Recent advances in studies of polymicrobial interactions in oral biofilms (2013)
Journal Article
James, C. (2013). Recent advances in studies of polymicrobial interactions in oral biofilms. Current Oral Health Reports, 1(1), 59-69. https://doi.org/10.1007/s40496-013-0006-3

The oral cavity supports a complex and finely balanced consortium of microbial species, many of which cooperate within structured biofilms. These communities develop through multitudinous synergistic and antagonistic interspecies relationships. Chang... Read More about Recent advances in studies of polymicrobial interactions in oral biofilms.

Somatic CALR Mutations in myeloproliferative neoplasms with nonmutated JAK2 (2013)
Journal Article
Nangalia, J., Massie, C., Baxter, E., Nice, F., Gundem, G., Wedge, D., …Aziz, A. E. A. (2013). Somatic CALR Mutations in myeloproliferative neoplasms with nonmutated JAK2. New England Journal of Medicine, 369(25), 2391-2405. https://doi.org/10.1056/NEJMoa1312542

BACKGROUND:
Somatic mutations in the Janus kinase 2 gene (JAK2) occur in many myeloproliferative neoplasms, but the molecular pathogenesis of myeloproliferative neoplasms with nonmutated JAK2 is obscure, and the diagnosis of these neoplasms remains... Read More about Somatic CALR Mutations in myeloproliferative neoplasms with nonmutated JAK2.

JNK1 stress signaling is hyper-activated in high breast density and the tumor stroma: Connecting fibrosis, inflammation, and stemness for cancer prevention (2013)
Journal Article
Lisanti, M., Reeves, K., Peiris-Pagès, M., Chadwick, A., Sanchez-Alvarez, R., Howell, A., …Sotgia, F. (2014). JNK1 stress signaling is hyper-activated in high breast density and the tumor stroma: Connecting fibrosis, inflammation, and stemness for cancer prevention. Cell Cycle, 13(4), 580-599. https://doi.org/10.4161/cc.27379

Mammography is an important screening modality for the early detection of DCIS and breast cancer lesions. More specifically, high mammographic density is associated with an increased risk of breast cancer. However, the biological processes underlying... Read More about JNK1 stress signaling is hyper-activated in high breast density and the tumor stroma: Connecting fibrosis, inflammation, and stemness for cancer prevention.

Toxoplasma gondii infection in the peritoneal macrophages of rats treated with glucocorticoids (2013)
Journal Article
Wang, T., Gao, J., Yi, S., Geng, G., Gao, X., Shen, J., …Lun, Z. (2014). Toxoplasma gondii infection in the peritoneal macrophages of rats treated with glucocorticoids. Parasitology Research, 113(1), 351-358. https://doi.org/10.1007/s00436-013-3661-3

It is well known that toxoplasmosis can be life
threatening to immunocompromised individuals such as
AIDS and organ transplantation patients. Glucocorticoids
(GCs) are widely used in the clinic for the treatment of
autoimmune diseases and organ t... Read More about Toxoplasma gondii infection in the peritoneal macrophages of rats treated with glucocorticoids.

Idiopathic pulmonary fibrosis is strongly associated with productive infection by herpesvirus saimiri (2013)
Journal Article
herpesvirus saimiri. Modern Pathology, 27, 851-862. https://doi.org/10.1038/modpathol.2013.198

Idiopathic pulmonary fibrosis is a fatal disease without effective therapy or diagnostic test. To investigate a
potential role for c�herpesviruses in this disease, 21 paraffin-embedded lung biopsies from patients diagnosed
with idiopathic pulmonary... Read More about Idiopathic pulmonary fibrosis is strongly associated with productive infection by herpesvirus saimiri.

Preparation and characterization of au nanoparticles capped with mercaptocarboranyl clusters (2013)
Journal Article
M. Cioran, A., Teixidor, F., Krpetic, Ž., Brust, M., & Viñas, C. (2014). Preparation and characterization of au nanoparticles capped with mercaptocarboranyl clusters. Dalton Transactions, 43(13), 5054-5061. https://doi.org/10.1039/C3DT52872C

The preparation of 3–4 nm and 10 nm gold nanoparticles capped with neutral carborane-based mercaptocarboranes, via two different preparative routes, is reported. The resulting boron-enriched nanomaterials exhibit complete dispersibility in water, ope... Read More about Preparation and characterization of au nanoparticles capped with mercaptocarboranyl clusters.

