Tremelimumab for the treatment of malignant mesothelioma (2015)
Journal Article
Guazzelli, A., Hussain, M., Krstic- Demonacos, M., & Mutti, L. (2015). Tremelimumab for the treatment of malignant mesothelioma. Expert Opinion on Biological Therapy, 15(12), 1819-1829. https://doi.org/10.1517/14712598.2015.1116515

Introduction: Tremelimumab demonstrated therapeutic activity in different malignancies, including malignant pleural mesothelioma (MPM); however, continued research could improve the therapeutic index of this agent. Areas covered: This review descr... Read More about Tremelimumab for the treatment of malignant mesothelioma.

Analysis of NEIL3 expression : a possible resistance factor to cancer chemotherapy in paediatric cancer cells (2015)
Thesis
Duweb, A. (in press). Analysis of NEIL3 expression : a possible resistance factor to cancer chemotherapy in paediatric cancer cells. (Dissertation). Enviroment and Life Science

NEIL3 is the largest of three homologs of the bacterial Nei protein in mammalian cells. It has been shown to have DNA glycosylase activity in vitro, excising oxidised purine and pyrimidine bases from both single- and double-stranded DNA. Additionally... Read More about Analysis of NEIL3 expression : a possible resistance factor to cancer chemotherapy in paediatric cancer cells.

Biphasic decay of the Ca transient results from increased sarcoplasmic reticulum Ca leak (2015)
Journal Article
Sankaranarayanan, R., Li, Y., Greensmith, D., Eisner, D., & Venetucci, L. (2016). Biphasic decay of the Ca transient results from increased sarcoplasmic reticulum Ca leak. Journal of Physiology, 594(3), 611-623. https://doi.org/10.1113/JP271473

In heart failure, a reduction in Ca transient amplitude and contractile dysfunction can by caused by Ca leak through the sarcoplasmic reticulum (SR) Ca channel (ryanodine receptor, RyR) and/or decreased activity of the SR Ca ATPase (SERCA). We have c... Read More about Biphasic decay of the Ca transient results from increased sarcoplasmic reticulum Ca leak.

Proteomic identification of prognostic tumour biomarkers, using chemotherapy-induced cancer-associated fibroblasts (2015)
Journal Article
Peiris-Pagès, M., Smith, D., Győrffy, B., Sotgia, F., & Lisanti, M. (2015). Proteomic identification of prognostic tumour biomarkers, using chemotherapy-induced cancer-associated fibroblasts. Aging, 7(10), 816-838. https://doi.org/10.18632/aging.100808

Cancer cells grow in highly complex stromal microenvironments, which through metabolic remodelling, catabolism, autophagy and inflammation nurture them and are able to facilitate metastasis and resistance to therapy. However, these changes in the met... Read More about Proteomic identification of prognostic tumour biomarkers, using chemotherapy-induced cancer-associated fibroblasts.

Solid phase microextraction (SPME) method development in analysis of volatile organic compounds (VOCs) as potential biomarkers of cancer (2015)
Journal Article
Schmidt, K., & Podmore, I. (2015). Solid phase microextraction (SPME) method development in analysis of volatile organic compounds (VOCs) as potential biomarkers of cancer. Journal of Molecular Biomarkers & Diagnosis, 6(6), https://doi.org/10.4172/2155-9929.1000253

The analysis of volatile organic compounds [VOCs] is an attractive approach to the discovery of potential cancer biomarkers due to its non-invasive nature and potential low costs of sampling and analysis. Solid phase microextraction [SPME] is one of... Read More about Solid phase microextraction (SPME) method development in analysis of volatile organic compounds (VOCs) as potential biomarkers of cancer.

Photoelectron spectroscopy at the graphene-liquid interface reveals the electronic structure of an electrodeposited cobalt/graphene electrocatalyst (2015)
Journal Article
Velasco-Vélez, J., Pfeifer, V., Hävecker, M., Weatherup, R., Arrigo, R., Chuang, C., …Knop-Gericke, A. (2018). Photoelectron spectroscopy at the graphene-liquid interface reveals the electronic structure of an electrodeposited cobalt/graphene electrocatalyst. Angewandte Chemie International Edition, 54(48), 14554-14558. https://doi.org/10.1002/anie.201506044

Electrochemically grown cobalt on graphene exhibits exceptional performance as a catalyst for the oxygen evolution reaction (OER) and provides the possibility of controlling the morphology and the chemical properties during deposition. However, the d... Read More about Photoelectron spectroscopy at the graphene-liquid interface reveals the electronic structure of an electrodeposited cobalt/graphene electrocatalyst.

High mitochondrial mass identifies a sub-population of stem-like cancer cells that are chemo-resistant (2015)
Journal Article
Farnie, G., Sotgia, F., & Lisanti, M. (2015). High mitochondrial mass identifies a sub-population of stem-like cancer cells that are chemo-resistant. Oncotarget, 6(31), 30472-30486. https://doi.org/10.18632/oncotarget.5401

Chemo-resistance is a clinical barrier to more effective anti-cancer therapy. In this context, cancer stem-like cells (CSCs) are thought to be chemo-resistant, resulting in tumor recurrence and distant metastasis. Our hypothesis is that chemo-resista... Read More about High mitochondrial mass identifies a sub-population of stem-like cancer cells that are chemo-resistant.

