All Outputs (113)

Cancer in the parasitic protozoans Trypanosoma brucei and Toxoplasma gondii (2015)
Journal Article
Lun, Z., Lai, D., Wen, Y., Zheng, L., Shen, J., Yang, T., …Ayala, F. (2015). Cancer in the parasitic protozoans Trypanosoma brucei and Toxoplasma gondii. Proceedings of the National Academy of Sciences of the United States of America, 112(29), 8835-8842. https://doi.org/10.1073/pnas.1502599112

Cancer is a general name for more than 100 malignant diseases. It is postulated that all cancers start from a single abnormal cell that grows out of control. Untreated cancers can cause serious consequences and deaths. Great progress has been made in... Read More about Cancer in the parasitic protozoans Trypanosoma brucei and Toxoplasma gondii.

Book review : Parasitism. The diversity and ecology of animal parasites, 2nd edn. By Timothy M. Goater,Cameron P. Goater and Gerald W. Esch,editors, p. 497. Cambridge University Press, UK, 2014. (2015)
Journal Article
Hide, G. (2015). Book review : Parasitism. The diversity and ecology of animal parasites, 2nd edn. By Timothy M. Goater,Cameron P. Goater and Gerald W. Esch,editors, p. 497. Cambridge University Press, UK, 2014. Parasitology, 142(10), 1348-1349. https://doi.org/10.1017/S0031182015000645

Infection by Toxoplasma gondii, a severe parasite in neonates and AIDS patients, causes impaired anion secretion in airway epithelia (2015)
Journal Article
Guo, H., Gao, J., Luo, Y., Wen, Y., Zhang, Y., Hide, G., …Lun, Z. (2015). Infection by Toxoplasma gondii, a severe parasite in neonates and AIDS patients, causes impaired anion secretion in airway epithelia. Proceedings of the National Academy of Sciences, 112(14), 4435-40. https://doi.org/10.1073/pnas.1503474112

The airway epithelia initiate and modulate the inflammatory responses to various pathogens. The cystic fibrosis transmembrane conductance regulator-mediated Cl(-) secretion system plays a key role in mucociliary clearance of inhaled pathogens. We hav... Read More about Infection by Toxoplasma gondii, a severe parasite in neonates and AIDS patients, causes impaired anion secretion in airway epithelia.

Investigation of infectivity of neonates and adults from different rat strains to toxoplasma gondii prugniaud shows both variation which correlates with iNOS and Arginase-1 activity and increased susceptibility of neonates to infection (2014)
Journal Article
Gao, J., Yi, S., Wu, M., Geng, G., Shen, J., Lu, F., …Lun, Z. (2015). Investigation of infectivity of neonates and adults from different rat strains to toxoplasma gondii prugniaud shows both variation which correlates with iNOS and Arginase-1 activity and increased susceptibility of neonates to infection. Experimental Parasitology, 149, 47-53. https://doi.org/10.1016/j.exppara.2014.12.008

Mouse models differ considerably fromhumans with regard to clinical symptoms of toxoplasmosis caused
by Toxoplasma gondii and, by comparison, the rat model is more representative of this disease in humans.
In the present study, we found that differ... Read More about Investigation of infectivity of neonates and adults from different rat strains to toxoplasma gondii prugniaud shows both variation which correlates with iNOS and Arginase-1 activity and increased susceptibility of neonates to infection.

Prevalence of Toxoplasma gondii in localized populations of Apodemus sylvaticus is linked to population genotype not to population location (2014)
Journal Article
Bajnok, J., Boyce, K., Rogan, M., Craig, P., Lun, Z., & Hide, G. (2015). Prevalence of Toxoplasma gondii in localized populations of Apodemus sylvaticus is linked to population genotype not to population location. Parasitology, 142(5), 680-690. https://doi.org/10.1017/S0031182014001760

Toxoplasma gondii is a globally distributed parasite infecting humans and warm-blooded animals. Although many surveys have been conducted for T. gondii infection in mammals, little is known about the detailed distribution in localized natural populat... Read More about Prevalence of Toxoplasma gondii in localized populations of Apodemus sylvaticus is linked to population genotype not to population location.