Dog ownership, dog behaviour and transmission of Echinococcus spp. in the Alay Valley, southern Kyrgyzstan (2013)
Journal Article
van Kesteren, F., Mastin, A., Mytynova, B., Ziadinov, I., Boufana, B., Torgerson, P., …Craig, P. (2013). Dog ownership, dog behaviour and transmission of Echinococcus spp. in the Alay Valley, southern Kyrgyzstan. Parasitology, 140(13), 1674-1684. https://doi.org/10.1017/S0031182013001182

Echinococcosis is a re-emerging zoonotic disease in Kyrgyzstan, and the incidence of human infection has increased substantially since the collapse of the Soviet Union in 1991. Domestic dogs are hosts of Echinococcus spp. and play an important role i... Read More about Dog ownership, dog behaviour and transmission of Echinococcus spp. in the Alay Valley, southern Kyrgyzstan.

Conjugation of PEG and gold nanoparticles to increase the accessibility and valency of tethered RNA splicing enhancers (2013)
Journal Article
Perrett, A., Dickinson, R., Krpetic, Z., Brust, M., Lewis, H., Eperon, I., & Burley, G. (2013). Conjugation of PEG and gold nanoparticles to increase the accessibility and valency of tethered RNA splicing enhancers. Chemical Science, 4(1), 257-265. https://doi.org/10.1039/C2SC20937C

Since alternative splicing patterns are exhibited by most mammalian genes, the functional properties of a gene may be changed for therapeutic purposes by nudging splicing from one pattern to another. Splicing to a refractory exon can be enhanced usin... Read More about Conjugation of PEG and gold nanoparticles to increase the accessibility and valency of tethered RNA splicing enhancers.

microRNAs in cancer (2013)
Journal Article
Di Leva, G., Garofalo, M., & Croce, C. (2014). microRNAs in cancer. https://doi.org/10.1146/annurev-pathol-012513-104715

MicroRNAs are small non coding RNAs that typically inhibit the translation and stability of
messanger RNAs (mRNAs), controlling genes involved in cellular processes such as
inflammation, cell cycle regulation, stress response, differentiation, apop... Read More about microRNAs in cancer.

High-resolution sizing of monolayer-protected gold clusters by differential centrifugal sedimentation (2013)
Journal Article
Krpetic, Z., Davidson, A., Volk, M., Lévy, R., Brust, M., & Cooper, D. (2013). High-resolution sizing of monolayer-protected gold clusters by differential centrifugal sedimentation. ACS nano, 7(10), 8881-8890. https://doi.org/10.1021/nn403350v

Differential centrifugal sedimentation (DCS) has been applied to accurately size ligand-protected gold hydrosols in the 10 to 50 nm range. A simple protocol is presented to correct for particle density variations due to the presence of the ligand she... Read More about High-resolution sizing of monolayer-protected gold clusters by differential centrifugal sedimentation.

Ca analysis : an Excel based program for the analysis of intracellular calcium transients including multiple, simultaneous regression analysis (2013)
Journal Article
Greensmith, D. (2014). Ca analysis : an Excel based program for the analysis of intracellular calcium transients including multiple, simultaneous regression analysis. Computer Methods and Programs in Biomedicine, 113(1), 241-250. https://doi.org/10.1016/j.cmpb.2013.09.004

Here I present an Excel based program for the analysis of intracellular Ca transients recorded using fluorescent indicators. The program can perform all the necessary steps which convert recorded raw voltage changes into meaningful physiological info... Read More about Ca analysis : an Excel based program for the analysis of intracellular calcium transients including multiple, simultaneous regression analysis.

Self-consistent field theory for the interactions between keratin intermediate filaments (2013)
Journal Article
Akinshina, A., Jambon-Puillet, E., Warren, P., & Noro, M. (2013). Self-consistent field theory for the interactions between keratin intermediate filaments. BMC Biophysics, 6(1), 12. https://doi.org/10.1186/2046-1682-6-12

Background: Keratins are important structural proteins found in skin, hair and nails. Keratin Intermediate Filaments are major components of corneocytes, nonviable horny cells of the Stratum Corneum, the outermost layer of skin. It is considered that... Read More about Self-consistent field theory for the interactions between keratin intermediate filaments.

The effects of tumor necrosis factor-alpha on systolic and diastolic function in rat ventricular myocytes (2013)
Journal Article
Greensmith, D., & Nirmalan, M. (2013). The effects of tumor necrosis factor-alpha on systolic and diastolic function in rat ventricular myocytes. Physiological Reports, 1(4), e00093. https://doi.org/10.1002/phy2.93

The proinflammatory cytokine tumor necrosis factor-alpha (TNF-α) is associated with myocardial dysfunction observed in sepsis and septic shock. There are two fundamental components to this dysfunction. (1) systolic dysfunction; and (2) diastolic dysf... Read More about The effects of tumor necrosis factor-alpha on systolic and diastolic function in rat ventricular myocytes.

