Plasma interleukin responses as predictors of outcome stratification in patients after major trauma: a prospective observational two centre study (2023)
Journal Article
Jones, M. A., Hanison, J., Apreutesei, R., Allarakia, B., Namvar, S., Ramaswamy, D. S., …Nirmalan, N. (2023). Plasma interleukin responses as predictors of outcome stratification in patients after major trauma: a prospective observational two centre study. Frontiers in Immunology, 14, 1276171. https://doi.org/10.3389/fimmu.2023.1276171

Background and objectives: There is a need to develop objective risk stratification tools to define efficient care pathways for trauma patients. Biomarker-based point of care testing may strengthen existing clinical tools currently available for this... Read More about Plasma interleukin responses as predictors of outcome stratification in patients after major trauma: a prospective observational two centre study.

Selected derivatives of erythromycin B- in silico and anti-malarial studies (2021)
Journal Article
Bhadra, P., Magwaza, R., Nirmalan, N., Freeman, S., Barber, J., & Arsic, B. (2021). Selected derivatives of erythromycin B- in silico and anti-malarial studies. Materials, 14(22), e6980. https://doi.org/10.3390/ma14226980

Erythromycin A is an established anti-bacterial agent against Gram-positive bacteria, but it is unstable to acid. This led to an evaluation of erythromycin B and its derivatives because these have improved acid stability. These compounds were investi... Read More about Selected derivatives of erythromycin B- in silico and anti-malarial studies.

Investigating Interleukin – 8 and TGF Beta as early biomarkers predicting poor clinical outcome in major trauma (2021)
Thesis
Abbood, L. Investigating Interleukin – 8 and TGF Beta as early biomarkers predicting poor clinical outcome in major trauma. (Dissertation). University of Salford

Trauma is a leading cause of death and disability. Globally, traumatic injury is the main cause of death under the age of 45. Recent studies from the UK report a demographic change in major trauma. The most common mechanism of traumatic injury is fal... Read More about Investigating Interleukin – 8 and TGF Beta as early biomarkers predicting poor clinical outcome in major trauma.

In vitro screening of Trametes versicolor and Acacia nilotica derivatives for antimalarial efficacy (2020)
Thesis
Dillon, M. In vitro screening of Trametes versicolor and Acacia nilotica derivatives for antimalarial efficacy. (Dissertation). University of Salford

Of the plethora of parasitic diseases that afflict mankind, malaria remains the most prevalent. The disease has caused severe global health problems, putting 3.2 billion people at risk of developing the Plasmodium infection. With current front-line t... Read More about In vitro screening of Trametes versicolor and Acacia nilotica derivatives for antimalarial efficacy.

“Omics”-Informed drug and biomarker discovery : opportunities, challenges and future perspectives (2016)
Journal Article
Matthews, H., Hanison, J., & Nirmalan, N. (2016). “Omics”-Informed drug and biomarker discovery : opportunities, challenges and future perspectives. Proteomes, 4(3), 28. https://doi.org/10.3390/proteomes4030028

The pharmaceutical industry faces unsustainable program failure despite significant increases in investment. Dwindling discovery pipelines, rapidly expanding R&D budgets and increasing regulatory control, predict significant gaps in the future drug m... Read More about “Omics”-Informed drug and biomarker discovery : opportunities, challenges and future perspectives.

Investigating calcium channel blockers as antimalarials
Thesis
Rajab, M. (in press). Investigating calcium channel blockers as antimalarials. (Thesis). University of Salford

The rise in resistance to current antimalarial drugs has led researchers to consider drug repositioning as a quicker alternative for drug development and discovery. Preliminary drug repositioning screens carried out at the University of Salford ident... Read More about Investigating calcium channel blockers as antimalarials.

Drug repositioning as a route to anti-malarial drug discovery: preliminary investigation of the in vitro anti-malarial efficacy of emetine dihydrochloride hydrate
Journal Article
Matthews, H., Usman-Idris, M., Khan, F., Read, M., & Nirmalan, N. Drug repositioning as a route to anti-malarial drug discovery: preliminary investigation of the in vitro anti-malarial efficacy of emetine dihydrochloride hydrate. Malaria Journal, 12(1), 359. https://doi.org/10.1186/1475-2875-12-359

Background

Drug repurposing or repositioning refers to the usage of existing drugs in diseases other than those it was originally used for. For diseases like malaria, where there is an urgent need for active drug candidates, the strategy offers a... Read More about Drug repositioning as a route to anti-malarial drug discovery: preliminary investigation of the in vitro anti-malarial efficacy of emetine dihydrochloride hydrate.