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Dr Zeljka Krpetic's Outputs (34)

Self-assembling ferritin nanoplatform for the development of infectious hematopoietic necrosis virus vaccine (2024)
Journal Article
Ahmadivand, S., Krpetic, Z., Martínez, M. M., Ordoñez, M. G., Roher, N., & Palić, D. (2024). Self-assembling ferritin nanoplatform for the development of infectious hematopoietic necrosis virus vaccine. Frontiers in Immunology, 15, 1346512. https://doi.org/10.3389/fimmu.2024.1346512

Self-assembling protein nanoparticles are used as a novel vaccine design platform to improve the stability and immunogenicity of safe subunit vaccines, while providing broader protection against viral infections. Infectious Hematopoietic Necrosis vir... Read More about Self-assembling ferritin nanoplatform for the development of infectious hematopoietic necrosis virus vaccine.

Role of nanoparticle size and shape in the design and characterisation of functional nanomaterials for applications in cancer nanotechnology (2022)
Thesis
applications in cancer nanotechnology. (Thesis). University of Salford

Gold nanoparticles are emerging novel theranostic agents with numerous applications as
diagnostic and therapeutic tools owing to their unique optical properties and highly
customisable surface chemistry, which allows for the careful design of perso... Read More about Role of nanoparticle size and shape in the design and characterisation of functional nanomaterials for applications in cancer nanotechnology.

Versailles project on advanced materials and standards (VAMAS) interlaboratory study on measuring the number concentration of colloidal gold nanoparticles (2022)
Journal Article
Minelli, C., Wywijas, M., Bartczak, D., Cuello-Nuñez, S., Infante, H. G., Deumer, J., …Shard, A. (2022). Versailles project on advanced materials and standards (VAMAS) interlaboratory study on measuring the number concentration of colloidal gold nanoparticles. Nanoscale, 14(12), 4690-4704. https://doi.org/10.1039/d1nr07775a

This study compared results of nanoparticle number concentration measurements collected from 74 instruments hosted across 50 laboratories, providing users with useful discussion and reference data to assess and benchmark their measurement capability.

In depth characterisation of the biomolecular coronas of polymer coated inorganic nanoparticles with differential centrifugal sedimentation (2021)
Journal Article
Perez-Potti, A., Lopez, H., Pelaz, B., Abdelmonem, A., Soliman, M., Schoen, I., …Monopoli, M. (2021). In depth characterisation of the biomolecular coronas of polymer coated inorganic nanoparticles with differential centrifugal sedimentation. Scientific reports, 11(1), 6443. https://doi.org/10.1038/s41598-021-84029-8

Advances in nanofabrication methods have enabled the tailoring of new strategies towards the controlled production of nanoparticles with attractive applications in healthcare. In many cases, their characterisation remains a big challenge, particularl... Read More about In depth characterisation of the biomolecular coronas of polymer coated inorganic nanoparticles with differential centrifugal sedimentation.

Influence of size and shape on the anatomical distribution of endotoxin-free gold nanoparticles (2017)
Journal Article
Talamini, L., Violato, M. B., Cai, Q., Monopoli, M., Kantner, K., Krpetic, Z., …Bigini, P. (2017). Influence of size and shape on the anatomical distribution of endotoxin-free gold nanoparticles. ACS nano, 11(6), 5519-5529. https://doi.org/10.1021/acsnano.7b00497

The transport and the delivery of drugs through nanocarriers is a great challenge of pharmacology. Since the production of liposomes to reduce the toxicity of doxorubicin in patients, a plethora of nanomaterials have been produced and characterized.... Read More about Influence of size and shape on the anatomical distribution of endotoxin-free gold nanoparticles.

Towards a classification strategy for complex nanostructures (2017)
Journal Article
Castagnola, V., Cookman, J., De Araujo, J., Polo, E., Cai, Q., Silviera, P., …Dawson, K. (2017). Towards a classification strategy for complex nanostructures. Nanoscale horizons (Print), 2017(2), 187-198. https://doi.org/10.1039/C6NH00219F

The range of possible nanostructures is so large and continuously growing, that collating and unifying the knowledge connected to them, including their biological activity, is a major challenge. Here we discuss a conception that is based on connectio... Read More about Towards a classification strategy for complex nanostructures.

