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Prototype software for the clinical evaluation of In-111 SPECT-CT dotatate images conducted prior to and immediately after Y-90 dotatate radionuclide therapy (2011)
Journal Article
Hogg, P., Swire, V., Orlinksi, M., Blindell, P., Vinjamuri, S., & Szczepura, K. (2011). Prototype software for the clinical evaluation of In-111 SPECT-CT dotatate images conducted prior to and immediately after Y-90 dotatate radionuclide therapy. European Journal of Nuclear Medicine and Molecular Imaging, 38(Sup. 2), S447. https://doi.org/10.1007/s00259-011-1913-y

Aim and Background Neuroendocrine tumours (NETs) are heterogenous and frequently express cell membrane specific peptide receptors such as somatostatin receptors (SSTRs). Radiolabelled receptor binding of somatostatin analogues can guide radioact... Read More about Prototype software for the clinical evaluation of In-111 SPECT-CT dotatate images conducted prior to and immediately after Y-90 dotatate radionuclide therapy.

Measuring whole-body neutrophil redistribution using a dedicated whole-body counter and ultra-low doses of 111 Indium (2011)
Journal Article
Szczepura, K., Ruparelia, P., Solanki, C., Balan, K., Newbold, P., Summers, C., …Peters, A. (2011). Measuring whole-body neutrophil redistribution using a dedicated whole-body counter and ultra-low doses of 111 Indium. European Journal of Clinical Investigation, 41(1), 77-83. https://doi.org/10.1111/j.1365-2362.2010.02382.x

Background - There is increasing interest in the ‘homing’ of neutrophils to bone marrow. The aim of this study was to measure the whole-body redistribution of 111In using a whole-body counter following the administration of ultra-small activities of... Read More about Measuring whole-body neutrophil redistribution using a dedicated whole-body counter and ultra-low doses of 111 Indium.

Quantification of neutrophil migration into the lungs of patients with chronic obstructive pulmonary disease (2011)
Journal Article
Ruparelia, P., Szczepura, K., Summers, C., Solanki, C., Balan, K., Newbold, P., …Chilvers, E. (2011). Quantification of neutrophil migration into the lungs of patients with chronic obstructive pulmonary disease. European Journal of Nuclear Medicine and Molecular Imaging, 38(5), 911-919. https://doi.org/10.1007/s00259-010-1715-7

Objective: to quantify neutrophil migration into the lungs of patients with chronic pulmonary obstructive disease (COPD). Methods: neutrophil loss via airways was assessed by dedicated whole-body counting 45 min, 24 h and 2, 4, 7 and 10 days after... Read More about Quantification of neutrophil migration into the lungs of patients with chronic obstructive pulmonary disease.

Determination of optimal CT exposure factors for lung lesions using an anthropomorphic chest phantom for SPECT-CT (2010)
Journal Article
Thompson, J., Szczepura, K., Tootell, A., Sil, J., Manning, D., & Hogg, P. (2010). Determination of optimal CT exposure factors for lung lesions using an anthropomorphic chest phantom for SPECT-CT. European Journal of Nuclear Medicine and Molecular Imaging, 37(Sup. 2), S494. https://doi.org/10.1007/s00259-010-1560-8

PURPOSE: SPECT‐CT is a valuable modality for diagnosis and staging of primary and secondary malignant disease and also diagnosing benign conditions. CT incurs a significant radiation burden; consequently CT acquisition parameters require optimisati... Read More about Determination of optimal CT exposure factors for lung lesions using an anthropomorphic chest phantom for SPECT-CT.

Does P-glycoprotein have a role in the lung clearances of inhaled 99m Tc-sestamibi and 99m Tc-tetrofosmin? (2009)
Journal Article
Cheow, H., Ruparelia, P., Shankar, S., Szczepura, K., Ballinger, J., Hartman, N., …Peters, A. (2009). Does P-glycoprotein have a role in the lung clearances of inhaled 99m Tc-sestamibi and 99m Tc-tetrofosmin?. Nuclear Medicine Communications, 30(8), 617-621. https://doi.org/10.1097/MNM.0b013e32832b9a2d

Objective - The clearance rate of inhaled 99mTc-sestamibi from the lungs of healthy nonsmoking individuals is much slower than would be expected from its physical properties. The clearance rate is even slower in healthy cigarette smokers. As 99mTc-s... Read More about Does P-glycoprotein have a role in the lung clearances of inhaled 99m Tc-sestamibi and 99m Tc-tetrofosmin?.

Does P-glycoprotein have a role in the lung clearances of inhaled 99mTc-sestamibi and 99mTc-tetrofosmin? (2009)
Journal Article
Cheow, H., Ruparelia, P., Shankar, S., Szczepura, K., Ballinger, J., Hartman, N., …Michael Peters, A. (2009). Does P-glycoprotein have a role in the lung clearances of inhaled 99mTc-sestamibi and 99mTc-tetrofosmin?. Nuclear Medicine Communications, 30(8), 617-621. https://doi.org/10.1097/mnm.0b013e32832b9a2d

Objective The clearance rate of inhaled 99mTc-sestamibi from the lungs of healthy nonsmoking individuals is much slower than would be expected from its physical properties. The clearance rate is even slower in healthy cigarette smokers. As 99mTc-se... Read More about Does P-glycoprotein have a role in the lung clearances of inhaled 99mTc-sestamibi and 99mTc-tetrofosmin?.

