Skip to main content

Research Repository

Advanced Search

Diblock polyampholytes grafted onto spherical particles : effect of stiffness, charge density, and grafting density (2007)
Journal Article
Akinchina, A., & Linse, P. (2007). Diblock polyampholytes grafted onto spherical particles : effect of stiffness, charge density, and grafting density. Langmuir, 23(3), 1465-1472. https://doi.org/10.1021/la062481r

The structure of spherical brushes formed by symmetric diblock polyampholytes end-grafted onto small spherical particles in aqueous solution is examined within the framework of the so-called primitive model using Monte Carlo simulations. The proper... Read More about Diblock polyampholytes grafted onto spherical particles : effect of stiffness, charge density, and grafting density.

A study of the cytotoxic effects of methionine depletion in human brain tumour cell lines (2007)
Thesis
Najim, N. A study of the cytotoxic effects of methionine depletion in human brain tumour cell lines. (Thesis). Salford : University of Salford

The aim of this project was to investigate the importance of methionine depletion as a cause of cytotoxicity for paediatric CNS tumour cell lines, and also to investigate the in vitro cellular biochemical responses, as measured by changes in cellul... Read More about A study of the cytotoxic effects of methionine depletion in human brain tumour cell lines.

An investigation into the congenital transmission of Toxoplasma gondii within ovine populations managed on working sheep farms in the United Kingdom (2007)
Thesis
Morley, E. An investigation into the congenital transmission of Toxoplasma gondii within ovine populations managed on working sheep farms in the United Kingdom. (Thesis). Salford : University of Salford

Toxoplasma gondii is an economically important parasite that can cause spontaneous abortion in sheep and humans. The importance of the different transmission routes of the parasite is unclear. However, three routes are recognised: (1) shedding of... Read More about An investigation into the congenital transmission of Toxoplasma gondii within ovine populations managed on working sheep farms in the United Kingdom.

Immunology and immunotherapy approaches for prostate cancer (2007)
Journal Article
Elkord, E. (2007). Immunology and immunotherapy approaches for prostate cancer. Prostate Cancer and Prostatic Diseases, 10(3), 224-236. https://doi.org/10.1038/sj.pcan.4500964

Several mechanisms that impair the immune response to promote tumour progression are reported. These mechanisms aim to reduce the ability of antigen-presenting cells to present antigen and activate naïve T cells to support an active immune response o... Read More about Immunology and immunotherapy approaches for prostate cancer.

Frequency of regulatory T cells in renal cell carcinoma patients and investigation of correlation with survival (2007)
Journal Article
Griffiths, R., Elkord, E., Gilham, D., Ramani, V., Clarke, N., Stern, P., & Hawkins, R. (2007). Frequency of regulatory T cells in renal cell carcinoma patients and investigation of correlation with survival. Cancer Immunology, Immunotherapy, 56(11), 1743-1753. https://doi.org/10.1007/s00262-007-0318-z

Regulatory T cells are important in maintaining immune homeostasis, mediating peripheral tolerance and preventing autoimmunity. Increased frequencies of CD4(+)CD25(high )T regulatory (T(Reg)) cells have been documented in the peripheral blood of pati... Read More about Frequency of regulatory T cells in renal cell carcinoma patients and investigation of correlation with survival.

Near infrared multiphoton-induced generation and detection of hydroxyl radicals in a biochemical system (2007)
Journal Article
Botchway, S., Crisostomo, A., Parker, A., & Bisby, R. (2007). Near infrared multiphoton-induced generation and detection of hydroxyl radicals in a biochemical system. Archives of Biochemistry and Biophysics, 464(2), 314-321. https://doi.org/10.1016/j.abb.2007.04.026

Solutions of tryptophan and N-hydroxypyridine-2-thione (mercaptopyridine-N-oxide, MPNO) were irradiated at 335 nm. Formation of 5-hydroxytryptophan was inferred from increased fluorescence at 334 nm on excitation at 315 nm, conditions chosen for sele... Read More about Near infrared multiphoton-induced generation and detection of hydroxyl radicals in a biochemical system.

