Skip to main content

Research Repository

Advanced Search

Prof Marija Krstic-Demonacos' Outputs (33)

Investigation of P53 and TTC5 function in lung cancer (2024)
Thesis
Menendez Creamer, D. P. (2024). Investigation of P53 and TTC5 function in lung cancer. (Thesis). University of Salford

Lung cancer represents 11.6% of the total cases with patients destined for a poor outcome due to late-stage detection, therefore it is important to find new approaches to detect and treat this disease. Current evidence suggests a role of p53 gene and... Read More about Investigation of P53 and TTC5 function in lung cancer.

Intratumor microbiota as a novel potential prognostic indicator in mesothelioma (2023)
Journal Article
Pentimalli, F., Krstic- Demonacos, M., Costa, C., Mutti, L., & Bakker, E. (2023). Intratumor microbiota as a novel potential prognostic indicator in mesothelioma. Frontiers in Immunology, 14, https://doi.org/10.3389/fimmu.2023.1129513

Introduction: Despite increased attention on immunotherapy, primarily immune checkpoint blockade, as a therapeutic approach for mesothelioma (MMe), its efficacy and tolerability remain questioned. One potential explanation for different responses to... Read More about Intratumor microbiota as a novel potential prognostic indicator in mesothelioma.

Elimination of Off-Target Effect by Chemical Modification of 5'-End of Small Interfering RNA (2022)
Journal Article
Shiohama, Y., Fujita, R., Sonokawa, M., Hisano, M., Kotake, Y., Krstic- Demonacos, M., …Fujii, M. (2022). Elimination of Off-Target Effect by Chemical Modification of 5'-End of Small Interfering RNA. Nucleic Acid Therapeutics, 32(5), 438-447. https://doi.org/10.1089/nat.2021.0068

In this study, the efficiency of RNA interference of small interfering RNAs (siRNAs) bearing 5′-O-methyl-2′-deoxythymidine (X) and 5′-amino-2′, 5′-dideoxythymidine (Z) at the 5′-end of the sense strand and the antisense strand of siRNA was investigat... Read More about Elimination of Off-Target Effect by Chemical Modification of 5'-End of Small Interfering RNA.

Comparison of 3 randomized clinical trials of frontline therapies for malignant pleural mesothelioma (2022)
Journal Article
Meirson, T., Pentimalli, F., Cerza, F., Baglio, G., Gray, S., Correale, P., …Mutti, L. (2022). Comparison of 3 randomized clinical trials of frontline therapies for malignant pleural mesothelioma. Jama Network Open, 5(3), e221490. https://doi.org/10.1001/jamanetworkopen.2022.1490

Importance: Some recently proposed frontline therapies for malignant pleural mesothelioma (MPM) are very costly, yet their impact on quality of life and overall survival of these patients remains arguable. Given the high social toll of this aggressiv... Read More about Comparison of 3 randomized clinical trials of frontline therapies for malignant pleural mesothelioma.

Protein disulfide isomerase A1‑associated pathways in the development of stratified breast cancer therapies (2022)
Journal Article
Bakker, E., Fujii, M., Krstic‑Demonacos, M., Demonacos, C., & Alhammad, R. (2022). Protein disulfide isomerase A1‑associated pathways in the development of stratified breast cancer therapies. International Journal of Oncology, 60(2), 16. https://doi.org/10.3892/ijo.2022.5306

The oxidoreductase protein disulfide isomerase A1 (PDIA1) functions as a cofactor for many transcription factors including estrogen receptor α (ERα), nuclear factor (NF)‑κB, nuclear factor erythroid 2‑like 2 (NRF2) and regulates the protein stability... Read More about Protein disulfide isomerase A1‑associated pathways in the development of stratified breast cancer therapies.