Pulmonary elimination rate of inhaled 99m Tc-sestamibi radioaerosol is delayed in healthy cigarette smokers (2008)
Journal Article
Ruparelia, P., Cheow, H., Evans, J., Banney, L., Shankar, S., Szczepura, K., …Peters, A. (2008). Pulmonary elimination rate of inhaled 99m Tc-sestamibi radioaerosol is delayed in healthy cigarette smokers. British Journal of Clinical Pharmacology, 65(4), 611-614. https://doi.org/10.1111/j.1365-2125.2008.03099.x

Aim - To explore inhaled technetium-99m-labelled hexakis-methoxy-isobutyl isonitrile (99mTc-sestamibi) for quantifying pulmonary P-glycoprotein(P-gp) expression. Methods - The elimination rate from the lungs of 99mTc-sestamibi was recorded scintigra... Read More about Pulmonary elimination rate of inhaled 99m Tc-sestamibi radioaerosol is delayed in healthy cigarette smokers.

Healthy passive cigarette smokers have increased pulmonary alveolar permeability (2007)
Journal Article
Beadsmoore, C., Cheow, H., Szczepura, K., Ruparelia, P., & Michael Peters, A. (2007). Healthy passive cigarette smokers have increased pulmonary alveolar permeability. Nuclear Medicine Communications, 28(2), 75-77. https://doi.org/10.1097/MNM.0b013e328013eb1e

Question Does passive smoking have a measurable effect on lung function in otherwise healthy subjects? There is current interest concerning passive smoking but no objective evidence showing that it has any impact on lung function. Methods The... Read More about Healthy passive cigarette smokers have increased pulmonary alveolar permeability.

P16 Healthy passive cigarette smokers have increased pulmonary alveolar permeability (2006)
Journal Article
Beadsmoore, C., Cheow, H., Szczepura, K., Ruparelia, P., & Peters, A. (2006). P16 Healthy passive cigarette smokers have increased pulmonary alveolar permeability. Nuclear Medicine Communications, 27(12), 1027-1028. https://doi.org/10.1097/00006231-200612000-00067

Background and aim To determine whether passive smoking has a measurable effect on lung function in otherwise healthy subjects? There is current interest concerning passive smoking but no objective evidence showing that it has any impact on lung func... Read More about P16 Healthy passive cigarette smokers have increased pulmonary alveolar permeability.

Granulocyte trafficking in chronic obstructive pulmonary disease (2006)
Journal Article
Ruparelia, P., Szczepura, K., Bilton, D., Peters, A., & Chilvers, E. (2006). Granulocyte trafficking in chronic obstructive pulmonary disease. Thorax, 61(Sup. 2), ii108-ii109

Introduction: Chronic obstructive pulmonary disease (COPD) is an inflammatory condition of the airways characterised by intense neutrophilia. We have used sub-imaging doses of 111 indium (111In) labelled granulocytes and high sensitivity whole body c... Read More about Granulocyte trafficking in chronic obstructive pulmonary disease.

A16 Using whole-body counting to determine neutrophil trafficking and loss in COPD (2006)
Journal Article
Szczepura, K., Ruparelia, P., Bilton, D., Chilvers, E., & Peters, A. (2006). A16 Using whole-body counting to determine neutrophil trafficking and loss in COPD. Nuclear Medicine Communications, 27(3), 285. https://doi.org/10.1097/00006231-200603000-00027

COPD is an inflammatory condition of the airways characterized by airway neutrophilia. Using a whole-body-counter (WBC) we have assessed neutrophil trafficking and loss in COPD using small activities of 111In-labelled neutrophils. Patients were scann... Read More about A16 Using whole-body counting to determine neutrophil trafficking and loss in COPD.

Quantification of disease activity in patients undergoing leucocyte scintigraphy for suspected inflammatory bowel disease (2004)
Journal Article
Cheow, H., Voutnis, D., Evans, J., Szczepura, K., Swift, E., Bird, N., …Peters, A. (2005). Quantification of disease activity in patients undergoing leucocyte scintigraphy for suspected inflammatory bowel disease. European Journal of Nuclear Medicine and Molecular Imaging, 32(3), 329-337. https://doi.org/10.1007/s00259-004-1617-7

Purpose Whole-body gamma camera counting is an alternative to faecal 111In collection for quantifying disease activity in inflammatory bowel disease (IBD) but requires administration of imaging activities of 111In. The aim of this study was to explo... Read More about Quantification of disease activity in patients undergoing leucocyte scintigraphy for suspected inflammatory bowel disease.

P25. Tolerance and diagnostic accuracy of myocardial scintigraphy with adenosine infusion, 6 min (standard) versus 3 min (abbreviated) protocol (2003)
Journal Article
Gopinath, G., Buscombe, J., Naojee, S., Szczepura, K., & Hilson, A. (2003). P25. Tolerance and diagnostic accuracy of myocardial scintigraphy with adenosine infusion, 6 min (standard) versus 3 min (abbreviated) protocol. Nuclear Medicine Communications, 24(4), 476. https://doi.org/10.1097/00006231-200304000-00114

Myocardial perfusion scintigraphy with adenosine is an effective and safe method for diagnosing coronary artery disease (CAD). Various reports suggest that a 3 min stress regime is as efficacious as a 6 min regime. The aim of the study was to study t... Read More about P25. Tolerance and diagnostic accuracy of myocardial scintigraphy with adenosine infusion, 6 min (standard) versus 3 min (abbreviated) protocol.