Region-dependent modulation of intestinal permeability by drug efflux transporters: In vitro studies in mdr1a(-/-) mouse intestine
(2002)
Journal Article
Stephens, R., Tanianis-Hughes, J., Higgs, N., Humphrey, M., & Warhurst, G. (2002). Region-dependent modulation of intestinal permeability by drug efflux transporters: In vitro studies in mdr1a(-/-) mouse intestine. Journal of Pharmacology and Experimental Therapeutics, 303(3), 1095-1101. https://doi.org/10.1124/jpet.102.041236
Information on the extent to which xenobiotics interact with P-glycoprotein (PGP) during transit through the intestine is crucial in determining the influence of PGP on oral drug absorption. We have recently described a novel use of isolated ileum fr... Read More about Region-dependent modulation of intestinal permeability by drug efflux transporters: In vitro studies in mdr1a(-/-) mouse intestine.