JNK1 stress signaling is hyper-activated in high breast density and the tumor stroma: Connecting fibrosis, inflammation, and stemness for cancer prevention

Lisanti, MP; Reeves, K; Peiris-Pagès, M; Chadwick, AL; Sanchez-Alvarez, R; Howell, A; Martinez-Outschoorn, UE; Sotgia, F

doi:10.4161/cc.27379

High mitochondrial mass identifies a sub-population of stem-like cancer cells that are chemo-resistant (2015)
Journal Article
Farnie, G., Sotgia, F., & Lisanti, M. (2015). High mitochondrial mass identifies a sub-population of stem-like cancer cells that are chemo-resistant. Oncotarget, 6(31), 30472-30486. https://doi.org/10.18632/oncotarget.5401

Chemo-resistance is a clinical barrier to more effective anti-cancer therapy. In this context, cancer stem-like cells (CSCs) are thought to be chemo-resistant, resulting in tumor recurrence and distant metastasis. Our hypothesis is that chemo-resista... Read More about High mitochondrial mass identifies a sub-population of stem-like cancer cells that are chemo-resistant.

Mitochondrial mass, a new metabolic biomarker for stem-like cancer cells : understanding WNT/FGF-driven anabolic signaling (2015)
Journal Article
Lamb, R., Bonuccelli, G., Ozsvári, B., Peiris-Pagès, M., Fiorillo, M., Smith DL, D., …Lisanti, M. (2015). Mitochondrial mass, a new metabolic biomarker for stem-like cancer cells : understanding WNT/FGF-driven anabolic signaling. Oncotarget, 6(31), 30453-30471. https://doi.org/10.18632/oncotarget.5852

Here, we developed an isogenic cell model of “stemness” to facilitate protein biomarker discovery in breast cancer. For this purpose, we used knowledge gained previously from the study of the mouse mammary tumor virus (MMTV). MMTV initiates mammary t... Read More about Mitochondrial mass, a new metabolic biomarker for stem-like cancer cells : understanding WNT/FGF-driven anabolic signaling.

Dissecting tumor metabolic heterogeneity : Telomerase and large cell size metabolically define a sub-population of stem-like, mitochondrial-rich, cancer cells (2015)
Journal Article
Lamb, R., Ozsvari, B., Bonuccelli, G., Smith, D., Pestell, R., Martinez-Outschoorn, U., …Lisanti, M. (2015). Dissecting tumor metabolic heterogeneity : Telomerase and large cell size metabolically define a sub-population of stem-like, mitochondrial-rich, cancer cells. Oncotarget, 6(26), 21892-21905. https://doi.org/10.18632/oncotarget.5260

Tumor cell metabolic heterogeneity is thought to contribute to tumor recurrence, distant metastasis and chemo-resistance in cancer patients, driving poor clinical outcome. To better understand tumor metabolic heterogeneity, here we used the MCF7 brea... Read More about Dissecting tumor metabolic heterogeneity : Telomerase and large cell size metabolically define a sub-population of stem-like, mitochondrial-rich, cancer cells.

Doxycycline and therapeutic targeting of the DNA damage response in cancer cells : old drug, new purpose (2015)
Journal Article
Peiris-Pagès, M., Sotgia, F., & Lisanti, M. (2015). Doxycycline and therapeutic targeting of the DNA damage response in cancer cells : old drug, new purpose. Oncoscience, 2(8), 696-699. https://doi.org/10.18632/oncoscience.215

There is a small proportion of cells within a tumour with self-renewing properties, which is resistant to conventional therapy, and is responsible for tumour initiation, maintenance and metastasis. These cells are known as cancer stem cells (CSCs) or... Read More about Doxycycline and therapeutic targeting of the DNA damage response in cancer cells : old drug, new purpose.

Estrogen related receptor α (ERRα) a promising target for the therapy of adrenocortical carcinoma (ACC) (2015)
Journal Article
Casaburi, I., Avena, P., De Luca, A., Chimento, A., Sirianni, R., Malivindi, R., …Pezzi, V. (2015). Estrogen related receptor α (ERRα) a promising target for the therapy of adrenocortical carcinoma (ACC). Oncotarget, 6(28), 25135-25148. https://doi.org/10.18632/oncotarget.4722

The pathogenesis of the adrenocortical cancer (ACC) involves integration of molecular signals and the interplay of different downstream pathways (i.e. IGFII/IGF1R, β-catenin, Wnt, ESR1). This tumor is characterized by limited therapeutic options and... Read More about Estrogen related receptor α (ERRα) a promising target for the therapy of adrenocortical carcinoma (ACC).

