Prof Geoff Hide's Outputs (113)

Cell cycle and cleavage events during in vitro cultivation of bloodstream forms of Trypanosoma lewisi, a zoonotic pathogen (2019)
Journal Article

Trypanosoma (Herpetosoma) lewisi is a globally distributed rat trypanosome, currently considered as a zoonotic pathogen; however, a detailed understanding of the morphological events occurring during the cell cycle is lacking. This study aimed to inv... Read More about Cell cycle and cleavage events during in vitro cultivation of bloodstream forms of Trypanosoma lewisi, a zoonotic pathogen.

Genotyping of Toxoplasma gondii from pigs in Yucatan, Mexico (2018)
Journal Article

Toxoplasmosis is a zoonotic disease of worldwide distribution. The parasite exhibits strong geographical patterns
of strain variation with contrasting high levels of diversity across South America and restricted variation across
North America. Litt... Read More about Genotyping of Toxoplasma gondii from pigs in Yucatan, Mexico.

Investigation into the genetic diversity in toll-like receptors 2 and 4 in the European badger Meles meles (2018)
Journal Article

The Toll-like receptor (TLR) genes are a conserved family of genes central to the innate immune response to pathogen infection. They encode receptor proteins, recognise pathogen associated molecular patterns (PAMPs) and trigger initial immune respons... Read More about Investigation into the genetic diversity in toll-like receptors 2 and 4 in the European badger Meles meles.

Skin swabs with FTA® cards as a dry storage source for amphibian DNA (2018)
Journal Article
Ward, A., Hide, G., & Jehle, R. (2019). Skin swabs with FTA® cards as a dry storage source for amphibian DNA. Conservation Genetics Resources, 11, 309-311. https://doi.org/10.1007/s12686-018-1018-z

Amphibians are the most endangered group of vertebrates, and conservation measures increasingly rely on information drawn from genetic markers. The present study explores skin swabs with Whatman FTA® cards as a method to retrieve PCR-amplifiable amph... Read More about Skin swabs with FTA® cards as a dry storage source for amphibian DNA.

The effect of normal human serum on the mouse trypanosome Trypanosoma musculi in vitro and in vivo (2017)
Journal Article

Trypanosoma musculi, a common blood flagellate found in mice, is similar in morphology and life cycle to the rat trypanosome T. lewisi. Both species belong to the subgenus Herpetosoma, and as T. lewisi has recently been shown to be a zoonotic pathoge... Read More about The effect of normal human serum on the mouse trypanosome Trypanosoma musculi in vitro and in vivo.

Nitric oxide blocks the development of the human parasite Schistosoma japonicum (2017)
Journal Article

Human schistosomiasis, caused by Schistosoma species, is a major public health problem affecting more than 700 million people in 78 countries, with over 40 mammalian host reservoir species complicating the transmission ecosystem. The primary cause of... Read More about Nitric oxide blocks the development of the human parasite Schistosoma japonicum.

Genetic analyses of Chinese isolates of Toxoplasma gondii reveal a new genotype with high virulence to murine hosts (2017)
Journal Article

A great deal of evidence demonstrates that a strongly clonal population structure of Toxoplasma gondii strains exists in humans and animals in North America and Europe, while the strains from South America are genetically separate and more diverse. P... Read More about Genetic analyses of Chinese isolates of Toxoplasma gondii reveal a new genotype with high virulence to murine hosts.

Recombinant α-actinin subunit antigens of Trichomonas vaginalis as potential vaccine candidates in protecting against trichomoniasis (2017)
Journal Article

BACKGROUND:
Human trichomoniasis caused by Trichomonas vaginalis is one of the most common sexually transmitted diseases with more than 200 million cases worldwide. It has caused a series of health problems to patients. For prevention and control of... Read More about Recombinant α-actinin subunit antigens of Trichomonas vaginalis as potential vaccine candidates in protecting against trichomoniasis.

Guanylate-binding Protein 1 (GBP1) contributes to the immunity of human mesenchymal stromal cells against toxoplasma gondii (2017)
Journal Article

Mesenchymal stromal cells (MSCs) have recently been shown to play important roles in mammalian host defenses against intracellular pathogens, but the molecular mechanism still needs to be clarified. We confirmed that human MSCs (hMSCs) pre-stimulated... Read More about Guanylate-binding Protein 1 (GBP1) contributes to the immunity of human mesenchymal stromal cells against toxoplasma gondii.

High frequency detection of Toxoplasma gondii DNA in human neonatal tissue from Libya (2016)
Journal Article

Background:
Toxoplasma gondii is a parasite that causes significant disease in humans. Toxoplasmosis is normally asymptomatic, unless associated with congenital transmission, or in immunocompromised people. Congenital transmission generally occurs... Read More about High frequency detection of Toxoplasma gondii DNA in human neonatal tissue from Libya.

Trehalose, an easy, safe and efficient cryoprotectant for the parasitic protozoan Trypanosoma brucei (2016)
Journal Article

Trehalose, a non-permeating cryoprotective agent (CPA), has been documented as less toxic and highly efficient at cryopreserving different kinds of cells or organisms. In the present study, trehalose was evaluated for its application in cryopreservat... Read More about Trehalose, an easy, safe and efficient cryoprotectant for the parasitic protozoan Trypanosoma brucei.