Mitochondrial mass, a new metabolic biomarker for stem-like cancer cells : understanding WNT/FGF-driven anabolic signaling (2015)
Journal Article
Lamb, R., Bonuccelli, G., Ozsvári, B., Peiris-Pagès, M., Fiorillo, M., Smith DL, D., …Lisanti, M. (2015). Mitochondrial mass, a new metabolic biomarker for stem-like cancer cells : understanding WNT/FGF-driven anabolic signaling. Oncotarget, 6(31), 30453-30471. https://doi.org/10.18632/oncotarget.5852

Here, we developed an isogenic cell model of “stemness” to facilitate protein biomarker discovery in breast cancer. For this purpose, we used knowledge gained previously from the study of the mouse mammary tumor virus (MMTV). MMTV initiates mammary t... Read More about Mitochondrial mass, a new metabolic biomarker for stem-like cancer cells : understanding WNT/FGF-driven anabolic signaling.

The expanded p53 interactome as a predictive model for cancer therapy (2015)
Journal Article
Hussain, M., Tian, K., Mutti, L., Krstic-Demonacos, M., & Schwartz, J. (2015). The expanded p53 interactome as a predictive model for cancer therapy. Genomics and computational biology, 1(1), e20. https://doi.org/10.18547/gcb.2015.vol1.iss1.e20

The tumour suppressor gene TP53 is implicated in the majority of all human cancers, thus pivotal to genomic integrity. Even though over 72,000 PubMed publications are linked with the keyword p53 and this number is continuously increasing, due to... Read More about The expanded p53 interactome as a predictive model for cancer therapy.

Ratiometric oxygen sensing using lanthanide luminescent emitting interfaces (2015)
Journal Article
Lehr, J., Tropiano, M., Beer, P., Faulkner, S., & Davis, J. (2015). Ratiometric oxygen sensing using lanthanide luminescent emitting interfaces. Chemical Communications, 51(88), 15944-15947. https://doi.org/10.1039/c5cc05738h

Herein we describe the first example of a ratiometric lanthanide luminescent oxygen sensing interface. Immobilisation of terbium and europium cyclen complexes on glass substrates was achieved by a novel aryl nitrene photografting approach. The result... Read More about Ratiometric oxygen sensing using lanthanide luminescent emitting interfaces.

Dissecting tumor metabolic heterogeneity : Telomerase and large cell size metabolically define a sub-population of stem-like, mitochondrial-rich, cancer cells (2015)
Journal Article
Lamb, R., Ozsvari, B., Bonuccelli, G., Smith, D., Pestell, R., Martinez-Outschoorn, U., …Lisanti, M. (2015). Dissecting tumor metabolic heterogeneity : Telomerase and large cell size metabolically define a sub-population of stem-like, mitochondrial-rich, cancer cells. Oncotarget, 6(26), 21892-21905. https://doi.org/10.18632/oncotarget.5260

Tumor cell metabolic heterogeneity is thought to contribute to tumor recurrence, distant metastasis and chemo-resistance in cancer patients, driving poor clinical outcome. To better understand tumor metabolic heterogeneity, here we used the MCF7 brea... Read More about Dissecting tumor metabolic heterogeneity : Telomerase and large cell size metabolically define a sub-population of stem-like, mitochondrial-rich, cancer cells.

Doxycycline and therapeutic targeting of the DNA damage response in cancer cells : old drug, new purpose (2015)
Journal Article
Peiris-Pagès, M., Sotgia, F., & Lisanti, M. (2015). Doxycycline and therapeutic targeting of the DNA damage response in cancer cells : old drug, new purpose. Oncoscience, 2(8), 696-699. https://doi.org/10.18632/oncoscience.215

There is a small proportion of cells within a tumour with self-renewing properties, which is resistant to conventional therapy, and is responsible for tumour initiation, maintenance and metastasis. These cells are known as cancer stem cells (CSCs) or... Read More about Doxycycline and therapeutic targeting of the DNA damage response in cancer cells : old drug, new purpose.

Transmission of Echinococcus species in pastoral communities in southern Kyrgyzstan (2015)
Presentation / Conference
Rogan, M., van Kesteren, F., Mastin, A., Craig, P., Torgerson, P., Mytova, B., …Raoul, F. (2015, August). Transmission of Echinococcus species in pastoral communities in southern Kyrgyzstan. Presented at 80. 25th International Conference of the World Association for the Advancement of Veterinary Parasitology (WAAVP), Liverpool, UK

Echinococcus granulosus and human cystic echinococcosis (CE) are highly endemic in Central Asia and western China. Human alveolar echinococcosis (AE) is an emergent public health problem in Kyrgyzstan and in the Region. Community, veterinary and ecol... Read More about Transmission of Echinococcus species in pastoral communities in southern Kyrgyzstan.