Mitochondrial biogenesis is required for the anchorage-independent survival and propagation of stem-like cancer cells (2015)
Journal Article
De Luca, A., Fiorillo, M., Peiris-Pagès, M., Ozsvari, B., Smith, D., Sanchez-Alvarez, R., …Sotgia, F. (2015). Mitochondrial biogenesis is required for the anchorage-independent survival and propagation of stem-like cancer cells. Oncotarget, 6(17), 14777-14795. https://doi.org/10.18632/oncotarget.4401

Here, we show that new mitochondrial biogenesis is required for the anchorage independent survival and propagation of cancer stem-like cells (CSCs). More specifically, we used the drug XCT790 as an investigational tool, as it functions as a specific... Read More about Mitochondrial biogenesis is required for the anchorage-independent survival and propagation of stem-like cancer cells.

Caveolae and signalling in cancer (2015)
Journal Article
Martinez-Outschoorn, U., Sotgia, F., & Lisanti, M. (2015). Caveolae and signalling in cancer. Nature Reviews Cancer, 15(4), 225-37. https://doi.org/10.1038/nrc3915

It has been over 20 years since the discovery that caveolar lipid rafts function as signalling organelles. Lipid rafts create plasma membrane heterogeneity, and caveolae are the most extensively studied subset of lipid rafts. A newly emerging paradig... Read More about Caveolae and signalling in cancer.

Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types : treating cancer like an infectious disease (2015)
Journal Article
Lamb, R., Ozsvari, B., Lisanti, C., Tanowitz, H., Howell, A., Martinez-Outschoorn, U., …Lisanti, M. (2015). Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types : treating cancer like an infectious disease. Oncotarget, 6(7), 4569-84. https://doi.org/10.18632/oncotarget.3174

Here, we propose a new strategy for the treatment of early cancerous lesions and advanced metastatic disease, via the selective targeting of cancer stem cells (CSCs), a.k.a., tumor-initiating cells (TICs). We searched for a global phenotypic characte... Read More about Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types : treating cancer like an infectious disease.

Metabolic asymmetry in cancer : a “balancing act” that promotes tumor growth (2014)
Journal Article
Martinez-Outschoorn, U., Sotgia, F., & Lisanti, M. (2014). Metabolic asymmetry in cancer : a “balancing act” that promotes tumor growth. Cancer Cell, 26(1), 5-7. https://doi.org/10.1016/j.ccr.2014.06.021

Profound metabolic differences between cancer cells and fibroblasts promote tumorigenesis. A study by Valencia and colleagues in this issue of Cancer Cell supports this assertion. They observed that metabolic asymmetry in prostate tumors drives aggre... Read More about Metabolic asymmetry in cancer : a “balancing act” that promotes tumor growth.

CAPER, a novel regulator of human breast cancer progression (2014)
Journal Article
Mercier, I., Gonzales, D., Quann, K., Pestell, T., Molchansky, A., Sotgia, F., …Jasmin, J. (2014). CAPER, a novel regulator of human breast cancer progression. Cell Cycle, 13(8), 1256-1264. https://doi.org/10.4161/cc.28156

CAPE R is an estrogen receptor (ER) co-activator that was recently shown to be involved in human breast cancer pathogenesis.
Indeed, we reported increased expression of CAPE R in human breast cancer specimens. We demonstrated that
CAPE R was undete... Read More about CAPER, a novel regulator of human breast cancer progression.

Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth (2014)
Journal Article
Martinez-Outschoorn, U., Lisanti, M., & Sotgia, F. (2014). Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth. Seminars in Cancer Biology, 25, 47-60. https://doi.org/10.1016/j.semcancer.2014.01.005

Fibroblasts are the most abundant “non-cancerous” cells in tumors. However, it remains largely
unknown how these cancer-associated fibroblasts (CAFs) promote tumor growth and metastasis, driving
chemotherapy resistance and poor clinical outcome. Th... Read More about Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth.

JNK1 stress signaling is hyper-activated in high breast density and the tumor stroma: Connecting fibrosis, inflammation, and stemness for cancer prevention (2013)
Journal Article
Lisanti, M., Reeves, K., Peiris-Pagès, M., Chadwick, A., Sanchez-Alvarez, R., Howell, A., …Sotgia, F. (2014). JNK1 stress signaling is hyper-activated in high breast density and the tumor stroma: Connecting fibrosis, inflammation, and stemness for cancer prevention. Cell Cycle, 13(4), 580-599. https://doi.org/10.4161/cc.27379

Mammography is an important screening modality for the early detection of DCIS and breast cancer lesions. More specifically, high mammographic density is associated with an increased risk of breast cancer. However, the biological processes underlying... Read More about JNK1 stress signaling is hyper-activated in high breast density and the tumor stroma: Connecting fibrosis, inflammation, and stemness for cancer prevention.

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