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G protein-coupled receptors at the crossroad between physiologic and pathologic angiogenesis : old paradigms and emerging concepts (2017)
Journal Article
De Francesco, E., Sotgia, F., Clarke, R., Lisanti, M., & Maggiolini, M. (2017). G protein-coupled receptors at the crossroad between physiologic and pathologic angiogenesis : old paradigms and emerging concepts. International Journal of Molecular Sciences, 18(12), https://doi.org/10.3390/ijms18122713

G protein-coupled receptors (GPCRs) have been implicated in transmitting signals across the extra- and intra-cellular compartments, thus allowing environmental stimuli to elicit critical biological responses. As GPCRs can be activated by an extensive... Read More about G protein-coupled receptors at the crossroad between physiologic and pathologic angiogenesis : old paradigms and emerging concepts.

The human DNA glycosylases NEIL1 and NEIL3 excise psoralen-induced DNA-DNA cross-links in a four-stranded DNA structure (2017)
Journal Article

Interstrand cross-links (ICLs) are highly cytotoxic DNA lesions that block DNA replication and transcription by preventing strand separation. Previously, we demonstrated that the bacterial and
human DNA glycosylases Nei and NEIL1 excise unhooked pso... Read More about The human DNA glycosylases NEIL1 and NEIL3 excise psoralen-induced DNA-DNA cross-links in a four-stranded DNA structure.

GPER mediates the angiocrine actions induced by IGF1 through the HIF-1α/VEGF pathway in the breast tumor microenvironment (2017)
Journal Article
De Francesco, E., Sims, A., Maggiolini, M., Sotgia, F., Lisanti, M., & Clarke, R. (2017). GPER mediates the angiocrine actions induced by IGF1 through the HIF-1α/VEGF pathway in the breast tumor microenvironment. Breast Cancer Research, 19(1), 129. https://doi.org/10.1186/s13058-017-0923-5

The G protein estrogen receptor GPER/GPR30 mediates estrogen action in breast cancer cells as well as in breast cancer-associated fibroblasts (CAFs), which are key components of microenvironment driving tumor progression. GPER is a transcriptional ta... Read More about GPER mediates the angiocrine actions induced by IGF1 through the HIF-1α/VEGF pathway in the breast tumor microenvironment.

Insight into glucocorticoid receptor signalling through interactome model analysis (2017)
Journal Article
Bakker, E., Tian, K., Mutti, L., Demonacos, C., Schwartz, J., & Krstic-Demonacos, M. (2017). Insight into glucocorticoid receptor signalling through interactome model analysis. PLoS Computational Biology, 13(11), https://doi.org/10.1371/journal.pcbi.1005825

Glucocorticoid hormones (GCs) are used to treat a variety of diseases because of their potent anti-inflammatory effect and their ability to induce apoptosis in lymphoid malignancies through the glucocorticoid receptor (GR). Despite ongoing research,... Read More about Insight into glucocorticoid receptor signalling through interactome model analysis.

Corticosteroid treatment is associated with increased filamentous fungal burden in allergic fungal disease (2017)
Journal Article
allergic fungal disease. Journal of Allergy and Clinical Immunology, 142(2), 407-414. https://doi.org/10.1016/j.jaci.2017.09.039

Background
Allergic diseases caused by fungi are common. The best understood conditions are allergic
bronchopulmonaryaspergillosis (ABPA) and severe asthma with fungal sensitisation (SAFS).
Our knowledge of the fungal microbiome (mycobiome) is li... Read More about Corticosteroid treatment is associated with increased filamentous fungal burden in allergic fungal disease.

miRNAs in bone metastasis (2017)
Journal Article
Cheung, D., Buzzetti, M., & Di Leva, G. (2017). miRNAs in bone metastasis. Expert Review of Endocrinology and Metabolism, 12(6), 451-461. https://doi.org/10.1080/17446651.2017.1383893

Introduction: Bone metastasis is one of the most common forms of metastasis from a number of different primary carcinomas. MicroRNAs (miRNAs) are short, endogenous RNAs that negatively regulate gene expression to control essential pathways, including... Read More about miRNAs in bone metastasis.

Pilot study demonstrating metabolic and anti-proliferative effects of in vivo anti-oxidant supplementation with N-Acetylcysteine in Breast Cancer (2017)
Journal Article

Background

High oxidative stress as defined by hydroxyl and peroxyl activity is often found in the stroma of human breast cancers. Oxidative stress induces stromal catabolism, which promotes cancer aggressiveness. Stromal cells exposed to oxidativ... Read More about Pilot study demonstrating metabolic and anti-proliferative effects of in vivo anti-oxidant supplementation with N-Acetylcysteine in Breast Cancer.

Interleukin-6 and Interleukin-10 concentrations as predictors of patient outcome following major traumatic injury (2017)
Thesis
Jones, M. Interleukin-6 and Interleukin-10 concentrations as predictors of patient outcome following major traumatic injury. (Dissertation). University of Salford

Trauma is one of the main causes of death worldwide, accounting for 4.8 million deaths per
year. This death rate has led to trauma being classed as the top cause of death for males,
aged between fifteen and twenty-nine. More recently, however, the... Read More about Interleukin-6 and Interleukin-10 concentrations as predictors of patient outcome following major traumatic injury.

