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Self-assembling ferritin nanoplatform for the development of infectious hematopoietic necrosis virus vaccine (2024)
Journal Article
Ahmadivand, S., Krpetic, Z., Martínez, M. M., Ordoñez, M. G., Roher, N., & Palić, D. (2024). Self-assembling ferritin nanoplatform for the development of infectious hematopoietic necrosis virus vaccine. Frontiers in Immunology, 15, 1346512. https://doi.org/10.3389/fimmu.2024.1346512

Self-assembling protein nanoparticles are used as a novel vaccine design platform to improve the stability and immunogenicity of safe subunit vaccines, while providing broader protection against viral infections. Infectious Hematopoietic Necrosis vir... Read More about Self-assembling ferritin nanoplatform for the development of infectious hematopoietic necrosis virus vaccine.

In depth characterisation of the biomolecular coronas of polymer coated inorganic nanoparticles with differential centrifugal sedimentation (2021)
Journal Article
Perez-Potti, A., Lopez, H., Pelaz, B., Abdelmonem, A., Soliman, M., Schoen, I., …Monopoli, M. (2021). In depth characterisation of the biomolecular coronas of polymer coated inorganic nanoparticles with differential centrifugal sedimentation. Scientific reports, 11(1), 6443. https://doi.org/10.1038/s41598-021-84029-8

Advances in nanofabrication methods have enabled the tailoring of new strategies towards the controlled production of nanoparticles with attractive applications in healthcare. In many cases, their characterisation remains a big challenge, particularl... Read More about In depth characterisation of the biomolecular coronas of polymer coated inorganic nanoparticles with differential centrifugal sedimentation.

Influence of size and shape on the anatomical distribution of endotoxin-free gold nanoparticles (2017)
Journal Article
Talamini, L., Violato, M. B., Cai, Q., Monopoli, M., Kantner, K., Krpetic, Z., …Bigini, P. (2017). Influence of size and shape on the anatomical distribution of endotoxin-free gold nanoparticles. ACS nano, 11(6), 5519-5529. https://doi.org/10.1021/acsnano.7b00497

The transport and the delivery of drugs through nanocarriers is a great challenge of pharmacology. Since the production of liposomes to reduce the toxicity of doxorubicin in patients, a plethora of nanomaterials have been produced and characterized.... Read More about Influence of size and shape on the anatomical distribution of endotoxin-free gold nanoparticles.

Towards a classification strategy for complex nanostructures (2017)
Journal Article
Castagnola, V., Cookman, J., De Araujo, J., Polo, E., Cai, Q., Silviera, P., …Dawson, K. (2017). Towards a classification strategy for complex nanostructures. Nanoscale horizons (Print), 2017(2), 187-198. https://doi.org/10.1039/C6NH00219F

The range of possible nanostructures is so large and continuously growing, that collating and unifying the knowledge connected to them, including their biological activity, is a major challenge. Here we discuss a conception that is based on connectio... Read More about Towards a classification strategy for complex nanostructures.

Detecting the shape of anisotropic gold nanoparticles in dispersion with single particle extinction and scattering (2017)
Journal Article
Marco A, C., P., Krpetic, Z., Tiziano, S., Qi, C., Marco, M., João M., D. A., …Kenneth A., D. (2017). Detecting the shape of anisotropic gold nanoparticles in dispersion with single particle extinction and scattering. Nanoscale, 8, https://doi.org/10.1039/C6NR08977A

The shape and size of nanoparticles are important parameters affecting the biodistribution, bioactivity, and toxicity. The
high-throughput characterisation of nanoparticle shape in the dispersion is a fundamental prerequisite for realistic in vitro... Read More about Detecting the shape of anisotropic gold nanoparticles in dispersion with single particle extinction and scattering.

Revealing DNA interactions with exogenous agents by surface-enhanced raman scattering (2014)
Journal Article
Masetti, M., Xie, H., Krpetic, Z., Recanatini, M., Alvarez-Puebla, R., & Guerrini, L. (2015). Revealing DNA interactions with exogenous agents by surface-enhanced raman scattering. Abstracts of papers / American Chemical Society, 137(1), 469-476. https://doi.org/10.1021/ja511398w

The standard protocols for DNA analysis largely involve polymerase chain reaction (PCR). However, DNA structures bound to chemical agents cannot be PCR-amplified, and therefore any sequence changes induced by external agents may be neglected. Thus, t... Read More about Revealing DNA interactions with exogenous agents by surface-enhanced raman scattering.

