A 2-step synthesis of Combretastatin A-4 and derivatives as potent tubulin assembly inhibitors (2020)
Journal Article
Barnes, N., Parker, A., Mal Ullah, A., Ragazzon, P., & Hadfield, J. (2020). A 2-step synthesis of Combretastatin A-4 and derivatives as potent tubulin assembly inhibitors. Bioorganic and Medicinal Chemistry, 28(19), 115684. https://doi.org/10.1016/j.bmc.2020.115684

A series of combretastatin derivatives were designed and synthesised by a two-step stereoselective synthesis by use of Wittig olefination followed by Suzuki cross-coupling. Interestingly, all new compounds (2a-2i) showed potent cell-based antiprolife... Read More about A 2-step synthesis of Combretastatin A-4 and derivatives as potent tubulin assembly inhibitors.

Omega 3 versus Omega 6 polyunsaturated fatty acids in cardio-metabolic health (2020)
Journal Article
Halim, M., & Halim, A. (2020). Omega 3 versus Omega 6 polyunsaturated fatty acids in cardio-metabolic health. https://doi.org/10.36502/2020/hcr.6166

Background: Cardiometabolic diseases like type 2 diabetes, metabolic syndrome, heart failure, and other cardiovascular complications are the leading cause of mortality and morbidity across the globe. These conditions are directly attributed to modifi... Read More about Omega 3 versus Omega 6 polyunsaturated fatty acids in cardio-metabolic health.

Vulnerability of drug‐resistant EML4‐ALK rearranged lung cancer to transcriptional inhibition (2020)
Journal Article
Paliouras, A. R., Buzzetti, M., Shi, L., Donaldson, I. J., Magee, P., Sahoo, S., …Garofalo, M. (2020). Vulnerability of drug‐resistant EML4‐ALK rearranged lung cancer to transcriptional inhibition. EMBO Molecular Medicine, 12(7), e11099. https://doi.org/10.15252/emmm.201911099

A subset of lung adenocarcinomas is driven by the EML4‐ALK translocation. Even though ALK inhibitors in the clinic lead to excellent initial responses, acquired resistance to these inhibitors due to on‐target mutations or parallel pathway alterations... Read More about Vulnerability of drug‐resistant EML4‐ALK rearranged lung cancer to transcriptional inhibition.

Vacuolar ATPase depletion contributes to dysregulation of endocytosis in bloodstream forms of Trypanosoma brucei (2020)
Journal Article
Xu, Z.-S., Li, F.-J., Hide, G., Lun, Z.-R., & Lai, D.-H. (2020). Vacuolar ATPase depletion contributes to dysregulation of endocytosis in bloodstream forms of Trypanosoma brucei. Parasites and Vectors, 13(1), 214. https://doi.org/10.1186/s13071-020-04068-4

BACKGROUND

Vacuolar H-ATPase (V-ATPase) is a highly conserved protein complex which hydrolyzes ATP and pumps protons to acidify vacuolar vesicles. Beyond its role in pH maintenance, the involvement of V-ATPase in endocytosis is well documented in... Read More about Vacuolar ATPase depletion contributes to dysregulation of endocytosis in bloodstream forms of Trypanosoma brucei.

Telomerase inhibition, Telomere attrition and proliferation arrest of cancer cells induced by Phosphorothioate ASO-NLS conjugates targeting hTERC and siRNAs targeting hTERT (2020)
Journal Article
Diala, I., Shiohama, Y., Fujita, T., Demonacos, C., Krstic- Demonacos, M., Di Leva, G., & Fujii, N. (2020). Telomerase inhibition, Telomere attrition and proliferation arrest of cancer cells induced by Phosphorothioate ASO-NLS conjugates targeting hTERC and siRNAs targeting hTERT. Nucleosides, Nucleotides and Nucleic Acids, 39(1-3), 407-425. https://doi.org/10.1080/15257770.2020.1713357

Telomerase activity has been regarded as a critical step in cellular immortalization and carcinogenesis and because of this, regulation of telomerase represents an attractive target for anti-tumor specific therapeutics. Recently, one avenue of cancer... Read More about Telomerase inhibition, Telomere attrition and proliferation arrest of cancer cells induced by Phosphorothioate ASO-NLS conjugates targeting hTERC and siRNAs targeting hTERT.

