Skip to main content

Research Repository

Advanced Search

Prof Geoff Hide's Outputs (113)

A new species of mammalian trypanosome, Trypanosoma (Megatrypanum) bubalisi sp. nov., found in the freshwater leech Hirudinaria manillensis (2021)
Journal Article
Su, B., Wang, J., Yang, T., Hide, G., Lai, D., & Lun, Z. (2021). A new species of mammalian trypanosome, Trypanosoma (Megatrypanum) bubalisi sp. nov., found in the freshwater leech Hirudinaria manillensis. International Journal for Parasitology, https://doi.org/10.1016/j.ijpara.2021.10.009

Leeches have long been considered potential vectors for the aquatic lineage of trypanosomes, while bloodsucking insects are generally considered as the vectors for the terrestrial lineage of trypanosomes. The freshwater leech, Hirudinaria manillensis... Read More about A new species of mammalian trypanosome, Trypanosoma (Megatrypanum) bubalisi sp. nov., found in the freshwater leech Hirudinaria manillensis.

Innate resistance to Leishmania amazonensis Infection in rat is dependent on NOS2 (2021)
Journal Article
Chen, Y., Yu, S., Wu, C., Wu, N., Shen, J., Shen, J., …Lun, Z. (2021). Innate resistance to Leishmania amazonensis Infection in rat is dependent on NOS2. Frontiers in Microbiology, 12, 733286. https://doi.org/10.3389/fmicb.2021.733286

Leishmania infection causes diverse clinical manifestations in humans. The disease outcome is complicated by the combination of many host and parasite factors. Inbred mouse strains vary in resistance to Leishmania major but are highly susceptible to... Read More about Innate resistance to Leishmania amazonensis Infection in rat is dependent on NOS2.

High resistance to Toxoplasma gondii infection in inducible nitric oxide synthase (iNOS) knockout rats (2021)
Journal Article
Wang, Z.-J., Yu, S.-M., Gao, J.-M., Zhang, P., Hide, G., Yamamoto, M., …Lun, Z.-R. (2021). High resistance to Toxoplasma gondii infection in inducible nitric oxide synthase (iNOS) knockout rats. iScience, 24(11), 103280. https://doi.org/10.1016/j.isci.2021.103280

Nitric oxide (NO) is an important immune molecule which acts against extra- and intracellular pathogens in most hosts. However, after knockout of inducible nitric oxide synthase (iNOS-/-) in Sprague Dawley (SD) rats, these iNOS-/- rats were found to... Read More about High resistance to Toxoplasma gondii infection in inducible nitric oxide synthase (iNOS) knockout rats.

The relationship between the infection of Toxoplasma gondii and Alzheimer’s disease (2021)
Thesis
Alawfi, B. (2021). The relationship between the infection of Toxoplasma gondii and Alzheimer’s disease. (Thesis). University of Salford

Toxoplasma gondii is a zoonotic parasite that commonly causes infections in a variety of warm-blooded animals including humans. This parasite causes a disease referred to as toxoplasmosis. T. gondii infections are known to have a significant impact o... Read More about The relationship between the infection of Toxoplasma gondii and Alzheimer’s disease.

Identification of an orally active carbazole aminoalcohol derivative with broad-spectrum anti-animal trypanosomiasis activity (2021)
Journal Article
Cai, X., Wang, W., Lai, D., Zhang, X., Yao, J., Yu, Y., …Lun, Z. (2021). Identification of an orally active carbazole aminoalcohol derivative with broad-spectrum anti-animal trypanosomiasis activity. Acta tropica, 219, 105919. https://doi.org/10.1016/j.actatropica.2021.105919

Animal trypanosomiasis, caused by the members of subgenus Trypanozoon (Trypanosoma brucei brucei, T. evansi and T. equiperdum), has reduced animal productivity leading to significant negative economic impacts in endemic regions. Due to limited drug d... Read More about Identification of an orally active carbazole aminoalcohol derivative with broad-spectrum anti-animal trypanosomiasis activity.

An investigation into Toxoplasma gondii infection and the expression of Arginase-1 and iNOS in human lung tissue (2021)
Thesis
Soothill, H. An investigation into Toxoplasma gondii infection and the expression of Arginase-1 and iNOS in human lung tissue. (Dissertation). University of Salford

This study aimed to investigate the relationship between Toxoplasma gondii infection and the expression of the immune modulating proteins Arginase-1 and iNOS in human lung biopsy samples. Previously, a 100% toxoplasmosis infection rate was found in 7... Read More about An investigation into Toxoplasma gondii infection and the expression of Arginase-1 and iNOS in human lung tissue.

