Deep tissue bio-imaging using two-photon excited CdTe fluorescent quantum dots working within the biological window

Martinez Maestro, L; Ramirez-Hernandez, JE; Bodgan, N; Capobianco, JA; Vetrone, F; Garcia Sole, J; Jaque, D

Abstract

A new approach to deep tissue imaging is presented based on 8 nm CdTe semiconductor quantum dots (QDs). The characteristic 800 nm emission was found to be efficiently excited via two-photon absorption of 900 nm photons. The fact that both excitation and emission wavelengths lie within the "biological window" allows for high resolution fluorescence imaging at depths close to 2 mm. These penetration depths have been used to obtain the first deep tissue multiphoton excited fluorescence image based on CdTe-QDs. Due to the large thermal sensitivity of CdTe-QDs, one may envisage, in the near future, their use in high resolution deep-tissue thermal imaging.

Citation

Martinez Maestro, L., Ramirez-Hernandez, J., Bodgan, N., Capobianco, J., Vetrone, F., Garcia Sole, J., & Jaque, D. (2012). Deep tissue bio-imaging using two-photon excited CdTe fluorescent quantum dots working within the biological window. Nanoscale, 4(1), 298-302. https://doi.org/10.1039/c1nr11285f

• Journal Article Type: Article
• Acceptance Date: Oct 8, 2011
• Online Publication Date: Nov 9, 2011
• Publication Date: Jan 1, 2012
• Deposit Date: Dec 5, 2019
• Journal: Nanoscale
• Print ISSN: 2040-3364
• Electronic ISSN: 2040-3372
• Publisher: Royal Society of Chemistry
• Volume: 4
• Issue: 1
• Pages: 298-302
• DOI: https://doi.org/10.1039/c1nr11285f
• Publisher URL: http://dx.doi.org/10.1039/C1NR11285F
• Related Public URLs: https://pubs.rsc.org/en/journals/journalissues/nr#!recentarticles&adv
• Additional Information: Funders : Universidad Autonoma de Madrid;Comunidad Autonoma de Madrid;Spanish Ministerio de Educacion y Ciencia;Banco Santander CEAL-UAM;Natural Sciences and Engineering Research Council (NSERC) of Canada;Concordia University Research Chairs