Detecting the shape of anisotropic gold nanoparticles in dispersion with single particle extinction and scattering (2017)
Journal Article
Marco A, C., P., Krpetic, Z., Tiziano, S., Qi, C., Marco, M., João M., D. A., …Kenneth A., D. (2017). Detecting the shape of anisotropic gold nanoparticles in dispersion with single particle extinction and scattering. Nanoscale, 8, https://doi.org/10.1039/C6NR08977A

The shape and size of nanoparticles are important parameters affecting the biodistribution, bioactivity, and toxicity. The
high-throughput characterisation of nanoparticle shape in the dispersion is a fundamental prerequisite for realistic in vitro... Read More about Detecting the shape of anisotropic gold nanoparticles in dispersion with single particle extinction and scattering.

Mapping protein binding sites on the biomolecular corona of nanoparticles (2015)
Journal Article
Kelly, P., Åberg, C., Polo, E., O'Connell, A., Cookman, J., Fallon, J., …Dawson, K. (2015). Mapping protein binding sites on the biomolecular corona of nanoparticles. Nature Nanotechnology, 10(5), 472-479. https://doi.org/10.1038/nnano.2015.47

Nanoparticles in a biological milieu are known to form a sufficiently long-lived and well-organized ‘corona’ of biomolecules to confer a biological identity to the particle. Because this nanoparticle–biomolecule complex interacts with cells and biolo... Read More about Mapping protein binding sites on the biomolecular corona of nanoparticles.

Revealing DNA interactions with exogenous agents by surface-enhanced raman scattering (2014)
Journal Article
Masetti, M., Xie, H., Krpetic, Z., Recanatini, M., Alvarez-Puebla, R., & Guerrini, L. (2015). Revealing DNA interactions with exogenous agents by surface-enhanced raman scattering. Abstracts of papers / American Chemical Society, 137(1), 469-476. https://doi.org/10.1021/ja511398w

The standard protocols for DNA analysis largely involve polymerase chain reaction (PCR). However, DNA structures bound to chemical agents cannot be PCR-amplified, and therefore any sequence changes induced by external agents may be neglected. Thus, t... Read More about Revealing DNA interactions with exogenous agents by surface-enhanced raman scattering.

Direct surface-enhanced raman scattering analysis of DNA duplexes (2014)
Journal Article
Guerrini, L., Krpetic, Z., Van Lierop, D., Alvarez-Puebla, R., & Graham, D. (2014). Direct surface-enhanced raman scattering analysis of DNA duplexes. Angewandte Chemie International Edition, 54(4), 1144-1148. https://doi.org/10.1002/anie.201408558

The exploration of the genetic information carried by DNA has become a major scientific challenge. Routine DNA analysis, such as PCR, still suffers from important intrinsic limitations. Surface-enhanced Raman spectroscopy (SERS) has emerged as an out... Read More about Direct surface-enhanced raman scattering analysis of DNA duplexes.

Interactions of gold nanoparticles with a phospholipid monolayer membrane on mercury (2014)
Journal Article
Gordillo, G., Krpetic, Z., & Brust, M. (2014). Interactions of gold nanoparticles with a phospholipid monolayer membrane on mercury. ACS nano, 8(6), 6074-6080. https://doi.org/10.1021/nn501395e

It is demonstrated that a compact monolayer of 1,2-dioleoyl-sn-glycero-3-phosphocholine adsorbed to a hanging mercury drop electrode can serve as a simple electrochemical model system to study biomembrane penetration by gold nanoparticles. The hydrog... Read More about Interactions of gold nanoparticles with a phospholipid monolayer membrane on mercury.

Nanomaterials : impact on cells and cell organelles (2014)
Book Chapter
Krpetic, Z., Anguissola, S., Garry, D., Kelly, P., & Dawson, K. (2014). Nanomaterials : impact on cells and cell organelles. In Nanomaterial : impacts on cell biology and medicine (135-156). Springer Netherlands. https://doi.org/10.1007/978-94-017-8739-0_8

Colloidal nanoparticles designed for the interactions with cells are very small, nanoscale objects usually consisting of inorganic cores and organic shells that are dispersed in a buffer or biological medium. By tuning the material properties of the... Read More about Nanomaterials : impact on cells and cell organelles.

Preparation and characterization of au nanoparticles capped with mercaptocarboranyl clusters (2013)
Journal Article
M. Cioran, A., Teixidor, F., Krpetic, Ž., Brust, M., & Viñas, C. (2014). Preparation and characterization of au nanoparticles capped with mercaptocarboranyl clusters. Dalton Transactions, 43(13), 5054-5061. https://doi.org/10.1039/C3DT52872C

The preparation of 3–4 nm and 10 nm gold nanoparticles capped with neutral carborane-based mercaptocarboranes, via two different preparative routes, is reported. The resulting boron-enriched nanomaterials exhibit complete dispersibility in water, ope... Read More about Preparation and characterization of au nanoparticles capped with mercaptocarboranyl clusters.