Estrogen related receptor α (ERRα) a promising target for the therapy of adrenocortical carcinoma (ACC) (2015)
Journal Article
Casaburi, I., Avena, P., De Luca, A., Chimento, A., Sirianni, R., Malivindi, R., …Pezzi, V. (2015). Estrogen related receptor α (ERRα) a promising target for the therapy of adrenocortical carcinoma (ACC). Oncotarget, 6(28), 25135-25148. https://doi.org/10.18632/oncotarget.4722

The pathogenesis of the adrenocortical cancer (ACC) involves integration of molecular signals and the interplay of different downstream pathways (i.e. IGFII/IGF1R, β-catenin, Wnt, ESR1). This tumor is characterized by limited therapeutic options and... Read More about Estrogen related receptor α (ERRα) a promising target for the therapy of adrenocortical carcinoma (ACC).

Altered expression and editing of miRNA-100 regulates iTreg differentiation (2015)
Journal Article
Negi, V., Paul, D., Das, S., Bajpai, P., Singh, S., Mukhopadhyay, A., …Ghosh, B. (2015). Altered expression and editing of miRNA-100 regulates iTreg differentiation. Nucleic Acids Research, 43(16), 8057-8065. https://doi.org/10.1093/nar/gkv752

RNA editing ofmiRNAs, especially in the seed region, adds another layer to miRNA mediated gene regulation which can modify its targets, altering cellular signaling involved in important processes such as differentiation. In this study, we have ex... Read More about Altered expression and editing of miRNA-100 regulates iTreg differentiation.

Cancer in the parasitic protozoans Trypanosoma brucei and Toxoplasma gondii (2015)
Journal Article
Lun, Z., Lai, D., Wen, Y., Zheng, L., Shen, J., Yang, T., …Ayala, F. (2015). Cancer in the parasitic protozoans Trypanosoma brucei and Toxoplasma gondii. Proceedings of the National Academy of Sciences of the United States of America, 112(29), 8835-8842. https://doi.org/10.1073/pnas.1502599112

Cancer is a general name for more than 100 malignant diseases. It is postulated that all cancers start from a single abnormal cell that grows out of control. Untreated cancers can cause serious consequences and deaths. Great progress has been made in... Read More about Cancer in the parasitic protozoans Trypanosoma brucei and Toxoplasma gondii.

Three-dimensional imaging and uptake of the anticancer drug combretastatin in cell spheroids and photoisomerization in gels with multiphoton excitation (2015)
Journal Article
Scherer, K., Bisby, R., Botchway, S., Hadfield, J., Haycock, J., & Parker, A. (2015). Three-dimensional imaging and uptake of the anticancer drug combretastatin in cell spheroids and photoisomerization in gels with multiphoton excitation. Journal of Biomedical Optics, 20(7), 78003. https://doi.org/10.1117/1.JBO.20.7.078003

The uptake of E-combretastatins, potential pro-drugs of the anticancer Z-isomers, into multicellular spheroids has been imaged by intrinsic fluorescence in three dimensions using two-photon excited fluorescence lifetime imaging with 625 nm ultrafast... Read More about Three-dimensional imaging and uptake of the anticancer drug combretastatin in cell spheroids and photoisomerization in gels with multiphoton excitation.

MYC is a major determinant of mitotic cell fate (2015)
Journal Article
Topham, C., Tighe, A., Ly, P., Bennett, A., Sloss, O., Nelson, L., …Taylor, S. (2015). MYC is a major determinant of mitotic cell fate. Cancer Cell, 28(1), 129-140. https://doi.org/10.1016/j.ccell.2015.06.001

Taxol and other antimitotic agents are frontline chemotherapy agents but the mechanisms responsible for patient benefit remain unclear. Following a genome-wide siRNA screen, we identified the oncogenic transcription factor Myc as a taxol sensitizer.... Read More about MYC is a major determinant of mitotic cell fate.

Cytotoxicity and genotoxicity of urban particulate matter in mammalian cells (2015)
Journal Article
Dumax-Vorzet, A., Tate, M., Walmsley, R., Elder, R., & Povey, A. (2015). Cytotoxicity and genotoxicity of urban particulate matter in mammalian cells. Mutagenesis, 30(5), 621-633. https://doi.org/10.1093/mutage/gev025

Ambient air particulate matter (PM)-associated reactive oxygen species (ROS) have been linked to a variety of altered cellular outcomes. In this study, three different PM samples from diesel exhaust particles (DEPs), urban dust standard reference mat... Read More about Cytotoxicity and genotoxicity of urban particulate matter in mammalian cells.

Human enhancement in sports (2015)
Book Chapter
Miah, A. (2015). Human enhancement in sports. In W. Bainbridge, & M. Roco (Eds.), Handbook of Science and Technology Convergence (1-13). Springer. https://doi.org/10.1007/978-3-319-04033-2_85-1

This chapter examines the range of sciences and technologies that converge around sports and the implications of this for issues of fairness and ethics. First, it outlines some of the recent scientific developments that speak to the convergence of di... Read More about Human enhancement in sports.