All Outputs (7)

Antifibrotic factor KLF4 is repressed by the miR-10/TFAP2A/TBX5 axis in dermal fibroblasts: insights from twins discordant for systemic sclerosis (2021)
Journal Article
Malaab, M., Renaud, L., Takamura, N., D Zimmerman, K., Abraham da Silveira, W., S Ramos, P., …A Feghali-Bostwick, C. (2021). Antifibrotic factor KLF4 is repressed by the miR-10/TFAP2A/TBX5 axis in dermal fibroblasts: insights from twins discordant for systemic sclerosis. Annals of the Rheumatic Diseases, 81(2), 268-277. https://doi.org/10.1136/annrheumdis-2021-221050

Objectives: Systemic sclerosis (SSc) is a complex disease of unknown aetiology in which inflammation and fibrosis lead to multiple organ damage. There is currently no effective therapy that can halt the progression of fibrosis or reverse it, thus stu... Read More about Antifibrotic factor KLF4 is repressed by the miR-10/TFAP2A/TBX5 axis in dermal fibroblasts: insights from twins discordant for systemic sclerosis.

Long non-coding RNAs and their potential impact on diagnosis, prognosis, and therapy in prostate cancer: Racial, ethnic, and geographical considerations (2021)
Journal Article
Morgan, R., Abraham da Silveira, W., Christopher Kelly, R., Overton, I., Allott, E. H., & Hardiman, G. (2021). Long non-coding RNAs and their potential impact on diagnosis, prognosis, and therapy in prostate cancer: Racial, ethnic, and geographical considerations. Expert Review of Molecular Diagnostics, 21(12), 1257-1271. https://doi.org/10.1080/14737159.2021.1996227

Introduction: Advances in high-throughput sequencing have greatly advanced our understanding of long non-coding RNAs (lncRNAs) in a relatively short period of time. This has expanded our knowledge of cancer, particularly how lncRNAs drive many import... Read More about Long non-coding RNAs and their potential impact on diagnosis, prognosis, and therapy in prostate cancer: Racial, ethnic, and geographical considerations.

Mammalian and Invertebrate Models as Complementary Tools for Gaining Mechanistic Insight on Muscle Responses to Spaceflight (2021)
Journal Article
Cahill, T., Cope, H., J. Bass, J., G. Overbey, E., Gilbert, R., Abraham da Silveira, W., …G. T. Tahimic, C. (2021). Mammalian and Invertebrate Models as Complementary Tools for Gaining Mechanistic Insight on Muscle Responses to Spaceflight. International Journal of Molecular Sciences, 22(17), 9470. https://doi.org/10.3390/ijms22179470

Bioinformatics approaches have proven useful in understanding biological responses to spaceflight. Spaceflight experiments remain resource intensive and rare. One outstanding issue is how to maximize scientific output from a limited number of omics d... Read More about Mammalian and Invertebrate Models as Complementary Tools for Gaining Mechanistic Insight on Muscle Responses to Spaceflight.

Immunological and hematological outcomes following protracted low dose/low dose rate ionizing radiation and simulated microgravity (2021)
Journal Article
M. Paul, A., G. Overbey, E., Abraham da Silveira, W., Szewczyk, N., C. Nishiyama, N., J. Pecaut, M., …Wen Mao, X. (2021). Immunological and hematological outcomes following protracted low dose/low dose rate ionizing radiation and simulated microgravity. Scientific reports, 11(1), https://doi.org/10.1038/s41598-021-90439-5

Using a ground-based model to simulate spaceflight [21-days of single-housed, hindlimb unloading (HLU) combined with continuous low-dose gamma irradiation (LDR, total dose of 0.04 Gy)], an in-depth survey of the immune and hematological systems of mi... Read More about Immunological and hematological outcomes following protracted low dose/low dose rate ionizing radiation and simulated microgravity.

NASA GeneLab RNA-seq consensus pipeline: Standardized processing of short-read RNA-seq data (2021)
Journal Article
Overbey, E. G., G Overbey, E., Saravia-Butler, A. M., M Saravia-Butler, A., Zhang, Z., Rathi, K. S., …M Galazka, J. (2021). NASA GeneLab RNA-seq consensus pipeline: Standardized processing of short-read RNA-seq data. iScience, 24(4), Article 102361. https://doi.org/10.1016/j.isci.2021.102361

With the development of transcriptomic technologies, we are able to quantify precise changes in gene expression profiles from astronauts and other organisms exposed to spaceflight. Members of NASA GeneLab and GeneLab-associated analysis working group... Read More about NASA GeneLab RNA-seq consensus pipeline: Standardized processing of short-read RNA-seq data.

Induced Torpor as a Countermeasure for Low Dose Radiation Exposure in a Zebrafish Model (2021)
Journal Article
Cahill, T., Abraham da Silveira, W., Renaud, L., Williamson, T., Wang, H., Chung, D., …Hardiman, G. (2021). Induced Torpor as a Countermeasure for Low Dose Radiation Exposure in a Zebrafish Model. Cells, 10(4), Article 906. https://doi.org/10.3390/cells10040906

The development of the Artemis programme with the goal of returning to the moon is spurring technology advances that will eventually take humans to Mars and herald a new era of interplanetary space travel. However, long-term space travel poses unique... Read More about Induced Torpor as a Countermeasure for Low Dose Radiation Exposure in a Zebrafish Model.

Differential DNA Methylation Landscape in Skin Fibroblasts from African Americans with Systemic Sclerosis (2021)
Journal Article
Baker Frost, D., Abraham da Silveira, W., Starr Hazard, E., Atanelishvili, I., C. Wilson, R., Flume, J., …S. Ramos, P. (2021). Differential DNA Methylation Landscape in Skin Fibroblasts from African Americans with Systemic Sclerosis. Genes, 12(2), Article 129. https://doi.org/10.3390/genes12020129

The etiology and reasons underlying the ethnic disparities in systemic sclerosis (SSc) remain unknown. African Americans are disproportionally affected by SSc and yet are underrepresented in research. The aim of this study was to comprehensively inve... Read More about Differential DNA Methylation Landscape in Skin Fibroblasts from African Americans with Systemic Sclerosis.