Hydatid cysts: does every picture tell a story? (2006)
Journal Article
Rogan, M., Hai, W., Richardson, R., Zeyhle, E., & Craig, P. (2006). Hydatid cysts: does every picture tell a story?. Trends in Parasitology, 22(9), 431-438. https://doi.org/10.1016/j.pt.2006.07.003

Ultrasound imaging is an effective aid to the detection of abdominal cystic echinococcosis. Recently, the images produced have provided more information than just a diagnosis. Different cyst morphologies have been classified into types, and such clas... Read More about Hydatid cysts: does every picture tell a story?.

Pathogenicity and protective immunogenicity of cysteine proteinase-deficient mutants of Leishmania mexicana in non-murine models (2006)
Journal Article
Saravia, N., Escoria, B., Osorio, Y., Valderramaa, L., Brooks, D., Arteaga, L., …Travi, B. (2006). Pathogenicity and protective immunogenicity of cysteine proteinase-deficient mutants of Leishmania mexicana in non-murine models. Vaccine, 24(19), 4247-4259. https://doi.org/10.1016/j.vaccine.2005.05.045

This study demonstrates that deletion of cysteine proteinase (CP) genes diminishes pathogenicity of Leishmania mexicana in non-murine experimental host models while preserving immunogenicity. Both cpb and cpa/cpb-deficient lines induced delayed disea... Read More about Pathogenicity and protective immunogenicity of cysteine proteinase-deficient mutants of Leishmania mexicana in non-murine models.

Post-survey follow-up for human cystic echinococcosis in northwest China (2006)
Journal Article
Wang, Y., He, T., Wen, X., Li, T., Waili, A., Zhang, W., …Craig, P. (2006). Post-survey follow-up for human cystic echinococcosis in northwest China. Acta tropica, 98(1), 43-51. https://doi.org/10.1016/j.actatropica.2006.01.009

In Hobukesar, Xinjiang Uygur Autonomous Region, (China), a mass-screening programme for human cystic echinococcosis (CE) was performed during 1995 and 1996. After the survey 51 cases were followed-up using ultrasound scan and serology for 1–8 years (... Read More about Post-survey follow-up for human cystic echinococcosis in northwest China.

Total internal reflection fluorescence imaging using an upconverting cover slip for multicolour evanescent excitation (2006)
Journal Article
Morgan, C., & Mitchell, A. (2006). Total internal reflection fluorescence imaging using an upconverting cover slip for multicolour evanescent excitation. Journal of Microscopy, 222(1), 48-57. https://doi.org/10.1111/j.1365-2818.2006.01568.x

Total internal reflection fluorescence microscopy is well known as a means of studying surface-bound structures in cell biology. It is usually measured either by coupling a light source to the sample using a prism or with a special objective where li... Read More about Total internal reflection fluorescence imaging using an upconverting cover slip for multicolour evanescent excitation.

Formation of singlet oxygen from solutions of vitamin E (2006)
Journal Article
Dad, S., Bisby, R., Clark, I., & Parker, A. (2006). Formation of singlet oxygen from solutions of vitamin E. Free Radical Research, 40(3), 333-338. https://doi.org/10.1080/10715760500491174

Vitamin E offers protection against oxidative stress and is an efficient quencher of singlet oxygen. A recent report suggests that photo-excitation of vitamin E results in the formation of a triplet state (Naqvi et al. Photochem Photobiol Sci 2, 381... Read More about Formation of singlet oxygen from solutions of vitamin E.

Asymmetric alkylation of diarylmethane derivatives (2006)
Journal Article
Wilkinson, J., Rossington, S., Ducki, S., Leonard, J., & Hussain, N. (2006). Asymmetric alkylation of diarylmethane derivatives. Tetrahedron, 62(8), 1833-1844. https://doi.org/10.1016/j.tet.2005.11.044

Deprotonation–alkylation of prochiral diarylmethane substrates using sec-BuLi and (−)-sparteine has been carried out in excellent yields and up to 94% ee. A variety of enantioselective alkylations, silylations and stannylations have been performed on... Read More about Asymmetric alkylation of diarylmethane derivatives.