Naturally occurring Toll-like receptor 11 (TLR11) and Toll-like receptor 12 (TLR12) polymorphisms are not associated with Toxoplasma gondii infection in wild wood mice (2014)
Journal Article
Morger, J., Bajnok, J., Boyce, K., Craig, P., Rogan, M., Lun, Z., …Tschirren, B. (2014). Naturally occurring Toll-like receptor 11 (TLR11) and Toll-like receptor 12 (TLR12) polymorphisms are not associated with Toxoplasma gondii infection in wild wood mice. Infection, Genetics and Evolution, 26, 180-184

Toxoplasma gondii is a highly successful parasite with a worldwide prevalence. Small rodents are the main intermediate hosts, and there is growing evidence that T. gondii modifies their behaviour. Chronically infected rodents show impaired learning c... Read More about Naturally occurring Toll-like receptor 11 (TLR11) and Toll-like receptor 12 (TLR12) polymorphisms are not associated with Toxoplasma gondii infection in wild wood mice.

Naturally occurring Toll-like receptor 11 (TLR11) and Toll-like receptor 12 (TLR12) polymorphisms are not associated with Toxoplasma gondii infection in wild wood mice (2014)
Journal Article
Morger, J., Bajnok, J., Boyce, K., Craig, P., Rogan, M., Lun, Z., …Tschirren, B. (2014). Naturally occurring Toll-like receptor 11 (TLR11) and Toll-like receptor 12 (TLR12) polymorphisms are not associated with Toxoplasma gondii infection in wild wood mice. Infection, Genetics and Evolution, 26, 180-184. https://doi.org/10.1016/j.meegid.2014.05.032

Toxoplasma gondii is a highly successful parasite with a worldwide prevalence. Small rodents are the main
intermediate hosts, and there is growing evidence that T. gondii modifies their behaviour. Chronically
infected rodents show impaired learning... Read More about Naturally occurring Toll-like receptor 11 (TLR11) and Toll-like receptor 12 (TLR12) polymorphisms are not associated with Toxoplasma gondii infection in wild wood mice.

Toxoplasma gondii: Prevalence in species and genotypes of British bats (Pipistrellus pipistrellus and P. pygmaeus) (2014)
Journal Article
Dodd, N. S., Lord, J. S., Jehle, R., Parker, S., Parker, F., Brooks, D. R., & Hide, G. (2014). Toxoplasma gondii: Prevalence in species and genotypes of British bats (Pipistrellus pipistrellus and P. pygmaeus). Experimental Parasitology, 139, 6-11. https://doi.org/10.1016/j.exppara.2014.02.007

Few studies have investigated Toxoplasma gondii infections in bat populations and none have reported its
presence in protected British bat species. Using a collection of dead/euthanased bats collected from Lancashire,
UK, two species of bats (Pipis... Read More about Toxoplasma gondii: Prevalence in species and genotypes of British bats (Pipistrellus pipistrellus and P. pygmaeus).

Toxoplasma gondii : prevalence in species and genotypes of British bats (Pipistrellus pipistrellus and P. pygmaeus) (2014)
Journal Article
Dodd, N., Lord, J., Jehle, R., Parker, S., Parker, F., Brooks, D., & Hide, G. (2014). Toxoplasma gondii : prevalence in species and genotypes of British bats (Pipistrellus pipistrellus and P. pygmaeus). Experimental Parasitology, 139, 6-11. https://doi.org/10.1016/j.exppara.2014.02.007

Few studies have investigated Toxoplasma gondii infections in bat populations and none have reported its
presence in protected British bat species. Using a collection of dead/euthanased bats collected from Lancashire,
UK, two species of bats (Pipis... Read More about Toxoplasma gondii : prevalence in species and genotypes of British bats (Pipistrellus pipistrellus and P. pygmaeus).

