Prevalence of Toxoplasma gondii in localized populations of Apodemus sylvaticus is linked to population genotype not to population location (2014)
Journal Article
Bajnok, J., Boyce, K., Rogan, M., Craig, P., Lun, Z., & Hide, G. (2015). Prevalence of Toxoplasma gondii in localized populations of Apodemus sylvaticus is linked to population genotype not to population location. Parasitology, 142(5), 680-690. https://doi.org/10.1017/S0031182014001760

Toxoplasma gondii is a globally distributed parasite infecting humans and warm-blooded animals. Although many surveys have been conducted for T. gondii infection in mammals, little is known about the detailed distribution in localized natural populat... Read More about Prevalence of Toxoplasma gondii in localized populations of Apodemus sylvaticus is linked to population genotype not to population location.

Thermodynamics of the self-assembly of non-ionic chromonic molecules using atomistic simulations. The case of TP6EO2M in aqueous solution (2014)
Journal Article
The case of TP6EO2M in aqueous solution. Soft Matter, 11(4), 680-691. https://doi.org/10.1039/c4sm02275k

Atomistic molecular dynamic simulations have been performed for the non-ionic chromonic liquid crystal 2,3,6,7,10,11-hexa-(1,4,7-trioxa-octyl)-triphenylene (TP6EO2M) in aqueous solution. TP6EO2M molecules consist of a central poly-aromatic core (a tr... Read More about Thermodynamics of the self-assembly of non-ionic chromonic molecules using atomistic simulations. The case of TP6EO2M in aqueous solution.

Perturbed atrial calcium handling in an ovine model of heart failure : potential roles for reductions in the L-type calcium current (2014)
Journal Article
Clarke, J., Caldwell, J., Horn, M., Bode, E., Richards, M., Hall, M., …Trafford, A. (2015). Perturbed atrial calcium handling in an ovine model of heart failure : potential roles for reductions in the L-type calcium current. Journal of Molecular and Cellular Cardiology, 79, 169-179. https://doi.org/10.1016/j.yjmcc.2014.11.017

Heart failure (HF) is commonly associated with reduced cardiac output and an increased risk of atrial arrhythmias particularly during β-adrenergic stimulation. The aim of the present study was to determine how HF alters systolic Ca(2+) and the respon... Read More about Perturbed atrial calcium handling in an ovine model of heart failure : potential roles for reductions in the L-type calcium current.

Direct surface-enhanced raman scattering analysis of DNA duplexes (2014)
Journal Article
Guerrini, L., Krpetic, Z., Van Lierop, D., Alvarez-Puebla, R., & Graham, D. (2014). Direct surface-enhanced raman scattering analysis of DNA duplexes. Angewandte Chemie International Edition, 54(4), 1144-1148. https://doi.org/10.1002/anie.201408558

The exploration of the genetic information carried by DNA has become a major scientific challenge. Routine DNA analysis, such as PCR, still suffers from important intrinsic limitations. Surface-enhanced Raman spectroscopy (SERS) has emerged as an out... Read More about Direct surface-enhanced raman scattering analysis of DNA duplexes.

Anticancer phototherapy using activation of E-combretastatins by two-photon–induced isomerization (2014)
Journal Article
Hadfield, J., Bisby, R., Scherer, K., Botchway, S., & Parker, A. (2014). Anticancer phototherapy using activation of E-combretastatins by two-photon–induced isomerization. Journal of Biomedical Optics, 20(5), 1004-1. https://doi.org/10.1117/1.JBO.20.5.051004

The photoisomerization of relatively nontoxic E-combretastatins to clinically active Z-isomers is shown to occur in solution through both one- and two-photon excitations at 340 and 625 nm, respectively. The photoisomerization is also demonstrated t... Read More about Anticancer phototherapy using activation of E-combretastatins by two-photon–induced isomerization.

Ultrafast vibrational spectroscopic Studies on the photoionization of the α-Tocopherol analogue Trolox C (2014)
Journal Article
Parker, A., Bisby, R., Greetham, G., Kukura, P., Scherer, K., & Towrie, M. (2014). Ultrafast vibrational spectroscopic Studies on the photoionization of the α-Tocopherol analogue Trolox C. Journal of Physical Chemistry B, 118(42), 12087-12097. https://doi.org/10.1021/jp505113k

The initial events after photoexcitation and photoionization of α-tocopherol (vitamin E) and the analogue Trolox C have been studied by femtosecond stimulated Raman spectroscopy, transient absorption spectroscopy and time-resolved infrared spectrosco... Read More about Ultrafast vibrational spectroscopic Studies on the photoionization of the α-Tocopherol analogue Trolox C.

