wedge resection rather than lobectomy for primary lung cancer remains controversial. Recent studies demonstrate no survival advantage for non-anatomical resection compared to lobectomy in patients with early-stage lung cancer.... Read More about Wedge resection versus lobectomy in T1 lung cancer patients: a propensity matched analysis.

Actin and myosin in non-neuronal exocytosis (2020)
Journal Article
Miklavc, P., & Frick, M. (2020). Actin and myosin in non-neuronal exocytosis. Cells, 9(6), e1455. https://doi.org/10.3390/cells9061455

Cellular secretion depends on exocytosis of secretory vesicles and discharge of vesicle contents. Actin and myosin are essential for pre-fusion and post-fusion stages of exocytosis. Secretory vesicles depend on actin for transport to and attachment a... Read More about Actin and myosin in non-neuronal exocytosis.

Interaction of microtubules and actin during the post-fusion phase of exocytosis (2019)
Journal Article
Muller, M., Schempp, R., Lutz, A., Felder, T., Felder, E., & Miklavc, P. (2019). Interaction of microtubules and actin during the post-fusion phase of exocytosis. Scientific reports, 9, 11973. https://doi.org/10.1038/s41598-019-47741-0

Exocytosis is the intracellular trafficking step where a secretory vesicle fuses with the plasma membrane to release vesicle content. Actin and microtubules both play a role in exocytosis; however, their interplay is not understood. Here we study the... Read More about Interaction of microtubules and actin during the post-fusion phase of exocytosis.

Silver nanoparticles impair retinoic acid-inducible gene I mediated mitochondrial anti-viral immunity by blocking the autophagic flux in lung epithelial cells (2018)
Journal Article
Villeret, B., Dieu, A., Straube, M., Solhonne, B., Miklavc, P., Hamadi, S., …Garcia-Verdugo, I. (2018). Silver nanoparticles impair retinoic acid-inducible gene I mediated mitochondrial anti-viral immunity by blocking the autophagic flux in lung epithelial cells. ACS nano, 12(2), 1188-1202. https://doi.org/10.1021/acsnano.7b06934

Silver nanoparticles (AgNPs) are microbicidal agents which could be potentially used as alternative to antivirals to treat human infectious diseases, especially Influenza virus infection where antivirals have generally proven unsuccessful. However, c... Read More about Silver nanoparticles impair retinoic acid-inducible gene I mediated mitochondrial anti-viral immunity by blocking the autophagic flux in lung epithelial cells.

A small key unlocks a heavy door : the essential function of the small hydrophobic proteins SP-B and SP-C to trigger adsorption of pulmonary surfactant lamellar bodies (2016)
Journal Article
Hobi, N., Giolai, M., Olmeda, B., Miklavc, P., Felder, E., Walther, P., …Haller, T. (2016). A small key unlocks a heavy door : the essential function of the small hydrophobic proteins SP-B and SP-C to trigger adsorption of pulmonary surfactant lamellar bodies. BBA - Molecular Cell Research, 1863(8), 2124-2134. https://doi.org/10.1016/j.bbamcr.2016.04.028

The molecular basis involving adsorption of pulmonary surfactant at the respiratory air–liquid interface and the specific roles of the surfactant proteins SP-B and SP-C in this process have not been completely resolved. The reasons might be found in... Read More about A small key unlocks a heavy door : the essential function of the small hydrophobic proteins SP-B and SP-C to trigger adsorption of pulmonary surfactant lamellar bodies.

The role of myosin 1c and myosin 1b in surfactant exocytosis (2016)
Journal Article
Kittelberger, N., Breunig, M., Martin, R., Knölker, H., & Miklavc, P. (2016). The role of myosin 1c and myosin 1b in surfactant exocytosis. Journal of Cell Science, 129(8), 1685-1696. https://doi.org/10.1242/jcs.181313

Actin and actin-associated proteins have a pivotal effect on regulated exocytosis in secretory cells and influence pre-fusion as well as post-fusion stages of exocytosis. Actin polymerization on secretory granules during the post-fusion phase (format... Read More about The role of myosin 1c and myosin 1b in surfactant exocytosis.

A new role for an old drug: Ambroxol triggers lysosomal exocytosis via pH-dependent Ca2+ release from acidic Ca2+ stores (2015)
Journal Article
Fois, G., Hobi, N., Felder, E., Ziegler, A., Miklavc, P., Walther, P., …Dietl, P. (2015). A new role for an old drug: Ambroxol triggers lysosomal exocytosis via pH-dependent Ca2+ release from acidic Ca2+ stores. Cell Calcium, 58(6), 628-637. https://doi.org/10.1016/j.ceca.2015.10.002

Ambroxol (Ax) is a frequently prescribed drug used to facilitate mucociliary clearance, but its mode of action is yet poorly understood. Here we show by X-ray spectroscopy that Ax accumulates in lamellar bodies (LBs), the surfactant storing, secretor... Read More about A new role for an old drug: Ambroxol triggers lysosomal exocytosis via pH-dependent Ca2+ release from acidic Ca2+ stores.

Actin depolymerisation and crosslinking join forces with myosin II to contract actin coats on fused secretory vesicles (2015)
Journal Article
Miklavc, P., Ehinger, K., Sultan, A., Felder, T., Paul, P., Gottschalk, K., & Frick, M. (2015). Actin depolymerisation and crosslinking join forces with myosin II to contract actin coats on fused secretory vesicles. Journal of Cell Science, 128(6), 1193-1203. https://doi.org/10.1242/jcs.165571

In many secretory cells actin and myosin are specifically recruited to the surface of secretory granules following their fusion with the plasma membrane. Actomyosin-dependent compression of fused granules is essential to promote active extrusion of c... Read More about Actin depolymerisation and crosslinking join forces with myosin II to contract actin coats on fused secretory vesicles.

Surfactant secretion in LRRK2 knock-out rats : changes in lamellar body morphology and rate of exocytosis (2014)
Journal Article
Miklavc, P., Ehinger, K., Thompson, K., Hobi, N., Shimshek, D., & Frick, M. (2014). Surfactant secretion in LRRK2 knock-out rats : changes in lamellar body morphology and rate of exocytosis. PLoS ONE, 9(1), e84926. https://doi.org/10.1371/journal.pone.0084926

Leucine-rich repeat kinase 2 (LRRK2) is known to play a role in the pathogenesis of various diseases including Parkinson disease, morbus Crohn, leprosy and cancer. LRRK2 is suggested to be involved in a number of cell biological processes such as ves... Read More about Surfactant secretion in LRRK2 knock-out rats : changes in lamellar body morphology and rate of exocytosis.