Dr Zeljka Krpetic's Outputs (35)

Evaluation of Novel Diketones as Anti-cancer Agents (2024)
Thesis

Recent studies indicated high levels of cytotoxicity of dibenzoylmethane (DBM) and its derivatives on some mammalian cancer cells. On the other hand, p53 tumour suppressor is a DNA damage inducible transcription factor mutated in over half of human c... Read More about Evaluation of Novel Diketones as Anti-cancer Agents.

Self-assembling ferritin nanoplatform for the development of infectious hematopoietic necrosis virus vaccine (2024)
Journal Article
Ahmadivand, S., Krpetic, Z., Martínez, M. M., Ordoñez, M. G., Roher, N., & Palić, D. (2024). Self-assembling ferritin nanoplatform for the development of infectious hematopoietic necrosis virus vaccine. Frontiers in Immunology, 15, 1346512. https://doi.org/10.3389/fimmu.2024.1346512

Self-assembling protein nanoparticles are used as a novel vaccine design platform to improve the stability and immunogenicity of safe subunit vaccines, while providing broader protection against viral infections. Infectious Hematopoietic Necrosis vir... Read More about Self-assembling ferritin nanoplatform for the development of infectious hematopoietic necrosis virus vaccine.

Role of nanoparticle size and shape in the design and characterisation of functional nanomaterials for applications in cancer nanotechnology (2022)
Thesis
applications in cancer nanotechnology. (Thesis). University of Salford

Gold nanoparticles are emerging novel theranostic agents with numerous applications as
diagnostic and therapeutic tools owing to their unique optical properties and highly
customisable surface chemistry, which allows for the careful design of perso... Read More about Role of nanoparticle size and shape in the design and characterisation of functional nanomaterials for applications in cancer nanotechnology.

Versailles project on advanced materials and standards (VAMAS) interlaboratory study on measuring the number concentration of colloidal gold nanoparticles (2022)
Journal Article

This study compared results of nanoparticle number concentration measurements collected from 74 instruments hosted across 50 laboratories, providing users with useful discussion and reference data to assess and benchmark their measurement capability.

In depth characterisation of the biomolecular coronas of polymer coated inorganic nanoparticles with differential centrifugal sedimentation (2021)
Journal Article

Advances in nanofabrication methods have enabled the tailoring of new strategies towards the controlled production of nanoparticles with attractive applications in healthcare. In many cases, their characterisation remains a big challenge, particularl... Read More about In depth characterisation of the biomolecular coronas of polymer coated inorganic nanoparticles with differential centrifugal sedimentation.

Cancer research, treatment, and COVID-19 (2020)
Journal Article
Curley, S., Currell, F., Kirshnan, S., & Krpetic, Z. (2020). Cancer research, treatment, and COVID-19. Cancer Nanotechnology, 11, 7. https://doi.org/10.1101/2020.05.27.20115303

This is an editorial article.

From basics to clinic : Cancer Nanotechnology (2017)
Journal Article
Currell, F., Curley, S., Krpetic, Z., & Bellringer, M. (2017). From basics to clinic : Cancer Nanotechnology. Cancer Nanotechnology, 8(8), https://doi.org/10.1186/s12645-017-0033-1

Influence of size and shape on the anatomical distribution of endotoxin-free gold nanoparticles (2017)
Journal Article

The transport and the delivery of drugs through nanocarriers is a great challenge of pharmacology. Since the production of liposomes to reduce the toxicity of doxorubicin in patients, a plethora of nanomaterials have been produced and characterized.... Read More about Influence of size and shape on the anatomical distribution of endotoxin-free gold nanoparticles.

Towards a classification strategy for complex nanostructures (2017)
Journal Article

The range of possible nanostructures is so large and continuously growing, that collating and unifying the knowledge connected to them, including their biological activity, is a major challenge. Here we discuss a conception that is based on connectio... Read More about Towards a classification strategy for complex nanostructures.

Detecting the shape of anisotropic gold nanoparticles in dispersion with single particle extinction and scattering (2017)
Journal Article

The shape and size of nanoparticles are important parameters affecting the biodistribution, bioactivity, and toxicity. The
high-throughput characterisation of nanoparticle shape in the dispersion is a fundamental prerequisite for realistic in vitro... Read More about Detecting the shape of anisotropic gold nanoparticles in dispersion with single particle extinction and scattering.

Mapping protein binding sites on the biomolecular corona of nanoparticles (2015)
Journal Article

Nanoparticles in a biological milieu are known to form a sufficiently long-lived and well-organized ‘corona’ of biomolecules to confer a biological identity to the particle. Because this nanoparticle–biomolecule complex interacts with cells and biolo... Read More about Mapping protein binding sites on the biomolecular corona of nanoparticles.

Revealing DNA interactions with exogenous agents by surface-enhanced raman scattering (2014)
Journal Article
Masetti, M., Xie, H., Krpetic, Z., Recanatini, M., Alvarez-Puebla, R., & Guerrini, L. (2015). Revealing DNA interactions with exogenous agents by surface-enhanced raman scattering. Abstracts of papers / American Chemical Society, 137(1), 469-476. https://doi.org/10.1021/ja511398w

The standard protocols for DNA analysis largely involve polymerase chain reaction (PCR). However, DNA structures bound to chemical agents cannot be PCR-amplified, and therefore any sequence changes induced by external agents may be neglected. Thus, t... Read More about Revealing DNA interactions with exogenous agents by surface-enhanced raman scattering.

