Synthesis and evaluation of novel kinase inhibitors as anti-cancer agents (2012)
Thesis
Kemp, T. Synthesis and evaluation of novel kinase inhibitors as anti-cancer agents. (Thesis). University of Salford

Disruption of protein kinase signalling pathways is often associated with cancer. The
RhoA/ROCK kinase pathway has been shown to be constitutively expressed in many cancers
and has also been shown to be involved in metastasis and apoptosis. ROCK is... Read More about Synthesis and evaluation of novel kinase inhibitors as anti-cancer agents.

Modulating protein-protein interactions : novel inhibitors of PDZ domains and tubulin dynamics (2008)
Thesis
Bennett, E. Modulating protein-protein interactions : novel inhibitors of PDZ domains and tubulin dynamics. (Thesis). University of Salford

Protein-protein interactions are essential for all living systems. The interactions
between tubulin dimers is already a broadly studied area, whereas the PDZ domain
interactions is a relatively recent area of study. The literature in these areas is... Read More about Modulating protein-protein interactions : novel inhibitors of PDZ domains and tubulin dynamics.