Infection with Trypanosoma lewisi or Trypanosoma musculi may promote the spread of Toxoplasma gondii (2021)
Journal Article
Gao, J., Yi, S., Geng, G., Xu, Z., Hide, G., Lun, Z., & Lai, D. (2021). Infection with Trypanosoma lewisi or Trypanosoma musculi may promote the spread of Toxoplasma gondii. Parasitology, 148(6), 703-711. https://doi.org/10.1017/S0031182021000196

Toxoplasma gondii can infect almost all warm-blooded vertebrates with pathogensis
being largely influenced by the host immune status. As important epidemiological
hosts, rodents are globally distributed and are also commonly found infected with
ha... Read More about Infection with Trypanosoma lewisi or Trypanosoma musculi may promote the spread of Toxoplasma gondii.

Investigation into the genetic variation of Toll-Like Receptor 9 in cattle using both Sanger and next-generation sequencing from FTA-Cards (2020)
Thesis
Alqurashi, A. Investigation into the genetic variation of Toll-Like Receptor 9 in cattle using both Sanger and next-generation sequencing from FTA-Cards. (Thesis). University of Salford

The susceptibility or resistance to infectious diseases depends on the host immune response. The genetic variation of immune-relevant genes such as Toll-Like Receptor (TLR) genes is associated with susceptibility or resistance to the pathogen. In thi... Read More about Investigation into the genetic variation of Toll-Like Receptor 9 in cattle using both Sanger and next-generation sequencing from FTA-Cards.

Long-term trends in helminth infections of wood mice (Apodemus sylvaticus) from the vicinity of Malham Tarn in North Yorkshire, England (2020)
Journal Article
Behnke, J., Rogan, M., Craig, P., Jackson, J., & Hide, G. (2021). Long-term trends in helminth infections of wood mice (Apodemus sylvaticus) from the vicinity of Malham Tarn in North Yorkshire, England. Parasitology, 184(4), 451-463. https://doi.org/10.1017/S0031182020002243

Helminth infections in wood mice (n=483), trapped over a period of 26 years in the woods
surrounding Malham Tarn in N. Yorkshire, were analysed. Although ten species of helminths
were identified, the overall mean species richness was 1.01 species/m... Read More about Long-term trends in helminth infections of wood mice (Apodemus sylvaticus) from the vicinity of Malham Tarn in North Yorkshire, England.

Investigation into Toxoplasma gondii infection in relation to expression of neurodegenerative disease markers in natural mice populations (2020)
Thesis
Alshammari, A. (2020). Investigation into Toxoplasma gondii infection in relation to expression of neurodegenerative disease markers in natural mice populations. (Thesis). University of Salford

Toxoplasma gondii is a highly prevalent opportunistic protozoan parasite that has a remarkable capacity to infect humans and a range of warm-blooded animals. This research had two broad aims. Firstly, to investigating whether detection of T. gondii i... Read More about Investigation into Toxoplasma gondii infection in relation to expression of neurodegenerative disease markers in natural mice populations.

Investigating the relationship between lung cancer and the infection with the parasite Toxoplasma gondii (2020)
Thesis
Tarabulsi, M. Investigating the relationship between lung cancer and the infection with the parasite Toxoplasma gondii. (Thesis). University of Salford

Toxoplasma gondii is an obligate intracellular organism that has a worldwide distribution and is highly prevalent among animals and humans. Although usually asymptomatic, it can cause serious diseases in immunocompromised individuals such as pneumoni... Read More about Investigating the relationship between lung cancer and the infection with the parasite Toxoplasma gondii.

Novel organization of mitochondrial minicircles and guide RNAs in the zoonotic pathogen Trypanosoma lewisi (2020)
Journal Article
Li, S., Zhang, X., Lukeš, J., Li, B., Wang, J., Qu, L., …Lun, Z. (2020). Novel organization of mitochondrial minicircles and guide RNAs in the zoonotic pathogen Trypanosoma lewisi. Nucleic Acids Research, 48(17), 9747-9761. https://doi.org/10.1093/nar/gkaa700

Abstract Kinetoplastid flagellates are known for several unusual features, one of which is their complex mitochondrial genome, known as kinetoplast (k) DNA, composed of mutually catenated maxi- and minicircles. Trypanosoma lewisi is a member of the S... Read More about Novel organization of mitochondrial minicircles and guide RNAs in the zoonotic pathogen Trypanosoma lewisi.

Temperature is a key factor influencing the invasion and proliferation of Toxoplasma gondii in fish cells (2020)
Journal Article
Yang, Y., Yu, S., Chen, K., Hide, G., Lun, Z., & Lai, D. (2020). Temperature is a key factor influencing the invasion and proliferation of Toxoplasma gondii in fish cells. Experimental Parasitology, 217, 107966. https://doi.org/10.1016/j.exppara.2020.107966

Toxoplasma gondii has long been considered a ubiquitous parasite possessing the capacity of infecting virtually all warm-blooded animals globally. Occasionally, this parasite can also infect cold-blooded animals such as fish if their body temperature... Read More about Temperature is a key factor influencing the invasion and proliferation of Toxoplasma gondii in fish cells.

