Novel therapies for cancer treatment : designing high affinity and selectivity ligands against SIRT1 (2015)
Presentation / Conference
Al-Sudani, B., Krstic- Demonacos, M., & Ragazzon, P. (2015, June). Novel therapies for cancer treatment : designing high affinity and selectivity ligands against SIRT1. Poster presented at EuroMedLab Paris 2015, Paris, France

The word ‘sirtuin’ (SIR) stands for Silent Information Regulator. SIRT1 is the most studied mammalian sirtuin and predominantly localises to the nucleus. Many sirtuins targets are involved in cancer and in many types of cancers, SIRT1 is found to be... Read More about Novel therapies for cancer treatment : designing high affinity and selectivity ligands against SIRT1.

Book review : Parasitism. The diversity and ecology of animal parasites, 2nd edn. By Timothy M. Goater,Cameron P. Goater and Gerald W. Esch,editors, p. 497. Cambridge University Press, UK, 2014. (2015)
Journal Article
Hide, G. (2015). Book review : Parasitism. The diversity and ecology of animal parasites, 2nd edn. By Timothy M. Goater,Cameron P. Goater and Gerald W. Esch,editors, p. 497. Cambridge University Press, UK, 2014. Parasitology, 142(10), 1348-1349. https://doi.org/10.1017/S0031182015000645

A set of NF-κB–regulated microRNAs induces acquired TRAIL resistance in lung cancer (2015)
Journal Article
Jeon, Y., Middleton, J., Kim, T., Laguna, A., Piovan, C., Secchiero, P., …Croce, C. (2015). A set of NF-κB–regulated microRNAs induces acquired TRAIL resistance in lung cancer. Proceedings of the National Academy of Sciences, 112(26), E3355-E3364. https://doi.org/10.1073/pnas.1504630112

TRAIL (TNF-related apoptosis-inducing ligand) is a promising anticancer agent that can be potentially used as an alternative or complementary therapy because of its specific antitumor activity. However, TRAIL can also stimulate the proliferation of c... Read More about A set of NF-κB–regulated microRNAs induces acquired TRAIL resistance in lung cancer.

Mitochondrial biogenesis is required for the anchorage-independent survival and propagation of stem-like cancer cells (2015)
Journal Article
De Luca, A., Fiorillo, M., Peiris-Pagès, M., Ozsvari, B., Smith, D., Sanchez-Alvarez, R., …Sotgia, F. (2015). Mitochondrial biogenesis is required for the anchorage-independent survival and propagation of stem-like cancer cells. Oncotarget, 6(17), 14777-14795. https://doi.org/10.18632/oncotarget.4401

Here, we show that new mitochondrial biogenesis is required for the anchorage independent survival and propagation of cancer stem-like cells (CSCs). More specifically, we used the drug XCT790 as an investigational tool, as it functions as a specific... Read More about Mitochondrial biogenesis is required for the anchorage-independent survival and propagation of stem-like cancer cells.

The effect of 2,5-di-(tert-butyl)-1,4-benzohydroquinone (TBQ) on intracellular Ca(2+) handling in rat ventricular myocytes (2015)
Journal Article
Miller, L., Greensmith, D., Sankaranarayanan, R., O'Neill, S., & Eisner, D. (2015). The effect of 2,5-di-(tert-butyl)-1,4-benzohydroquinone (TBQ) on intracellular Ca(2+) handling in rat ventricular myocytes. Cell Calcium, 58(2), 208-14. https://doi.org/10.1016/j.ceca.2015.05.002

2,5-Di-(tert-butyl)-1,4-benzohydroquinone (TBQ) is a reversible inhibitor of SERCA, potentially making it a useful tool to study the effects of SERCA inhibition in cardiac cells. However, it is unknown if TBQ also has effects on other components of v... Read More about The effect of 2,5-di-(tert-butyl)-1,4-benzohydroquinone (TBQ) on intracellular Ca(2+) handling in rat ventricular myocytes.

Asymmetric synthesis of diarylmethane derivatives by dynamic kinetic resolution (2015)
Journal Article
kinetic resolution. Tetrahedron Letters, 56(26), 4025-4027. https://doi.org/10.1016/j.tetlet.2015.05.006

Asymmetric allylation of ortho-methoxydiphenylmethane has been carried out with high yields and ee of up to 94% using the chiral ligand (−)-sparteine as an additive. Results of reactions performed under various conditions suggest that a dynamic kinet... Read More about Asymmetric synthesis of diarylmethane derivatives by dynamic kinetic resolution.

Caveolae and signalling in cancer (2015)
Journal Article
Martinez-Outschoorn, U., Sotgia, F., & Lisanti, M. (2015). Caveolae and signalling in cancer. Nature Reviews Cancer, 15(4), 225-37. https://doi.org/10.1038/nrc3915

It has been over 20 years since the discovery that caveolar lipid rafts function as signalling organelles. Lipid rafts create plasma membrane heterogeneity, and caveolae are the most extensively studied subset of lipid rafts. A newly emerging paradig... Read More about Caveolae and signalling in cancer.

