All Outputs (5)

Neuronal differentiation by TAp73 is mediated by microRNA-34a regulation of synaptic protein targets (2011)
Journal Article
Agostini, M., Tucci, P., Killick, R., Candi, E., & Sayan, B. (2011). Neuronal differentiation by TAp73 is mediated by microRNA-34a regulation of synaptic protein targets. Proceedings of the National Academy of Sciences, 108(52), https://doi.org/10.1073/pnas.1112061109

The p53-family member TAp73 is a transcription factor that plays a key role in many biological processes. Here, we show that p73 drives the expression of microRNA (miR)-34a, but not miR-34b and -c, by acting on specific binding sites on the miR-34a p... Read More about Neuronal differentiation by TAp73 is mediated by microRNA-34a regulation of synaptic protein targets.

MicroRNA control of invasion and metastasis pathways (2011)
Journal Article
Sreekumar, R., Sayan, B., Mirnezami, A., & Sayan, A. (2011). MicroRNA control of invasion and metastasis pathways. Frontiers in Genetics, 2, https://doi.org/10.3389/fgene.2011.00058

Despite recent advances, cancer remains a leading cause of death worldwide. In developed countries, the incidence of colorectal and breast cancer has been stable, but no improvement in prognosis has been observed if the patient presents with metastas... Read More about MicroRNA control of invasion and metastasis pathways.

P73 regulates cisplatin-induced apoptosis in ovarian cancer cells via a calcium/calpain-dependent mechanism (2011)
Journal Article
Al-Bahlani, S., Fraser, M., Wong, A., Sayan, B., Bergeron, R., Melino, G., & Tsang, B. (2011). P73 regulates cisplatin-induced apoptosis in ovarian cancer cells via a calcium/calpain-dependent mechanism. Oncogene, 30, https://doi.org/10.1038/onc.2011.134

P73 is important in drug-induced apoptosis in some cancer cells, yet its role in the regulation of chemosensitivity in ovarian cancer (OVCA) is poorly understood. Furthermore, if and how the deregulation of p73-mediated apoptosis confers resistance t... Read More about P73 regulates cisplatin-induced apoptosis in ovarian cancer cells via a calcium/calpain-dependent mechanism.

P73 in cancer (2011)
Journal Article
Rufini, A., Agostini, M., Grespi, F., Tomasini, R., & Sayan, B. (2011). P73 in cancer. Genes and Cancer, 2(4), 491-502. https://doi.org/10.1177/1947601911408890

p73 is a tumor suppressor belonging to the p53 family of transcription factors. Distinct isoforms are transcribed from the p73 locus. The use of 2 promoters at the N-terminus allows the expression of an isoform containing (TAp73) or not containing (Δ... Read More about P73 in cancer.

p73: a multifunctional protein in neurobiology (2011)
Journal Article
Killick, R., Niklison-Chirou, M., Tomasini, R., Bano, D., Rufini, A., Grespi, F., …et, A. (2011). p73: a multifunctional protein in neurobiology. Molecular Neurobiology, 43, 139-146. https://doi.org/10.1007/s12035-011-8172-6

p73, a transcription factor of the p53 family, plays a key role in many biological processes including neuronal development. Indeed, mice deficient for both TAp73 and ΔNp73 isoforms display neuronal pathologies, including hydrocephalus and hippocampa... Read More about p73: a multifunctional protein in neurobiology.