Photochemical DNA cleavage by a Berenil analog

Burr, SJ; Mselati, A; Thomas, EW

Abstract

Berenil [bis(4-amidinophenyl)1,3-triazene] is a photostable DNA-binding ligand. We describe here the synthesis of N-(3-hydroxypropyl)-Berenil, which in contrast to Berenil is photosensitive to 360 nm irradiation, behaving as a caged diazonium salt. The 4-amidinobenzenediazonium fragment produced by photolysis induces DNA modification and cleavage.

Citation

Burr, S., Mselati, A., & Thomas, E. (2003). Photochemical DNA cleavage by a Berenil analog. Tetrahedron Letters, 44(39), 7307-7309. https://doi.org/10.1016/j.tetlet.2003.08.002

• Journal Article Type: Article
• Publication Date: Sep 1, 2003
• Deposit Date: Aug 8, 2007
• Journal: Tetrahedron Letters
• Print ISSN: 0040-4039
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 44
• Issue: 39
• Pages: 7307-7309
• DOI: https://doi.org/10.1016/j.tetlet.2003.08.002
• Publisher URL: http://dx.doi.org/10.1016/j.tetlet.2003.08.002