Toxoplasma gondii infection in the peritoneal macrophages of rats treated with glucocorticoids (2013)
Journal Article
Wang, T., Gao, J., Yi, S., Geng, G., Gao, X., Shen, J., …Lun, Z. (2014). Toxoplasma gondii infection in the peritoneal macrophages of rats treated with glucocorticoids. Parasitology Research, 113(1), 351-358. https://doi.org/10.1007/s00436-013-3661-3

It is well known that toxoplasmosis can be life
threatening to immunocompromised individuals such as
AIDS and organ transplantation patients. Glucocorticoids
(GCs) are widely used in the clinic for the treatment of
autoimmune diseases and organ t... Read More about Toxoplasma gondii infection in the peritoneal macrophages of rats treated with glucocorticoids.

Development and evaluation of loop-mediated isothermal amplification (LAMP) for rapid detection of Clonorchis sinensis from its first intermediate hosts, freshwater snails. (2013)
Journal Article
Y, C., T, W., DH, L., YZ, W., ZD, W., TB, Y., …ZR, L. (2013). Development and evaluation of loop-mediated isothermal amplification (LAMP) for rapid detection of Clonorchis sinensis from its first intermediate hosts, freshwater snails. Parasitology, 140(11), https://doi.org/10.1017/S0031182013000498

Clonorchiasis, caused by Clonorchis sinensis, is a key foodborne zoonosis, which is mainly found in China, Korea and Vietnam. Detection of this parasite from the second intermediate host, the freshwater fish is the common method for epidemiological s... Read More about Development and evaluation of loop-mediated isothermal amplification (LAMP) for rapid detection of Clonorchis sinensis from its first intermediate hosts, freshwater snails..

Lower expression of inducible nitric oxide synthase and higher expression of arginase in rat alveolar macrophages are linked to their susceptibility to Toxoplasma gondii infection. (2013)
Journal Article
ZJ, Z., J, Z., J, W., Z, L., T, W., SQ, Y., …ZR, L. (2013). Lower expression of inducible nitric oxide synthase and higher expression of arginase in rat alveolar macrophages are linked to their susceptibility to Toxoplasma gondii infection. PLoS ONE, https://doi.org/10.1371/journal.pone.0063650

Rats are naturally resistant to Toxoplasma gondii infection, particularly the RH strain, while mice are not. Previous studies have demonstrated that inducible nitric oxide synthase (iNOS) and arginase-1 of rodent peritoneal macrophages are linked to... Read More about Lower expression of inducible nitric oxide synthase and higher expression of arginase in rat alveolar macrophages are linked to their susceptibility to Toxoplasma gondii infection..

A molecular and ecological analysis of the trematode plagiorchis elegans in the wood mouse apodemus sylvaticus from a periaquatic ecosystem in the UK (2013)
Journal Article
Boyce, K., Hide, G., Craig, P., Reynolds, C., Hussain, M., Bodell, A., …Rogan, M. (2013). A molecular and ecological analysis of the trematode plagiorchis elegans in the wood mouse apodemus sylvaticus from a periaquatic ecosystem in the UK. Journal of Helminthology, 88(03), 310-320. https://doi.org/10.1017/S0022149X13000199

The prevalence of the digenean Plagiorchis sp. was investigated in a natural
wood mouse population (Apodemus sylvaticus) in a periaquatic environment.
Classical identification was complemented with the use of molecular
differentiation to determine... Read More about A molecular and ecological analysis of the trematode plagiorchis elegans in the wood mouse apodemus sylvaticus from a periaquatic ecosystem in the UK.

Human parasitology - book review (2013)
Journal Article
Hide, G. (2013). Human parasitology - book review. British Journal of Biomedical Science, 70(4), 184-184

Identification of a new species of digenean Notocotylus malhamensis n. sp. (Digenea: Notocotylidae) from the bank vole (Myodes glareolus) and the field vole (Microtus agrestis) (2012)
Journal Article
vole (Myodes glareolus) and the field vole (Microtus agrestis). Parasitology, 139(12), 1630-1639. https://doi.org/10.1017/S0031182012000911

Notocotylus malhamensis n. sp. is described from the caecum of the bank vole (Myodes glareolus) and the field vole (Microtus
agrestis) from Malham Tarn Nature Reserve in North Yorkshire, UK. In total, 581 specimens were collected from rodents
trapp... Read More about Identification of a new species of digenean Notocotylus malhamensis n. sp. (Digenea: Notocotylidae) from the bank vole (Myodes glareolus) and the field vole (Microtus agrestis).

