Isolation and characterization of a glycosaminoglycan with anticancer activity
Thesis
Ogundipe, O. (in press). Isolation and characterization of a glycosaminoglycan with anticancer activity. (Thesis). University of Salford

Glycosaminoglycans (GAGs) are a family of complex mixture of linear polysaccharides that are present in both vertebrates and invertebrates. This polysaccharide plays important roles in physiological and pathological conditions, including cancer. In t... Read More about Isolation and characterization of a glycosaminoglycan with anticancer activity.

Genetic diversity of African isolates of Toxoplasma gondii
Thesis
Alruhaili, M. (in press). Genetic diversity of African isolates of Toxoplasma gondii. (Thesis). University of Salford

Toxoplasma gondii is an intracellular protozoan parasite and has the ability to infect all
warm-blooded animals, including humans. While the three clonal lineages of T. gondii (I, II
and III) predominate in North America and Europe, strains from ot... Read More about Genetic diversity of African isolates of Toxoplasma gondii.

Canine echinococcosis in Kyrgyzstan : detection, diagnosis, and dynamics
Thesis
Mastin, A. (in press). Canine echinococcosis in Kyrgyzstan : detection, diagnosis, and dynamics. (Thesis). University of Salford

Human echinococcosis is an increasing public health issue in Kyrgyzstan, where Echinococcus granulosus and Echinococcus multilocularis are coendemic and domestic dogs are considered the primary source of human infection. A control scheme based upon d... Read More about Canine echinococcosis in Kyrgyzstan : detection, diagnosis, and dynamics.

The use of molecular tools for Pan-Trypanosoma analysis and epigenetics of the host
Thesis
Ideozu, E. (in press). The use of molecular tools for Pan-Trypanosoma analysis and epigenetics of the host. (Thesis). University of Salford Manchester

Trypanosomes are a major cause of disease and death in both animal and human populations.
Resistance or susceptibility to African trypanosomes has been associated with TLR9 gene.
Hence, the primary objectives of this study were to apply molecular... Read More about The use of molecular tools for Pan-Trypanosoma analysis and epigenetics of the host.

Canine echinococcosis in the Alay Valley, southern Kyrgyzstan
Thesis
van Kesteren, F. Canine echinococcosis in the Alay Valley, southern Kyrgyzstan. (Thesis). University of Salford

Echinococcosis is a serious and often fatal zoonotic disease caused by parasites in the genus Echinococcus. Echinococcus spp. cycle between intermediate and final hosts, and it is the accidental ingestion of eggs in faeces of final hosts (usually can... Read More about Canine echinococcosis in the Alay Valley, southern Kyrgyzstan.

The characterisation of flavone-DNA isoform interactions as a basis for anticancer drug development
Journal Article
Ragazzon, P., Bradshaw, T., Mathews, C., Iley, J., & Missailidis, S. The characterisation of flavone-DNA isoform interactions as a basis for anticancer drug development. Anticancer Research, 29(6), 2273-2283

BACKGROUND:

The interactions of small molecules with nucleic acids are of considerable interest for the design of novel anticancer compounds. The physical properties and sequence specificity observed in the interactions between a group of flavonoi... Read More about The characterisation of flavone-DNA isoform interactions as a basis for anticancer drug development.

Synthesis and biological evaluation of bisindenoisoquinolines as topoisomerase I inhibitors
Journal Article
Muthukaman, N., Morrell, A., Smitha, A., Kohlhagen, G., Agama, K., Pommier, Y., …Cushman, M. Synthesis and biological evaluation of bisindenoisoquinolines as topoisomerase I inhibitors. Journal of Medicinal Chemistry, 24(49), 5129-5140

The indenoisoquinolines represent a class of non-camptothecin topoisomerase I (Top1) inhibitors that exert cytotoxicity by trapping the covalent complex formed between DNA and Top1 during relaxation of DNA supercoils. As an ongoing evaluation of Top1... Read More about Synthesis and biological evaluation of bisindenoisoquinolines as topoisomerase I inhibitors.