Evaluation of the role of p53 tumour suppressor posttranslational modifications and TTC5 cofactor in lung cancer (2021)
Journal Article
Alhebshi, H., Tian, K., Patnaik, L., Taylor, R., Bezecny, P., Hall, C., …Krstic- Demonacos, M. (2021). Evaluation of the role of p53 tumour suppressor posttranslational modifications and TTC5 cofactor in lung cancer. International Journal of Molecular Sciences, 22(24), e13198. https://doi.org/10.3390/ijms222413198

Mutations in the p53 tumor suppressor are found in over 50% of cancers. p53 function is controlled through posttranslational modifications and cofactor interactions. In this study, we investigated the posttranslationally modified p53, including p53 a... Read More about Evaluation of the role of p53 tumour suppressor posttranslational modifications and TTC5 cofactor in lung cancer.

Circular and linear : a tale of aptamer selection for the activation of SIRT1 to induce death in cancer cells (2020)
Journal Article
Al-Sudani, B., Ragazzon-Smith, A., Aziz, A., Alansari, R., Ferry, N., Krstic- Demonacos, M., & Ragazzon, P. (2020). Circular and linear : a tale of aptamer selection for the activation of SIRT1 to induce death in cancer cells. RSC Advances, 10(73), 45008-45018. https://doi.org/10.1039/D0RA07857C

It is a challenge to select the right target to treat conditions without affecting non-diseased cells. Cancer belongs to the top 10 causes of death in the world and it remains difficult to treat. Amongst cancer emerging targets, silent information re... Read More about Circular and linear : a tale of aptamer selection for the activation of SIRT1 to induce death in cancer cells.

Protein disulfide isomerase A1 regulates breast cancer cell immunorecognition in a manner dependent on redox state (2020)
Journal Article
Alhammad, R., Khunchai, S., Tongmuang, N., Limjindaporn, T., Yenchitsomanus, P., Mutti, L., …Demonacos, C. (2020). Protein disulfide isomerase A1 regulates breast cancer cell immunorecognition in a manner dependent on redox state. Oncology Reports, 44(6), 2406-2418. https://doi.org/10.3892/or.2020.7816

Oxidoreductase protein disulphide isomerases (PDI) are involved in the regulation of a variety of biological processes including the modulation of endoplasmic reticulum (ER) stress, unfolded protein response (UPR), ER‑mitochondria communication and t... Read More about Protein disulfide isomerase A1 regulates breast cancer cell immunorecognition in a manner dependent on redox state.

Endoplasmic reticulum stress, unfolded protein response and autophagy contribute to resistance to glucocorticoid treatment in human acute lymphoblastic leukaemia cells (2020)
Journal Article
Sudsaward, S., Khunchai, S., Thepmalee, C., Othman, A., Limjindaporn, T., Yenchitsomanus, P., …Demonacos, C. (2020). Endoplasmic reticulum stress, unfolded protein response and autophagy contribute to resistance to glucocorticoid treatment in human acute lymphoblastic leukaemia cells. International Journal of Oncology, 57(3), 835-844. https://doi.org/10.3892/ijo.2020.5089

Acute lymphoblastic leukaemia (ALL) is the most frequent childhood cancer and, although it is highly treatable, resistance to therapy, toxicity and side effects remain challenging. The synthetic glucocorticoid (GC) dexamethasone (Dex) is commonly use... Read More about Endoplasmic reticulum stress, unfolded protein response and autophagy contribute to resistance to glucocorticoid treatment in human acute lymphoblastic leukaemia cells.

Telomerase inhibition, Telomere attrition and proliferation arrest of cancer cells induced by Phosphorothioate ASO-NLS conjugates targeting hTERC and siRNAs targeting hTERT (2020)
Journal Article
Diala, I., Shiohama, Y., Fujita, T., Demonacos, C., Krstic- Demonacos, M., Di Leva, G., & Fujii, N. (2020). Telomerase inhibition, Telomere attrition and proliferation arrest of cancer cells induced by Phosphorothioate ASO-NLS conjugates targeting hTERC and siRNAs targeting hTERT. Nucleosides, Nucleotides and Nucleic Acids, 39(1-3), 407-425. https://doi.org/10.1080/15257770.2020.1713357

Telomerase activity has been regarded as a critical step in cellular immortalization and carcinogenesis and because of this, regulation of telomerase represents an attractive target for anti-tumor specific therapeutics. Recently, one avenue of cancer... Read More about Telomerase inhibition, Telomere attrition and proliferation arrest of cancer cells induced by Phosphorothioate ASO-NLS conjugates targeting hTERC and siRNAs targeting hTERT.

