Prof David Greensmith's Outputs (5)

The Role Of Interleukin-1β In Coronary Artery Disease (2024)
Thesis
Pearson, L. The Role Of Interleukin-1β In Coronary Artery Disease. (Thesis). University of Salford

Coronary artery disease (CAD) is a leading cause of mortality worldwide, with an estimated 17.8 million CAD-associated deaths each year. A prominent pathogenic factor in CAD is inflammation, which is associated with elevated levels of the cytokine in... Read More about The Role Of Interleukin-1β In Coronary Artery Disease.

Brief response to Terrar (2024)
Journal Article
Eisner, D. A., Greensmith, D. J., & Trafford, A. W. (2024). Brief response to Terrar. Journal of Physiology, https://doi.org/10.1113/JP288008

Calcium flux balance in the heart: how many of the important questions are really unanswered? (2024)
Journal Article
Eisner, D. A., Greensmith, D. J., & Trafford, A. W. (2024). Calcium flux balance in the heart: how many of the important questions are really unanswered?. Journal of Physiology, https://doi.org/10.1113/jp287849

The Journal of Physiology recently published an Opinion article which criticised our interpretation of work carried out over several years relating to calcium flux balance in cardiac myocytes (Terrar, 2024). Here,
we reply and show the importance o... Read More about Calcium flux balance in the heart: how many of the important questions are really unanswered?.

The Role of Tumour Necrosis Factor-α in Coronary Artery Disease (2024)
Thesis
Staley, A. (2024). The Role of Tumour Necrosis Factor-α in Coronary Artery Disease. (Thesis). University of Salford

Coronary artery disease (CAD) is a chronic inflammatory condition associated with high rates
of mortality worldwide. Pro-inflammatory cytokines such as tumour necrosis factor (TNFα)
play a key role in CAD pathogenesis, though the degree to which TN... Read More about The Role of Tumour Necrosis Factor-α in Coronary Artery Disease.

Calcium signaling in endothelial and vascular smooth muscle cells: sex differences and the influence of estrogens and androgens (2024)
Journal Article
Asunción-Alvarez, D., Palacios, J., Ybañez-Julca, R. O., Rodriguez-Silva, C. N., Nwokocha, C., Cifuentes, F., & Greensmith, D. J. (2024). Calcium signaling in endothelial and vascular smooth muscle cells: sex differences and the influence of estrogens and androgens. American journal of physiology. Heart and circulatory physiology, 326(4), H950-H970. https://doi.org/10.1152/ajpheart.00600.2023

Calcium signaling in vascular endothelial cells (ECs) and smooth muscle cells (VSMCs) is essential for the regulation of vascular tone. However, the changes to intracellular Ca2+ concentrations are often influenced by sex differences. Furthermore, a... Read More about Calcium signaling in endothelial and vascular smooth muscle cells: sex differences and the influence of estrogens and androgens.