Infection by Toxoplasma gondii, a severe parasite in neonates and AIDS patients, causes impaired anion secretion in airway epithelia (2015)
Journal Article
Guo, H., Gao, J., Luo, Y., Wen, Y., Zhang, Y., Hide, G., …Lun, Z. (2015). Infection by Toxoplasma gondii, a severe parasite in neonates and AIDS patients, causes impaired anion secretion in airway epithelia. Proceedings of the National Academy of Sciences, 112(14), 4435-40. https://doi.org/10.1073/pnas.1503474112

The airway epithelia initiate and modulate the inflammatory responses to various pathogens. The cystic fibrosis transmembrane conductance regulator-mediated Cl(-) secretion system plays a key role in mucociliary clearance of inhaled pathogens. We hav... Read More about Infection by Toxoplasma gondii, a severe parasite in neonates and AIDS patients, causes impaired anion secretion in airway epithelia.

Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types : treating cancer like an infectious disease (2015)
Journal Article
Lamb, R., Ozsvari, B., Lisanti, C., Tanowitz, H., Howell, A., Martinez-Outschoorn, U., …Lisanti, M. (2015). Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types : treating cancer like an infectious disease. Oncotarget, 6(7), 4569-84. https://doi.org/10.18632/oncotarget.3174

Here, we propose a new strategy for the treatment of early cancerous lesions and advanced metastatic disease, via the selective targeting of cancer stem cells (CSCs), a.k.a., tumor-initiating cells (TICs). We searched for a global phenotypic characte... Read More about Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types : treating cancer like an infectious disease.

Reversible redox modulation of a lanthanide emissive molecular film (2015)
Journal Article
Lehr, J., Tropiano, M., Beer, P., Faulkner, S., & Davis, J. (2015). Reversible redox modulation of a lanthanide emissive molecular film. Chemical Communications, 51(30), 6515-6517. https://doi.org/10.1039/c5cc01097g

Herein we demonstrate redox switchable emission from a sensitised, europium–ferrocene containing, molecular film assembled by a novel nitrene-based strategy. Electrochemical modulation of europium emission upon switching the ferrocene moiety's redox... Read More about Reversible redox modulation of a lanthanide emissive molecular film.

Antimicrobial peptide FF/CAP18 induces apoptotic cell death in HCT116 colon cancer cells via changes in the metabolic profile (2015)
Journal Article
Kuroda, K., Fukuda, T., Isogai, H., Okumura K, K., Krstic-Demonacos, M., & Isogai, E. (2015). Antimicrobial peptide FF/CAP18 induces apoptotic cell death in HCT116 colon cancer cells via changes in the metabolic profile. International Journal of Oncology, 46(4), 1516-1526. https://doi.org/10.3892/ijo.2015.2887

Metabolic reprogramming is one of the hallmarks of cancer and can be targeted by therapeutic agents. We previously reported that cathelicidin-related or modified antimicrobial peptides, such as FF/CAP18, have antiproliferative effects on the squamous... Read More about Antimicrobial peptide FF/CAP18 induces apoptotic cell death in HCT116 colon cancer cells via changes in the metabolic profile.

A series of flexible design adaptations to the Nikon E-C1 and E-C2 confocal microscope systems for UV, multiphoton and FLIM imaging (2015)
Journal Article
Botchway, S., Scherer, K., Hook, S., Stubbs, C., Weston, E., Bisby, R., & Parker, A. (2015). A series of flexible design adaptations to the Nikon E-C1 and E-C2 confocal microscope systems for UV, multiphoton and FLIM imaging. Journal of Microscopy, 258(1), 68-78. https://doi.org/10.1111/jmi.12218

Multiphoton microscopy in combination with Fluorescence Lifetime Imaging Microscopy (FLIM) is now a key technique in biomedical and life-science research for live cell and whole animal imaging providing several advantages over the one photon confocal... Read More about A series of flexible design adaptations to the Nikon E-C1 and E-C2 confocal microscope systems for UV, multiphoton and FLIM imaging.

Independent evaluation of a canine Echinococcosis control programme in Hobukesar County, Xinjiang, China (2015)
Journal Article
van Kesteren, F., Qi, X., Tao, J., Feng, X., Mastin, A., Craig, P., …Wen, H. (2015). Independent evaluation of a canine Echinococcosis control programme in Hobukesar County, Xinjiang, China. Acta tropica, 145, 1-7. https://doi.org/10.1016/j.actatropica.2015.01.009

The Xinjiang Uyghur Autonomous Region in northwest China is one of the world's most important foci for cystic echinococcosis. Domestic dogs are the main source for human infection, and previous studies in Xinjiang have found a canine Echinococcus spp... Read More about Independent evaluation of a canine Echinococcosis control programme in Hobukesar County, Xinjiang, China.