Sirtuin family members selectively regulate autophagy in osteosarcoma and mesothelioma cells in response to cellular stress (2019)
Journal Article
Garva, R., Thepmalee, C., Yasamut, U., Sudsaward, S., Guazzelli, A., Rajendran, R., …Demonacos, C. (2019). Sirtuin family members selectively regulate autophagy in osteosarcoma and mesothelioma cells in response to cellular stress. Frontiers in Oncology, 9, 949. https://doi.org/10.3389/fonc.2019.00949

The class III NAD+ dependent deacetylases-sirtuins (SIRTs) link transcriptional regulation to DNA damage response and reactive oxygen species generation thereby modulating a wide range of cellular signalling pathways. Here the contribution of SIRT1,... Read More about Sirtuin family members selectively regulate autophagy in osteosarcoma and mesothelioma cells in response to cellular stress.

What can independent research for Mesothelioma achieve to treat this orphan disease? (2019)
Journal Article
Guazzelli, A., Meysami, P., Bakker, E., Bonanni, E., Demonacos, C., Krstic- Demonacos, M., & Mutti, L. (2019). What can independent research for Mesothelioma achieve to treat this orphan disease?. Expert Opinion on Investigational Drugs, 28(8), 719-732. https://doi.org/10.1080/13543784.2019.1638363

Introduction: Malignant pleural mesothelioma (MPM) is a rare neoplasm with a poor prognosis, as current therapies are ineffective. Despite the increased understanding of the molecular biology of mesothelioma, there is still a lack of drugs that drama... Read More about What can independent research for Mesothelioma achieve to treat this orphan disease?.

BAP1 status determines the sensitivity of malignant mesothelioma cells to gemcitabine treatment (2019)
Journal Article
Guazzelli, A., Meysami, P., Bakker, E., Demonacos, C., Giordano, A., Krstic- Demonacos, M., & Mutti, L. (2019). BAP1 status determines the sensitivity of malignant mesothelioma cells to gemcitabine treatment. International Journal of Molecular Sciences, 20(2), 429. https://doi.org/10.3390/ijms20020429

Malignant mesothelioma (MMe) is a cancer with poor prognosis and resistance to standard treatments. Recent reports have highlighted the role of the BRCA associated protein 1 gene BAP1 in the development of MMe. In this study, the chemosensitivity of... Read More about BAP1 status determines the sensitivity of malignant mesothelioma cells to gemcitabine treatment.

p53 modeling as a route to mesothelioma patients' stratification and novel therapeutic identification (2018)
Journal Article
Tian, K., Bakker, E., Hussain, M., Guazzelli, A., Alhebshi, H., Meysami, P., …Krstic-Demonacos, M. (2018). p53 modeling as a route to mesothelioma patients' stratification and novel therapeutic identification. Journal of Translational Medicine, 16(282), https://doi.org/10.1186/s12967-018-1650-0

Background: Malignant pleural mesothelioma (MPM) is an orphan disease that is difficult to treat using traditional chemotherapy, an approach which has been effective in other types of cancer. Most chemotherapeutics cause DNA damage leading to cell de... Read More about p53 modeling as a route to mesothelioma patients' stratification and novel therapeutic identification.

Insight into glucocorticoid receptor signalling through interactome model analysis (2017)
Journal Article
Bakker, E., Tian, K., Mutti, L., Demonacos, C., Schwartz, J., & Krstic-Demonacos, M. (2017). Insight into glucocorticoid receptor signalling through interactome model analysis. PLoS Computational Biology, 13(11), https://doi.org/10.1371/journal.pcbi.1005825

Glucocorticoid hormones (GCs) are used to treat a variety of diseases because of their potent anti-inflammatory effect and their ability to induce apoptosis in lymphoid malignancies through the glucocorticoid receptor (GR). Despite ongoing research,... Read More about Insight into glucocorticoid receptor signalling through interactome model analysis.