Aspergillus fumigatus proteases, Asp f 5 and Asp f 13, are essential for airway inflammation and remodelling in a murine inhalation model (2014)
Journal Article
Namvar, S., Warn, P., Farnell, E., Bromley, M., Fraczek, M., Bowyer, P., & Herrick, S. (2015). Aspergillus fumigatus proteases, Asp f 5 and Asp f 13, are essential for airway inflammation and remodelling in a murine inhalation model. Clinical and Experimental Allergy, 45(5), 982-993. https://doi.org/10.1111/cea.12426

BACKGROUND: In susceptible individuals, exposure to Aspergillus fumigatus can lead to the development of atopic lung diseases such as allergic bronchopulmonary aspergillosis (ABPA) and severe asthma with fungal sensitization (SAFS). Protease allergen... Read More about Aspergillus fumigatus proteases, Asp f 5 and Asp f 13, are essential for airway inflammation and remodelling in a murine inhalation model.

Pluripotent stem cell miRNAs and metastasis in invasive breast cancer (2014)
Journal Article
Volinia, S., Nuovo, G., Drusco, A., Costinean, S., Abujarour, R., Desponts, C., …Croce, C. (2014). Pluripotent stem cell miRNAs and metastasis in invasive breast cancer. JNCI: Journal of the National Cancer Institute, 106(12), https://doi.org/10.1093/jnci/dju324

Background The purpose of this study is to determine whether microRNA for pluripotent stem cells are also expressed in breast cancer and are associated with metastasis and outcome. Methods We studied global microRNA profiles during differentiati... Read More about Pluripotent stem cell miRNAs and metastasis in invasive breast cancer.

Longstanding complex regional pain syndrome is associated with activating autoantibodies against alpha-1a adrenoceptors (2014)
Journal Article
Dubuis, E., Thompson, V., Leite, M., Blaes, F., Maihöfner, C., Greensmith, D., …Goebel, A. (2014). Longstanding complex regional pain syndrome is associated with activating autoantibodies against alpha-1a adrenoceptors. PAIN, 155(11), 2408-2417. https://doi.org/10.1016/j.pain.2014.09.022

Complex regional pain syndrome (CRPS) is a limb-confined posttraumatic pain syndrome with sympathetic features. The cause is unknown, but the results of a randomized crossover trial on low-dose intravenous immunoglobulins (IVIG) treatment point to a... Read More about Longstanding complex regional pain syndrome is associated with activating autoantibodies against alpha-1a adrenoceptors.

Network analysis reveals that bacteria and fungi form modules that correlate independently with soil parameters (2014)
Journal Article
soil parameters. Environmental Microbiology, 17(8), 2677-2689. https://doi.org/10.1111/1462-2920.12559

Network and multivariate statistical analyses were performed to determine interactions between bacterial and fungal community terminal restriction length polymorphisms as well as soil properties in paired woodland and pasture sites. Canonical cor... Read More about Network analysis reveals that bacteria and fungi form modules that correlate independently with soil parameters.

Spectroscopy and fluorescence lifetime imaging in live cells of a cyano-substituted combretastatin (2014)
Journal Article
combretastatin. Biomedical Spectroscopy and Imaging, 3, 211-218. https://doi.org/10.3233/BSI-140067

Fluorescence lifetime imaging has been used to observe the real-time uptake in live mammalian cells of a combretastatin-type drug analogue that is a substituted stilbene with a cyano group at the bridging olefinic bond. Fluorescence spectra in a ran... Read More about Spectroscopy and fluorescence lifetime imaging in live cells of a cyano-substituted combretastatin.

Metabolic asymmetry in cancer : a “balancing act” that promotes tumor growth (2014)
Journal Article
Martinez-Outschoorn, U., Sotgia, F., & Lisanti, M. (2014). Metabolic asymmetry in cancer : a “balancing act” that promotes tumor growth. Cancer Cell, 26(1), 5-7. https://doi.org/10.1016/j.ccr.2014.06.021

Profound metabolic differences between cancer cells and fibroblasts promote tumorigenesis. A study by Valencia and colleagues in this issue of Cancer Cell supports this assertion. They observed that metabolic asymmetry in prostate tumors drives aggre... Read More about Metabolic asymmetry in cancer : a “balancing act” that promotes tumor growth.

The effects of 2',5'-di(tert-butyl)-1,4-benzohydroquinone (TBQ) on calcium handling in rat ventricular myocytes (2014)
Journal Article
Greensmith, D., Miller, L., & Eisner, D. (2014). The effects of 2',5'-di(tert-butyl)-1,4-benzohydroquinone (TBQ) on calcium handling in rat ventricular myocytes. Proceedings of the Physiological Society (Online), 31, PCA042

2',5'-di(tert-butyl)-1,4-benzohydroquinone (TBQ) is a reversible inhibitor of SERCA, potentially making it a useful tool to study the effects of SERCA inhibition. It has been used in a variety of cell types including ventricular myocytes (1). However... Read More about The effects of 2',5'-di(tert-butyl)-1,4-benzohydroquinone (TBQ) on calcium handling in rat ventricular myocytes.

