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Gene expression of DNA repair proteins in colorectal cancer and medulloblastoma
Thesis
Odufuwa, K. Gene expression of DNA repair proteins in colorectal cancer and medulloblastoma. (Thesis). University of Salford

DNA repair plays a critical role in maintaining the integrity of the genome and the dysregulation of key DNA repair genes has been implicated in the development, progression and chemotherapeutic resistance of different cancer types. Consequently, man... Read More about Gene expression of DNA repair proteins in colorectal cancer and medulloblastoma.

Ecology and molecular epidemiology of tick-borne infection in Kachia Grazing Reserve, Nigeria
Thesis
Adam, B. Ecology and molecular epidemiology of tick-borne infection in Kachia Grazing Reserve, Nigeria. (Thesis). University of Salford

Ticks and tick-borne infections (TBIs) are serious veterinary and medical concerns in much of sub-Saharan Africa (SSA). Despite their economic importance, information on the epidemiology of these infections in many SSA countries, including Nigeria, i... Read More about Ecology and molecular epidemiology of tick-borne infection in Kachia Grazing Reserve, Nigeria.

Isolation and characterisation of novel glycosaminoglycan-like polysaccharides derived from marine molluscs with antiproliferative activity
Thesis
Aldairi, A. (in press). Isolation and characterisation of novel glycosaminoglycan-like polysaccharides derived from marine molluscs with antiproliferative activity. (Thesis). University of Salford

Although various anticancer therapeutic tools have been launched, such as immunotherapy and targeted therapy, newly developed drugs with antiproliferative/cytotoxic effects are still in demand; hence, newly discovered anticancer drugs with an improve... Read More about Isolation and characterisation of novel glycosaminoglycan-like polysaccharides derived from marine molluscs with antiproliferative activity.

The role of the human endonuclease VIII-like 1 and 3 in the repair of DNA replication blocking lesions
Thesis
Martin, P. (in press). The role of the human endonuclease VIII-like 1 and 3 in the repair of DNA replication blocking lesions. (Thesis). University of Salford

The endonuclease VIII family of DNA glycosylases initiate repair of oxidative DNA base damage through BER and have been shown to resolve DNA inter-strand crosslinks (ICLs), arising from exogenous agents. Human NEIL1 (hNEIL1) activity on psoralen gene... Read More about The role of the human endonuclease VIII-like 1 and 3 in the repair of DNA replication blocking lesions.

Antimicrobial hand rub : an investigation of the various chemicals used in the concentrate skin formula to enhance the product performance
Thesis
Ibbotson, J. (in press). Antimicrobial hand rub : an investigation of the various chemicals used in the concentrate skin formula to enhance the product performance. (Dissertation). University of Salford

The following research project was conducted in order to evaluate the antimicrobial efficacy of an alcohol-free skin concentrate formula intended for use on hands. Substitute compounds for alcohol in antimicrobial formulae is receiving much interest... Read More about Antimicrobial hand rub : an investigation of the various chemicals used in the concentrate skin formula to enhance the product performance.

Investigating calcium channel blockers as antimalarials
Thesis
Rajab, M. (in press). Investigating calcium channel blockers as antimalarials. (Thesis). University of Salford

The rise in resistance to current antimalarial drugs has led researchers to consider drug repositioning as a quicker alternative for drug development and discovery. Preliminary drug repositioning screens carried out at the University of Salford ident... Read More about Investigating calcium channel blockers as antimalarials.

New molecular and cellular aspects of mutant calreticulin in Myeloproliferative Neoplasms
Thesis
Morlan-mairal, M. (in press). New molecular and cellular aspects of mutant calreticulin in Myeloproliferative Neoplasms. (Thesis). University of Salford

Calreticulin (CALR) is an endoplasmic reticulum (ER) protein that plays an important role as a calcium (Ca2+) buffering chaperone. Mutations in CALR exon 9 have been identified in essential thrombocythemia and primary myelofibrosis, two myeloprolifer... Read More about New molecular and cellular aspects of mutant calreticulin in Myeloproliferative Neoplasms.

Arthropod-borne infections in the United Kingdom and Saudi Arabia
Thesis
Alharbi, B. (in press). Arthropod-borne infections in the United Kingdom and Saudi Arabia. (Thesis). University of Salford

Arthropod vectors can transmit different diseases that are both a significant and widespread cause of mortality and morbidity in both human and wildlife species. However, further studies are required to identify the role of wildlife species as reserv... Read More about Arthropod-borne infections in the United Kingdom and Saudi Arabia.

Investigation of DNA variation in genes of the immune system in wild populations of Apodemus sylvaticus in relation to infection by Toxoplasma gondii and helminth parasites
Thesis
Shater, A. (in press). Investigation of DNA variation in genes of the immune system in wild populations of Apodemus sylvaticus in relation to infection by Toxoplasma gondii and helminth parasites. (Thesis). University of Salford

The aims of this study are to investigate DNA sequence variation in immune genes from Apodemus sylvaticus in relation to parasite infection. The purpose is to investigate the hypothesis that immune gene variation can influence parasite infection. Evi... Read More about Investigation of DNA variation in genes of the immune system in wild populations of Apodemus sylvaticus in relation to infection by Toxoplasma gondii and helminth parasites.