Immunotherapy advances for mesothelioma treatment (2017)
Journal Article
Bakker, E., Guazzelli, A., Ashtiani, F., Demonacos, C., Krstic-Demonacos, M., & Mutti, L. (2017). Immunotherapy advances for mesothelioma treatment. Expert Review of Anticancer Therapy, 17(9), 799-814. https://doi.org/10.1080/14737140.2017.1358091

Introduction: Mesothelioma is a rare type of cancer that is strongly tied to asbestos exposure. Despite application of different modalities such as chemotherapy, radiotherapy and surgery, patient prognosis remains very poor and therapies are ineffect... Read More about Immunotherapy advances for mesothelioma treatment.

Promising investigational drug candidates in phase I and phase II clinical trials for mesothelioma (2017)
Journal Article
Guazzelli, A., Bakker, E., Tian, K., Demonacos, C., Krstic- Demonacos, M., & Mutti, L. (2017). Promising investigational drug candidates in phase I and phase II clinical trials for mesothelioma. Expert Opinion on Investigational Drugs, 26(8), 933-944. https://doi.org/10.1080/13543784.2017.1351545

Introduction: Malignant mesothelioma is a rare and lethal malignancy primarily affecting the pleura and peritoneum. Mesothelioma incidence is expected to increase worldwide and current treatments remain ineffective, leading to poor prognosis. Within... Read More about Promising investigational drug candidates in phase I and phase II clinical trials for mesothelioma.

Differential regulation of cell death pathways by the microenvironment correlates with chemoresistance and survival in leukaemia (2017)
Journal Article
Qattan, M., Bakker, E., Rajendran, R., Wei-Chen Chen, D., Saha, V., Liu, J., …Krstic- Demonacos, M. (2017). Differential regulation of cell death pathways by the microenvironment correlates with chemoresistance and survival in leukaemia. PLoS ONE, 12(6), e0178606. https://doi.org/10.1371/journal.pone.0178606

Glucocorticoids (GCs) and topoisomerase II inhibitors are used to treat acute lymphoblastic leukaemia (ALL) as they induce death in lymphoid cells through the glucocorticoid receptor (GR) and p53 respectively. Mechanisms underlying ALL cell death and... Read More about Differential regulation of cell death pathways by the microenvironment correlates with chemoresistance and survival in leukaemia.

Current and prospective pharmacotherapies for the treatment of pleural mesothelioma (2017)
Journal Article
Bakker, E., Guazzelli, A., Krstic-Demonacos, M., Lisanti, M., Sotgia, F., & Mutti, L. (2017). Current and prospective pharmacotherapies for the treatment of pleural mesothelioma. Expert Opinion on Orphan Drugs, 5(6), 455-465. https://doi.org/10.1080/21678707.2017.1325358

Introduction: Mesothelioma is a rare asbestos-linked cancer with an expected incidence peak between 2015–2030. Therapies remain ineffective, thus developing and testing novel treatments is important for both oncologists and researchers.


Areas co... Read More about Current and prospective pharmacotherapies for the treatment of pleural mesothelioma.

Anti-CTLA-4 therapy for malignant mesothelioma (2017)
Journal Article
Guazzelli, A., Bakker, E., Krstic-Demonacos, M., Lisanti, M., Sotgia, F., & Mutti, L. (2017). Anti-CTLA-4 therapy for malignant mesothelioma. Immunotherapy, 9(3), 273-280. https://doi.org/10.2217/imt-2016-0123

Immunotherapy is an emerging therapeutic strategy with a promising clinical outcome in some solid tumors, particularly metastatic melanoma. One approach to immunotherapy is immune checkpoint inhibitors, such as blockage of CTLA-4 and PD-1/PD-L1. This... Read More about Anti-CTLA-4 therapy for malignant mesothelioma.