Human African trypanosomiasis : the current situation in endemic regions and the risks for non-endemic regions from imported cases (2020)
Journal Article
Gao, J., Qian, Z., Hide, G., Lai, D., Lun, Z., & Wu, Z. (2020). Human African trypanosomiasis : the current situation in endemic regions and the risks for non-endemic regions from imported cases. Parasitology, 147(9), 922-931. https://doi.org/10.1017/S0031182020000645

Human African trypanosomiasis (HAT) is caused by Trypanosoma brucei
gambiense and T. b. rhodesiense and caused devastating epidemics during the 20th
century. Due to effective control programs implemented in the last two decades, the
number of repo... Read More about Human African trypanosomiasis : the current situation in endemic regions and the risks for non-endemic regions from imported cases.

Vacuolar ATPase depletion contributes to dysregulation of endocytosis in bloodstream forms of Trypanosoma brucei (2020)
Journal Article
Xu, Z.-S., Li, F.-J., Hide, G., Lun, Z.-R., & Lai, D.-H. (2020). Vacuolar ATPase depletion contributes to dysregulation of endocytosis in bloodstream forms of Trypanosoma brucei. Parasites and Vectors, 13(1), 214. https://doi.org/10.1186/s13071-020-04068-4

BACKGROUND

Vacuolar H-ATPase (V-ATPase) is a highly conserved protein complex which hydrolyzes ATP and pumps protons to acidify vacuolar vesicles. Beyond its role in pH maintenance, the involvement of V-ATPase in endocytosis is well documented in... Read More about Vacuolar ATPase depletion contributes to dysregulation of endocytosis in bloodstream forms of Trypanosoma brucei.

Investigation of genetic and epigenetic mechanisms of iNOS gene expression in infection of natural populations of Apodemus sylvaticus with the parasite Toxoplasma gondii (2020)
Thesis
Eshenshani, A. Investigation of genetic and epigenetic mechanisms of iNOS gene expression in infection of natural populations of Apodemus sylvaticus with the parasite Toxoplasma gondii. (Thesis). University of Salford

Toxoplasma gondii is a ubiquitous parasite that infects all warm blooded animals. It can cause pathology in both infected humans and infected animals. There have been many studies investigating the factors the affect infection of laboratory animals,... Read More about Investigation of genetic and epigenetic mechanisms of iNOS gene expression in infection of natural populations of Apodemus sylvaticus with the parasite Toxoplasma gondii.

MAT Seroprevalence infers low rates of Toxoplasma gondii in domestic pigs from Yucatan, Mexico (2019)
Journal Article
Cubas-Atienzar, A., Hide, G., & Smith, J. (2019). MAT Seroprevalence infers low rates of Toxoplasma gondii in domestic pigs from Yucatan, Mexico. Journal of Parasitology, 105(5), 738-747. https://doi.org/10.1645/18-188

Toxoplasma gondii is a zoonotic parasite of worldwide distribution. The consumption of infected pork meat has been suggested to be an important source for human infection in the tropical area of Yucatan, Mexico. We performed a cross-sectional study o... Read More about MAT Seroprevalence infers low rates of Toxoplasma gondii in domestic pigs from Yucatan, Mexico.

High frequency of infection of lung cancer patients with the parasite Toxoplasma gondii (2019)
Journal Article
Bajnok, J., Tarabulsi, M., Carlin, H., Bown, K., Southworth, T., Dungwa, J., …Hide, G. (2019). High frequency of infection of lung cancer patients with the parasite Toxoplasma gondii. ERJ Open Research, 5(2), 1-10. https://doi.org/10.1183/23120541.00143-2018

Toxoplasma gondii is an intracellular protozoan parasite that can cause a wide range of clinical conditions, including miscarriage and pneumonia. The global prevalence is 30% in humans but varies locally (e.g. UK is typically 10%). The association be... Read More about High frequency of infection of lung cancer patients with the parasite Toxoplasma gondii.

The association between Toxoplasma gondii infection and postpartum blues (2019)
Journal Article
Gao, J.-M., He, Z.-H., Xie, Y.-T., Hide, G., Lai, D.-H., & Lun, Z.-R. (2019). The association between Toxoplasma gondii infection and postpartum blues. Journal of Affective Disorders, 250, 404-409. https://doi.org/10.1016/j.jad.2019.03.013

Introduction and Aim: Toxoplasma gondii is an intracellular protozoan parasite infecting approximately 30% of
the global human population. It has often been suggested that chronic infection with T. gondii is related to
personality changes and vario... Read More about The association between Toxoplasma gondii infection and postpartum blues.