Nanoscale hydroxyl radical generation from multiphoton ionization of tryptophan
Journal Article
Bisby, R., Crisostomo, A., Botchway, S., & Parker, A. Nanoscale hydroxyl radical generation from multiphoton ionization of tryptophan. Photochemistry and Photobiology, 85(1), 353-357. https://doi.org/10.1111/j.1751-1097.2008.00447.x

Exposure of solutions containing both tryptophan and hydrogen peroxide to a pulsed (~180 fs) laser beam at 750 nm induces luminescence characteristic of 5 hydroxytryptophan. The results indicate that 3-photon excitation of tryptophan results in photo... Read More about Nanoscale hydroxyl radical generation from multiphoton ionization of tryptophan.

Biochemical characteristics and antimicrobial potential of seed and nut oils against Staphylococcus aureus
Thesis
Yangomodou, O. (in press). Biochemical characteristics and antimicrobial potential of seed and nut oils against Staphylococcus aureus. (Thesis). University of Salford

The antibacterial activities of oils and extracts from walnut, cashew and pumpkin were investigated on methicillin resistant and susceptible strain MRSA 252 and S. aureus ATCC 6538 using the disc agar diffusion technique. Results revealed that the te... Read More about Biochemical characteristics and antimicrobial potential of seed and nut oils against Staphylococcus aureus.

Transmission ecology of gastrointestinal trematodes of small mammals, malham tarn, North Yorkshire, UK
Thesis
Boyce, K. Transmission ecology of gastrointestinal trematodes of small mammals, malham tarn, North Yorkshire, UK. (Thesis). University of Salford

In 2007, Rogan et al. reported the rare occurrence of the digenean Plagiorchis muris from the wood mouse Apodemus sylvaticus at Malham Tarn Nature Reserve in North Yorkshire, UK. The life cycle of this trematode is not well understood. Therefore, in... Read More about Transmission ecology of gastrointestinal trematodes of small mammals, malham tarn, North Yorkshire, UK.

Expression and characterization of recombinant human NEIL3 from Escherichia coli
Thesis
Albelazi, M. (in press). Expression and characterization of recombinant human NEIL3 from Escherichia coli. (Thesis). University of Salford

The DNA glycosylase NEIL3 is one of a family of proteins that release oxidized bases from DNA, thereby initiating base excision repair. NEIL3 gene expression is normally tightly regulated and expressed only in certain rapidly dividing cells, however,... Read More about Expression and characterization of recombinant human NEIL3 from Escherichia coli.

Characterising human lung tissue for biomarkers of EMT-fibrosis and functional steroid receptor components in chronic obstructive pulmonary disease (COPD) patients and control subjects
Thesis
Patel, H. (in press). Characterising human lung tissue for biomarkers of EMT-fibrosis and functional steroid receptor components in chronic obstructive pulmonary disease (COPD) patients and control subjects. (Dissertation). University of Salford

COPD is a poorly reversible airflow obstruction commonly induced by cigarette smoke. Pathology is linked to a series of inflammatory and fibrotic events in the small airways and lung parenchyma; including fibrosis, emphysema and mucus plugging. Thi... Read More about Characterising human lung tissue for biomarkers of EMT-fibrosis and functional steroid receptor components in chronic obstructive pulmonary disease (COPD) patients and control subjects.

Immunodiagnosis of human and canine echinococcosis and community studies in northwestern China
Thesis
Feng, X. Immunodiagnosis of human and canine echinococcosis and community studies in northwestern China. (Thesis). University of Salford

Echinococcosis is highly endemic in northwestern China. In order to improve sero-testing in support of community screening and for hospital use, a dot immunogold filtration assay (DIGFA) for rapid serodiagnosis of human CE and AE was developed. DIGFA... Read More about Immunodiagnosis of human and canine echinococcosis and community studies in northwestern China.

SPARC 2022 book of abstracts
Book
Ardo, A., Abdullahi, A., Bennett, A., Mbabu, A., Woodman, A., Foster, A., …Taylor, T. T. Ireland (Ed.), SPARC 2022 book of abstracts. Salford, United Kingdom: University of Salford

Welcome to the Book of Abstracts for the 2022 SPARC conference. Our conference is called “Moving
Forwards” reflecting our re-emergence from the pandemic and our desire to reconnect our PGR
community, in celebration of their research. PGRs have co... Read More about SPARC 2022 book of abstracts.