miR-663a regulates growth of colon cancer cells, after administration of antimicrobial peptides, by targeting CXCR4-p21 pathway (2017)
Journal Article
peptides, by targeting CXCR4-p21 pathway. BMC Cancer, 17, 33-43. https://doi.org/10.1186/s12885-016-3003-9

Abstract
Background: Antimicrobial peptides (AMPs) play important roles in the innate immune system of all life forms and
recently have been characterized as multifunctional peptides that have a variety of biological roles such as anticancer
agent... Read More about miR-663a regulates growth of colon cancer cells, after administration of antimicrobial peptides, by targeting CXCR4-p21 pathway.

Oxidative stress and breast cancer biomarkers : the case of the cytochrome P450 2E1 (2016)
Journal Article
Singh, S., Rajendran, R., Kuroda, K., Isogai, E., Krstic-Demonacos, M., & Demonacos, C. (2016). Oxidative stress and breast cancer biomarkers : the case of the cytochrome P450 2E1. Journal of Cancer Metastasis and Treatment, 2, 268-276. https://doi.org/10.20517/2394-4722.2016.42

Aim: The aim of the study is to investigate the impact of the cytochrome P450 2E1, which is the most efficient CYP450 family
member in generating reactive oxygen species (ROS), on cellular energy metabolism of breast cancer cells and therefore the... Read More about Oxidative stress and breast cancer biomarkers : the case of the cytochrome P450 2E1.

Repurposing atovaquone : targeting mitochondrial complex III and OXPHOS to eradicate cancer stem cells (2016)
Journal Article
Fiorillo, M., Lamb, R., Tanowitz, H., Mutti, L., Krstic- Demonacos, M., Cappello, A., …Lisanti, M. (2016). Repurposing atovaquone : targeting mitochondrial complex III and OXPHOS to eradicate cancer stem cells. Oncotarget, 7(23), 34084-34099. https://doi.org/10.18632/oncotarget.9122

Atovaquone is an FDA-approved anti-malarial drug, which first became clinically available in the year 2000. Currently, its main usage is for the treatment of pneumocystis pneumonia (PCP) and/or toxoplasmosis in immune-compromised patients. Atovaquone... Read More about Repurposing atovaquone : targeting mitochondrial complex III and OXPHOS to eradicate cancer stem cells.

Tremelimumab for the treatment of malignant mesothelioma (2015)
Journal Article
Guazzelli, A., Hussain, M., Krstic- Demonacos, M., & Mutti, L. (2015). Tremelimumab for the treatment of malignant mesothelioma. Expert Opinion on Biological Therapy, 15(12), 1819-1829. https://doi.org/10.1517/14712598.2015.1116515

Introduction: Tremelimumab demonstrated therapeutic activity in different malignancies, including malignant pleural mesothelioma (MPM); however, continued research could improve the therapeutic index of this agent.

Areas covered: This review descr... Read More about Tremelimumab for the treatment of malignant mesothelioma.

The expanded p53 interactome as a predictive model for cancer therapy (2015)
Journal Article
Hussain, M., Tian, K., Mutti, L., Krstic-Demonacos, M., & Schwartz, J. (2015). The expanded p53 interactome as a predictive model for cancer therapy. Genomics and computational biology, 1(1), e20. https://doi.org/10.18547/gcb.2015.vol1.iss1.e20

The tumour suppressor gene TP53 is implicated in
the majority of all human cancers, thus pivotal to
genomic integrity. Even though over 72,000 PubMed
publications are linked with the keyword p53 and this
number is continuously increasing, due to... Read More about The expanded p53 interactome as a predictive model for cancer therapy.