An investigation into the diversity of genes of the innate immune system in the European Badger (Meles meles) and possible associations with trypanosome infection
Thesis
Whiteoak, A. (in press). An investigation into the diversity of genes of the innate immune system in the European Badger (Meles meles) and possible associations with trypanosome infection. (Dissertation). University of Salford

Toll-like receptor (TLR) genes encode for conserved proteins of the innate immune system which trigger pathways in response to pathogen invasion by recognising molecules essential for endoparasite survival. An endoparasite lives within the host and r... Read More about An investigation into the diversity of genes of the innate immune system in the European Badger (Meles meles) and possible associations with trypanosome infection.

HIV protease inhibitors are substrates for OATP1A2, OATP1B1 and OATP1B3 and lopinavir plasma concentrations are influenced by SLCO1B1 polymorphisms
Journal Article
Hartkoorn, R., Kwan, W., Shallcross, V., Chaikan, A., Liptrott, N., Egan, D., …Owen, A. HIV protease inhibitors are substrates for OATP1A2, OATP1B1 and OATP1B3 and lopinavir plasma concentrations are influenced by SLCO1B1 polymorphisms. Pharmacogenetics and Genomics, 20(2), 112-120. https://doi.org/10.1097/FPC.0b013e328335b02d

OBJECTIVE: OATP1B1 and OATP1B3 are major hepatic drug transporters whilst OATP1A2 is mainly located in the brain but is also located in liver and several other organs. These transporters affect the distribution and clearance of many endobiotics and x... Read More about HIV protease inhibitors are substrates for OATP1A2, OATP1B1 and OATP1B3 and lopinavir plasma concentrations are influenced by SLCO1B1 polymorphisms.

Novel therapeutic strategies to counter pseudomonas aeruginosa infections
Journal Article
Fothergill, J., Winstanley, C., & James, C. Novel therapeutic strategies to counter pseudomonas aeruginosa infections. Expert Review of Anti-infective Therapy, 10(2), 219-235. https://doi.org/10.1586/eri.11.168

Pseudomonas aeruginosa is a highly successful opportunistic pathogen that displays intrinsic
multidrug resistance and has a tremendous capacity to acquire further resistance mechanisms.
During chronic infection, the bacterium can form a protective... Read More about Novel therapeutic strategies to counter pseudomonas aeruginosa infections.

Inflammatory bowel disease and trichuris muris
Presentation / Conference
Bhardwaj, E., Else, K., Warhurst, G., & Rogan, M. Inflammatory bowel disease and trichuris muris. Poster presented at Crohns and Colitis Foundations National Clinical and Research Conference on Advances in Inflammatory Bowel Diseases, Hollywood, Florida

Inflammatory bowel disease (IBD) is a group of idiopathic chronic relapsing inflammatory
conditions of the gastrointestinal tract. The precise etiology of IBD is unknown,
although it is clearly multifactorial resulting from interplay of genetic, en... Read More about Inflammatory bowel disease and trichuris muris.

An MVA-based vaccine targeting the oncofetal antigen 5T4 in patients undergoing surgical resection of colorectal cancer liver metastases
Journal Article
Elkord, E., Dangoor, A., Drury, N., Harrop, R., Burt, D., Drijfhout, J., …Stern, P. An MVA-based vaccine targeting the oncofetal antigen 5T4 in patients undergoing surgical resection of colorectal cancer liver metastases. Journal of Immunotherapy, 31(9), 820-829

We investigated the use of a therapeutic vaccine, TroVax in patients undergoing surgical resection of colorectal cancer liver metastases. Systemic immunity generated by vaccination before and after resection of metastases was measured in addition to... Read More about An MVA-based vaccine targeting the oncofetal antigen 5T4 in patients undergoing surgical resection of colorectal cancer liver metastases.