Different types of small RNAs in protozoa (2016)
Book Chapter
Zheng, L., Liao, J., Wen, Y., Hide, G., Qu, L., & Lun, Z. (2016). Different types of small RNAs in protozoa. In A. Leitao, & F. Enguita (Eds.), Non-coding RNAs and inter-kingdom communication (177-196). Springer International Publishing. https://doi.org/10.1007/978-3-319-39496-1_11

The origin and evolution of small RNA molecules is a long-standing mystery. The protozoa represent the earliest eukaryotes and encompass rich diverse genetic resources. However, there are many contradictions and disputes prevalent in studies on proto... Read More about Different types of small RNAs in protozoa.

Angiostrongylus cantonensis and human angiostrongyliasis (2016)
Journal Article
Lai, D., Dai, X., Hide, G., & Lun, Z. (2016). Angiostrongylus cantonensis and human angiostrongyliasis

Further evidence from SSCP and ITS DNA sequencing support Trypanosoma evansi and Trypanosoma equiperdum as subspecies or even strains of Trypanosoma brucei (2016)
Journal Article

The subgenus Trypanozoon includes three species Trypanosoma brucei, Trypanosoma evansi and Trypanosoma equiperdum, which are morphologically identical and indistinguishable even using some molecular methods. In this study, PCR-based single strand con... Read More about Further evidence from SSCP and ITS DNA sequencing support Trypanosoma evansi and Trypanosoma equiperdum as subspecies or even strains of Trypanosoma brucei.

Role of vertical transmission ofToxoplasma gondiiin prevalence of infection (2016)
Journal Article
Hide, G. (2016). Role of vertical transmission ofToxoplasma gondiiin prevalence of infection. Expert Review of Anti-infective Therapy, 14(3), https://doi.org/10.1586/14787210.2016.1146131

The parasite, Toxoplasma gondii, is a highly successful pathogen that infects around 30% of the global human population. Additionally, it is able to infect all warm blooded animals with high prevalence. This is surprising as it is a parasite of the c... Read More about Role of vertical transmission ofToxoplasma gondiiin prevalence of infection.

Role of vertical transmission of Toxoplasma gondii in prevalence of infection (2016)
Journal Article

The parasite, Toxoplasma gondii, is a highly successful pathogen that infects around 30% of the global human population. Additionally, it is able to infect all warm blooded animals with high prevalence. This is surprising as it is a parasite of the c... Read More about Role of vertical transmission of Toxoplasma gondii in prevalence of infection.

Erratum to : Analysis of the mitochondrial maxicircle of Trypanosoma lewisi, a neglected human pathogen (2016)
Journal Article
Lin, R., Lai, D., Zheng, L., Wu, J., Lukeš, J., Hide, G., & Lun, Z. (2016). Erratum to : Analysis of the mitochondrial maxicircle of Trypanosoma lewisi, a neglected human pathogen. Parasites and Vectors, 9(1), https://doi.org/10.1186/s13071-016-1297-8

Current status of Clonorchis sinensis and clonorchiasis in China (2016)
Journal Article

The oriental liver fluke, Clonorchis sinensis, a pathogen causing clonorchiasis, is of major socio-economic importance
in East Asia, including China, Korea and Vietnam. This parasite is nowrecognized as a biocarcinogen strongly
linked to cholangioc... Read More about Current status of Clonorchis sinensis and clonorchiasis in China.

Analysis of the mitochondrial maxicircle of Trypanosoma lewisi, a neglected human pathogen (2015)
Journal Article
Lin, R., Lai, D., Zheng, L., Wu, J., Lukeš, J., Hide, G., & Lun, Z. (2015). Analysis of the mitochondrial maxicircle of Trypanosoma lewisi, a neglected human pathogen. Parasites and Vectors, 8(1), 665. https://doi.org/10.1186/s13071-015-1281-8

BACKGROUND

The haemoflagellate Trypanosoma lewisi is a kinetoplastid parasite which, as it has been recently reported to cause human disease, deserves increased attention. Characteristic features of all kinetoplastid flagellates are a uniquely st... Read More about Analysis of the mitochondrial maxicircle of Trypanosoma lewisi, a neglected human pathogen.

High prevalence of trypanosomes in European badgers detected using ITS-PCR (2015)
Journal Article
Ideozu, E., Whiteoak, A., Tomlinson, A., Robertson, A., Delahay, R., & Hide, G. (2015). High prevalence of trypanosomes in European badgers detected using ITS-PCR. Parasites and Vectors, 8(480), https://doi.org/10.1186/s13071-015-1088-7

Background
Wildlife can be important sources and reservoirs for pathogens. Trypanosome infections are common in many mammalian species, and are pathogenic in some. Molecular detection tools were used to measure trypanosome prevalence in a well-stud... Read More about High prevalence of trypanosomes in European badgers detected using ITS-PCR.