Fatty-acid uptake in prostate cancer cells using dynamic microfluidic raman technology (2020)
Journal Article
Tang, N., D. Snook, R., Brown, M., Haines, B., Ridley, A., Gardner, P., & Denbigh, J. (2020). Fatty-acid uptake in prostate cancer cells using dynamic microfluidic raman technology. Molecules, 25(7), e1652. https://doi.org/10.3390/molecules25071652

It is known that intake of dietary fatty acid (FA) is strongly correlated with prostate cancer progression but is highly dependent on the type of FAs. High levels of palmitic acid (PA) or arachidonic acid (AA) can stimulate the progression of cancer.... Read More about Fatty-acid uptake in prostate cancer cells using dynamic microfluidic raman technology.

Genetic landscape of autism spectrum disorder in Vietnamese children (2020)
Journal Article
Tran, K., Le, V., Bui, H., Do, D., Ly, H., Nguyen, H., …Nguyen, L. (2020). Genetic landscape of autism spectrum disorder in Vietnamese children. Scientific reports, 10(1), 5034. https://doi.org/10.1038/s41598-020-61695-8

Autism spectrum disorder (ASD) is a complex disorder with an unclear aetiology and an estimated global prevalence of 1%. However, studies of ASD in the Vietnamese population are limited. Here, we first conducted whole exome sequencing (WES) of 100 ch... Read More about Genetic landscape of autism spectrum disorder in Vietnamese children.

5-(carbamoylmethylene)-oxazolidin-2-ones as a promising class of heterocycles inducing apoptosis triggered by increased ROS levels and mitochondrial dysfunction in breast and cervical cancer (2020)
Journal Article
Armentano, B., Curcio, R., Brindisi, M., Mancuso, R., Rago, V., Ziccarelli, I., …Cappello, A. (2020). 5-(carbamoylmethylene)-oxazolidin-2-ones as a promising class of heterocycles inducing apoptosis triggered by increased ROS levels and mitochondrial dysfunction in breast and cervical cancer. Biomedicines, 8(2), e35. https://doi.org/10.3390/biomedicines8020035

Oxazolidinones are antibiotics that inhibit protein synthesis by binding the 50S ribosomal subunit. Recently, numerous worldwide researches focused on their properties and possible involvement in cancer therapy have been conducted. Here, we evaluated... Read More about 5-(carbamoylmethylene)-oxazolidin-2-ones as a promising class of heterocycles inducing apoptosis triggered by increased ROS levels and mitochondrial dysfunction in breast and cervical cancer.

Transcriptomic profiling of tumor-infiltrating CD4 + TIM-3 + T Cells reveals their suppressive, exhausted, and metastatic characteristics in colorectal cancer patients (2020)
Journal Article
Sasidharan Nair, V., Toor, S., Taha, R., Ahmed, A., Kurer, M., Murshed, K., …Elkord, E. (2020). Transcriptomic profiling of tumor-infiltrating CD4 + TIM-3 + T Cells reveals their suppressive, exhausted, and metastatic characteristics in colorectal cancer patients. Vaccines, 8(1), e71. https://doi.org/10.3390/vaccines8010071

T cell immunoglobulin mucin-3 (TIM-3) is an immune checkpoint identified as one of the key players in regulating T-cell responses. Studies have shown that TIM-3 is upregulated in the tumor microenvironment (TME). However, the precise role of TIM-3 in... Read More about Transcriptomic profiling of tumor-infiltrating CD4 + TIM-3 + T Cells reveals their suppressive, exhausted, and metastatic characteristics in colorectal cancer patients.