Selective entrance of gold nanoparticles into cancer cells (2006)
Journal Article
Krpetic, Z., Porta, F., & Scarì, G. (2006). Selective entrance of gold nanoparticles into cancer cells. Gold Bulletin, 39(2), 66-68. https://doi.org/10.1007/BF03215278

We report that Au(0) nanoparticles, stabilized by 5-aminovaleric acid, selectively penetrate into K562 cancer cells in a short time. These experiments were carried out in order to verify the specific recognition of gold sol by abnormal cells. The obs... Read More about Selective entrance of gold nanoparticles into cancer cells.

Correlation between CD8+ T cells specific for prostate-specific antigen and level of disease in patients with prostate cancer (2006)
Journal Article
Elkord, E., Rowbottom, A., Kynaston, H., & Wiiliams, P. (2006). Correlation between CD8+ T cells specific for prostate-specific antigen and level of disease in patients with prostate cancer. Clinical Immunology, 120(1), 91-98. https://doi.org/10.1016/j.clim.2005.12.008

Modest work has been performed to improve the sensitivity of residual disease detection or investigate the contribution that the immune system makes in controlling metastatic tumor growth, in particular, the frequency and biological actions of peptid... Read More about Correlation between CD8+ T cells specific for prostate-specific antigen and level of disease in patients with prostate cancer.

Role of regulatory T cells in allergy: implications for therapeutic strategy (2006)
Journal Article
Elkord, E. (2006). Role of regulatory T cells in allergy: implications for therapeutic strategy. Inflammation and Allergy - Drug Targets, 5(4), 211-217. https://doi.org/10.2174/187152806779010945

The interest in regulatory T cells (Tregs) has been revived following the discovery of developing multiorgan autoimmune diseases as a result of depleting CD4+CD25+ T cells from mice. The importance of Tregs is being recognized in various clinical fie... Read More about Role of regulatory T cells in allergy: implications for therapeutic strategy.

Alkylpurine-DNA-N-glycosylase excision of 7-(hydroxymethyl)-1,N6-ethenoadenine, a glycidaldehyde-derived DNA adduct (2006)
Journal Article
Wang, P., Guliaev, A., Elder, R., & Hang, B. (2006). Alkylpurine-DNA-N-glycosylase excision of 7-(hydroxymethyl)-1,N6-ethenoadenine, a glycidaldehyde-derived DNA adduct. DNA Repair, 5(1), 23-31. https://doi.org/10.1016/j.dnarep.2005.07.013

Glycidaldehyde (GDA) is a bifunctional alkylating agent that has been shown to be mutagenic in vitro and carcinogenic in rodents. However, the molecular mechanism by which it exerts these effects is not established. GDA is capable of forming exocycli... Read More about Alkylpurine-DNA-N-glycosylase excision of 7-(hydroxymethyl)-1,N6-ethenoadenine, a glycidaldehyde-derived DNA adduct.

Single- and multi-photon excited fluorescence from serotonin complexed with B-cyclodextrin (2006)
Journal Article
Botchway, S., Bisby, R., Dad, S., & Parker, A. (2006). Single- and multi-photon excited fluorescence from serotonin complexed with B-cyclodextrin. Photochemical & Photobiological Sciences Photochemical and Photobiological Sciences, 5, 122-126. https://doi.org/10.1039/b508602g

The fluorescence of serotonin on binding with B-cyclodextrin has been studied using both steady-state and time-resolved methods. Steady state fluorescence intensity of serotonin at 340 nm showed ~ 30% increase in intensity on binding with Ka ~ 60 dm3... Read More about Single- and multi-photon excited fluorescence from serotonin complexed with B-cyclodextrin.

Human cystic echinococcosis in two Mongolian communities in Hobukesar (China) and Bulgan (Mongolia). (2005)
Journal Article
Craig, P., Wang, Y., Zhang, W., Zhou, H., He, T., Rogan, M., …Mukhar, T. (2005). Human cystic echinococcosis in two Mongolian communities in Hobukesar (China) and Bulgan (Mongolia). Transactions of The Royal Society of Tropical Medicine and Hygiene, 99(9), 692-698. https://doi.org/10.1016/j.trstmh.2005.01.004

In order to investigate the prevalence of human cystic echinococcosis (CE) in traditional Mongolian communities in western Mongolia and Xinjiang (northwest China), studies were carried out between 1995 and 2000, on two ethnically identical population... Read More about Human cystic echinococcosis in two Mongolian communities in Hobukesar (China) and Bulgan (Mongolia)..