Novel fusion proteins based on recombinant lectins for delivery of a cytotoxic peptide specifically to cancer cells
Thesis
Mohammed, S. Novel fusion proteins based on recombinant lectins for delivery of a cytotoxic peptide specifically to cancer cells. (Thesis). University of Salford

One of the most common post-translational modifications is covalent attachment of carbohydrates to proteins. At the cell surface, molecular recognition events involved in cancer metastasis are mediated by sugar moieties of glycoproteins. Evidence fro... Read More about Novel fusion proteins based on recombinant lectins for delivery of a cytotoxic peptide specifically to cancer cells.

Single-phase bimetallic system for the selective oxidation of glycerol to glycerate
Journal Article
Prati, L., Villa, A., Su, D., Wang, D., Krpetic, Z., & Porta, F. Single-phase bimetallic system for the selective oxidation of glycerol to glycerate. Studies in surface science and catalysis, 162, 553-560. https://doi.org/10.1016/S0167-2991%2806%2980952-3

Au-Pd bimetallic systems on carbon, (Pd@Au)/C (1) and Pd@Au/C (2), have been prepared by using metallic colloidal solutions, following two different procedures. The total metal loading was 1%wt and Au/Pd molar ratio 6/4. The catalytic activities have... Read More about Single-phase bimetallic system for the selective oxidation of glycerol to glycerate.

In vitro analysis of volatile organic compounds in search of potential biomarkers of lung cancer
Thesis
Schmidt, K. (in press). In vitro analysis of volatile organic compounds in search of potential biomarkers of lung cancer. (Thesis). University of Salford

Lung cancer is a leading cause of death from cancer worldwide. An early diagnosis and appropriate treatment are crucial in reducing mortality among people suffering from the disease. Therefore, one of the main focuses of lung cancer studies is on a... Read More about In vitro analysis of volatile organic compounds in search of potential biomarkers of lung cancer.

Antimicrobial evaluation of selected medicinal plants using molecular approach
Thesis
Qaddoori, A. G. Antimicrobial evaluation of selected medicinal plants using molecular approach. (Thesis). University of Salford

Resistance to antibiotics is one of the greatest menaces to the success of modern medication. It has lately become more dangerous because we can no longer be certain that any antibiotic chosen will work and because of the emergence of multidrug res... Read More about Antimicrobial evaluation of selected medicinal plants using molecular approach.

An investigation into the diversity of genes of the innate immune system in the European Badger (Meles meles) and possible associations with trypanosome infection
Thesis
Whiteoak, A. (in press). An investigation into the diversity of genes of the innate immune system in the European Badger (Meles meles) and possible associations with trypanosome infection. (Dissertation). University of Salford

Toll-like receptor (TLR) genes encode for conserved proteins of the innate immune system which trigger pathways in response to pathogen invasion by recognising molecules essential for endoparasite survival. An endoparasite lives within the host and r... Read More about An investigation into the diversity of genes of the innate immune system in the European Badger (Meles meles) and possible associations with trypanosome infection.

Canine echinococcosis in the Alay Valley, southern Kyrgyzstan
Thesis
van Kesteren, F. Canine echinococcosis in the Alay Valley, southern Kyrgyzstan. (Thesis). University of Salford

Echinococcosis is a serious and often fatal zoonotic disease caused by parasites in the genus Echinococcus. Echinococcus spp. cycle between intermediate and final hosts, and it is the accidental ingestion of eggs in faeces of final hosts (usually can... Read More about Canine echinococcosis in the Alay Valley, southern Kyrgyzstan.

The characterisation of flavone-DNA isoform interactions as a basis for anticancer drug development
Journal Article
Ragazzon, P., Bradshaw, T., Mathews, C., Iley, J., & Missailidis, S. The characterisation of flavone-DNA isoform interactions as a basis for anticancer drug development. Anticancer Research, 29(6), 2273-2283

BACKGROUND: The interactions of small molecules with nucleic acids are of considerable interest for the design of novel anticancer compounds. The physical properties and sequence specificity observed in the interactions between a group of flavonoi... Read More about The characterisation of flavone-DNA isoform interactions as a basis for anticancer drug development.

Inflammatory bowel disease and trichuris muris
Presentation / Conference
Bhardwaj, E., Else, K., Warhurst, G., & Rogan, M. Inflammatory bowel disease and trichuris muris. Poster presented at Crohns and Colitis Foundations National Clinical and Research Conference on Advances in Inflammatory Bowel Diseases, Hollywood, Florida

Inflammatory bowel disease (IBD) is a group of idiopathic chronic relapsing inflammatory conditions of the gastrointestinal tract. The precise etiology of IBD is unknown, although it is clearly multifactorial resulting from interplay of genetic, en... Read More about Inflammatory bowel disease and trichuris muris.

An MVA-based vaccine targeting the oncofetal antigen 5T4 in patients undergoing surgical resection of colorectal cancer liver metastases
Journal Article
Elkord, E., Dangoor, A., Drury, N., Harrop, R., Burt, D., Drijfhout, J., …Stern, P. An MVA-based vaccine targeting the oncofetal antigen 5T4 in patients undergoing surgical resection of colorectal cancer liver metastases. Journal of Immunotherapy, 31(9), 820-829

We investigated the use of a therapeutic vaccine, TroVax in patients undergoing surgical resection of colorectal cancer liver metastases. Systemic immunity generated by vaccination before and after resection of metastases was measured in addition to... Read More about An MVA-based vaccine targeting the oncofetal antigen 5T4 in patients undergoing surgical resection of colorectal cancer liver metastases.