Dr Pika Miklavc's Outputs (6)

An ultra fast detection method reveals strain-induced Ca2+ entry via TRPV2 in alveolar type II cells (2011)
Journal Article
Fois, G., Wittekindt, O., Zheng, X., Felder, E. T., Miklavc, P., Frick, M., …Felder, E. (2012). An ultra fast detection method reveals strain-induced Ca2+ entry via TRPV2 in alveolar type II cells. Biomechanics and Modeling in Mechanobiology, 11(7), 959-971. https://doi.org/10.1007/s10237-011-0365-4

A commonly used technique to investigate strain-induced responses of adherent cells is culturing them on an elastic membrane and globally stretching the membrane. However, it is virtually impossible to acquire microscopic images immediately after the... Read More about An ultra fast detection method reveals strain-induced Ca2+ entry via TRPV2 in alveolar type II cells.

Molecular basis of early epithelial response to streptococcal exotoxin: role of STIM1 and Orai1 proteins: Streptolysin O activates SOC entry (2011)
Journal Article
Usmani, S. M., von Einem, J., Frick, M., Miklavc, P., Mayenburg, M., Husmann, M., …Wittekindt, O. H. (2012). Molecular basis of early epithelial response to streptococcal exotoxin: role of STIM1 and Orai1 proteins: Streptolysin O activates SOC entry. Cellular Microbiology, 14(3), 299-315. https://doi.org/10.1111/j.1462-5822.2011.01724.x

Streptolysin O (SLO) is a cholesterol-dependent cytolysin (CDC) from Streptococcus pyogenes. SLO induces diverse types of Ca2+ signalling in host cells which play a key role in membrane repair and cell fate determination. The mechanisms behind SLO-in... Read More about Molecular basis of early epithelial response to streptococcal exotoxin: role of STIM1 and Orai1 proteins: Streptolysin O activates SOC entry.

Vesicular calcium channels as regulators of the exocytotic post-fusion phase (2011)
Journal Article
Miklavc, P., & Frick, M. (2011). Vesicular calcium channels as regulators of the exocytotic post-fusion phase. Communicative and Integrative Biology, 4(6), 796-798. https://doi.org/10.4161/cib.17935

Regulated secretion is a fundamental cellular process in many different types of eukaryotic cells with Ca2+-triggered exocytosis taking centre stage. Elevations of the cytoplasmic Ca2+ concentration ([Ca2+]c) regulate multiple steps from vesicle fusi... Read More about Vesicular calcium channels as regulators of the exocytotic post-fusion phase.

Chemotopy of Amino Acids on the Olfactory Bulb Predicts Olfactory Discrimination Capabilities of Zebrafish Danio rerio (2011)
Journal Article
Miklavc, P., & Valentincic, T. (2012). Chemotopy of Amino Acids on the Olfactory Bulb Predicts Olfactory Discrimination Capabilities of Zebrafish Danio rerio. Chemical Senses, 37(1), 65-75. https://doi.org/10.1093/chemse/bjr066

Amino acids reliably evoke strong responses in fish olfactory system. The molecular olfactory receptors (ORs) are located in the membrane of cilia and microvilli of the olfactory receptor neurons (ORNs). Axons of ORNs converge on specific olfactory b... Read More about Chemotopy of Amino Acids on the Olfactory Bulb Predicts Olfactory Discrimination Capabilities of Zebrafish Danio rerio.

Olfactory discrimination of complex mixtures of amino acids by the black bullhead Ameiurus melas (2011)
Journal Article
Valentincic, T., Miklavc, P., Kralj, S., & Zgonik, V. (2011). Olfactory discrimination of complex mixtures of amino acids by the black bullhead Ameiurus melas. Journal of Fish Biology, 79(1), 33-52. https://doi.org/10.1111/j.1095-8649.2011.02976.x

On the basis of previous findings of behavioural discrimination of amino acids and on the knowledge of electrophysiology of the catfish (genera Ictalurus and Ameiurus) olfactory organs, behavioural experiments that investigated olfactory discriminati... Read More about Olfactory discrimination of complex mixtures of amino acids by the black bullhead Ameiurus melas.

Fusion-activated Ca2+ entry via vesicular P2X4 receptors promotes fusion pore opening and exocytotic content release in pneumocytes (2011)
Journal Article
Miklavc, P., Mair, N., Wittekindt, O., Haller, T., Dietl, P., Felder, E., …Frick, M. (2011). Fusion-activated Ca2+ entry via vesicular P2X4 receptors promotes fusion pore opening and exocytotic content release in pneumocytes. Proceedings of the National Academy of Sciences of the United States of America, 108(35), 14503-14508. https://doi.org/10.1073/pnas.1101039108

Ca2+ is considered a key element in multiple steps during regulated exocytosis. During the postfusion phase, an elevated cytoplasmic Ca2+ concentration ([Ca2+])c leads to fusion pore dilation. In neurons and neuroendocrine cells, this results from ac... Read More about Fusion-activated Ca2+ entry via vesicular P2X4 receptors promotes fusion pore opening and exocytotic content release in pneumocytes.