Circulating regulatory T cells in endometrial cancer: a role for age and menopausal status (2011)
Journal Article
Sawan, S., Burt, D., Stern, P., Holland, C., & Elkord, E. (2011). Circulating regulatory T cells in endometrial cancer: a role for age and menopausal status. Immunological Investigations, 40(1), 62-75. https://doi.org/10.3109/08820139.2010.513022

Regulatory T cells (Treg) are a sub-population of T cells that suppress self-reactivity and are implicated in immune tolerance towards malignant cells. Circulating Treg cells are increased in several cancers. In endometrial cancer Treg cells have bee... Read More about Circulating regulatory T cells in endometrial cancer: a role for age and menopausal status.

Tremelimumab (anti-CTLA4) mediates immune responses mainly by direct activation of T effector cells rather than by affecting T regulatory cells (2011)
Journal Article
Khan, S., Burt, D., Ralph, C., Hawkins, R., & Elkord, E. (2011). Tremelimumab (anti-CTLA4) mediates immune responses mainly by direct activation of T effector cells rather than by affecting T regulatory cells. Clinical Immunology, 138(1), 85-96. https://doi.org/10.1016/j.clim.2010.09.011

Cytotoxic T Lymphocyte Antigen 4 (CTLA4) blockade has shown antitumor activity against common cancers. However, the exact mechanism of immune mediation by anti-CTLA4 remains to be elucidated. Further understanding of how CTLA4 blockade with tremelimu... Read More about Tremelimumab (anti-CTLA4) mediates immune responses mainly by direct activation of T effector cells rather than by affecting T regulatory cells.

Novel IFNγ ELISPOT assay for detection of functional carcinoembryonic antigen-specific chimeric antigen receptor-redirected T cells (2011)
Journal Article
Elkord, E., & Burt, D. (2011). Novel IFNγ ELISPOT assay for detection of functional carcinoembryonic antigen-specific chimeric antigen receptor-redirected T cells. Scandinavian Journal of Immunology, 74(4), 419-422. https://doi.org/10.1111/j.1365-3083.2011.02588.x

We here describe the development of a novel ELISPOT assay for the detection and enumeration of IFNγ-secreting functional chimeric antigen receptor (CAR)-redirected T cells against carcinoembryonic antigen (CEA). This method is valuable for clinical t... Read More about Novel IFNγ ELISPOT assay for detection of functional carcinoembryonic antigen-specific chimeric antigen receptor-redirected T cells.

The effect of antibiotic treatment on bacteriophage production by a cystic fibrosis epidemic strain of Pseudomonas aeruginosa (2011)
Journal Article
Fothergill, J., Mowat, E., Walshaw, M., Ledson, M., James, C., & Winstanley, C. (2011). The effect of antibiotic treatment on bacteriophage production by a cystic fibrosis epidemic strain of Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy, 55(1), 426-428. https://doi.org/10.1128/AAC.01257-10

Phage production in response to antibiotics varied among four isolates of a Pseudomonas aeruginosa cystic fibrosis (CF) epidemic strain. Whereas ciprofloxacin induced higher levels of phage production, other CF-relevant antibiotics led to reduced p... Read More about The effect of antibiotic treatment on bacteriophage production by a cystic fibrosis epidemic strain of Pseudomonas aeruginosa.

Tubulin-binding Dibenz[c,e]oxepines as Colchinol analogues for targeting tumour vasculature (2010)
Journal Article
targeting tumour vasculature. Organic and Biomolecular Chemistry, 9(1), 219-231. https://doi.org/10.1039/c0ob00500b

Various methoxy- and hydroxy-substituted dibenz[c,e]oxepines were prepared via the copper(I)-induced coupling of ether-tethered arylstannanes or the dehydrative cyclisation of 1,1'- biphenyl-2,2'-dimethanols, assembled using the Ullmann cross-coupl... Read More about Tubulin-binding Dibenz[c,e]oxepines as Colchinol analogues for targeting tumour vasculature.

Inflicting controlled nonthermal damage to subcellular structures by laser-activated gold nanoparticles (2010)
Journal Article
Krpetic, Z., Nativo, P., Sée, V., Prior, I., Brust, M., & Volk, M. (2010). Inflicting controlled nonthermal damage to subcellular structures by laser-activated gold nanoparticles. Nano Letters, 10(11), 4549-4554. https://doi.org/10.1021/nl103142t

We show that low-intensity laser irradiation of cancer cells containing endosomal gold nanoparticles leads to endosome rupture and escape of the nanoparticles into the cytosol without affecting the cells’ viability. The low light intensity of our exp... Read More about Inflicting controlled nonthermal damage to subcellular structures by laser-activated gold nanoparticles.

Phagocytosis of biocompatible gold nanoparticles (2010)
Journal Article
Krpeticc, Z., Porta, F., Caneva, E., Dal Santo, V., & Scarì, G. (2010). Phagocytosis of biocompatible gold nanoparticles. Langmuir, 26(18), 14799-14805. https://doi.org/10.1021/la102758f

We report the evidence for the cellular uptake of gold nanoparticles via the phagocytosis mechanism in murine macrophage cells strongly supported by TEM and optical microscopy. Nanoparticles were prepared using several biocompatible molecules of choi... Read More about Phagocytosis of biocompatible gold nanoparticles.