A molecular and ecological analysis of the trematode plagiorchis elegans in the wood mouse apodemus sylvaticus from a periaquatic ecosystem in the UK (2013)
Journal Article
Boyce, K., Hide, G., Craig, P., Reynolds, C., Hussain, M., Bodell, A., …Rogan, M. (2013). A molecular and ecological analysis of the trematode plagiorchis elegans in the wood mouse apodemus sylvaticus from a periaquatic ecosystem in the UK. Journal of Helminthology, 88(03), 310-320. https://doi.org/10.1017/S0022149X13000199

The prevalence of the digenean Plagiorchis sp. was investigated in a natural
wood mouse population (Apodemus sylvaticus) in a periaquatic environment.
Classical identification was complemented with the use of molecular
differentiation to determine... Read More about A molecular and ecological analysis of the trematode plagiorchis elegans in the wood mouse apodemus sylvaticus from a periaquatic ecosystem in the UK.

Diastolic spontaneous calcium release from the sarcoplasmic reticulum increases beat-to-beat variability of repolarization in canine ventricular myocytes after β-adrenergic stimulation (2013)
Journal Article
Johnson, D., Heijman, J., Bode, E., Greensmith, D., van der Linde, H., Abi-Gerges, N., …Volders, P. (2013). Diastolic spontaneous calcium release from the sarcoplasmic reticulum increases beat-to-beat variability of repolarization in canine ventricular myocytes after β-adrenergic stimulation. Circulation Research, 112(2), 246-56. https://doi.org/10.1161/CIRCRESAHA.112.275735

RATIONALE

Spontaneous Ca(2+) release (SCR) from the sarcoplasmic reticulum can cause delayed afterdepolarizations and triggered activity, contributing to arrhythmogenesis during β-adrenergic stimulation. Excessive beat-to-beat variability of repol... Read More about Diastolic spontaneous calcium release from the sarcoplasmic reticulum increases beat-to-beat variability of repolarization in canine ventricular myocytes after β-adrenergic stimulation.

Myeloid-derived suppressor cells in cancer: recent progress and prospects (2013)
Journal Article
Khaled, Y., Ammori, B., & Elkord, E. (2013). Myeloid-derived suppressor cells in cancer: recent progress and prospects. Immunology and Cell Biology, 91(8), 493-502. https://doi.org/10.1038/icb.2013.29

Immunosuppressive cells, mainly myeloid-derived suppressor cells (MDSCs) and T regulatory cells, downregulate antitumour immunity and cancer immunotherapy. MDSCs are a heterogeneous group of immature myeloid cells that negatively regulate the immune... Read More about Myeloid-derived suppressor cells in cancer: recent progress and prospects.

Human parasitology - book review (2013)
Journal Article
Hide, G. (2013). Human parasitology - book review. British Journal of Biomedical Science, 70(4), 184-184

Antimicrobial activity of novel nanostructured Cu-SiO2 coatings prepared by chemical vapour deposition against hospital related pathogens (2013)
Journal Article
Varghese, S., ElFakhri, S., Sheel, D., Sheel, P., Bolton, F., & Foster, H. (2013). Antimicrobial activity of novel nanostructured Cu-SiO2 coatings prepared by chemical vapour deposition against hospital related pathogens. AMB Express, 2(53), https://doi.org/10.1186/2191-0855-3-53

There is increasing recognition that the healthcare environment acts as an important reservoir for transmission of healthcare acquired infections (HCAI). One method of reducing environmental contamination would be use of antimicrobial materials. The... Read More about Antimicrobial activity of novel nanostructured Cu-SiO2 coatings prepared by chemical vapour deposition against hospital related pathogens.

The effect of Msh2 knockdown on toxicity induced by tert-butyl-hydroperoxide, potassium bromate, and hydrogen peroxide in base excision repair proficient and deficient cells (2013)
Journal Article
Cooley, N., Elder, R., & Povey, A. (2013). The effect of Msh2 knockdown on toxicity induced by tert-butyl-hydroperoxide, potassium bromate, and hydrogen peroxide in base excision repair proficient and deficient cells. BioMed Research International, 2013, https://doi.org/10.1155/2013/152909

The DNA mismatch repair (MMR) and base excision repair (BER) systems are important determinants of cellular toxicity following exposure to agents that cause oxidative DNA damage. To examine the interactions between these different repair systems, we... Read More about The effect of Msh2 knockdown on toxicity induced by tert-butyl-hydroperoxide, potassium bromate, and hydrogen peroxide in base excision repair proficient and deficient cells.