Investigating small extracellular vesicle miRNA as biomarkers for Alzheimer’s disease (2023)
Thesis

Alzheimer’s disease (AD) is the leading cause of dementia, a syndrome impacting over 900,000 people in the UK alone. There are currently no disease modifying treatments for AD, which is largely attributable to the heterogenous basis of the disease wh... Read More about Investigating small extracellular vesicle miRNA as biomarkers for Alzheimer’s disease.

Evaluation of small extracellular vesicular microRNAs as biomarkers for exposure of nicotine and E-liquids on human lung cells (2022)
Thesis
for exposure of nicotine and E-liquids on human lung cells. (Thesis). University of Salford

Nicotine intake and E-Cigarette or vaping product use-associated lung injury (EVALI) can cause pulmonary disease with damaging health effects. In this study, we explored miRNAs from small extracellular vesicles (sEVs) for nicotine and E-liquid-associ... Read More about Evaluation of small extracellular vesicular microRNAs as biomarkers for exposure of nicotine and E-liquids on human lung cells.

Investigation of de-novo copy number variants in patients with Autism Spectrum Disorder in Vietnam (2021)
Thesis
Bui, H. Investigation of de-novo copy number variants in patients with Autism Spectrum Disorder in Vietnam. (Thesis). University of Salford

Autism spectrum disorder (ASD) is a neurodevelopmental disorder with a prevalence of approximately 1% children worldwide. ASD is characterized by deficits in social communication and interaction and the presence of restricted interests and repetitive... Read More about Investigation of de-novo copy number variants in patients with Autism Spectrum Disorder in Vietnam.

Genetic landscape of autism spectrum disorder in Vietnamese children (2020)
Journal Article

Autism spectrum disorder (ASD) is a complex disorder with an unclear aetiology and an estimated global prevalence of 1%. However, studies of ASD in the Vietnamese population are limited. Here, we first conducted whole exome sequencing (WES) of 100 ch... Read More about Genetic landscape of autism spectrum disorder in Vietnamese children.

Novel internal regulators and candidate miRNAs within miR-379/miR-656 miRNA cluster can alter cellular phenotype of human glioblastoma (2018)
Journal Article

Clustered miRNAs can affect functioning of downstream pathways due to possible coordinated function. We
observed 78-88% of the miR-379/miR-656 cluster (C14MC) miRNAs were downregulated in three sub-types
of diffuse gliomas, which was also corrobora... Read More about Novel internal regulators and candidate miRNAs within miR-379/miR-656 miRNA cluster can alter cellular phenotype of human glioblastoma.

Human brain harbors single nucleotide somatic variations in functionally relevant genes possibly mediated by oxidative stress (2016)
Journal Article

Somatic variation in DNA can cause cells to deviate from the preordained
genomic path in both disease and healthy conditions. Here, using exome
sequencing of paired tissue samples, we show that the normal human brain
harbors somatic single base va... Read More about Human brain harbors single nucleotide somatic variations in functionally relevant genes possibly mediated by oxidative stress.

TBK1 duplication is found in normal tension and not in high tension glaucoma patients of Indian origin (2016)
Journal Article
Kaurani, L., Vishal, M., Ray, J., Sen, A., Ray, K., & Mukhopadhyay, A. (2016). TBK1 duplication is found in normal tension and not in high tension glaucoma patients of Indian origin. Journal of Genetics, 95(2), 459-461. https://doi.org/10.1007/s12041-016-0637-y

Genetic association and stress mediated down-regulation in trabecular meshwork implicates MPP7 as a novel candidate gene in primary open angle glaucoma (2016)
Journal Article

Background: Glaucoma is the largest cause of irreversible blindness affecting more than 60 million people globally.
The disease is defined as a gradual loss of peripheral vision due to death of Retinal Ganglion Cells (RGC). The RGC death is largely... Read More about Genetic association and stress mediated down-regulation in trabecular meshwork implicates MPP7 as a novel candidate gene in primary open angle glaucoma.

Altered expression and editing of miRNA-100 regulates iTreg differentiation (2015)
Journal Article

RNA editing ofmiRNAs, especially in the seed region,
adds another layer to miRNA mediated gene regulation
which can modify its targets, altering cellular signaling
involved in important processes such as differentiation.
In this study, we have ex... Read More about Altered expression and editing of miRNA-100 regulates iTreg differentiation.

Evaluation of genetic association of the INK4 locus with primary open angle glaucoma in East Indian population (2014)
Journal Article
angle glaucoma in East Indian population. Scientific reports, 4, 5115. https://doi.org/10.1038/srep05115

INK4 locus at chromosome 9p21 has been reported to be associated with primary open angle glaucoma (POAG) and its subtypes along with the associated optic disc parameters across the populations of European, Japanese and African ancestries. The locus e... Read More about Evaluation of genetic association of the INK4 locus with primary open angle glaucoma in East Indian population.