Mitoketoscins : novel mitochondrial inhibitors for targeting ketone metabolism in cancer stem cells (CSCs). (2017)
Journal Article
Ozsvari, B., Sotgia, F., Simmons, K., Trowbridge, R., Foster, R., & Lisanti, M. (2017). Mitoketoscins : novel mitochondrial inhibitors for targeting ketone metabolism in cancer stem cells (CSCs). Oncotarget, 8(45), 78340-78350. https://doi.org/10.18632/oncotarget.21259

Previous studies have now well-established that epithelial cancer cells can utilize ketone bodies (3-hydroxybutyrate and aceto-acetate) as mitochondrial fuels, to actively promote tumor growth and metastatic dissemination. The two critical metabolic... Read More about Mitoketoscins : novel mitochondrial inhibitors for targeting ketone metabolism in cancer stem cells (CSCs)..

Characterisation of a novel bioactive complex polysaccharide from a marine invertebrate with potent anticancer and antimalarial activities (2017)
Thesis
Khurshid, C. A. Characterisation of a novel bioactive complex polysaccharide from a marine invertebrate with potent anticancer and antimalarial activities. (Thesis). ELS

Considerable excitement has been generated by the discovery of active compounds from marine organisms. These compounds have a remarkable role in cancer treatment, with fewer side effects on general health. Sulphated glycosaminoglycan (GAGs) are prese... Read More about Characterisation of a novel bioactive complex polysaccharide from a marine invertebrate with potent anticancer and antimalarial activities.

The effect of environmental stress and selective glucocorticoid receptor modulators on chicken and human leukaemia cells (2017)
Thesis
Al-ibadi, I. The effect of environmental stress and selective glucocorticoid receptor modulators on chicken and human leukaemia cells. (Thesis). University of Salford

Glucocorticoids (GCs) play important functions in human physiology, and are commonly prescribed anti-inflammatory and immunosuppressive drugs. GCs are used in treatment of childhood acute lymphocytic leukemia (ALL), however resistance to therapy and... Read More about The effect of environmental stress and selective glucocorticoid receptor modulators on chicken and human leukaemia cells.

Assessment of the efficacy of BTI Larvicide, VectoBac 12AS® (BTI AM65-52) against “nuisance” flies at water treatment plants in North West England (2017)
Thesis
Wenjere, S. Assessment of the efficacy of BTI Larvicide, VectoBac 12AS® (BTI AM65-52) against “nuisance” flies at water treatment plants in North West England. (Dissertation). University of Salford

In treating wastewater using percolating filters, nature employs diverse biota, which includes
nematoceran larvae, to sustain filter function. This study sought to generate evidence on the
efficacy of a Bacillus thuringiensis var. israelensis-deriv... Read More about Assessment of the efficacy of BTI Larvicide, VectoBac 12AS® (BTI AM65-52) against “nuisance” flies at water treatment plants in North West England.

Promising investigational drug candidates in phase I and phase II clinical trials for mesothelioma (2017)
Journal Article
Guazzelli, A., Bakker, E., Tian, K., Demonacos, C., Krstic- Demonacos, M., & Mutti, L. (2017). Promising investigational drug candidates in phase I and phase II clinical trials for mesothelioma. Expert Opinion on Investigational Drugs, 26(8), 933-944. https://doi.org/10.1080/13543784.2017.1351545

Introduction: Malignant mesothelioma is a rare and lethal malignancy primarily affecting the pleura and peritoneum. Mesothelioma incidence is expected to increase worldwide and current treatments remain ineffective, leading to poor prognosis. Within... Read More about Promising investigational drug candidates in phase I and phase II clinical trials for mesothelioma.

Novel therapies for cancer treatment : designing high affinity selective ligands against SIRT1 enzyme (2017)
Thesis
Al-Sudani, B. Novel therapies for cancer treatment : designing high affinity selective ligands against SIRT1 enzyme. (Thesis). University of Salford

The word ‘Sirtuin’ or Sir2 proteins are a class of proteins that possess either mono-ADP-ribosyltransferase, or deacylase activity, including deacetylase. SIRT1 is the most studied mammalian Sirtuins and predominantly localised in the nucleus and cyt... Read More about Novel therapies for cancer treatment : designing high affinity selective ligands against SIRT1 enzyme.

Systolic [Ca2+ ]i regulates diastolic levels in rat ventricular myocytes (2017)
Journal Article
Sankaranarayanan, R., Kistamas, K., Greensmith, D., Venetucci, L., & Eisner, D. (2017). Systolic [Ca2+ ]i regulates diastolic levels in rat ventricular myocytes. Journal of Physiology, 595(16), 5545-5555. https://doi.org/10.1113/JP274366

[Ca2+]i must be low enough in diastole so that the ventricle is relaxed and can refill with blood. Interference with this will impair relaxation. The factors responsible for regulation of diastolic [Ca2+]i, in particular the relative roles of the sar... Read More about Systolic [Ca2+ ]i regulates diastolic levels in rat ventricular myocytes.

Probing the action of a novel anti-leukaemic drug therapy at the single cell level using modern vibrational spectroscopy techniques (2017)
Journal Article

Acute myeloid leukaemia (AML) is a life threatening cancer for which there is an urgent clinical need for novel therapeutic approaches. A redeployed drug combination of bezafibrate and medroxyprogesterone acetate (BaP) has shown anti-leukaemic activi... Read More about Probing the action of a novel anti-leukaemic drug therapy at the single cell level using modern vibrational spectroscopy techniques.

Hodgkin lymphoma : a complex metabolic ecosystem with glycolytic reprogramming of the tumor microenvironment (2017)
Journal Article

Background

Twenty percent of patients with classical Hodgkin Lymphoma (cHL) have aggressive disease defined as relapsed or refractory disease to initial therapy. At present we cannot identify these patients pre-treatment. The microenvironment is v... Read More about Hodgkin lymphoma : a complex metabolic ecosystem with glycolytic reprogramming of the tumor microenvironment.