Direct surface-enhanced raman scattering analysis of DNA duplexes (2014)
Journal Article
Guerrini, L., Krpetic, Z., Van Lierop, D., Alvarez-Puebla, R., & Graham, D. (2014). Direct surface-enhanced raman scattering analysis of DNA duplexes. Angewandte Chemie International Edition, 54(4), 1144-1148. https://doi.org/10.1002/anie.201408558

The exploration of the genetic information carried by DNA has become a major scientific challenge. Routine DNA analysis, such as PCR, still suffers from important intrinsic limitations. Surface-enhanced Raman spectroscopy (SERS) has emerged as an out... Read More about Direct surface-enhanced raman scattering analysis of DNA duplexes.

Interactions of gold nanoparticles with a phospholipid monolayer membrane on mercury (2014)
Journal Article
Gordillo, G., Krpetic, Z., & Brust, M. (2014). Interactions of gold nanoparticles with a phospholipid monolayer membrane on mercury. ACS nano, 8(6), 6074-6080. https://doi.org/10.1021/nn501395e

It is demonstrated that a compact monolayer of 1,2-dioleoyl-sn-glycero-3-phosphocholine adsorbed to a hanging mercury drop electrode can serve as a simple electrochemical model system to study biomembrane penetration by gold nanoparticles. The hydrog... Read More about Interactions of gold nanoparticles with a phospholipid monolayer membrane on mercury.

Preparation and characterization of au nanoparticles capped with mercaptocarboranyl clusters (2013)
Journal Article
M. Cioran, A., Teixidor, F., Krpetic, Ž., Brust, M., & Viñas, C. (2014). Preparation and characterization of au nanoparticles capped with mercaptocarboranyl clusters. Dalton Transactions, 43(13), 5054-5061. https://doi.org/10.1039/C3DT52872C

The preparation of 3–4 nm and 10 nm gold nanoparticles capped with neutral carborane-based mercaptocarboranes, via two different preparative routes, is reported. The resulting boron-enriched nanomaterials exhibit complete dispersibility in water, ope... Read More about Preparation and characterization of au nanoparticles capped with mercaptocarboranyl clusters.

Conjugation of PEG and gold nanoparticles to increase the accessibility and valency of tethered RNA splicing enhancers (2013)
Journal Article
Perrett, A., Dickinson, R., Krpetic, Z., Brust, M., Lewis, H., Eperon, I., & Burley, G. (2013). Conjugation of PEG and gold nanoparticles to increase the accessibility and valency of tethered RNA splicing enhancers. Chemical Science, 4(1), 257-265. https://doi.org/10.1039/C2SC20937C

Since alternative splicing patterns are exhibited by most mammalian genes, the functional properties of a gene may be changed for therapeutic purposes by nudging splicing from one pattern to another. Splicing to a refractory exon can be enhanced usin... Read More about Conjugation of PEG and gold nanoparticles to increase the accessibility and valency of tethered RNA splicing enhancers.

High-resolution sizing of monolayer-protected gold clusters by differential centrifugal sedimentation (2013)
Journal Article
Krpetic, Z., Davidson, A., Volk, M., Lévy, R., Brust, M., & Cooper, D. (2013). High-resolution sizing of monolayer-protected gold clusters by differential centrifugal sedimentation. ACS nano, 7(10), 8881-8890. https://doi.org/10.1021/nn403350v

Differential centrifugal sedimentation (DCS) has been applied to accurately size ligand-protected gold hydrosols in the 10 to 50 nm range. A simple protocol is presented to correct for particle density variations due to the presence of the ligand she... Read More about High-resolution sizing of monolayer-protected gold clusters by differential centrifugal sedimentation.

Directed assembly of DNA-functionalized gold nanoparticles using pyrrole–imidazole polyamides (2012)
Journal Article
Krpetic, Z., Singh, I., Su, W., Guerrini, L., Faulds, K., Burley, G., & Graham, D. (2012). Directed assembly of DNA-functionalized gold nanoparticles using pyrrole–imidazole polyamides. Abstracts of papers / American Chemical Society, 134(20), 8356-8359. https://doi.org/10.1021/ja3014924

Traditional methods for the construction of nanoparticle arrays and lattices exploit Watson–Crick base pairing of single-stranded DNA sequences as a proxy for self-assembly. Although this approach has been utilized in a variety of applications in nan... Read More about Directed assembly of DNA-functionalized gold nanoparticles using pyrrole–imidazole polyamides.