The role of microenvironment and immunity in drug response in leukemia (2015)
Journal Article
Bakker, E., Qattan, M., Mutti, L., Demonacos, C., & Krstic- Demonacos, M. (2015). The role of microenvironment and immunity in drug response in leukemia. BBA - Molecular Cell Research, 1863(3), 414-426. https://doi.org/10.1016/j.bbamcr.2015.08.003

Leukemia is a cancer of the white blood cells, with over 54,000 new cases per year diagnosed worldwide and a 5-year survival rate below 60%. This highlights a need for research into the mechanisms behind its etiology and causes of therapy failure. Th... Read More about The role of microenvironment and immunity in drug response in leukemia.

Novel therapies for cancer treatment : designing high affinity and selectivity ligands against SIRT1 (2015)
Presentation / Conference
Al-Sudani, B., Krstic- Demonacos, M., & Ragazzon, P. (2015, June). Novel therapies for cancer treatment : designing high affinity and selectivity ligands against SIRT1. Poster presented at EuroMedLab Paris 2015, Paris, France

The word ‘sirtuin’ (SIR) stands for Silent Information Regulator. SIRT1 is the most studied mammalian sirtuin and predominantly localises to the nucleus. Many sirtuins targets are involved in cancer and in many types of cancers, SIRT1 is found to be... Read More about Novel therapies for cancer treatment : designing high affinity and selectivity ligands against SIRT1.

Antimicrobial peptide FF/CAP18 induces apoptotic cell death in HCT116 colon cancer cells via changes in the metabolic profile (2015)
Journal Article
Kuroda, K., Fukuda, T., Isogai, H., Okumura K, K., Krstic-Demonacos, M., & Isogai, E. (2015). Antimicrobial peptide FF/CAP18 induces apoptotic cell death in HCT116 colon cancer cells via changes in the metabolic profile. International Journal of Oncology, 46(4), 1516-1526. https://doi.org/10.3892/ijo.2015.2887

Metabolic reprogramming is one of the hallmarks of cancer and can be targeted by therapeutic agents. We previously reported that cathelicidin-related or modified antimicrobial peptides, such as FF/CAP18, have antiproliferative effects on the squamous... Read More about Antimicrobial peptide FF/CAP18 induces apoptotic cell death in HCT116 colon cancer cells via changes in the metabolic profile.

Applications of p53 interactome analysis to personalised drug discovery (2014)
Presentation / Conference
Hussain, M., Stutchbury, B., Tian, K., Atalay, R., Schwartz, J., & Krstic-Demonacos, M. (2014, April). Applications of p53 interactome analysis to personalised drug discovery. Presented at Conference: International Work-Conference on Bioinformatics and Biomedical Engineering (IWBBIO 2014), Universidad de Granada, Granada, Spain

The stress responsive transcription factor p53 is a powerful tumor suppressor implicated in over 50 % of all human cancers. The complexity and nonlinear dynamics of p53 network coupled with extensive literature is challenging. Sys-tems biology method... Read More about Applications of p53 interactome analysis to personalised drug discovery.

Regulation of autophagy, endoplasmic reticulum and unfolded protein response by glucocorticoids in physiology and disease
Thesis
Sudsaward, S. (in press). Regulation of autophagy, endoplasmic reticulum and unfolded protein response by glucocorticoids in physiology and disease. (Thesis). University of Salford

Acute lymphoblastic leukemia (ALL) is the most frequent cancer in children, and although highly treatable, challenges remain due to significant side effects of therapy and the poor outcome for some patients. Synthetic glucocorticoid, Dexamethasone (D... Read More about Regulation of autophagy, endoplasmic reticulum and unfolded protein response by glucocorticoids in physiology and disease.

The role of the human endonuclease VIII-like 1 and 3 in the repair of DNA replication blocking lesions
Thesis
Martin, P. (in press). The role of the human endonuclease VIII-like 1 and 3 in the repair of DNA replication blocking lesions. (Thesis). University of Salford

The endonuclease VIII family of DNA glycosylases initiate repair of oxidative DNA base damage through BER and have been shown to resolve DNA inter-strand crosslinks (ICLs), arising from exogenous agents. Human NEIL1 (hNEIL1) activity on psoralen gene... Read More about The role of the human endonuclease VIII-like 1 and 3 in the repair of DNA replication blocking lesions.