All Outputs (2)

Biphasic decay of the Ca transient results from increased sarcoplasmic reticulum Ca leak (2015)
Journal Article
Sankaranarayanan, R., Li, Y., Greensmith, D., Eisner, D., & Venetucci, L. (2016). Biphasic decay of the Ca transient results from increased sarcoplasmic reticulum Ca leak. Journal of Physiology, 594(3), 611-623. https://doi.org/10.1113/JP271473

In heart failure, a reduction in Ca transient amplitude and contractile dysfunction can by caused by Ca leak through the sarcoplasmic reticulum (SR) Ca channel (ryanodine receptor, RyR) and/or decreased activity of the SR Ca ATPase (SERCA). We have c... Read More about Biphasic decay of the Ca transient results from increased sarcoplasmic reticulum Ca leak.

The effect of 2,5-di-(tert-butyl)-1,4-benzohydroquinone (TBQ) on intracellular Ca(2+) handling in rat ventricular myocytes (2015)
Journal Article
Miller, L., Greensmith, D., Sankaranarayanan, R., O'Neill, S., & Eisner, D. (2015). The effect of 2,5-di-(tert-butyl)-1,4-benzohydroquinone (TBQ) on intracellular Ca(2+) handling in rat ventricular myocytes. Cell Calcium, 58(2), 208-14. https://doi.org/10.1016/j.ceca.2015.05.002

2,5-Di-(tert-butyl)-1,4-benzohydroquinone (TBQ) is a reversible inhibitor of SERCA, potentially making it a useful tool to study the effects of SERCA inhibition in cardiac cells. However, it is unknown if TBQ also has effects on other components of v... Read More about The effect of 2,5-di-(tert-butyl)-1,4-benzohydroquinone (TBQ) on intracellular Ca(2+) handling in rat ventricular myocytes.