Transcriptome of CD8+ tumor-infiltrating T cells : a link between diabetes and colorectal cancer (2021)
Journal Article
Saleh, R., Sasidharan Nair, V., Murshed, K., Abu Nada, M., Elkord, E., & Shaheen, R. (2021). Transcriptome of CD8+ tumor-infiltrating T cells : a link between diabetes and colorectal cancer. Cancer Immunology, Immunotherapy, 70(9), 2625-2638. https://doi.org/10.1007/s00262-021-02879-7

There is an increased risk of colorectal cancer (CRC) development in patients with non-insulin-dependent type 2 diabetes. CD8 T cells have been implicated in diabetes and are crucial for anti-tumor immunity. However, transcriptomic profiling for CD8... Read More about Transcriptome of CD8+ tumor-infiltrating T cells : a link between diabetes and colorectal cancer.

Role of circular RNAs in colorectal tumor microenvironment (2021)
Journal Article
Viralippurath Ashraf, J., Sasidharan Nair, V., Saleh, R., & Elkord, E. (2021). Role of circular RNAs in colorectal tumor microenvironment. Biomedicine and Pharmacotherapy, 137, 111351. https://doi.org/10.1016/j.biopha.2021.111351

Circular RNAs (circRNAs) are a class of endogenous noncoding RNA, which were previously considered as a byproduct of RNA splicing error. Numerous studies have demonstrated the altered expression of circRNAs in organ tissues during pathological condit... Read More about Role of circular RNAs in colorectal tumor microenvironment.

Infection with Trypanosoma lewisi or Trypanosoma musculi may promote the spread of Toxoplasma gondii (2021)
Journal Article
Gao, J., Yi, S., Geng, G., Xu, Z., Hide, G., Lun, Z., & Lai, D. (2021). Infection with Trypanosoma lewisi or Trypanosoma musculi may promote the spread of Toxoplasma gondii. Parasitology, 148(6), 703-711. https://doi.org/10.1017/S0031182021000196

Toxoplasma gondii can infect almost all warm-blooded vertebrates with pathogensis
being largely influenced by the host immune status. As important epidemiological
hosts, rodents are globally distributed and are also commonly found infected with
ha... Read More about Infection with Trypanosoma lewisi or Trypanosoma musculi may promote the spread of Toxoplasma gondii.

Metabolic reprogramming of T regulatory cells in the hypoxic tumor microenvironment (2021)
Journal Article
Sasidharan Nair, V., Saleh, R., Toor, S., Cyprian, F., & Elkord, E. (2021). Metabolic reprogramming of T regulatory cells in the hypoxic tumor microenvironment. Cancer Immunology, Immunotherapy, 70(8), 2103-2121. https://doi.org/10.1007/s00262-020-02842-y

Metabolic dysregulation in the hypoxic tumor microenvironment (TME) is considered as a hallmark of solid tumors, leading to changes in biosynthetic pathways favoring onset, survival and proliferation of malignant cells. Within the TME, hypoxic milieu... Read More about Metabolic reprogramming of T regulatory cells in the hypoxic tumor microenvironment.