Conjugation of PEG and gold nanoparticles to increase the accessibility and valency of tethered RNA splicing enhancers (2013)
Journal Article
Perrett, A., Dickinson, R., Krpetic, Z., Brust, M., Lewis, H., Eperon, I., & Burley, G. (2013). Conjugation of PEG and gold nanoparticles to increase the accessibility and valency of tethered RNA splicing enhancers. Chemical Science, 4(1), 257-265. https://doi.org/10.1039/C2SC20937C

Since alternative splicing patterns are exhibited by most mammalian genes, the functional properties of a gene may be changed for therapeutic purposes by nudging splicing from one pattern to another. Splicing to a refractory exon can be enhanced usin... Read More about Conjugation of PEG and gold nanoparticles to increase the accessibility and valency of tethered RNA splicing enhancers.

High-resolution sizing of monolayer-protected gold clusters by differential centrifugal sedimentation (2013)
Journal Article
Krpetic, Z., Davidson, A., Volk, M., Lévy, R., Brust, M., & Cooper, D. (2013). High-resolution sizing of monolayer-protected gold clusters by differential centrifugal sedimentation. ACS nano, 7(10), 8881-8890. https://doi.org/10.1021/nn403350v

Differential centrifugal sedimentation (DCS) has been applied to accurately size ligand-protected gold hydrosols in the 10 to 50 nm range. A simple protocol is presented to correct for particle density variations due to the presence of the ligand she... Read More about High-resolution sizing of monolayer-protected gold clusters by differential centrifugal sedimentation.

Directed assembly of DNA-functionalized gold nanoparticles using pyrrole–imidazole polyamides (2012)
Journal Article
Krpetic, Z., Singh, I., Su, W., Guerrini, L., Faulds, K., Burley, G., & Graham, D. (2012). Directed assembly of DNA-functionalized gold nanoparticles using pyrrole–imidazole polyamides. Abstracts of papers / American Chemical Society, 134(20), 8356-8359. https://doi.org/10.1021/ja3014924

Traditional methods for the construction of nanoparticle arrays and lattices exploit Watson–Crick base pairing of single-stranded DNA sequences as a proxy for self-assembly. Although this approach has been utilized in a variety of applications in nan... Read More about Directed assembly of DNA-functionalized gold nanoparticles using pyrrole–imidazole polyamides.

Positively charged silver nanoparticles and their effect on surface-enhanced Raman scattering of dye-labelled oligonucleotides (2012)
Journal Article
van Lierop, D., Krpetic, Z., Guerrini, L., Larmour, I., Dougan, J., Faulds, K., & Graham, D. (2012). Positively charged silver nanoparticles and their effect on surface-enhanced Raman scattering of dye-labelled oligonucleotides. Chemical Communications, 48(66), 8192. https://doi.org/10.1039/C2CC31731A

Improved positively charged nanoparticles are described to provide a simplified SERS substrate for DNA detection. Complete flocculation of the nanoparticles is prevented due to the controlled analyte induced aggregation. This provides a stable aggreg... Read More about Positively charged silver nanoparticles and their effect on surface-enhanced Raman scattering of dye-labelled oligonucleotides.

Importance of Nanoparticle Size in Colorimetric and SERS-Based Multimodal Trace Detection of Ni(II) Ions with Functional Gold Nanoparticles (2012)
Journal Article
Krpetic, Z., Guerrini, L., Larmour, I., Reglinski, J., Faulds, K., & Graham, D. (2012). Importance of Nanoparticle Size in Colorimetric and SERS-Based Multimodal Trace Detection of Ni(II) Ions with Functional Gold Nanoparticles. Small, 8(5), 707-714. https://doi.org/10.1002/smll.201101980

Colorimetric detection of analytes using gold nanoparticles along with surface-enhanced Raman spectroscopy (SERS) are areas of intense research activity since they both offer sensing of very low concentrations of target species. Multimodal detection... Read More about Importance of Nanoparticle Size in Colorimetric and SERS-Based Multimodal Trace Detection of Ni(II) Ions with Functional Gold Nanoparticles.

Mercaptocarborane-capped gold nanoparticles : electron pools and ion traps with switchable hydrophilicity (2012)
Journal Article
Cioran, A., Musteti, A., Teixidor, F., Krpetic, Z., Prior, I., He, Q., …Viñas, C. (2012). Mercaptocarborane-capped gold nanoparticles : electron pools and ion traps with switchable hydrophilicity. Abstracts of papers / American Chemical Society, 134(1), 212-221. https://doi.org/10.1021/ja203367h

A simple single-phase method for the preparation of ca. 2 nm gold nanoparticles capped with mercaptocarborane ligands is introduced. The resultant monolayer protected clusters (MPCs) exhibit redox-dependent solubility and readily phase transfer betwe... Read More about Mercaptocarborane-capped gold nanoparticles : electron pools and ion traps with switchable hydrophilicity.