Fusion transcripts in normal human cortex increase with age and show distinct genomic features for single cells and tissues (2020)
Journal Article
Mehani, B., Narta, K., Paul, D., Raj, A., Kumar, D., Sharma, A., …Mukhopadhyay, A. (2020). Fusion transcripts in normal human cortex increase with age and show distinct genomic features for single cells and tissues. Scientific reports, 10(1), 1368. https://doi.org/10.1038/s41598-020-58165-6

Fusion transcripts can contribute to diversity of molecular networks in the human cortex. In this study, we explored the occurrence of fusion transcripts in normal human cortex along with single neurons and astrocytes. We identified 1305 non-redundan... Read More about Fusion transcripts in normal human cortex increase with age and show distinct genomic features for single cells and tissues.

MiRNAs as novel adipokines : obesity-related circulating MiRNAs influence chemosensitivity in cancer patients (2020)
Journal Article
Withers, S., Dewhurst, T., Hammond, C., & Topham, C. (2020). MiRNAs as novel adipokines : obesity-related circulating MiRNAs influence chemosensitivity in cancer patients. Non-Coding RNA, 6(1), e5. https://doi.org/10.3390/ncrna6010005

Adipose tissue is an endocrine organ, capable of regulating distant physiological processes in other tissues via the release of adipokines into the bloodstream. Recently, circulating adipose-derived microRNAs (miRNAs) have been proposed as a novel cl... Read More about MiRNAs as novel adipokines : obesity-related circulating MiRNAs influence chemosensitivity in cancer patients.

Transcriptomic profiling disclosed the role of DNA methylation and histone modifications in tumor-infiltrating myeloid-derived suppressor cell subsets in colorectal cancer (2020)
Journal Article
Sasidharan Nair, V., Saleh, R., Toor, S., Taha, R., Ahmed, A., Kurer, M., …Elkord, E. (2020). Transcriptomic profiling disclosed the role of DNA methylation and histone modifications in tumor-infiltrating myeloid-derived suppressor cell subsets in colorectal cancer. Clinical Epigenetics, 12(1), 13. https://doi.org/10.1186/s13148-020-0808-9

Increased numbers of myeloid-derived suppressor cells (MDSCs) are positively correlated with poor prognosis and reduced survivals of cancer patients. They play central roles in tumor immune evasion and tumor metastasis. However, limited data are avai... Read More about Transcriptomic profiling disclosed the role of DNA methylation and histone modifications in tumor-infiltrating myeloid-derived suppressor cell subsets in colorectal cancer.

Mechanisms of medulloblastoma vulnerability and new targeted therapies (2020)
Thesis
Buzzetti, M. Mechanisms of medulloblastoma vulnerability and new targeted therapies. (Thesis). University of Salford

Medulloblastoma (MB) is the most common malignant paediatric brain tumour accounting for about 20% of all childhood brain cancers. Over the last decade, a consensus has been reached over the existence of 4 main molecular subtypes, known as WNT-activa... Read More about Mechanisms of medulloblastoma vulnerability and new targeted therapies.

The synthesis, isolation and evaluation of novel anticancer and antibacterial therapeutics derived from natural products (2020)
Thesis
Omonga, N. The synthesis, isolation and evaluation of novel anticancer and antibacterial therapeutics derived from natural products. (Thesis). University of Salford

This study focused on isolation, synthesis, development and evaluation of novel antimicrobial and anticancer agents from natural product. Natural products have found lead applications in the pharmaceutical industry as sources of chemotherapeutics aga... Read More about The synthesis, isolation and evaluation of novel anticancer and antibacterial therapeutics derived from natural products.

Immune checkpoints in circulating and tumor-Infiltrating CD4 + T Cell Subsets in Colorectal cancer patients (2019)
Journal Article
Toor, S., Murshed, K., Al-Dhaheri, M., Khawar, M., Abu Nada, M., & Elkord, E. (2019). Immune checkpoints in circulating and tumor-Infiltrating CD4 + T Cell Subsets in Colorectal cancer patients. Frontiers in Immunology, 10, 2936. https://doi.org/10.3389/fimmu.2019.02936

Blockade of inhibitory immune checkpoints (ICs) is a promising therapeutic approach; however, it has shown limited success in some cancers including colorectal cancer (CRC). The tumor microenvironment (TME) is largely responsible for response to ther... Read More about Immune checkpoints in circulating and tumor-Infiltrating CD4 + T Cell Subsets in Colorectal cancer patients.