Development of novel heterocyclic compounds as vascular targeting agents (2015)
Thesis
Killoran, P. Development of novel heterocyclic compounds as vascular targeting agents. (Thesis)

In chapter one the biology of cancer is introduced along with a brief history of drug treatment and the status quo of cancer therapeutics. This includes a general overview of cancer prevalence, carcinogenesis, and biochemistry. The main targets for c... Read More about Development of novel heterocyclic compounds as vascular targeting agents.

Current challenges in volatile organic compounds analysis as potential biomarkers of cancer (2015)
Journal Article
Schmidt, K., & Podmore, I. (2015). Current challenges in volatile organic compounds analysis as potential biomarkers of cancer. Journal of Biomarkers (Online), 2015(981458), https://doi.org/10.1155/2015/981458

An early diagnosis and appropriate treatment are crucial in reducing mortality among people suffering from cancer. There is a lack of characteristic early clinical symptoms in most forms of cancer, which highlights the importance of investigating new... Read More about Current challenges in volatile organic compounds analysis as potential biomarkers of cancer.

Post-encystment/established immunity in cystic echinococcosis : is it really that simple? (2015)
Journal Article
Rogan, M., Bodell, A., & Craig, P. (2015). Post-encystment/established immunity in cystic echinococcosis : is it really that simple?. Parasite Immunology, 37(1), 1-9. https://doi.org/10.1111/pim.12149

In 1982, Rickard & Williams stated that immunity to larval taeniid cestodes could be divided into two different phases: the establishment phase, operating against oncospheres, and the established phase, operating against established metacestodes in t... Read More about Post-encystment/established immunity in cystic echinococcosis : is it really that simple?.

Investigation of infectivity of neonates and adults from different rat strains to toxoplasma gondii prugniaud shows both variation which correlates with iNOS and Arginase-1 activity and increased susceptibility of neonates to infection (2014)
Journal Article
Gao, J., Yi, S., Wu, M., Geng, G., Shen, J., Lu, F., …Lun, Z. (2015). Investigation of infectivity of neonates and adults from different rat strains to toxoplasma gondii prugniaud shows both variation which correlates with iNOS and Arginase-1 activity and increased susceptibility of neonates to infection. Experimental Parasitology, 149, 47-53. https://doi.org/10.1016/j.exppara.2014.12.008

Mouse models differ considerably fromhumans with regard to clinical symptoms of toxoplasmosis caused by Toxoplasma gondii and, by comparison, the rat model is more representative of this disease in humans. In the present study, we found that differ... Read More about Investigation of infectivity of neonates and adults from different rat strains to toxoplasma gondii prugniaud shows both variation which correlates with iNOS and Arginase-1 activity and increased susceptibility of neonates to infection.

Graphene oxide interfaces in serum based autoantibody quantification (2014)
Journal Article
Xu, Q., Cheng, H., Lehr, J., Patil, A., & Davis, J. (2015). Graphene oxide interfaces in serum based autoantibody quantification. Analytical Chemistry, 87(1), 346-350. https://doi.org/10.1021/ac503890e

A reliable quantification of protein markers will undoubtedly underpin profound developments in disease surveillance, diagnostics, and improved therapy. Although there potentially exist numerous means of achieving this, electrochemical impedimetric t... Read More about Graphene oxide interfaces in serum based autoantibody quantification.

Revealing DNA interactions with exogenous agents by surface-enhanced raman scattering (2014)
Journal Article
Masetti, M., Xie, H., Krpetic, Z., Recanatini, M., Alvarez-Puebla, R., & Guerrini, L. (2015). Revealing DNA interactions with exogenous agents by surface-enhanced raman scattering. Abstracts of papers / American Chemical Society, 137(1), 469-476. https://doi.org/10.1021/ja511398w

The standard protocols for DNA analysis largely involve polymerase chain reaction (PCR). However, DNA structures bound to chemical agents cannot be PCR-amplified, and therefore any sequence changes induced by external agents may be neglected. Thus, t... Read More about Revealing DNA interactions with exogenous agents by surface-enhanced raman scattering.

Antimicrobial susceptibility patterns of Methicillin-resistant staphylococcus aureus isolates collected from healthcare and community facilities in Libya show a high level of resistance to fusidic acid (2014)
Journal Article
Warag, S., Foster, H., & Daw, M. (2014). Antimicrobial susceptibility patterns of Methicillin-resistant staphylococcus aureus isolates collected from healthcare and community facilities in Libya show a high level of resistance to fusidic acid. Journal of infectious disease and therapy, 2(189), https://doi.org/10.4172/2332-0877.1000189

Staphylococcus aureus is an important human pathogen and is implicated in a wide variety of infections in the healthcare and community settings. The organism is often subcategorized as community-associated MRSA (CA-MRSA) or health care-associated MRS... Read More about Antimicrobial susceptibility patterns of Methicillin-resistant staphylococcus aureus isolates collected from healthcare and community facilities in Libya show a high level of resistance to fusidic acid.