Investigating alterations in autophagy in Alzheimer’s disease using human brain tissue and skin-derived fibroblasts
Thesis
Stan, D.-M. (in press). Investigating alterations in autophagy in Alzheimer’s disease using human brain tissue and skin-derived fibroblasts. (Thesis). University of Salford

Alzheimer’s disease (AD) is the main cause of dementia, affecting 500,000 people in the UK. Pathology of AD is characterised by the accumulation of abnormally phosphorylated tau protein within neurofibrillary tangles and plaques containing amyloid-β... Read More about Investigating alterations in autophagy in Alzheimer’s disease using human brain tissue and skin-derived fibroblasts.

Synthesis and evaluation of novel antivascular agents for two-photon activation
Thesis
Barnes, N. (in press). Synthesis and evaluation of novel antivascular agents for two-photon activation. (Thesis). University of Salford

Cancer is one of the major causes of death worldwide, hence the development of novel effective treatments to combat this disease is important. Combretastatins are powerful anticancer drugs with some derivatives in advanced clinical trials for cancer... Read More about Synthesis and evaluation of novel antivascular agents for two-photon activation.

Use of an 18s rRNA metagenomics approach as a method of detection of multiple infections in field blood samples collected on FTA cards from cattle
Thesis
West, D. (in press). Use of an 18s rRNA metagenomics approach as a method of detection of multiple infections in field blood samples collected on FTA cards from cattle. (Dissertation). University of Salford

Parasitic disease causes major health problems in humans and animals globally. Diseases in tropical and remote areas, sometimes known as neglected tropical diseases, pose some of the greater problems due to the difficulty in collecting and analysing... Read More about Use of an 18s rRNA metagenomics approach as a method of detection of multiple infections in field blood samples collected on FTA cards from cattle.

Novel markers for human T regulatory cells in healthy donors and cancer patients
Thesis
Abd Al Samid, M. (in press). Novel markers for human T regulatory cells in healthy donors and cancer patients. (Thesis). University of Salford

CD4+CD25+FoxP3+ T regulatory cells (Tregs) are essential for maintaining self-tolerance and preventing autoimmune diseases. However, FoxP3+ Tregs contribute to the progression of cancer and their levels expand in cancer patients compared to healthy d... Read More about Novel markers for human T regulatory cells in healthy donors and cancer patients.

Bats and their endoparasites : characterising pipistrelle infections and toll-like receptor (TLR2 and TLR4) gene variations
Thesis
Gattan, H. (in press). Bats and their endoparasites : characterising pipistrelle infections and toll-like receptor (TLR2 and TLR4) gene variations. (Thesis). University of Salford

Bats are unique mammals since they are able to fly and due to their crucial ecosystem roles, they are designated as keystone species. However, in many parts of the world, it is difficult to study bats due to the existence of protective legislation ca... Read More about Bats and their endoparasites : characterising pipistrelle infections and toll-like receptor (TLR2 and TLR4) gene variations.

An investigation into the diversity of genes of the innate immune system in the European Badger (Meles meles) and possible associations with trypanosome infection
Thesis
Whiteoak, A. (in press). An investigation into the diversity of genes of the innate immune system in the European Badger (Meles meles) and possible associations with trypanosome infection. (Dissertation). University of Salford

Toll-like receptor (TLR) genes encode for conserved proteins of the innate immune system which trigger pathways in response to pathogen invasion by recognising molecules essential for endoparasite survival. An endoparasite lives within the host and r... Read More about An investigation into the diversity of genes of the innate immune system in the European Badger (Meles meles) and possible associations with trypanosome infection.

Isolation and characterization of a glycosaminoglycan with anticancer activity
Thesis
Ogundipe, O. (in press). Isolation and characterization of a glycosaminoglycan with anticancer activity. (Thesis). University of Salford

Glycosaminoglycans (GAGs) are a family of complex mixture of linear polysaccharides that are present in both vertebrates and invertebrates. This polysaccharide plays important roles in physiological and pathological conditions, including cancer. In t... Read More about Isolation and characterization of a glycosaminoglycan with anticancer activity.

Induction of the stringent response in staphylococcus aureus by mupirocin and its effect on global transcription and virulence factors
Thesis
Alhoufie, S. Induction of the stringent response in staphylococcus aureus by mupirocin and its effect on global transcription and virulence factors. (Thesis). University of Salford, Manchester

Staphylococcus aureus is a major pathogen in both hospital and community settings and it causes infections ranging from mild skin and wound infections to life-threatening systemic illness and, together with the emergence of antibiotic resistance, has... Read More about Induction of the stringent response in staphylococcus aureus by mupirocin and its effect on global transcription and virulence factors.