Cytosolic aminopeptidase P (APP-1): a possible role in meiotic progression in Caenorhabditis elegans.
Presentation / Conference
Isaac, R., Craig, H., Martinez-Perez, E., & Brooks, D. Cytosolic aminopeptidase P (APP-1): a possible role in meiotic progression in Caenorhabditis elegans. Poster presented at 17th International C. elegans Meeting, UCLA, Los Angeles

The PAM-1 aminopeptidase regulates microtubule dynamics during meiosis and polarity establishment in the early C. elegans embryo
Presentation / Conference
Greene, P., Marshall, S., Brady, L., Reeves, C., Brooks, D., Isaac, E., & Lyczak, R. The PAM-1 aminopeptidase regulates microtubule dynamics during meiosis and polarity establishment in the early C. elegans embryo. Poster presented at 17th International C. elegans Meeting, UCLA, Los Angeles

Bats and their endoparasites : characterising pipistrelle infections and toll-like receptor (TLR2 and TLR4) gene variations
Thesis
Gattan, H. (in press). Bats and their endoparasites : characterising pipistrelle infections and toll-like receptor (TLR2 and TLR4) gene variations. (Thesis). University of Salford

Bats are unique mammals since they are able to fly and due to their crucial ecosystem roles, they are designated as keystone species. However, in many parts of the world, it is difficult to study bats due to the existence of protective legislation ca... Read More about Bats and their endoparasites : characterising pipistrelle infections and toll-like receptor (TLR2 and TLR4) gene variations.

Biochemical characteristics and antimicrobial potential of seed and nut oils against Staphylococcus aureus
Thesis
Yangomodou, O. (in press). Biochemical characteristics and antimicrobial potential of seed and nut oils against Staphylococcus aureus. (Thesis). University of Salford

The antibacterial activities of oils and extracts from walnut, cashew and pumpkin were investigated on methicillin resistant and susceptible strain MRSA 252 and S. aureus ATCC 6538 using the disc agar diffusion technique. Results revealed that the te... Read More about Biochemical characteristics and antimicrobial potential of seed and nut oils against Staphylococcus aureus.

Transmission ecology of gastrointestinal trematodes of small mammals, malham tarn, North Yorkshire, UK
Thesis
Boyce, K. Transmission ecology of gastrointestinal trematodes of small mammals, malham tarn, North Yorkshire, UK. (Thesis). University of Salford

In 2007, Rogan et al. reported the rare occurrence of the digenean Plagiorchis muris from the wood mouse Apodemus sylvaticus at Malham Tarn Nature Reserve in North Yorkshire, UK. The life cycle of this trematode is not well understood. Therefore, in... Read More about Transmission ecology of gastrointestinal trematodes of small mammals, malham tarn, North Yorkshire, UK.

Expression and characterization of recombinant human NEIL3 from Escherichia coli
Thesis
Albelazi, M. (in press). Expression and characterization of recombinant human NEIL3 from Escherichia coli. (Thesis). University of Salford

The DNA glycosylase NEIL3 is one of a family of proteins that release oxidized bases from DNA, thereby initiating base excision repair. NEIL3 gene expression is normally tightly regulated and expressed only in certain rapidly dividing cells, however,... Read More about Expression and characterization of recombinant human NEIL3 from Escherichia coli.

Characterising human lung tissue for biomarkers of EMT-fibrosis and functional steroid receptor components in chronic obstructive pulmonary disease (COPD) patients and control subjects
Thesis
Patel, H. (in press). Characterising human lung tissue for biomarkers of EMT-fibrosis and functional steroid receptor components in chronic obstructive pulmonary disease (COPD) patients and control subjects. (Dissertation). University of Salford

COPD is a poorly reversible airflow obstruction commonly induced by cigarette smoke. Pathology is linked to a series of inflammatory and fibrotic events in the small airways and lung parenchyma; including fibrosis, emphysema and mucus plugging. Thi... Read More about Characterising human lung tissue for biomarkers of EMT-fibrosis and functional steroid receptor components in chronic obstructive pulmonary disease (COPD) patients and control subjects.

Immunodiagnosis of human and canine echinococcosis and community studies in northwestern China
Thesis
Feng, X. Immunodiagnosis of human and canine echinococcosis and community studies in northwestern China. (Thesis). University of Salford

Echinococcosis is highly endemic in northwestern China. In order to improve sero-testing in support of community screening and for hospital use, a dot immunogold filtration assay (DIGFA) for rapid serodiagnosis of human CE and AE was developed. DIGFA... Read More about Immunodiagnosis of human and canine echinococcosis and community studies in northwestern China.