Direct measurements of SR free Ca reveal the mechanism underlying the transient effects of RyR potentiation under physiological conditions (2014)
Journal Article
Greensmith, D., Galli, G., Trafford, A., & Eisner, D. (2014). Direct measurements of SR free Ca reveal the mechanism underlying the transient effects of RyR potentiation under physiological conditions. Cardiovascular Research, 103(4), 554-563. https://doi.org/10.1093/cvr/cvu158

AIMS: Most of the calcium that activates contraction is released from the sarcoplasmic reticulum (SR) through the ryanodine receptor (RyR). It is controversial whether activators of the RyR produce a maintained increase in the amplitude of the systol... Read More about Direct measurements of SR free Ca reveal the mechanism underlying the transient effects of RyR potentiation under physiological conditions.

MicroRNA profiles discriminate among colon cancer metastasis (2014)
Journal Article
Drusco, A., Nuovo, G., Zanesi, N., Di Leva, G., Pichiorri, F., Volinia, S., …Croce, C. (2014). MicroRNA profiles discriminate among colon cancer metastasis. PLoS ONE, 9(6), e96670. https://doi.org/10.1371/journal.pone.0096670

MicroRNAs are being exploited for diagnosis, prognosis and monitoring of cancer and other diseases. Their high tissue specificity and critical role in oncogenesis provide new biomarkers for the diagnosis and classification of cancer as well as predic... Read More about MicroRNA profiles discriminate among colon cancer metastasis.

Understanding digital health as public pedagogy : a critical framework (2014)
Journal Article
Rich, E., & Miah, A. (2014). Understanding digital health as public pedagogy : a critical framework. Societies, 4(2), 296-315. https://doi.org/10.3390/soc4020296

This paper argues on behalf of a public pedagogy approach to developing a critical understanding of digital health technologies. It begins by appraising the hitherto polarised articulations of digital innovation as either techno-utopian or techno-dys... Read More about Understanding digital health as public pedagogy : a critical framework.

Naturally occurring Toll-like receptor 11 (TLR11) and Toll-like receptor 12 (TLR12) polymorphisms are not associated with Toxoplasma gondii infection in wild wood mice (2014)
Journal Article
Morger, J., Bajnok, J., Boyce, K., Craig, P., Rogan, M., Lun, Z., …Tschirren, B. (2014). Naturally occurring Toll-like receptor 11 (TLR11) and Toll-like receptor 12 (TLR12) polymorphisms are not associated with Toxoplasma gondii infection in wild wood mice. Infection, Genetics and Evolution, 26, 180-184. https://doi.org/10.1016/j.meegid.2014.05.032

Toxoplasma gondii is a highly successful parasite with a worldwide prevalence. Small rodents are the main intermediate hosts, and there is growing evidence that T. gondii modifies their behaviour. Chronically infected rodents show impaired learning... Read More about Naturally occurring Toll-like receptor 11 (TLR11) and Toll-like receptor 12 (TLR12) polymorphisms are not associated with Toxoplasma gondii infection in wild wood mice.

Evaluation of genetic association of the INK4 locus with primary open angle glaucoma in East Indian population (2014)
Journal Article
angle glaucoma in East Indian population. Scientific reports, 4, 5115. https://doi.org/10.1038/srep05115

INK4 locus at chromosome 9p21 has been reported to be associated with primary open angle glaucoma (POAG) and its subtypes along with the associated optic disc parameters across the populations of European, Japanese and African ancestries. The locus e... Read More about Evaluation of genetic association of the INK4 locus with primary open angle glaucoma in East Indian population.

Interactions of gold nanoparticles with a phospholipid monolayer membrane on mercury (2014)
Journal Article
Gordillo, G., Krpetic, Z., & Brust, M. (2014). Interactions of gold nanoparticles with a phospholipid monolayer membrane on mercury. ACS nano, 8(6), 6074-6080. https://doi.org/10.1021/nn501395e

It is demonstrated that a compact monolayer of 1,2-dioleoyl-sn-glycero-3-phosphocholine adsorbed to a hanging mercury drop electrode can serve as a simple electrochemical model system to study biomembrane penetration by gold nanoparticles. The hydrog... Read More about Interactions of gold nanoparticles with a phospholipid monolayer membrane on mercury.

Mechanisms of adiponectin-associated perivascular function in vascular disease (2014)
Journal Article
Withers, S., Bussey, C., Saxton, S., Melrose, H., Watkins, A., & Heagerty, A. (2014). Mechanisms of adiponectin-associated perivascular function in vascular disease. Arteriosclerosis, Thrombosis, and Vascular Biology, 34(8), 1637-42. https://doi.org/10.1161/ATVBAHA.114.303031

The concept that fat cells could influence the circulation and indeed cardiac function has been in existence for ≥20 years and has gained a wide interest and no less excitement as evidence has accrued to suggest that such effects may be profound enou... Read More about Mechanisms of adiponectin-associated perivascular function in vascular disease.