Positively charged silver nanoparticles and their effect on surface-enhanced Raman scattering of dye-labelled oligonucleotides (2012)
Journal Article
van Lierop, D., Krpetic, Z., Guerrini, L., Larmour, I., Dougan, J., Faulds, K., & Graham, D. (2012). Positively charged silver nanoparticles and their effect on surface-enhanced Raman scattering of dye-labelled oligonucleotides. Chemical Communications, 48(66), 8192. https://doi.org/10.1039/C2CC31731A

Improved positively charged nanoparticles are described to provide a simplified SERS substrate for DNA detection. Complete flocculation of the nanoparticles is prevented due to the controlled analyte induced aggregation. This provides a stable aggreg... Read More about Positively charged silver nanoparticles and their effect on surface-enhanced Raman scattering of dye-labelled oligonucleotides.

Importance of Nanoparticle Size in Colorimetric and SERS-Based Multimodal Trace Detection of Ni(II) Ions with Functional Gold Nanoparticles (2012)
Journal Article
Krpetic, Z., Guerrini, L., Larmour, I., Reglinski, J., Faulds, K., & Graham, D. (2012). Importance of Nanoparticle Size in Colorimetric and SERS-Based Multimodal Trace Detection of Ni(II) Ions with Functional Gold Nanoparticles. Small, 8(5), 707-714. https://doi.org/10.1002/smll.201101980

Colorimetric detection of analytes using gold nanoparticles along with surface-enhanced Raman spectroscopy (SERS) are areas of intense research activity since they both offer sensing of very low concentrations of target species. Multimodal detection... Read More about Importance of Nanoparticle Size in Colorimetric and SERS-Based Multimodal Trace Detection of Ni(II) Ions with Functional Gold Nanoparticles.

Mercaptocarborane-capped gold nanoparticles : electron pools and ion traps with switchable hydrophilicity (2012)
Journal Article
Cioran, A., Musteti, A., Teixidor, F., Krpetic, Z., Prior, I., He, Q., …Viñas, C. (2012). Mercaptocarborane-capped gold nanoparticles : electron pools and ion traps with switchable hydrophilicity. Abstracts of papers / American Chemical Society, 134(1), 212-221. https://doi.org/10.1021/ja203367h

A simple single-phase method for the preparation of ca. 2 nm gold nanoparticles capped with mercaptocarborane ligands is introduced. The resultant monolayer protected clusters (MPCs) exhibit redox-dependent solubility and readily phase transfer betwe... Read More about Mercaptocarborane-capped gold nanoparticles : electron pools and ion traps with switchable hydrophilicity.

Energy dependence of gold nanoparticle radiosensitization in plasmid DNA (2011)
Journal Article
McMahon, S., Hyland, W., Brun, E., Butterworth, K., Coulter, J., Douki, T., …Sicard-Roselli, C. (2011). Energy dependence of gold nanoparticle radiosensitization in plasmid DNA. Journal of Physical Chemistry C, 115(41), 20160-20167. https://doi.org/10.1021/jp206854s

Gold nanopa rticles (GNPs) are of considerableinterest for use as a radiosensitizer, because of their biocompat-ibility and their ability to increase dose deposited because oftheir high mass energy absorption coefficient. Their sensitizingproperties ha... Read More about Energy dependence of gold nanoparticle radiosensitization in plasmid DNA.

Intracellular mapping with SERS-encoded gold nanostars (2011)
Journal Article
Rodríguez-Lorenzo, L., Krpetic, Z., Barbosa, S., Alvarez-Puebla, R., Liz-Marzán, L., Prior, I., & Brust, M. (2011). Intracellular mapping with SERS-encoded gold nanostars. Integrative Biology, 3(9), 922-926. https://doi.org/10.1039/C1IB00029B

Here we report on the design, synthesis and application of small, highly bright, star-shaped SERS encoded single nanoparticles with the ability of providing an optical signal upon excitation with near infrared light. These particles are colloidally s... Read More about Intracellular mapping with SERS-encoded gold nanostars.

Acrylate-facilitated cellular uptake of gold nanoparticles (2011)
Journal Article
Krpetic, Z., Nativo, P., Prior, I., & Brust, M. (2011). Acrylate-facilitated cellular uptake of gold nanoparticles. Small, 7(14), 1982-1986. https://doi.org/10.1002/smll.201100462

Uptake of PEGylated gold nanoparticles by HeLa cells in the presence of acrylate is described. Nanoparticles that are usually not taken up readily cross the plasma membrane into the cytosol in the presence of acrylate. In addition, a method is descri... Read More about Acrylate-facilitated cellular uptake of gold nanoparticles.