Isolation of 1,4-Li2-C6H4 and its reaction with [(Ph3P)AuCl] (2010)
Journal Article
Flower, K., Mcgown, A., Miles, P., Pritchard, R., & Warren, J. (2010). Isolation of 1,4-Li2-C6H4 and its reaction with [(Ph3P)AuCl]. Dalton Transactions, 39(14), 3509-3520. https://doi.org/10.1039/b925355f

The difficulty in generating 1,4-Li2-C6H4 utilising the lithium halogen exchange reaction on 1,4-Br2-C6H4, 1,4-I2-C6H4 and 1-Br-4-I-C6H4 is revisited and only on treatment of 1,4-I2-C6H4 with 2 molar equivalents of n-BuLi can 1,4-Li2-C6H4 1 be isolat... Read More about Isolation of 1,4-Li2-C6H4 and its reaction with [(Ph3P)AuCl].

Cross-resistance of Cry1Ab-selected Asian corn borer to other Cry toxins (2010)
Journal Article
Xu, L., Wang, Z., Zhang, J., Ferry, N., & Gatehouse, A. (2010). Cross-resistance of Cry1Ab-selected Asian corn borer to other Cry toxins. Journal of Applied Entomology, 134(5), 429-438. https://doi.org/10.1111/j.1439-0418.2010.01517.x

The Asian corn borer, Ostrinia furnacalis (Guene´e) (Lepidoptera: Crambidae), is the most important insect pest of maize in China. Despite the proven track record of biotech Bacillus thuringiensis (Bt) maize to provide an effective means to control l... Read More about Cross-resistance of Cry1Ab-selected Asian corn borer to other Cry toxins.

Phase phenomena in supported lipid films under varying electric potential (2010)
Journal Article
Brukhno, A., Akinshina, A., Coldrick, Z., Nelson, A., & Auer, S. (2011). Phase phenomena in supported lipid films under varying electric potential. Soft Matter, 7(3), 1006-1017. https://doi.org/10.1039/C0SM00724B

We model cyclic voltammetry experiments on supported lipid films where a non-trivial dependence of the capacitance on the applied voltage is observed. Previously, based on a mean-field treatment of the Flory–Huggins type, under the assumption of stro... Read More about Phase phenomena in supported lipid films under varying electric potential.

The effect of Msh2 knockdown on methylating agent induced toxicity in DNA glycosylase deficient cells (2010)
Journal Article
Cooley, N., Elder, R., & Povey, A. (2010). The effect of Msh2 knockdown on methylating agent induced toxicity in DNA glycosylase deficient cells. Toxicology, 268(1-2), 111-117. https://doi.org/10.1016/j.tox.2009.12.008

The DNA structure recognition protein MSH2 is an important protein in DNA mismatch repair due to its role in initiating the repair process. To examine the potential interactions between mismatch repair and base excision repair (BER) we have examined... Read More about The effect of Msh2 knockdown on methylating agent induced toxicity in DNA glycosylase deficient cells.

Investigation of the effects of schistosoma mansoni eggs on hepatic stellate cell phenotype (2010)
Thesis
Anthony, B. Investigation of the effects of schistosoma mansoni eggs on hepatic stellate cell phenotype. (Thesis). Salford : University of Salford

Schistosomiasis is one of the most important helminth infections in man, infecting an estimated 200 million people worldwide leaving 20 million people with severe morbidity and causing 20,000 deaths a year. Of chronically infected patients approxi... Read More about Investigation of the effects of schistosoma mansoni eggs on hepatic stellate cell phenotype.

T regulatory cells in cancer: recent advances and therapeutic potential (2010)
Journal Article
Elkord, E., Alcantar-Orozco, E., Dovedi, S., & Tran, D. (2010). T regulatory cells in cancer: recent advances and therapeutic potential. Expert Opinion on Biological Therapy, 10(11), 1573-1586. https://doi.org/10.1517/14712598.2010.529126

IMPORTANCE OF THE FIELD: The active suppression of immune responses against tumor is a major barrier to the likely success of cancer immunotherapy. There is now compelling evidence implicating T regulatory cells (Tregs) as being key players driving i... Read More about T regulatory cells in cancer: recent advances and therapeutic potential.

Can the solid state structures of the dihalogen adducts R3EX2 (E = P, As; R = alkyl, aryl; X = Br, I) with the molecular spoke geometry be considered good mimics of the gold(I) systems [(R3E)AuX] (E = As, P; R = alkyl, aryl; X = Cl, Br, I)? (2010)
Journal Article
Barnes, N., Flower, K., Fyyaz, S., Godfrey, S., Mcgown, A., Miles, P., …Warren, J. (2010). Can the solid state structures of the dihalogen adducts R3EX2 (E = P, As; R = alkyl, aryl; X = Br, I) with the molecular spoke geometry be considered good mimics of the gold(I) systems [(R3E)AuX] (E = As, P; R = alkyl, aryl; X = Cl, Br, I)?. CrystEngComm, 12(3), 784-794. https://doi.org/10.1039/b917245a

The solid-state structures of compounds of the type R3EX2 and [(R3E)AuX] (R = alkyl, aryl, E = As, P, X = Cl, Br, I) have been compared on the basis that they have similar molecular shape and volume with a view to determine whether this is a good app... Read More about Can the solid state structures of the dihalogen adducts R3EX2 (E = P, As; R = alkyl, aryl; X = Br, I) with the molecular spoke geometry be considered good mimics of the gold(I) systems [(R3E)AuX] (E = As, P; R = alkyl, aryl; X = Cl, Br, I)?.

