All Outputs (25)

Genetic association and stress mediated down-regulation in trabecular meshwork implicates MPP7 as a novel candidate gene in primary open angle glaucoma (2016)
Journal Article
Vishal, M., Sharma, A., Kaurani, L., Alfano, G., Mookerjee, S., Narta, K., …Mukhopadhyay, A. (2016). Genetic association and stress mediated down-regulation in trabecular meshwork implicates MPP7 as a novel candidate gene in primary open angle glaucoma. BMC Medical Genomics, 9(15), https://doi.org/10.1186/s12920-016-0177-6

Background: Glaucoma is the largest cause of irreversible blindness affecting more than 60 million people globally.
The disease is defined as a gradual loss of peripheral vision due to death of Retinal Ganglion Cells (RGC). The RGC death is largely... Read More about Genetic association and stress mediated down-regulation in trabecular meshwork implicates MPP7 as a novel candidate gene in primary open angle glaucoma.

Altered expression and editing of miRNA-100 regulates iTreg differentiation (2015)
Journal Article
Negi, V., Paul, D., Das, S., Bajpai, P., Singh, S., Mukhopadhyay, A., …Ghosh, B. (2015). Altered expression and editing of miRNA-100 regulates iTreg differentiation. Nucleic Acids Research, 43(16), 8057-8065. https://doi.org/10.1093/nar/gkv752

RNA editing ofmiRNAs, especially in the seed region,
adds another layer to miRNA mediated gene regulation
which can modify its targets, altering cellular signaling
involved in important processes such as differentiation.
In this study, we have ex... Read More about Altered expression and editing of miRNA-100 regulates iTreg differentiation.

Evaluation of genetic association of the INK4 locus with primary open angle glaucoma in East Indian population (2014)
Journal Article
angle glaucoma in East Indian population. Scientific reports, 4, 5115. https://doi.org/10.1038/srep05115

INK4 locus at chromosome 9p21 has been reported to be associated with primary open angle glaucoma (POAG) and its subtypes along with the associated optic disc parameters across the populations of European, Japanese and African ancestries. The locus e... Read More about Evaluation of genetic association of the INK4 locus with primary open angle glaucoma in East Indian population.

Gene-rich large deletions are overrepresented in POAG patients of Indian and Caucasian origins (2014)
Journal Article
Kaurani, L., Vishal, M., Kumar, D., Sharma, A., Mehani, B., Sharma, C., …Mukhopadhyay, A. (2014). Gene-rich large deletions are overrepresented in POAG patients of Indian and Caucasian origins. https://doi.org/10.1167/iovs.14-14339

PURPOSE:
Large copy number variations (CNV) can contribute to increased burden for neurodegenerative diseases. In this study, we analyzed the genome-wide burden of large CNVs > 100 kb in primary open angle glaucoma (POAG), a neurodegenerative diseas... Read More about Gene-rich large deletions are overrepresented in POAG patients of Indian and Caucasian origins.

Genome-wide analysis identifies common CNVs associated with primary open angle glaucoma (2014)
Journal Article
Kaurani, L., Vishal, M., Kumar, D., Mehani, B., Sharma, C., Sharma, A., …Mukhopadhyay, A. (2014). Genome-wide analysis identifies common CNVs associated with primary open angle glaucoma. Molecular Cytogenetics, 7, Article 131. https://doi.org/10.1186/1755-8166-7-s1-p131

Background
Copy number variation (CNV) is one of the major factors contributing to genomic diversity and diseases. Glaucoma is a major neurodegenerative disease causing irreversible vision loss across the globe. We wanted to analyze the impact of co... Read More about Genome-wide analysis identifies common CNVs associated with primary open angle glaucoma.