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Circular and linear : a tale of aptamer selection for the activation of SIRT1 to induce death in cancer cells (2020)
Journal Article
Al-Sudani, B., Ragazzon-Smith, A., Aziz, A., Alansari, R., Ferry, N., Krstic- Demonacos, M., & Ragazzon, P. (2020). Circular and linear : a tale of aptamer selection for the activation of SIRT1 to induce death in cancer cells. RSC Advances, 10(73), 45008-45018. https://doi.org/10.1039/D0RA07857C

It is a challenge to select the right target to treat conditions without affecting non-diseased cells. Cancer belongs to the top 10 causes of death in the world and it remains difficult to treat. Amongst cancer emerging targets, silent information re... Read More about Circular and linear : a tale of aptamer selection for the activation of SIRT1 to induce death in cancer cells.

Investigation into the genetic variation of Toll-Like Receptor 9 in cattle using both Sanger and next-generation sequencing from FTA-Cards (2020)
Thesis
Alqurashi, A. Investigation into the genetic variation of Toll-Like Receptor 9 in cattle using both Sanger and next-generation sequencing from FTA-Cards. (Thesis). University of Salford

The susceptibility or resistance to infectious diseases depends on the host immune response. The genetic variation of immune-relevant genes such as Toll-Like Receptor (TLR) genes is associated with susceptibility or resistance to the pathogen. In thi... Read More about Investigation into the genetic variation of Toll-Like Receptor 9 in cattle using both Sanger and next-generation sequencing from FTA-Cards.

Synthesis and evaluation of benzoyl containing compounds as potential anti-cancer agents (2020)
Thesis
Ahmed, S. Synthesis and evaluation of benzoyl containing compounds as potential anti-cancer agents. (Dissertation). University of Salford

Seen as one of the major causes of death worldwide, Cancer requires the development of effective treatments in order to combat the disease. However, pharmaceutical companies are faced by the challenge of finding and developing a suitable compound tha... Read More about Synthesis and evaluation of benzoyl containing compounds as potential anti-cancer agents.

RNA-seq analysis of colorectal tumor-infiltrating myeloid-derived suppressor cell subsets revealed gene signatures of poor prognosis (2020)
Journal Article
Saleh, R., Sasidharan Nair, V., Al-Dhaheri, M., Khawar, M., Abu Nada, M., Alajez, N., & Elkord, E. (2020). RNA-seq analysis of colorectal tumor-infiltrating myeloid-derived suppressor cell subsets revealed gene signatures of poor prognosis. Frontiers in Oncology, 10, 604906. https://doi.org/10.3389/fonc.2020.604906

Elevated levels of myeloid-derived suppressor cells (MDSCs), including polymorphonuclear MDSCs (PMN-MDSCs) and immature MDSCs (I-MDSCs), are usually associated with disease progression in cancer patients, including colorectal cancer (CRC). However, b... Read More about RNA-seq analysis of colorectal tumor-infiltrating myeloid-derived suppressor cell subsets revealed gene signatures of poor prognosis.

Targeting TIM-3 in solid tumors : innovations in the preclinical and translational realm and therapeutic potential (2020)
Journal Article
Saleh, R., Toor, S., & Elkord, E. (2020). Targeting TIM-3 in solid tumors : innovations in the preclinical and translational realm and therapeutic potential. Expert Opinion on Therapeutic Targets, 24(12), 1251-1262. https://doi.org/10.1080/14728222.2020.1841750

Introduction

Immune checkpoint inhibitors (ICIs) have shown a great therapeutic efficacy in cancer patients. However, a significant proportion of cancer patients remain unresponsive or show limited response. T cell immunoglobulin and mucin-domain... Read More about Targeting TIM-3 in solid tumors : innovations in the preclinical and translational realm and therapeutic potential.

Detection and identification of ethanal-derived spin-trapped free radicals using headspace thermal desorption gas chromatography-mass spectrometry (TD-GC-MS) (2020)
Journal Article
Manzoor, K., Mishra, S., & Podmore, I. (2020). Detection and identification of ethanal-derived spin-trapped free radicals using headspace thermal desorption gas chromatography-mass spectrometry (TD-GC-MS). Free Radical Research, 54(10), 745-755. https://doi.org/10.1080/10715762.2020.1841183

In this study, we demonstrate a novel approach to the detection and identification of the
products of spin-trapped free radicals. Hydroxyl free radicals were generated by Fenton-based
chemistry in the presence of ethanal and the spin-trapping agent... Read More about Detection and identification of ethanal-derived spin-trapped free radicals using headspace thermal desorption gas chromatography-mass spectrometry (TD-GC-MS).

Protein disulfide isomerase A1 regulates breast cancer cell immunorecognition in a manner dependent on redox state (2020)
Journal Article

Oxidoreductase protein disulphide isomerases (PDI) are involved in the regulation of a variety of biological processes including the modulation of endoplasmic reticulum (ER) stress, unfolded protein response (UPR), ER‑mitochondria communication and t... Read More about Protein disulfide isomerase A1 regulates breast cancer cell immunorecognition in a manner dependent on redox state.

An evaluation of sorter induced cell stress (SICS) on peripheral blood mononuclear cells (PBMCs) after different sort conditions - are your sorted cells getting SICS? (2020)
Journal Article
Pfister, G., Toor, S., Sasidharan Nair, V., & Elkord, E. (2020). An evaluation of sorter induced cell stress (SICS) on peripheral blood mononuclear cells (PBMCs) after different sort conditions - are your sorted cells getting SICS?. Journal of Immunological Methods, 487, 112902. https://doi.org/10.1016/j.jim.2020.112902

Flow cytometry and fluorescence-activated cell sorting have become invaluable tools to analyze and isolate specific cell populations in a wide range of biomedical research and clinical applications. In countless approaches worldwide, scientists are u... Read More about An evaluation of sorter induced cell stress (SICS) on peripheral blood mononuclear cells (PBMCs) after different sort conditions - are your sorted cells getting SICS?.