Cells deficient in PARP-1 show an accelerated accumulation of DNA single strand breaks, but not AP sites, over the PARP-1-proficient cells exposed to MMS. (2009)
Journal Article
Pachkowski, B., Tano, K., Afonin, V., Elder, R., Takeda, S., Watanabe, M., …Nakamura, J. (2009). Cells deficient in PARP-1 show an accelerated accumulation of DNA single strand breaks, but not AP sites, over the PARP-1-proficient cells exposed to MMS. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 671(1-2), 93-9. https://doi.org/10.1016/j.mrfmmm.2009.09.006

Poly(ADP-ribose) polymerase-1 (PARP-1) is a base excision repair (BER) protein that binds to DNA single strand breaks (SSBs) and subsequently synthesizes and transfers poly(ADP-ribose) polymers to various nuclear proteins. Numerous biochemical studie... Read More about Cells deficient in PARP-1 show an accelerated accumulation of DNA single strand breaks, but not AP sites, over the PARP-1-proficient cells exposed to MMS..

A riot of rhythms : neuronal and glial circadian oscillators in the mediobasal hypothalamus (2009)
Journal Article
Guilding, C., Hughes, A., Brown, T., Namvar, S., & Piggins, H. (2009). A riot of rhythms : neuronal and glial circadian oscillators in the mediobasal hypothalamus. Molecular Brain, 2(28), https://doi.org/10.1186/1756-6606-2-28

Background: In mammals, the synchronized activity of cell autonomous clocks in the suprachiasmatic nuclei (SCN) enables this structure to function as the master circadian clock, coordinating daily rhythms in physiology and behavior. However, the domi... Read More about A riot of rhythms : neuronal and glial circadian oscillators in the mediobasal hypothalamus.

Structure-activity studies of the binding of the flavonoid scaffold to DNA (2009)
Journal Article
Ragazzon, P., Iley, J., & Missailidis, S. (2009). Structure-activity studies of the binding of the flavonoid scaffold to DNA. Anticancer Research, 29(6), 2285-2293

BACKGROUND: Flavonoids have been shown to have a wide variety of biological activities and proven to be good scaffolds for the design of DNA-binding agents as anticancer therapeutics. MATERIALS AND METHODS: In structure-activity relationship s... Read More about Structure-activity studies of the binding of the flavonoid scaffold to DNA.

How beta-lactam antibiotics enter bacteria: a dialogue with the porins (2009)
Journal Article
James, C., Mahendran, K., Molitor, A., Bolla, J., Bessonov, A., Winterhalter, M., & Pages, J. (2009). How beta-lactam antibiotics enter bacteria: a dialogue with the porins. PLoS ONE, 4(5), e5453. https://doi.org/10.1371/journal.pone.0005453

BACKGROUND:Multi-drug resistant (MDR) infections have become a major concern in hospitals worldwide. This study investigates membrane translocation, which is the first step required for drug action on internal bacterial targets. beta-lactams, a major... Read More about How beta-lactam antibiotics enter bacteria: a dialogue with the porins.

Gold nanoparticles prepared using cape aloe active components (2009)
Journal Article
Krpetic, Z., Scarì, G., Caneva, E., Speranza, G., & Porta, F. (2009). Gold nanoparticles prepared using cape aloe active components. Langmuir, 25(13), 7217-7221. https://doi.org/10.1021/la9009674

A novel use of two components of Cape aloe, aloin A and aloesin, acting as stabilizers in the preparation of gold and silver nanoparticles, is reported. Stable water-soluble particles of different size and shape are prepared by varying the reaction c... Read More about Gold nanoparticles prepared using cape aloe active components.

Photoreactivity of biologically active compounds. XIX: Excited states and free radicals from the antimalarial drug primaquine (2009)
Journal Article
Kristensen, S., Edge, R., Tønnesen, H., Bisby, R., & Navaratnam, S. (2009). Photoreactivity of biologically active compounds. XIX: Excited states and free radicals from the antimalarial drug primaquine. Journal of Photochemistry and Photobiology B: Biology, 94(3), 147-157. https://doi.org/10.1016/j.jphotobiol.2008.11.006

The formation and reactivity of excited states and free radicals from primaquine was studied in order to evaluate the primary photochemical reaction mechanisms. The excited primaquine triplet was not detected, but is likely to be formed with a short... Read More about Photoreactivity of biologically active compounds. XIX: Excited states and free radicals from the antimalarial drug primaquine.