Energy dependence of gold nanoparticle radiosensitization in plasmid DNA (2011)
Journal Article
McMahon, S., Hyland, W., Brun, E., Butterworth, K., Coulter, J., Douki, T., …Sicard-Roselli, C. (2011). Energy dependence of gold nanoparticle radiosensitization in plasmid DNA. Journal of Physical Chemistry C, 115(41), 20160-20167. https://doi.org/10.1021/jp206854s

Gold nanopa rticles (GNPs) are of considerableinterest for use as a radiosensitizer, because of their biocompat-ibility and their ability to increase dose deposited because oftheir high mass energy absorption coefficient. Their sensitizingproperties ha... Read More about Energy dependence of gold nanoparticle radiosensitization in plasmid DNA.

Intracellular mapping with SERS-encoded gold nanostars (2011)
Journal Article
Rodríguez-Lorenzo, L., Krpetic, Z., Barbosa, S., Alvarez-Puebla, R., Liz-Marzán, L., Prior, I., & Brust, M. (2011). Intracellular mapping with SERS-encoded gold nanostars. Integrative Biology, 3(9), 922-926. https://doi.org/10.1039/C1IB00029B

Here we report on the design, synthesis and application of small, highly bright, star-shaped SERS encoded single nanoparticles with the ability of providing an optical signal upon excitation with near infrared light. These particles are colloidally s... Read More about Intracellular mapping with SERS-encoded gold nanostars.

Acrylate-facilitated cellular uptake of gold nanoparticles (2011)
Journal Article
Krpetic, Z., Nativo, P., Prior, I., & Brust, M. (2011). Acrylate-facilitated cellular uptake of gold nanoparticles. Small, 7(14), 1982-1986. https://doi.org/10.1002/smll.201100462

Uptake of PEGylated gold nanoparticles by HeLa cells in the presence of acrylate is described. Nanoparticles that are usually not taken up readily cross the plasma membrane into the cytosol in the presence of acrylate. In addition, a method is descri... Read More about Acrylate-facilitated cellular uptake of gold nanoparticles.

Negotiation of intracellular membrane barriers by TAT-Modified gold nanoparticles (2011)
Journal Article
Krpeticc, Z., Saleemi, S., Prior, I., Sée, V., Qureshi, R., & Brust, M. (2011). Negotiation of intracellular membrane barriers by TAT-Modified gold nanoparticles. ACS nano, 5(6), 5195-5201. https://doi.org/10.1021/nn201369k

This paper contributes to the debate on how nanosized objects negotiate membrane barriers inside biological cells. The uptake of peptide-modified gold nanoparticles by HeLa cells has been quantified using atomic emission spectroscopy. The TAT peptide... Read More about Negotiation of intracellular membrane barriers by TAT-Modified gold nanoparticles.

Inflicting controlled nonthermal damage to subcellular structures by laser-activated gold nanoparticles (2010)
Journal Article
Krpetic, Z., Nativo, P., Sée, V., Prior, I., Brust, M., & Volk, M. (2010). Inflicting controlled nonthermal damage to subcellular structures by laser-activated gold nanoparticles. Nano Letters, 10(11), 4549-4554. https://doi.org/10.1021/nl103142t

We show that low-intensity laser irradiation of cancer cells containing endosomal gold nanoparticles leads to endosome rupture and escape of the nanoparticles into the cytosol without affecting the cells’ viability. The low light intensity of our exp... Read More about Inflicting controlled nonthermal damage to subcellular structures by laser-activated gold nanoparticles.

Phagocytosis of biocompatible gold nanoparticles (2010)
Journal Article
Krpeticc, Z., Porta, F., Caneva, E., Dal Santo, V., & Scarì, G. (2010). Phagocytosis of biocompatible gold nanoparticles. Langmuir, 26(18), 14799-14805. https://doi.org/10.1021/la102758f

We report the evidence for the cellular uptake of gold nanoparticles via the phagocytosis mechanism in murine macrophage cells strongly supported by TEM and optical microscopy. Nanoparticles were prepared using several biocompatible molecules of choi... Read More about Phagocytosis of biocompatible gold nanoparticles.