Detection of Trypanosoma lewisi from wild rats in Southern China and its genetic diversity based on the ITS1 and ITS2 sequences (2012)
Journal Article
Tang, H., Lan, Y., Wen, Y., Zhang, X., Desquesnes, M., Yang, T., …Lun, Z. (2012). Detection of Trypanosoma lewisi from wild rats in Southern China and its genetic diversity based on the ITS1 and ITS2 sequences. Infection, Genetics and Evolution, 12(5), 1046-1051. https://doi.org/10.1016/j.meegid.2012.02.018

Trypanosoma lewisi has widely been considered as a non-pathogenic rat trypanosome. However, more
and more cases of humans infected with T. lewisi have been reported around the world, indicating that
it can infect humans in some undetermined circums... Read More about Detection of Trypanosoma lewisi from wild rats in Southern China and its genetic diversity based on the ITS1 and ITS2 sequences.

Differences in iNOS and arginase expression and activity in the macrophages of rats are responsible for the resistance against T. gondii infection (2012)
Journal Article
Gruner, A., Li, Z., Zhao, Z., Zhu, X., Ren, Q., Nie, F., …Lun, Z. (2012). Differences in iNOS and arginase expression and activity in the macrophages of rats are responsible for the resistance against T. gondii infection. PLoS ONE, 7(4), e35834. https://doi.org/10.1371/journal.pone.0035834

Toxoplasma gondii infects humans and warm blooded animals causing devastating disease worldwide. It has long been a
mystery as to why the peritoneal macrophages of rats are naturally resistant to T. gondii infection while those of mice are
not. Her... Read More about Differences in iNOS and arginase expression and activity in the macrophages of rats are responsible for the resistance against T. gondii infection.

Toxoplasma gondii infection in pregnant women in China. (2011)
Journal Article
XJ, G., ZJ, Z., ZH, H., T, W., TB, Y., XG, C., …ZR, L. (2012). Toxoplasma gondii infection in pregnant women in China. Parasitology, 139(2), https://doi.org/10.1017/S0031182011001880

Toxoplasmosis, caused by the protozoan parasite Toxoplasma gondii, is one of the most common parasitic infections in humans. Primary infection in pregnant women can be transmitted to the fetus leading to miscarriage or congenital toxoplasmosis. Caref... Read More about Toxoplasma gondii infection in pregnant women in China..

Genotyping of Toxoplasma gondii isolates from cats in different geographic regions of China. (2011)
Journal Article
ZW, C., JM, G., XX, H., L, W., L, Y., F, H.-L., …ZR, L. (2011). Genotyping of Toxoplasma gondii isolates from cats in different geographic regions of China. Veterinary Parasitology, 183(1-2), 166-170. https://doi.org/10.1016/j.vetpar.2011.06.013

Fourteen isolates of Toxoplamsa gondii were isolated from cats from 4 different geographic provinces (Anhui, Hubei, Shanxi and Guangdong) in China and their genetic diversity with 8 nuclear loci SAG2, SAG3, BTUB, GRA6, L358, PK1, c22-8, c29-2, and an... Read More about Genotyping of Toxoplasma gondii isolates from cats in different geographic regions of China..

An investigation in congenital transmission of Toxoplasma gondii as a potential mode of transmission in mice and humans (2011)
Thesis
Thomasson, D. An investigation in congenital transmission of Toxoplasma gondii as a potential mode of transmission in mice and humans. (Thesis). Salford : University of Salford

Toxoplasma gondii is a pathogenic Apicomplexan parasite with a worldwide
distribution in almost all warm blooded animals. The parasite is transmitted to hosts in
three ways; via oocysts that are passed from the definitive host the cat; by the... Read More about An investigation in congenital transmission of Toxoplasma gondii as a potential mode of transmission in mice and humans.