Investigating the relationship between lung cancer and the infection with the parasite Toxoplasma gondii (2020)
Thesis
Tarabulsi, M. Investigating the relationship between lung cancer and the infection with the parasite Toxoplasma gondii. (Thesis). University of Salford

Toxoplasma gondii is an obligate intracellular organism that has a worldwide distribution and is highly prevalent among animals and humans. Although usually asymptomatic, it can cause serious diseases in immunocompromised individuals such as pneumoni... Read More about Investigating the relationship between lung cancer and the infection with the parasite Toxoplasma gondii.

T‐cell responses and therapies against SARS‐CoV‐2 infection (2020)
Journal Article
Toor, S., Saleh, R., Sasidharan Nair, V., Taha, R., & Elkord, E. (2021). T‐cell responses and therapies against SARS‐CoV‐2 infection. Immunology, 162(1), 30-43. https://doi.org/10.1111/imm.13262

Coronavirus disease 2019 (COVID‐19) is caused by SARS‐CoV‐2, a novel coronavirus strain. Some studies suggest that COVID‐19 could be an immune‐related disease, and failure of effective immune responses in initial stages of viral infection could contr... Read More about T‐cell responses and therapies against SARS‐CoV‐2 infection.

In vitro screening of Trametes versicolor and Acacia nilotica derivatives for antimalarial efficacy (2020)
Thesis
Dillon, M. In vitro screening of Trametes versicolor and Acacia nilotica derivatives for antimalarial efficacy. (Dissertation). University of Salford

Of the plethora of parasitic diseases that afflict mankind, malaria remains the most prevalent. The disease has caused severe global health problems, putting 3.2 billion people at risk of developing the Plasmodium infection. With current front-line t... Read More about In vitro screening of Trametes versicolor and Acacia nilotica derivatives for antimalarial efficacy.

Novel organization of mitochondrial minicircles and guide RNAs in the zoonotic pathogen Trypanosoma lewisi (2020)
Journal Article

Abstract Kinetoplastid flagellates are known for several unusual features, one of which is their complex mitochondrial genome, known as kinetoplast (k) DNA, composed of mutually catenated maxi- and minicircles. Trypanosoma lewisi is a member of the S... Read More about Novel organization of mitochondrial minicircles and guide RNAs in the zoonotic pathogen Trypanosoma lewisi.

SARS-CoV-2 infection and lung cancer : potential therapeutic modalities (2020)
Journal Article
Gupta, I., Rizeq, B., Elkord, E., Vranic, S., & Al Moustafa, A. (2020). SARS-CoV-2 infection and lung cancer : potential therapeutic modalities. Cancers, 12(8), e2186. https://doi.org/10.3390/cancers12082186

Human coronaviruses, especially SARS-CoV-2, are emerging pandemic infectious diseases with high morbidity and mortality in certain group of patients. In general, SARS-CoV-2 causes symptoms ranging from the common cold to severe conditions accompanied... Read More about SARS-CoV-2 infection and lung cancer : potential therapeutic modalities.

Telomerase inhibition, Telomere attrition and proliferation arrest of cancer cells induced by Phosphorothioate ASO-NLS conjugates targeting hTERC and siRNAs targeting hTERT (2020)
Journal Article
Diala, I., Shiohama, Y., Fujita, T., Demonacos, C., Krstic- Demonacos, M., Di Leva, G., & Fujii, N. (2020). Telomerase inhibition, Telomere attrition and proliferation arrest of cancer cells induced by Phosphorothioate ASO-NLS conjugates targeting hTERC and siRNAs targeting hTERT. Nucleosides, Nucleotides and Nucleic Acids, 39(1-3), 407-425. https://doi.org/10.1080/15257770.2020.1713357

Telomerase activity has been regarded as a critical step in cellular immortalization and carcinogenesis and because of this, regulation of telomerase represents an attractive target for anti-tumor specific therapeutics. Recently, one avenue of cancer... Read More about Telomerase inhibition, Telomere attrition and proliferation arrest of cancer cells induced by Phosphorothioate ASO-NLS conjugates targeting hTERC and siRNAs targeting hTERT.

Fatty-acid uptake in prostate cancer cells using dynamic microfluidic raman technology (2020)
Journal Article
Tang, N., D. Snook, R., Brown, M., Haines, B., Ridley, A., Gardner, P., & Denbigh, J. (2020). Fatty-acid uptake in prostate cancer cells using dynamic microfluidic raman technology. Molecules, 25(7), e1652. https://doi.org/10.3390/molecules25071652

It is known that intake of dietary fatty acid (FA) is strongly correlated with prostate cancer progression but is highly dependent on the type of FAs. High levels of palmitic acid (PA) or arachidonic acid (AA) can stimulate the progression of cancer.... Read More about Fatty-acid uptake in prostate cancer cells using dynamic microfluidic raman technology.

5-(carbamoylmethylene)-oxazolidin-2-ones as a promising class of heterocycles inducing apoptosis triggered by increased ROS levels and mitochondrial dysfunction in breast and cervical cancer (2020)
Journal Article

Oxazolidinones are antibiotics that inhibit protein synthesis by binding the 50S ribosomal subunit. Recently, numerous worldwide researches focused on their properties and possible involvement in cancer therapy have been conducted. Here, we evaluated... Read More about 5-(carbamoylmethylene)-oxazolidin-2-ones as a promising class of heterocycles inducing apoptosis triggered by increased ROS levels and mitochondrial dysfunction in breast and cervical cancer.