Gold nanoparticles prepared using cape aloe active components (2009)
Journal Article
Krpetic, Z., Scarì, G., Caneva, E., Speranza, G., & Porta, F. (2009). Gold nanoparticles prepared using cape aloe active components. Langmuir, 25(13), 7217-7221. https://doi.org/10.1021/la9009674

A novel use of two components of Cape aloe, aloin A and aloesin, acting as stabilizers in the preparation of gold and silver nanoparticles, is reported. Stable water-soluble particles of different size and shape are prepared by varying the reaction c... Read More about Gold nanoparticles prepared using cape aloe active components.

A multidentate peptide for stabilization and facile bioconjugation of gold nanoparticles (2009)
Journal Article
Krpetic, Z., Nativo, P., Porta, F., & Brust, M. (2009). A multidentate peptide for stabilization and facile bioconjugation of gold nanoparticles. Bioconjugate Chemistry, 20(3), 619-624. https://doi.org/10.1021/bc8003028

Gold nanoparticles of two different sizes stabilized by a 15-mer peptide ligand specifically designed for this purpose have been prepared in aqueous solution and characterized by UV−vis spectroscopy and TEM. The presence of the ligand and its binding... Read More about A multidentate peptide for stabilization and facile bioconjugation of gold nanoparticles.

Electroreductions on silver-based electrocatalysts : the use of Ag Nanoparticles for CHCl3to CH4Conversion (2009)
Journal Article
Rondinini, S., Aricci, G., Krpetic, Z., Locatelli, C., Minguzzi, A., Porta, F., & Vertova, A. (2009). Electroreductions on silver-based electrocatalysts : the use of Ag Nanoparticles for CHCl3to CH4Conversion. Fuel Cells, 9(3), 253-263. https://doi.org/10.1002/fuce.200800083

A preliminary investigation on a new class on electrocatalytic
materials for the electroreduction of organic halides is
presented and discussed. The electrocatalysts are based on
silver nanoparticles (Ag_NP), ad hoc synthesised by chemical
reduct... Read More about Electroreductions on silver-based electrocatalysts : the use of Ag Nanoparticles for CHCl3to CH4Conversion.

Gold-ligand interaction studies of water-soluble aminoalcohol capped gold nanoparticles by NMR (2008)
Journal Article
Porta, F., Krpetic, Z., Prati, L., Gaiassi, A., & Scarì, G. (2008). Gold-ligand interaction studies of water-soluble aminoalcohol capped gold nanoparticles by NMR. Langmuir, 24(14), 7061-7064. https://doi.org/10.1021/la8008392

Novel reproducible preparations of gold nanoparticles capped by aminoalcohols have been set up by reduction of HAuCl4 with NaBH4 in aqueous solution. The characterization of Au@aminoalcohol nanoparticles performed by 1H NMR, ATR-FTIR, UV−vis spectros... Read More about Gold-ligand interaction studies of water-soluble aminoalcohol capped gold nanoparticles by NMR.

Gold nanoparticles capped by peptides (2007)
Journal Article
Porta, F., Speranza, G., Krpetic, Z., Dal Santo, V., Francescato, P., & Scarì, G. (2007). Gold nanoparticles capped by peptides. Materials Science and Engineering: B, 140(3), 187-194. https://doi.org/10.1016/j.mseb.2007.03.019

Two dipeptides (GK and GC) and two 15-aminoacid peptides (GK15 and GC15) were used as capping agents in the preparation of monolayer-protected gold nanoparticles (MPCs). They were characterized by TEM microscopy, UV–vis, NMR and IR spectroscopy.

Selective entrance of gold nanoparticles into cancer cells (2006)
Journal Article
Krpetic, Z., Porta, F., & Scarì, G. (2006). Selective entrance of gold nanoparticles into cancer cells. Gold Bulletin, 39(2), 66-68. https://doi.org/10.1007/BF03215278

We report that Au(0) nanoparticles, stabilized by 5-aminovaleric acid, selectively penetrate into K562 cancer cells in a short time. These experiments were carried out in order to verify the specific recognition of gold sol by abnormal cells. The obs... Read More about Selective entrance of gold nanoparticles into cancer cells.

Single-phase bimetallic system for the selective oxidation of glycerol to glycerate
Journal Article
Prati, L., Villa, A., Su, D., Wang, D., Krpetic, Z., & Porta, F. Single-phase bimetallic system for the selective oxidation of glycerol to glycerate. Studies in surface science and catalysis, 162, 553-560. https://doi.org/10.1016/S0167-2991%2806%2980952-3

Au-Pd bimetallic systems on carbon, (Pd@Au)/C (1) and Pd@Au/C (2), have been prepared by using metallic colloidal solutions, following two different procedures. The total metal loading was 1%wt and Au/Pd molar ratio 6/4. The catalytic activities have... Read More about Single-phase bimetallic system for the selective oxidation of glycerol to glycerate.