Influence of synthesis conditions on the structure of nickel nanoparticles and their reactivity in selective asymmetric hydrogenation (2019)
Journal Article
Arrigo, R., Gallarati, S., Schuster, M., Seymour, J., Gianolio, D., da Silva, I., …Held, G. (2020). Influence of synthesis conditions on the structure of nickel nanoparticles and their reactivity in selective asymmetric hydrogenation. ChemCatChem, 12(5), 1491-1503. https://doi.org/10.1002/cctc.201901955

Unsupported and SiO2-supported Ni nanoparticles (NPs), were synthesised via hot-injection colloidal route using oleylamine (OAm) and trioctylphosphine (TOP) as reducing and protective agents, respectively. By adopting a multi-length scale structural... Read More about Influence of synthesis conditions on the structure of nickel nanoparticles and their reactivity in selective asymmetric hydrogenation.

FoxO3a as a positive prognostic marker and a therapeutic target in Tamoxifen-resistant breast cancer (2019)
Journal Article
Pellegrino, M., Rizza, P., Donà, A., Nigro, A., Ricci, E., Fiorillo, M., …Morelli, C. (2019). FoxO3a as a positive prognostic marker and a therapeutic target in Tamoxifen-resistant breast cancer. Cancers, 11(12), e1858. https://doi.org/10.3390/cancers11121858

Background: Resistance to endocrine treatments is a major clinical challenge in the management of estrogen receptor positive breast cancers. Although multiple mechanisms leading to endocrine resistance have been proposed, the poor outcome of this sub... Read More about FoxO3a as a positive prognostic marker and a therapeutic target in Tamoxifen-resistant breast cancer.

Thioalbamide, a thioamidated peptide from amycolatopsis alba, affects tumor growth and stemness by inducing metabolic dysfunction and oxidative stress (2019)
Journal Article
Frattaruolo, L., Fiorillo, M., Brindisi, M., Curcio, R., Dolce, V., Lacret, R., …Cappello, A. (2019). Thioalbamide, a thioamidated peptide from amycolatopsis alba, affects tumor growth and stemness by inducing metabolic dysfunction and oxidative stress. Cells, 8(11), e1408. https://doi.org/10.3390/cells8111408

Thioalbamide, a thioamidated peptide biosynthesized by Amycolatopsis alba, is a thioviridamide-like molecule, and is part of a family of natural products representing a focus of biotechnological and pharmaceutical research in recent years due to thei... Read More about Thioalbamide, a thioamidated peptide from amycolatopsis alba, affects tumor growth and stemness by inducing metabolic dysfunction and oxidative stress.

Is digital health care more equitable? The framing of health inequalities within England's digital health policy 2010–2017 (2019)
Journal Article
Rich, E., Miah, A., & Lewis, S. (2019). Is digital health care more equitable? The framing of health inequalities within England's digital health policy 2010–2017. Sociology of Health and Illness, 41(S1), 31-49. https://doi.org/10.1111/1467-9566.12980

Informed by a discourse analysis, this article examines the framing of equity within the UK's digital health policies between 2010 and 2017, focusing on England's development of NHS Digital and its situation within the UK Government's wider digital s... Read More about Is digital health care more equitable? The framing of health inequalities within England's digital health policy 2010–2017.

MAT Seroprevalence infers low rates of Toxoplasma gondii in domestic pigs from Yucatan, Mexico (2019)
Journal Article
Cubas-Atienzar, A., Hide, G., & Smith, J. (2019). MAT Seroprevalence infers low rates of Toxoplasma gondii in domestic pigs from Yucatan, Mexico. Journal of Parasitology, 105(5), 738-747. https://doi.org/10.1645/18-188

Toxoplasma gondii is a zoonotic parasite of worldwide distribution. The consumption of infected pork meat has been suggested to be an important source for human infection in the tropical area of Yucatan, Mexico. We performed a cross-sectional study o... Read More about MAT Seroprevalence infers low rates of Toxoplasma gondii in domestic pigs from Yucatan, Mexico.