Direct surface-enhanced raman scattering analysis of DNA duplexes (2014)
Journal Article
Guerrini, L., Krpetic, Z., Van Lierop, D., Alvarez-Puebla, R., & Graham, D. (2014). Direct surface-enhanced raman scattering analysis of DNA duplexes. Angewandte Chemie International Edition, 54(4), 1144-1148. https://doi.org/10.1002/anie.201408558

The exploration of the genetic information carried by DNA has become a major scientific challenge. Routine DNA analysis, such as PCR, still suffers from important intrinsic limitations. Surface-enhanced Raman spectroscopy (SERS) has emerged as an out... Read More about Direct surface-enhanced raman scattering analysis of DNA duplexes.

Interactions of gold nanoparticles with a phospholipid monolayer membrane on mercury (2014)
Journal Article
Gordillo, G., Krpetic, Z., & Brust, M. (2014). Interactions of gold nanoparticles with a phospholipid monolayer membrane on mercury. ACS nano, 8(6), 6074-6080. https://doi.org/10.1021/nn501395e

It is demonstrated that a compact monolayer of 1,2-dioleoyl-sn-glycero-3-phosphocholine adsorbed to a hanging mercury drop electrode can serve as a simple electrochemical model system to study biomembrane penetration by gold nanoparticles. The hydrog... Read More about Interactions of gold nanoparticles with a phospholipid monolayer membrane on mercury.

Nanomaterials : impact on cells and cell organelles (2014)
Book Chapter
Krpetic, Z., Anguissola, S., Garry, D., Kelly, P., & Dawson, K. (2014). Nanomaterials : impact on cells and cell organelles. In Nanomaterial : impacts on cell biology and medicine (135-156). Springer Netherlands. https://doi.org/10.1007/978-94-017-8739-0_8

Colloidal nanoparticles designed for the interactions with cells are very small, nanoscale objects usually consisting of inorganic cores and organic shells that are dispersed in a buffer or biological medium. By tuning the material properties of the... Read More about Nanomaterials : impact on cells and cell organelles.

Preparation and characterization of au nanoparticles capped with mercaptocarboranyl clusters (2013)
Journal Article
M. Cioran, A., Teixidor, F., Krpetic, Ž., Brust, M., & Viñas, C. (2014). Preparation and characterization of au nanoparticles capped with mercaptocarboranyl clusters. Dalton Transactions, 43(13), 5054-5061. https://doi.org/10.1039/C3DT52872C

The preparation of 3–4 nm and 10 nm gold nanoparticles capped with neutral carborane-based mercaptocarboranes, via two different preparative routes, is reported. The resulting boron-enriched nanomaterials exhibit complete dispersibility in water, ope... Read More about Preparation and characterization of au nanoparticles capped with mercaptocarboranyl clusters.

Conjugation of PEG and gold nanoparticles to increase the accessibility and valency of tethered RNA splicing enhancers (2013)
Journal Article
Perrett, A., Dickinson, R., Krpetic, Z., Brust, M., Lewis, H., Eperon, I., & Burley, G. (2013). Conjugation of PEG and gold nanoparticles to increase the accessibility and valency of tethered RNA splicing enhancers. Chemical Science, 4(1), 257-265. https://doi.org/10.1039/C2SC20937C

Since alternative splicing patterns are exhibited by most mammalian genes, the functional properties of a gene may be changed for therapeutic purposes by nudging splicing from one pattern to another. Splicing to a refractory exon can be enhanced usin... Read More about Conjugation of PEG and gold nanoparticles to increase the accessibility and valency of tethered RNA splicing enhancers.

High-resolution sizing of monolayer-protected gold clusters by differential centrifugal sedimentation (2013)
Journal Article
Krpetic, Z., Davidson, A., Volk, M., Lévy, R., Brust, M., & Cooper, D. (2013). High-resolution sizing of monolayer-protected gold clusters by differential centrifugal sedimentation. ACS nano, 7(10), 8881-8890. https://doi.org/10.1021/nn403350v

Differential centrifugal sedimentation (DCS) has been applied to accurately size ligand-protected gold hydrosols in the 10 to 50 nm range. A simple protocol is presented to correct for particle density variations due to the presence of the ligand she... Read More about High-resolution sizing of monolayer-protected gold clusters by differential centrifugal sedimentation.

Directed assembly of DNA-functionalized gold nanoparticles using pyrrole–imidazole polyamides (2012)
Journal Article
Krpetic, Z., Singh, I., Su, W., Guerrini, L., Faulds, K., Burley, G., & Graham, D. (2012). Directed assembly of DNA-functionalized gold nanoparticles using pyrrole–imidazole polyamides. Abstracts of papers / American Chemical Society, 134(20), 8356-8359. https://doi.org/10.1021/ja3014924

Traditional methods for the construction of nanoparticle arrays and lattices exploit Watson–Crick base pairing of single-stranded DNA sequences as a proxy for self-assembly. Although this approach has been utilized in a variety of applications in nan... Read More about Directed assembly of DNA-functionalized gold nanoparticles using pyrrole–imidazole polyamides.

Positively charged silver nanoparticles and their effect on surface-enhanced Raman scattering of dye-labelled oligonucleotides (2012)
Journal Article
van Lierop, D., Krpetic, Z., Guerrini, L., Larmour, I., Dougan, J., Faulds, K., & Graham, D. (2012). Positively charged silver nanoparticles and their effect on surface-enhanced Raman scattering of dye-labelled oligonucleotides. Chemical Communications, 48(66), 8192. https://doi.org/10.1039/C2CC31731A

Improved positively charged nanoparticles are described to provide a simplified SERS substrate for DNA detection. Complete flocculation of the nanoparticles is prevented due to the controlled analyte induced aggregation. This provides a stable aggreg... Read More about Positively charged silver nanoparticles and their effect on surface-enhanced Raman scattering of dye-labelled oligonucleotides.